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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
291

Defective Immunometabolism Pathways in Cystic Fibrosis Macrophages

Hamilton, Kaitlin January 2021 (has links)
No description available.
292

Local Redox Imbalance Induced by Intraorganellar Accumulation of Misfolded Proteins / オルガネラ内に蓄積した凝集タンパク質が引き起こす局所的なレドックス破綻

Oku, Yuki 25 March 2019 (has links)
学位プログラム名: 京都大学大学院思修館 / 京都大学 / 0048 / 新制・課程博士 / 博士(総合学術) / 甲第21931号 / 総総博第6号 / 新制||総総||1(附属図書館) / 京都大学大学院総合生存学館総合生存学専攻 / (主査)教授 阪井 康能, 教授 山口 栄一, 教授 積山 薫 / 学位規則第4条第1項該当 / Doctor of Philosophy / Kyoto University / DGAM
293

Understanding the role of SABP2-interacting proteins (SIP) 428: an NAD+-Dependent Deacetylase Enzyme in Abiotic Stress Signaling of Nicotiana tabacum

Onabanjo, Mariam, Kumar, Dhirendra, PhD. 25 April 2023 (has links) (PDF)
Abiotic stresses like salinity, drought, and extreme temperature are constantly on the rise, posing a very high risk to global agricultural productivity and food security. Hence, understanding stress signaling pathways can help engineer plants that can better withstand stress in unfavorable conditions. The salicylic acid (SA) signaling pathway has been widely studied for its important role in mediating abiotic stress in plants. In tobacco plants, Salicylic Acid Binding Protein 2 (SABP2), a methyl esterase enzyme, catalyzes the conversion of methyl salicylate (MeSA) to SA, which triggers the defense response via the SA-mediated signaling pathway. SIP-428 (SABP2 Interacting Protein-428) is an NAD+ dependent SIR2-like (Silent Information Regulator) deacetylase enzyme that likely interacts with SABP2 during SA biosynthesis. In previous studies, SIP-428 has been shown to be a negative regulator of plant growth under abiotic stress (NaCl and mannitol in vivo). Reactive Oxygen Species (ROS) are oxidizing oxygen products that accumulate under stress conditions, and at high levels can be very harmful to plants. Antioxidant enzymes such as catalase (CAT), guaiacol peroxidase (POD), ascorbate peroxidase (APX), and superoxide dismutase (SOD) are actively involved in lowering the ROS levels in the cell by combating the oxidative stress. The objective of this study was to analyze the regulatory functions of SIP-428 in ROS signaling of tobacco plants through the biochemical quantification of POD and CAT activities. We investigated the SIP-428 RNAi-silenced tobacco plants for the POD and CAT enzyme activities in Osmotic (Mannitol) and Salinity (NaCl) stressed plants. Our results showed that SIP-428 plays a significant role in modulating antioxidant enzymes in stressed plants. This study has improved our understanding of some regulatory roles of SIP428, and its application can be used to enhance stress tolerance via the use of synthetic biology.
294

Intermittent Hypoxia and Neonatal Carotid Body Function

Pawar, Anita 21 July 2009 (has links)
No description available.
295

The Role of Nitric Oxide in Immune Responses to T cell-stimulating Polysaccharide Antigens; Implications for Chronic Granulomatous Disease

Lewis, Colleen Jenna January 2010 (has links)
No description available.
296

Vascular Biochemistry of Vitmain B<sub>12</sub>: Exploring the Relationship between Intracellular Cobalamin and Redox Status in Human Aortic Endothelial Cells

Suarez Moreira, Edward 13 April 2010 (has links)
No description available.
297

Cardiovascular Complications of Ischemic Renal Disease: The Effect of Renal Dysfunction on Cardiac Disease and the Central Role of Cardiotonic Steroids in the Pathogenesis of Uremic Cardiomyopathy

Kennedy, David Joseph 17 April 2006 (has links)
No description available.
298

Inhibition of Ovarian Cancer Cell Proliferation by Oleoylethanolamide and its Metabolically Stable Analog AM3102

Kisgeropoulos, Effie Christine 23 December 2013 (has links)
No description available.
299

Derivation of Hydroquinone to Produce Selective, Oxidatively Activated Chemotherapeutic Agents

Bell-Horwath, Tiffany R. 12 September 2014 (has links)
No description available.
300

Derivation of Hydroquinone to Produce Selective, Oxidatively Activated Chemotherapeutic Agents

Bell-Horwath, Tiffany R. 17 October 2014 (has links)
No description available.

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