Osteocytes (resident bone cells) are believed to sense loading-induced interstitial fluid flow in bone and transduce the signals to osteoclasts (bone resorption cells) and osteoblasts (bone formation cells) to regulate bone remodeling. Recent studies have shown that bone disuse causes osteocyte apoptosis, which precedes osteoclast activity at the local remodeling site. Although osteoclast precursors are known to travel via the circulation, the specific mechanism by which they are transported to the remodeling site is unclear. We hypothesized that lack of fluid flow induces osteocyte apoptosis. Furthermore, we hypothesized that osteocyte populations containing apoptotic osteocytes secrete cytokines that: 1) promote angiogenesis, and 2) activate the endothelium to promote osteoclast precursor adhesion to the endothelium such that osteoclast precursors can be delivered closer and directly to the remodeling site. In our in vitro studies, we found that lack of oscillatory fluid flow (mimicking mechanical disuse) promotes osteocyte apoptosis. In addition, osteocyte populations containing apoptotic cells promote endothelial cell proliferation, migration, and tubule formation. Inhibition of the potent angiogenic cytokine, vascular endothelial growth factor (VEGF), abrogated osteocyte apoptosis-mediated angiogenesis. Furthermore, we found that osteocyte populations containing apoptotic cells secrete cytokines that promoted osteoclast precursor adhesion. Upon further investigation, we found that apoptotic osteocytes secreted elevated levels of inflammatory cytokine interleukin 6 (IL-6), and its soluble receptor, sIL-6R. We demonstrated that both IL-6 and sIL-6R are required to activate the endothelium to express ICAM-1. Inhibition of ICAM-1 and IL-6 by blocking antibodies abolished apoptotic osteocyte-mediated osteoclast precursor adhesion. Our findings suggest for the first time that osteocytes communicate to endothelial cells directly to mediate angiogenesis and osteoclast precursor adhesion. Results from this study may assist in a better understanding of osteoclast precursor recruitment at the initial onset of bone resorption.

There are two purposes of this study: to examine the institutional strategies that two Canadian universities have developed in attracting international undergraduate students to study on campus, and to gain an understanding of the factors that influence undergraduate students to choose Canada as a destiny for education, and their views on the institutional marketing and recruitment strategies. This study employed a marketing model and institutional theory as key conceptual frameworks. The data collected for the two case study universities include interviews with university leaders and international students, and an on-line survey with international students. Institutional initiatives for international student recruitment have been influenced by various factors, such as provincial government policies, institutional leadership, university traditions and organizational structure, financial status, the capacity of institution, and the provincial higher education system. While one of the case study universities adopted a decentralized and the other adopted a centralized approach to international student recruitment, the different organization structure does not make a great difference since international student enrolment increased at a similar pace in the last decade. The two case study universities shared similarities in marketing and recruitment strategies, which was to influence international students’ university choice by providing information through diversified means and interacting with students at different stages in their university selection process. The major marketing activities, which are designed to present information and convince students to apply, can be categorized into three groups: (1) outreach activities, which include school visits, post-offer events and attending fairs; (2) intermediate activities, which include attending and holding professional conferences to influence high school counsellors; (3) on-campus events, which include a visitors’ center, on-line chat and video conferences, and maintaining a university website to provide up-to-date information to students. The study showed that most international students chose a university based on its reputation and program quality, followed by the recognition of the degree in their home country, tuition and expenses, and the quick response of the university. Therefore, the academic pull factor is core and dominant, followed by the recognition factor, the financial factor, and the administrator factor. Degree being recognized by home country and the advice of family members remain the two dominant push factors. International students sought university information from over six sources on average. The information sources provided by the universities are rated more important than public information sources, and are exactly what most students seek information from. Therefore, the marketing and recruitment strategies of the two Canadian universities are congruent with the process of international students’ university choice.

Both feminist and mainstream political science has taken an institutional ‘turn’, opening up possibilities for dialogue between the two fields. Yet, despite sharing a number of common interests and preoccupations, there has been little interplay between mainstream new institutionalist scholars and feminist political scientists working on institutions. This thesis attempts to fill this gap and evaluates the potential for theoretical synthesis between feminist gender analysis and new institutional theory. It argues that there is potential for mutual benefit from a synthesis of these two approaches, and that a ‘feminist institutionalism’ offers a promising theoretical approach for the study of gender and institutions. The thesis evaluates the potential of a feminist institutionalist approach in the context of the comparative literature on gender and political recruitment. It critically evaluates the supply and demand model (Norris and Lovenduski, 1995), one of the only models that attempts to systematically integrate gender into the dynamics of the recruitment process. The thesis contends that a feminist institutionalist approach offers a way to take the supply and demand forward, developing the theoretical interconnections that are present implicitly in Pippa Norris and Joni Lovenduski’s work on political recruitment and reintegrating and reformulating the key features of the model into a feminist and institutionalist framework. The thesis develops this theory-building project through an illustrative case study – the institutions of political recruitment in post-devolution Scotland. Using a multi-method approach – including discourse analysis, process tracing, and political interviewing – the thesis combines a macro-level analysis of gendered patterns of selection and recruitment in Scottish political parties over time with a micro-level case study of a Scottish Labour Party constituency seat selection contest in the run-up to the 2007 Scottish Parliament elections. The case study finds some evidence of institutional innovation and reform in the candidate selection process, but also highlights underlying continuities in the institutions of political recruitment. The case study illustrates the specific and gendered difficulties of institutionalizing a ‘new’ more gender-balanced politics within a pre-existing institutional context. Findings from the case study suggest that the ‘success’ of institutional innovation in candidate selection is a complex and contingent question, and that elements of the ‘old’ continue to co-exist with elements of the ‘new’, constraining and shaping each other. The Scottish case, then, underscores the need to rethink conventional models of political recruitment, illustrating the difficulties of reforming and redesigning the institutions of political recruitment in the face of powerful institutional and gendered legacies. As such, the thesis generates new theoretical and empirical insights into the gendered dynamics of institutional power, continuity and change that contribute to the growing body of research on gender and institutions and inform the wider literature on both new institutional theory and feminist political science.

When O2 uptake at the lung is used to characterise the oxidative metabolic response to increased contractile activity ( O2 kinetics) in exercising muscle, the O2 profile reflects the combined influence of all involved muscle fibres. Consequently, during high-intensity exercise that mandates activation of fibres with considerable metabolic diversity (e.g., both principal fibre types), response characteristics specific to discrete segments of the recruited pool cannot be determined. The purpose of this thesis was to identify fibre-type-specific effects of conditions that might impact O2 delivery and/or motor unit recruitment patterns on O2 kinetics by using two models that increase fibre recruitment homogeneity during exercise transitions. In four experiments, subjects initiated high-intensity exercise from a moderate baseline (i.e., performed ‘work-to-work’ transitions; M→H) to target higher-order fibres, and in two experiments, subjects cycled at extremely slow and fast pedal rates to skew recruitment toward slow- and fast-twitch fibres, respectively. At mid-range contraction frequency, O2 kinetics (as indicated by the primary time constant, τp) was slower for M→H compared to unloaded-to-high-intensity transitions (U→H) (e.g., 42 v. 33 s; Ch 4) and this slowing was ~50% greater for M→H in a supine body position (decreased oxygenation; Ch 6). Slower kinetics was also present for U→H cycling at fast compared to slow pedal rates (τp, 48 v. 31 s; Ch 8). Conversely, M→H slowing relative to U→H was absent at extreme cadences (36 v. 31 s and 53 v. 48 s for slow and fast, respectively; Ch 7). After ‘priming’ (increased oxygenation), τp was reduced for U→H after fast-cadence priming only (Ch 8) and for M→H in the supine position (Ch 6), but unaffected for upright cycle and prone knee-extension M→H, for which priming reduced the O2 slow component and delayed-onset fibre activation (as indicated by iEMG; Chs 4 and 5). These results provide evidence in exercising humans that high-order fibres possess innately slow O2 kinetics and are acutely susceptible to interventions that might alter O2 delivery to muscle.

This study is focused on the spreading wave of militancy in the Muslim youth after 9/11 era.  The role Al Qaeda is researched in understanding this problem in the case study of Pakistan. Al Qaeda is considered as the nursery for the rising of militancy in the Muslims while Pakistan is the birthplace of Al Qaeda. The problem of militancy rose to the alarming level in Pakistan after 9/11 when the Pakistani state started to support the US in the war against terror which Al Qaeda and other Islamists consider as the war against Islam. The recruitment strategies of Al Qaeda and other Pakistani militant groups like Tihreak Taliban Pakistan (TTP or Pakistani Taliban movement) are studied through the discourse analysis. The primary data from the militant sources like the speeches, books and interviews of their leadership and ideologues, their official magazines and press releases are selected for this research. All this data is available in Urdu language which is translated to the English for this research. The theoretical framework of this research is based on the “Soft theory” of Josef Nye (2006) and the “three dimensions of Power” theory of Steven Lukes (2005). The results of this research show that the militants mostly use different types of arguments in their messages to the youth in their efforts for recruiting them to the path of militancy which include mostly the religious arguments. Along with it, they also attract youth to their path on targeting their grievances and hopes. They present to them the path of militancy as an end and the only way of revenge for their all grievances. These results also show that the militants also present militancy to the youth as the only mean for achievement of their various hopes which they believe these Muslims youth cannot get without militancy.

UA Open Access Publishing Fund / Background: Internet and mobile health (mHealth) apps hold promise for expanding the reach of evidence-based health interventions. Research in this area is rapidly expanding. However, these studies may experience problems with recruitment and retention. Web-based and mHealth studies are in need of a wide-reaching and low-cost method of recruitment that will also effectively retain participants for the duration of the study. Online recruitment may be a low-cost and wide-reaching tool in comparison to traditional recruitment methods, although empirical evidence is limited. Objective: This study aims to review the literature on online recruitment for, and retention in, mHealth studies. Methods: We conducted a review of the literature of studies examining online recruitment methods as a viable means of obtaining mHealth research participants. The data sources used were PubMed, CINAHL, EbscoHost, PyscINFO, and MEDLINE. Studies reporting at least one method of online recruitment were included. A narrative approach enabled the authors to discuss the variability in recruitment results, as well as in recruitment duration and study design. Results: From 550 initial publications, 12 studies were included in this review. The studies reported multiple uses and outcomes for online recruitment methods. Web-based recruitment was the only type of recruitment used in 67% (8/12) of the studies. Online recruitment was used for studies with a variety of health domains: smoking cessation (58%; 7/12) and mental health (17%; 2/12) being the most common. Recruitment duration lasted under a year in 67% (8/12) of the studies, with an average of 5 months spent on recruiting. In those studies that spent over a year (33%; 4/12), an average of 17 months was spent on recruiting. A little less than half (42%; 5/12) of the studies found Facebook ads or newsfeed posts to be an effective method of recruitment, a quarter (25%; 3/12) of the studies found Google ads to be the most effective way to reach participants, and one study showed better outcomes with traditional (eg in-person) methods of recruitment. Only one study recorded retention rates in their results, and half (50%; 6/12) of the studies recorded survey completion rates. Conclusions: Although online methods of recruitment may be promising in experimental research, more empirical evidence is needed to make specific recommendations. Several barriers to using online recruitment were identified, including participant retention. These unique challenges of virtual interventions can affect the generalizability and validity of findings from Web-based and mHealth studies. There is a need for additional research to evaluate the effectiveness of online recruitment methods and participant retention in experimental mHealth studies.

Title: Football recruitment campaign in the Czech Republic Objectives: The main objective of this study is based on mapping and analysis of current practice and implemented recruitment campaigns in Czech football to find the flaws and the ideal model for devising measures to improve and effectiveness of these campaigns. Then identify and get to know the target group of parents of young footballers. Methods: In this work we were used methods of case studies, statistical data analysis and involved observation in the context of mapping the current practice of football recruitment campaigns in the Czech Republic. Further, a questionnaire survey among parents of current footballers to 18 years to identify the target group of football recruitment campaigns. Everything was supplemented by expert interview with a representative of the FACR. Results: In the Czech Republic there are two major football recruitment campaign, My first club and My first goal. Communication channels and tools of both campaigns were analysed in detail and presented their results. The questionnaire survey brought the identification of target groups for these recruitment campaigns. Thanks to lessons learned were proposed recommendations for researched campaigns. Keywords: football, campaign, marketing, communication, recruitment,

Resumé Human resources management in a small enterprise In my work I deal with the topic of human resources management in a small enterprise. In the first chapter I deal with the definition of the concept and historical development of this area. The second chapter is devoted to circumstances regarding the origin and termination of the employment. Human resources management in this stage begins with planning. Planning means determining the needs of the organization, especially in planning the required number of suitable, adequately trained and properly motivated employees at the right time. The planning is continued by recruitment. This phase ensures that the vacancies will attract sufficient number of suitable candidates. To identify which of the candidates is best suited to fill the job, you need to invite suitable candidates to the selection interview. The aim of the selection process is to find a suitable candidate with whom the contract will be concluded. An important area is the protection of personal data. The end of this chapter deals with the circumstances of termination of employment as defined in § 48-73 LC. The last chapter covers the main areas of human resources management in a small business. In the subsection "Performance management and evaluation" is devoted to the importance of implementing...

Title: Analysis of sporting career of members of the cyclo-cross youth center Tábor Objectivess: The aim of my thesis is to find out what are the most common causes of the exodus of young children from SCM Tabor and to suggest how to prevent premature termination of a career. Methods: I used a systematic opinion poll asking as the main research method for data collection, using open and closed questions. For purpose of research sample, 27 cyclist were included as an active and inactive respondents from SCM Tabor. All respondents were male with the age range between 14-33 years old. I was sending out questionnaires via e-mail or I have met concerned respondents in person. Based on the answers I came up with results and I converted them into text and graphs in the thesis. Results: The results showed that most of young cyclists career end due to loss of motivation for training and for improving performance, thus responded 10 respondents, 45%. Six respondents, 27% of the total, pointed out as the reason for termination the failure in their sport career. Another two had as a reason to end financial problems in the family, furthermore one pointed out injury as a reason. Six parents of respondents had no sport history and three of them rather did not want their child to be a cyclist. For 26% of the...

In purpose to investigate what highly educated employees born from 1981 and forward found motivating this basic qualitative study is based on interviews regarding nine individual’s perceptions about their work and employers. Nine interviews were conducted with individuals born between 1981 to 1994 regarding motivation at work, which led to six themes being presented, “Developing”, “Feeling secure”, “Good leadership”, “Experience of autonomy”, “Identifying with values” and “Thrive in the organizational structure”. The results were analyzed based on previous research regarding intrinsic and extrinsic motivation and studies of individuals born between 1980 and late 1990. It could be concluded that the participants preferred development, challenge and leadership to permanent employment and high wages. / I syfte att undersöka vad som motiverar högutbildade arbetstagare födda från 1981 och framåt har den här grundläggande kvalitativa studien baserats på intervjuer med individer om deras uppfattning om arbete och arbetsgivare. Nio personer födda mellan 1981 och 1994 blev intervjuade gällande upplevelser av motivation i arbetet varav sex teman lyftes fram, “Att utvecklas”, “Känna trygghet”, “Ett bra ledarskap”, “Upplevelse av autonomi”, “Identifiera sig med värderingar” och “Trivas i organisationsstrukturen”. Resultaten analyserades utifrån tidigare forskning om intern och extern motivation och studier av individer födda från 1980 och framåt. Det kunde antas att studiens deltagare värderade utveckling, utmaning och ledarskap framför en fast anställning och hög lön.