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This thesis provides a deep study of the Reach Control Problem (RCP) for affine systems defined on simplices. Necessary conditions for solvability of the problem by open loop control are presented, improving upon the results in the literature which are for continuous state feedback only. So-called reach control indices are introduced and developed which inform on the structural properties of the system which cause continuous state feedbacks to fail. A novel synthesis method is presented consisting of a subdivision algorithm based on these indices and an associated piecewise affine feedback. The method is shown to solve RCP for all cases in the literature where continuous state feedback fails, provided it is solvable by open loop control. Textbook examples of existing synthesis methods for RCP are provided. The motivation for studying RCP and its relevance to complex control specifications is illustrated using a biomedical application.

This thesis provides a deep study of the Reach Control Problem (RCP) for affine systems defined on simplices. Necessary conditions for solvability of the problem by open loop control are presented, improving upon the results in the literature which are for continuous state feedback only. So-called reach control indices are introduced and developed which inform on the structural properties of the system which cause continuous state feedbacks to fail. A novel synthesis method is presented consisting of a subdivision algorithm based on these indices and an associated piecewise affine feedback. The method is shown to solve RCP for all cases in the literature where continuous state feedback fails, provided it is solvable by open loop control. Textbook examples of existing synthesis methods for RCP are provided. The motivation for studying RCP and its relevance to complex control specifications is illustrated using a biomedical application.

Inference of regulatory networks has received attention of researchers from many fields. The challenge offered by this problem is its being a typical modeling problem under insufficient information about the process. Hence, we need to derive the apriori unavailable information from the empirical observations. Modeling by inference consists of selecting or defining the most appropriate model structure and inferring the parameters. An appropriate model structure should have the following properties. The model parameters should be inferable. Given the observation and the model class, all parameters used in the model should have a unique solution restriction of the solution space). The forward model should be accurately computable (restriction of the solution space). The model should be capable of exhibiting the essential qualitative features of the system (limit of the restriction). The model should be relevant with the process (limit of the restriction). A piecewise linear formulation, described by a switching state transition matrix and a switching state transition vector with a Boolean function indicating the switching conditions is proposed for the inference of gene regulatory networks. This thesis mainly concerns using a formulation of switching networks obeying all the above mentioned requirements and developing an inference algorithm for estimating the parameters of the formulation. The methodologies used or developed during this study are applicable to various fields of science and engineering.

Thesis (M.S.)--Duquesne University, 2004. / Title from document title page. Abstract included in electronic submission form. Includes bibliographical references (p. 30).

Made available in DSpace on 2014-06-11T19:26:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-22Bitstream added on 2014-06-13T19:54:22Z : No. of bitstreams: 1 moraes_jr_me_sjrp.pdf: 1163228 bytes, checksum: 853fa9bee4a6a3c25b24de14990f3221 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Consideramos dois casos principais de bifurcação de órbitas periódicas não hiperbólicas que dão origem a ciclos limite. Nosso estudo é feito para sistemas lineares por partes com três zonas em sua fórmula mais geral, que inclui situações sem simetria. Obtemos estimativas tanto para a amplitude como para o período do ciclo limite e apresentamos uma aplicação de interesse em engenharia: sistemas de controle. / We consider two main cases of bifurcation of non hyperbolic periodic orbits that give rise to limit cycles. Our study is done concerning piecewise linear systems with three zones in the more general formula that includes situations without symmetry. We obtain estimates for both the amplitude and the period of limit cycles and we present a applications of interest in engineering: control systems.

Made available in DSpace on 2014-06-11T19:26:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-28Bitstream added on 2014-06-13T19:06:23Z : No. of bitstreams: 1 morettijunior_a_me_sjrp.pdf: 762570 bytes, checksum: 59d4b94fad96e41726548c623175fe4e (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Neste trabalho temos como objetivo estudar o número e a distribuição de ciclos limites em sistemas diferenciais lineares por partes. Em particular estudamos o número de ciclos limites do sistema diferencial linear por partes planar ˙x = −y − ε φ ( x) , ˙y = x, onde ε 6= 0 é um parâmetro pequeno e φ é uma função periódica linear por partes ímpar de período 4 . Provamos que dado um inteiro arbitário positivo n, o sistema acima possui exatamente n ciclos limites na faixa |x| ≤ 2 (n + 1 ). Consequentemente, existem sistemas diferenciais lineares por partes contendo uma infinidade de ciclos limites no plano real. Inicialmente obtemos uma quota inferior par a o número destes ciclos limites na faixa | x| ≤ 2 (n + 1 ) via Teoria do Averaging . Em seguida , utilizando a Teoria de Campos de Vetores Rodados, verificamos que o sistema acima tem exatamente n ciclos limites na faixa | x| ≤ 2 (n + 1 ) / The main goal of this work aim to study the number and distribution of limit cycles in piecewise linear differential systems. In particular we consider the planar piecewise linear differential system ˙x = −y − ε φ ( x) , ˙y = x, where ε 6= 0 is a small parameter and φ is an odd piecewise linear periodic function of period 4 . We prove that given an arbitrary positive integer n, the system above has exactly n limit cycles in the strip | x| ≤ 2 (n + 1 ) . Consequently, there are piecewise differential systems containing an infinite number of limit cycles in the real plane. First we get a lower bound on the number of limit cycles in the strip |x| ≤ 2 (n + 1 ) via Averaging Theory. In the following , using the Theory of Rotated Vector Fields, we see that above system has exactly n limit cycles in the strip | x| ≤ 2 (n + 1 )

abstract: Diabetes is a disease characterized by reduced insulin action and secretion, leading to elevated blood glucose. In the 1990s, studies showed that intravenous injection of fatty acids led to a sharp negative response in insulin action that subsided hours after the injection. The molecule associated with diminished insulin signalling response was a byproduct of fatty acids, diacylglycerol. This dissertation is focused on the formulation of a model built around the known mechanisms of glucose and fatty acid storage and metabolism within myocytes, as well as downstream effects of diacylglycerol on insulin action. Data from euglycemic-hyperinsulinemic clamp with fatty acid infusion studies are used to validate the qualitative behavior of the model and estimate parameters. The model closely matches clinical data and suggests a new metric to determine quantitative measurements of insulin action downregulation. Analysis and numerical simulation of the long term, piecewise smooth system of ordinary differential equations demonstrates a discontinuous bifurcation implicating nutrient excess as a driver of muscular insulin resistance. / Dissertation/Thesis / Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2017

Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-06-28T17:43:40Z No. of bitstreams: 2 Dissertação - Marcos Tsujii - 2015.pdf: 919903 bytes, checksum: e6e6bb36b7e9700b446e1807f1854651 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Cláudia Bueno (claudiamoura18@gmail.com) on 2017-07-07T19:52:00Z (GMT) No. of bitstreams: 2 Dissertação - Marcos Tsujii - 2015.pdf: 919903 bytes, checksum: e6e6bb36b7e9700b446e1807f1854651 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-07-07T19:52:00Z (GMT). No. of bitstreams: 2 Dissertação - Marcos Tsujii - 2015.pdf: 919903 bytes, checksum: e6e6bb36b7e9700b446e1807f1854651 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2015-03-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / In this work, we will study the dynamics in smooth vector elds, in vector elds near the boundary and in piecewise-smooth vector elds and each of their most popular types of bifurcations up to now. / Neste trabalho, estudaremos a dinâmica em campos de vetores suaves, em campos de vetores em variedades com bordo e em campos de vetores suaves por partes e cada um dos seus respectivos tipos de bifurcações mais conhecidos.

京都大学 / 0048 / 新制・課程博士 / 博士(人間・環境学) / 甲第22521号 / 人博第924号 / 新制||人||221(附属図書館) / 2019||人博||924(吉田南総合図書館) / 京都大学大学院人間・環境学研究科共生人間学専攻 / (主査)准教授 木坂 正史, 教授 角 大輝, 教授 足立 匡義 / 学位規則第4条第1項該当 / Doctor of Human and Environmental Studies / Kyoto University / DFAM