The purpose of this study was to examine the influence of a supplement containing polyunsaturated phoshphatidylcholine (PPC) on physical performance, delayed muscle soreness (DOMS), markers of membrane damage, and lipid peroxidation after repeated bouts of whole body resistance on men ages 18-35 years. Subjects were randomly assigned to receive either PPC or placebo supplements for 31 days. After 3 weeks of supplementation, subjects were to perform 3 whole body resistance exercise sessions with 3 days of recovery between sessions. In order to document the effects of supplementation on recovery, fasting blood samples for determination of creatine kinase (CK) and malondialdehyde (MDA), and muscle soreness ratings were obtained each day in the morning after the initial 3 weeks of supplementation. The data was analyzed using a two-way ANOVA. The results indicate notable trends favoring PPC supplementation, such as lower ratings of perceived muscle soreness, lower CK and MDA responses to repeated bouts, improved maintenance of upper body strength and power, and increased lean body mass. However, these findings were not statistically different when compared to the placebo group. / School of Physical Education

Les enchaînements polyéniques linéaires sont des motifs couramment rencontrés dans de nombreuses molécules naturelles. L'accès à ces structures nécessite souvent des réactifs fonctionnalisés dont la synthèse est parfois longue et laborieuse. Nous décrivons dans ce manuscrit une nouvelle méthode efficace et rapide de couplage de Heck entre un iodure vinylique fonctionnalisé par un boronate MIDA et des oléfines variées pour accéder à des boronates MIDA diéniques. Ces briques moléculaires stables ont été valorisées par la formation de polyènes fonctionnalisés.Cette stratégie a été appliquée à la synthèse du système pentaénique de la mirabaline, un macrolide à activité anticancéreuse isolé d'une éponge marine. Ce manuscrit présente la synthèse des différents fragments de la mirabaline impliqués dans une approche synthétique mise au point en collaboration avec l'équipe de Chimie ParisTech. Outre les enchaînements polyéniques, les motifs 1,2-diol, 1,3-diol et 1,3-aminoalcool représentent aussi des structures d’intérêt. Nous avons mis au point une méthode écocompatible de cyclisation d’éthers d’hydroxylamine, d’hydroxylamines et de carbonates linéaires sur des acétates allyliques activés par un acide de Lewis pour accéder de manière diastéréosélective à des isoxazolidines vinyliques ou des carbonates cycliques vinyliques. / Linear polyenic units are ubiquitous motifs in natural products. Accessing these structures often requires bifunctionalized reagents whose syntheses are sometimes long and tough. We describe in this manuscript a new efficient and fast method of Heck coupling between a alkenyl iodide functionalized with a MIDA boronate group and various olefins to access dienic MIDA boronates. Those stable building blocks have been used for the formation of functionalized polyenes. This strategy has been applied to the synthesis of the pentaenic moiety of the mirabalin, a macrolide isolated from a marine sponge exhibiting an anticancer activity. This manuscript presents the syntheses of the different fragments of mirabaline involved in a synthetic approach developed in collaboration with the Chimie ParisTech team. Apart from polyenic moieties, 1,2-diol, 1,3-diol and 1,3-aminoalcohol units also represent interesting structures. We have developed an ecofriendly cyclization of hydroxylamine ethers, hydroxylamines and linear carbonates on allylic acetates activated by a Lewis acid to access diastereoselectively vinylic isoxazolidines or vinylic cyclic carbonates.

Charles University, Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Ondřej Kratochvíl Supervisor: prof. RNDr. Milan Pour, Ph.D. Supervisor - specialist: Mgr. Rastislav Antal Title of Thesis: Reduction of electron-deficient dendralenes by hydride reagents This diploma thesis is focused on the preparation of electron-deficient [3]dendralenes containing electron withdrawing groups such as carbonyl and ester functionalities. The synthesis is based on a palladium-catalyzed Migita-Stille coupling between stannylated diene and iodinated alkene (cycloalkene). Subsequent reaction of these substituted [3]dendralenes with hydride anion leads to a 1,2- or 1,4-addition to the α, β-unsaturated carbonyl group, resulting in the formation of an enolate or alcoholate, which are further transformed to various products depending on the type of the [3]dendralene.

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