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Defective Immunometabolism Pathways in Cystic Fibrosis MacrophagesHamilton, Kaitlin January 2021 (has links)
No description available.
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Local Redox Imbalance Induced by Intraorganellar Accumulation of Misfolded Proteins / オルガネラ内に蓄積した凝集タンパク質が引き起こす局所的なレドックス破綻Oku, Yuki 25 March 2019 (has links)
学位プログラム名: 京都大学大学院思修館 / 京都大学 / 0048 / 新制・課程博士 / 博士(総合学術) / 甲第21931号 / 総総博第6号 / 新制||総総||1(附属図書館) / 京都大学大学院総合生存学館総合生存学専攻 / (主査)教授 阪井 康能, 教授 山口 栄一, 教授 積山 薫 / 学位規則第4条第1項該当 / Doctor of Philosophy / Kyoto University / DGAM
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Understanding the role of SABP2-interacting proteins (SIP) 428: an NAD+-Dependent Deacetylase Enzyme in Abiotic Stress Signaling of Nicotiana tabacumOnabanjo, Mariam, Kumar, Dhirendra, PhD. 25 April 2023 (has links) (PDF)
Abiotic stresses like salinity, drought, and extreme temperature are constantly on the rise, posing a very high risk to global agricultural productivity and food security. Hence, understanding stress signaling pathways can help engineer plants that can better withstand stress in unfavorable conditions. The salicylic acid (SA) signaling pathway has been widely studied for its important role in mediating abiotic stress in plants. In tobacco plants, Salicylic Acid Binding Protein 2 (SABP2), a methyl esterase enzyme, catalyzes the conversion of methyl salicylate (MeSA) to SA, which triggers the defense response via the SA-mediated signaling pathway. SIP-428 (SABP2 Interacting Protein-428) is an NAD+ dependent SIR2-like (Silent Information Regulator) deacetylase enzyme that likely interacts with SABP2 during SA biosynthesis. In previous studies, SIP-428 has been shown to be a negative regulator of plant growth under abiotic stress (NaCl and mannitol in vivo). Reactive Oxygen Species (ROS) are oxidizing oxygen products that accumulate under stress conditions, and at high levels can be very harmful to plants. Antioxidant enzymes such as catalase (CAT), guaiacol peroxidase (POD), ascorbate peroxidase (APX), and superoxide dismutase (SOD) are actively involved in lowering the ROS levels in the cell by combating the oxidative stress. The objective of this study was to analyze the regulatory functions of SIP-428 in ROS signaling of tobacco plants through the biochemical quantification of POD and CAT activities. We investigated the SIP-428 RNAi-silenced tobacco plants for the POD and CAT enzyme activities in Osmotic (Mannitol) and Salinity (NaCl) stressed plants. Our results showed that SIP-428 plays a significant role in modulating antioxidant enzymes in stressed plants. This study has improved our understanding of some regulatory roles of SIP428, and its application can be used to enhance stress tolerance via the use of synthetic biology.
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Intermittent Hypoxia and Neonatal Carotid Body FunctionPawar, Anita 21 July 2009 (has links)
No description available.
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The Role of Nitric Oxide in Immune Responses to T cell-stimulating Polysaccharide Antigens; Implications for Chronic Granulomatous DiseaseLewis, Colleen Jenna January 2010 (has links)
No description available.
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Vascular Biochemistry of Vitmain B<sub>12</sub>: Exploring the Relationship between Intracellular Cobalamin and Redox Status in Human Aortic Endothelial CellsSuarez Moreira, Edward 13 April 2010 (has links)
No description available.
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Cardiovascular Complications of Ischemic Renal Disease: The Effect of Renal Dysfunction on Cardiac Disease and the Central Role of Cardiotonic Steroids in the Pathogenesis of Uremic CardiomyopathyKennedy, David Joseph 17 April 2006 (has links)
No description available.
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Inhibition of Ovarian Cancer Cell Proliferation by Oleoylethanolamide and its Metabolically Stable Analog AM3102Kisgeropoulos, Effie Christine 23 December 2013 (has links)
No description available.
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Derivation of Hydroquinone to Produce Selective, Oxidatively Activated Chemotherapeutic AgentsBell-Horwath, Tiffany R. 12 September 2014 (has links)
No description available.
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Derivation of Hydroquinone to Produce Selective, Oxidatively Activated Chemotherapeutic AgentsBell-Horwath, Tiffany R. 17 October 2014 (has links)
No description available.
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