Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-01-04T17:34:16Z No. of bitstreams: 1 waldemarschmittjunior.pdf: 968833 bytes, checksum: f2ac3370b1913b126d5a44b681149636 (MD5) / Approved for entry into archive by Diamantino Mayra (mayra.diamantino@ufjf.edu.br) on 2017-01-31T10:33:51Z (GMT) No. of bitstreams: 1 waldemarschmittjunior.pdf: 968833 bytes, checksum: f2ac3370b1913b126d5a44b681149636 (MD5) / Made available in DSpace on 2017-01-31T10:33:51Z (GMT). No. of bitstreams: 1 waldemarschmittjunior.pdf: 968833 bytes, checksum: f2ac3370b1913b126d5a44b681149636 (MD5) Previous issue date: 2016-07-08 / INTRODUCÃO: A ejaculação precoce tem prevalência de 20 a 25% em homens e está associada à baixa libido, depressão, ansiedade e estresse. A acupuntura previne, trata e cura doenças por meio da inserção de agulhas em pontos específicos da pele. A acupuntura já apresenta evidências científicas como uma alternativa para o tratamento da ejaculação precoce. O objetivo do presente estudo é avaliar a eficácia da acupuntura no tratamento da ejaculação precoce em uma série de pacientes. PACIENTES E MÉTODO: Foi realizado um estudo intervencionista prospectivo do tipo série de casos para avaliação da ação da acupuntura na ejaculação precoce. A amostra foi composta por 23 homens, com queixa clínica de ejaculação precoce e Taxa de Latência Ejaculatória Intravaginal (TLEI) menor que quatro minutos. Os pacientes foram submetidos a sessões de acupuntura, duas vezes por semana, durante quatro semanas. Foi avaliada a alteração da TLEI e a satisfação do paciente pelo questionário PATIENT GLOBAL IMPRESSION OF IMPROVEMENT QUESTIONNAIRE. RESULTADOS: Foram avaliados 23 homens com idade média de 41,57 ± 12,33 anos ( extremos de 21 e 73). A TLEI antes da acupuntura foi de 2,13 ± 1,31 min (extremos de 0,40 e 4,55 min) e após a acupuntura aumentou para 4,50 ± 2,89 min (extremos de 0,49 e 12,10 min) (p=0,001). Esta melhora do TLEI também foi acompanhada pela avaliação do questionário de percepção de avaliação global: 95% dos pacientes declararam estar melhor. CONCLUSÃO: O estudo permitiu concluir que a acupuntura no tratamento da Ejaculação Precoce provocou aumento na TLEI dos pacientes em média de cerca de 120 segundos, e 95% de percepção subjetiva de melhora pelos pacientes. / INTRODUCTION: Premature ejaculation is defined as ejaculation that occurs with minimal sexual stimulation before, during or immediately after penetration. Has a prevalence of 20 to 25% in men 18 to 70 years, is associated with low libido, depression, anxiety and estresse.A acupuncture prevents, treats and cures diseases by inserting needles into specific points of the skin. Acupuncture has already scientific evidence and is recognized since 1997 by the American North Consensus Health, as an alternative for the treatment of premature ejaculation, through the energy flow circulation. The aim of this study is to evaluate the effectiveness of acupuncture in treating premature ejaculation in a number of patients. PATIENT AND METHODS: A prospective interventional study case series to evaluate acupuncture action on premature ejaculation was conducted. The sample consisted of 23 men, mean age 41.57 ± 12.33 years (extremes of 21 and 73). to calculate a rate Intravaginal Ejaculatory Latency for six days .. After this analysis IELT, patients underwent acupuncture twice a week for four weeks. Shortly after the sessions, new measurement rate. For comparison compared to pre-treatment values and the questionnaire PATIENT OVERALL IMPRESSION OF IMPROVEMENT QUESTIONNAIRE to assess its percentage of improvement. The values of IELT and questionnaire were described by mean and standard deviation for numeric variables and absolute and relative frequencies for categorical variables. Pre difference and post treatment was carried out by Student's t test. The significance level was set at p <0.05. RESULTS: A total of 23 men with a mean age of 41.57 ± 12.33 years (extremes of 21 and 73). The IELT before acupuncture was 2.13 ± 1.31 min (extremes of 0.40 and 4.55 min). After acupuncture this rate increased to 4.50 ± 2.89 min (extremes of 0.49 and 12.10 minutes). That is, the latency rate Ejaculatory Intravaginal patients increased about 2 minutes, delaying the premature ejaculation framework and statistical difference between pre and post acupuncture with p = 0.001 This improvement in IELT was also accompanied by the assessment by questionnaire perception overall assessment: 95% of patients reported being better. CONCLUSION: The study found that acupuncture in the treatment of premature ejaculation caused an increase in latency rate Intravaginal Ejaculatory patients on average about 2 minutes and 95% of subjective perception of improvement by patients.

Made available in DSpace on 2016-04-04T18:29:36Z (GMT). No. of bitstreams: 1 Tese_Paulo_Martins-1a.pdf: 788651 bytes, checksum: 66edf099572f1af49c83a76318e1c47c (MD5) Previous issue date: 2007-04-18 / The objective of this research is to investigate that consist of the collective imaginary of students about male sex problems, as well as to elucidate the non conscious psychological field, in other words, the emotional logic of agreement according to which they are organized. Therefore, the psychoanalytic method was operated through the Fields Theory, having as groundwork the psychoanalytic theory of Jos? Bleger. The Procedure of Thematic Drawing-and-Telling Stories was used in a collective approach in a classroom of Law students. It could be observed that the sexual problems are predominantly defined as erectile dysfunction and premature ejaculation. The psychoanalytic analysis indicated that the imaginary figure is organized starting from fields linked to the need of reaching a certain pattern of competent behavior (the competent lover), to the difficulties to get a stable relationship (happy ever after) and linked to the sexual vague stances ( will it be that he is? ). Knowing the collective imaginary figure, as well as the psychological-living fields on which it is organized, can enable transformations in the way that different social groups conceive sexual life, setting the human being free of adhesions to restrictive conceptions about sexuality that tend to impoverish the way of living. / A presente pesquisa tem como objetivo investigar o imagin?rio coletivo de universit?rios sobre dificuldades sexuais masculinas, bem como elucidar os campos psicol?gicos n?o conscientes, ou seja, a l?gica emocional de acordo com a qual se organizam. Para tanto, o m?todo psicanal?tico foi operado atrav?s da Teoria dos Campos, em pr?xima interlocu??o com a sistematiza??o epistemol?gica proposta pelo psicanalista Jos? Bleger. O Procedimento de Desenhos-Est?rias com Tema foi utilizado na abordagem coletiva de uma classe de estudantes de Direito. Constatou-se que as dificuldades sexuais s?o predominantemente definidas como disfun??o er?til e ejacula??o precoce. A an?lise psicanal?tica indicou que o imagin?rio se organiza a partir de campos vinculados a necessidade de alcan?ar certo padr?o em termos de desempenho (o amante competente), as dificuldades no relacionamento est?vel (felizes para sempre) e as indefini??es sexuais (ser? que ele e?). Conhecer o imagin?rio coletivo, bem como os campos psicol?gico-vivenciais sobre os quais se organiza, pode facilitar transforma??es no modo como diferentes grupos sociais concebem a vida sexual, libertando o ser humano de ades?es a concep??es restritivas sobre sexualidade que tendem a empobrecer o viver.

Ce projet de maitrise implique le développement et l’optimisation de deux méthodes utilisant la chromatographie liquide à haute performance couplée à la spectrométrie de masse en tandem (HPLC-MS/MS). L'objectif du premier projet était de séparer le plus rapidement possible, simultanément, 71 médicaments traitant la dysfonction érectile (ED) et 11 ingrédients naturels parfois retrouvés avec ces médicaments dans les échantillons suspectés d’être adultérés ou contrefaits. L'objectif du deuxième projet était de développer une méthode de dépistage permettant l'analyse rapide simultanée de 24 cannabinoïdes synthétiques et naturels pour une grande variété d'échantillons tels que les mélanges à base de plantes, des bâtons d'encens, de sérums et de cannabis. Dans les deux projets, la séparation a été réalisée en moins de 10 min et cela en utilisant une colonne C18 à noyau solide 100 x 2,1 mm avec des particules de 2,6 µm de diamètre couplée à un système MS avec trappe ionique orbitale fonctionnant en électronébulisation positive. En raison du nombre élevé de composés dans les deux méthodes et de l’émergence de nouveaux analogues sur le marché qui pourraient être présents dans les échantillons futurs, une méthode de dépistage LC-MS/MS ciblée/non-ciblée a été développée. Pour les deux projets, les limites de détection étaient sous les ng/mL et la variation de la précision et de l’exactitude étaient inférieures de 10,5%. Le taux de recouvrement à partir des échantillons réels variait entre 92 à 111%. L’innovation des méthodes LC-MS/MS développées au cours des projets est que le spectre de masse obtenu en mode balayage lors de l'acquisition, fournit une masse exacte pour tous les composés détectés et permet l'identification des composés initialement non-ciblés, comme des nouveaux analogues. Cette innovation amène une dimension supplémentaire aux méthodes traditionnellement utilisées, en permettant une analyse à haute résolution sur la masse de composés non-ciblés. / This master’s project involved the development and optimization of two rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) methods. The objective of the first project was to simultaneously separate, as rapidly as possible, 71 erectile dysfunction (ED) treatment drugs and 11 natural ingredients sometimes found alongside ED drugs present in suspected adulterated or counterfeit samples. The objective of the second project was to develop a screening method allowing rapid, simultaneous analysis of 24 synthetic and natural cannabinoids for a wide variety of samples such as herbal smoking mixtures, incense sticks, serums and Cannabis plant material. In both projects, the separations were achieved in ≤ 10 min using 2.6 µm fused-core C18 particles packed into a 100 x 2.1 mm column coupled to an LTQ Orbitrap XL mass spectrometer operated in positive electrospray mode. Because of the very high number of compounds in both methods and the knowledge that future analogues are always immerging on the market that could thus be present in samples, a targeted/untargeted LC-MS/MS screening method was developed. For both projects, detection limits were in the sub ng/mL range and intra- and inter-assay precisions were below 10.5%. Recovery from real samples ranged from 92 to 111%. The innovation of the developed LC-MS/MS methods is that the full scan event in the MS acquisition provides accurate masses for all detected species and thus allows post-analysis identification of initially untargeted compounds, i.e., the immerging analogues. This innovation adds an additional dimension to traditional MS/MS methods, allowing high mass resolution of untargeted compounds.