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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Efeito do estado nutricional bioqu?mico de retinol e alfatocoferol sobre seus n?veis em lactantes

Lira, Larissa Queiroz de 01 April 2011 (has links)
Made available in DSpace on 2014-12-17T14:03:37Z (GMT). No. of bitstreams: 1 LarissaQL_DISSERT.pdf: 2541848 bytes, checksum: 732cfe4b835f5fc4a48b57022760627a (MD5) Previous issue date: 2011-04-01 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Vitamins A and E are essential nutrients in many biological processes, so that their adequate supply to the neonate is crucial. However, the bioavailability of vitamins may be limited by factors such as maternal nutritional status and the interaction between nutrients. This study aimed to investigate the effect of biochemical nutritional status of retinol and alpha-tocopherol levels in serum and colostrum. The study included 103 healthy puerperal women treated at the reference state maternity hospital (Natal-RN). Colostrum and serum samples were collected fasting in the immediate postpartum period and the analysis of retinol and alpha-tocopherol were determined by high-performance liquid chromatography. Specific cutoff points were adopted to characterize the biochemical status of vitamins A and E. For the total group of lactanting women the average concentration of retinol in serum (1.49 ? 0.4 &#956;mol/L-1) and colostrum (2.18 ? 0.8 &#956;mol/L-1), as well as alpha-tocopherol in serum (26.4 ? 8.0 &#956;mol/L-1) and colostrum (26.1 ? 12.8 &#956;mol/L-1), indicated adequate biochemical state. However, when evaluating the individual, was found a high prevalence of deficient serum (15%) and colostrum retinol (50%), and also alphatocopherol in serum (16%) and colostrum (61%). In women with serum retinol &#8805; 1.05 &#956;mol/L-1, found an inverse correlation between serum retinol and alpha-tocopherol in colostrum (p = 0.008, r = -0.28). This association was not observed in women with serum retinol <1.05 &#956;mol/L-1. This situation demonstrates for the first time in humans that high physiological levels of serum retinol, without supplementation, can negatively influence the transfer of alpha-tocopherol in breast milk. Although the diagnosis of satisfactory nutritional status lactanting women showed high risk of subclinical deficiency of vitamins A and E from measurements made in the colostrum / As vitaminas A e E s?o nutrientes essenciais em muitos processos biol?gicos, de modo que seu adequado fornecimento ao neonato ? fundamental. No entanto, a biodisponibilidade dessas vitaminas pode ser limitada por fatores como o estado nutricional materno e a intera??o entre nutrientes. Este trabalho teve como objetivo investigar o efeito do estado nutricional bioqu?mico de retinol e de alfa-tocoferol sobre seus n?veis no soro e no colostro materno. Participaram do estudo 103 pu?rperas saud?veis atendidas em maternidade p?blica de refer?ncia estadual (Natal-RN). Amostras de soro e colostro foram coletadas em jejum no p?s-parto imediato e as an?lises de retinol e alfa-tocoferol foram feitas por cromatografia l?quida de alta efici?ncia. Os valores de 1,05 &#956;mol/L-1 de retinol no soro e de 2,09 &#956;mol/L-1 de retinol no colostro foram adotados como pontos de cortes para caracterizar a condi??o bioqu?mica referente ? vitamina A. Valores de 11,6 &#956;mol/L-1 de alfa-tocoferol no soro e de 26,1 &#956;mol/L-1 de alfa-tocoferol no colostro foram adotados como pontos de cortes para caracterizar a condi??o bioqu?mica referente ? vitamina E. No grupo total de lactantes, a concentra??o m?dia de retinol no soro (1,49 ? 0,4 &#956;mol/L-1) e no colostro (2,18 ? 0,8 &#956;mol/L-1), assim como, de alfatocoferol no soro (26,4 ? 8,0 &#956;mol/L-1) e no colostro (26,1 ? 12,8 &#956;mol/L-1) indicou adequado estado bioqu?mico. No entanto, ao se avaliar o indiv?duo, foi constatada elevada preval?ncia de defici?ncia de retinol no soro (15%) e no colostro (50%), como tamb?m, de alfa-tocoferol no soro (16%) e no colostro (61%). Em mulheres com retinol s?rico &#8805; 1,05 &#956;mol/L-1, foi encontrado correla??o inversa entre retinol s?rico e alfa-tocoferol do colostro (p = 0.008, r = -0.28). Esta associa??o n?o foi observada em mulheres com retinol s?rico < 1,05 &#956;mol/L-1. Tal situa??o evidencia pela primeira vez em humanos, que n?veis fisiol?gicos adequados de retinol s?rico podem influenciar negativamente a passagem de alfa-tocoferol para o leite materno. Apesar do diagn?stico de satisfat?rio estado nutricional do grupo total de lactantes, ao se avaliar o indiv?duo, foi constatado elevado risco de defici?ncia subcl?nica para as vitaminas A e E a partir das dosagens feitas no colostro

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