Les traumatismes crâniens peuvent provoquer des troubles de la perception de molécules odorantes chez l’homme. Les causes de ces troubles post-traumatiques peuvent être : une altération mécanique dans la cavité nasale, des cisaillements des filets nerveux olfactifs et des lésions des régions cérébrales impliquées dans le traitement de l’information olfactive.Il est crucial en clinique ORL de pouvoir déterminer objectivement la fonctionnalité de l’odorat.Pour cela, nous avons conçu une méthode d’enregistrement électrophysiologique des potentiels évoqués olfactifs incluant, en plus de la composante classique P2/P3, une composante cognitive reflétant la perception du stimulus odorant : la variation de contingence négative (CNV).Cette méthode a été tout d’abord validée avec 24 sujets normosmiques et 8 sujets totalement anosmiques (absence congénitale des bulbes olfactifs). La CNV était présente chez tous les normosmiques contrairement à l’onde P2/P3 présente dans seulement 82% (28/34 cavités nasales stimulées) des observations. Les signaux sont tous absents chez les anosmiques.Nous avons aussi examiné 41 patients se plaignant d’anosmie ou d’une hyposmie associée à une perception déformée des odeurs. Dans la plupart des cas ces troubles étaient consécutifs à un choc occipital et/ou temporal. Les enregistrements ont été confrontés aux observations IRM focalisées sur la région des bulbes olfactifs : aspect des bulbes olfactifs et lésions dans le gyrus rectus et le gyrus orbitaire médian.Dans la grande majorité des cas, les deux bulbes présentaient un aspect anormal et les enregistrements électrophysiologiques montraient une absence totale de fonctionnalité.Cependant pour quelques patients, l’anormalité de l’aspect des bulbes n’empêchait pas la transmission de l’information au cerveau, comme indiqué par l’enregistrement des potentiels évoqués. Dans ce cas, la lésion bulbaire était associée à une parosmie (perception déformée des odeurs) et à une incapacité d’identification de celles-ci.Au bilan, notre méthode d’enregistrement permet, au niveau de chaque individu, d’obtenir de façon objective des informations essentielles permettant le diagnostic objectif de l’existence d’un trouble de l’odorat. Notre étude des traumatisés crâniens montre que la région des bulbes olfactifs est fragile et susceptible d’être endommagée partiellement ou totalement, même en cas de traumatisme crânien de relativement faible importance. / Head traumas can cause trouble of odor perception in humans. The causes of these post-traumatic troubles can be either mechanical damage to the nasal cavity, shearing of olfactory nerve fibers or lesions of the brain regions involved in processing olfactory information.In clinical ENT, it is crucial to objectively determine olfaction functionality.We developed electrophysiological recording of olfactory evoked potentials including, in addition to the classic P2/P3 component, a cognitive component reflecting the perception of odorants i.e.: the contingent negative variation (CNV).This method was first validated with 24 normosmic subjects and 8 completely anosmic subjects (congenital anosmia without olfactory bulb). The CNV was present in all normosmic subjects whereas P2/P3 was present in only 82 % (28/34 nasal cavities stimulated) of the observations. No signal was observed in any anosmic subjects.We also examined 41 patients complaining of anosmia or hyposmia associated with a distorted perception of odorants. In most cases, these troubles were consecutive to an occipital and / or temporal impact. The recordings were compared to MRI observations focusing on the region of the olfactory bulbs which exhibited olfactory bulbs lesions and lesions in the gyrus rectus and in the medial orbital gyrus. In most cases, the two bulbs had an abnormal appearance and electrophysiological recordings showed a complete lack of functionality. However, for some patients, the abnormal aspect of the bulb did not prevent the transmission of information to the brain, as indicated by the electrophysiological responses. In this case, the bulbar lesion was associated with parosmia (distorted perception of smell) and an inability to identify odors.In conclusion, our recording method allows obtaining, for each subject, the essential information for an objective diagnosis of the existence of a smell disorder. Our study of patients with head trauma shows that the region of the olfactory bulbs is fragile and can be damaged either partially or completely, even for light head trauma.

This study takes as its focus Ted Hughes’s composition techniques throughout his career, arguing that his self-conscious experimentation with the processes by which he wrote affected the style and subject matter of his work. Hughes’s poetry has lent itself to a number of familiar critical approaches, focusing on his preoccupation with mythology, his interaction with the natural world and his creative partnership with his first wife, Sylvia Plath. Yet no study, until now, has looked systematically at his literary drafts and the extent to which Hughes’s method of composition radically altered during his writing career. Archive material at Emory University, accessible since 2000, and new archive materials held at the British Library and made available for study for the first time in 2010, have opened up possibilities for much greater depth of research into Hughes’s writing processes and the birth and evolution of individual poems. By engaging with these materials, my research complements new studies which are tackling under-examined areas of Hughes’s work, whilst contributing more broadly to an increased awareness of the central importance of archival work in the study of literature. Literary manuscript drafts have often been used to study writers whose writing methods consciously foreground the drafting process. Whilst Hughes has not previously been considered in this light, my original investigations into his archival materials reveal a poet for whom the nature of the compositional process was a central concern which defines and redefines his poetry across his career.

Previous research has demonstrated the effectiveness of programs that include a videotaped self-observation component. The self-observation protocols, however, have not been clearly specified within programs that teach and report parents’ use of general teaching strategies. The current study investigates the effects of a training package with a self-observation component to teach parents to improve teaching interactions with their children at-risk for a developmental delay using an AB design replicated across participants. Data were collected across play interactions to assess the number of parent teaching episodes, child target responses, and various parent and child relationship qualities. Relationship quality measures included parent and child affect and engagement, parent directives, parent confidence and stress, and parent and child interest. The results of this study suggest that the training package was effective in that parents engaged in higher rates of teaching, their children engaged in more desired responding, and certain aspects of the parent-child interaction were enhanced. These results are discussed in terms of the effects on the parent-child teaching interaction and implications for future use of parent self-observation techniques.

No description available.

Les récepteurs NMDA (NMDARs) sont des canaux cationiques activés par le glutamate. Les NMDARs participent au développement cérébral, à la plasticité synaptique, à l'apprentissage, à la mémoire et aux fonctions cognitives supérieures. Des variants pathogènes de GRIN2A, codant pour la sous-unité GluN2A des NMDARs, peuvent causer des épilepsies focales et encéphalopathies épileptiques de l'enfance avec troubles du langage et de la parole, connue sous le nom de spectre des épilepsies-aphasies (EAS). Les caractéristiques communes de l'EAS comprennent une activité épileptiforme âge-dépendante activée pendant le sommeil lent associées à des troubles de la parole, de la cognition et du comportement qui peuvent persister à l'âge adulte. Afin de commencer à identifier les événements précoces possiblement associés aux altérations de GluN2A, nous avons exploré le modèle correspondant de souris knock-out (KO) du gène Grin2a. Nous avons notamment recherché des altérations précoces de la communication vocale, de la (micro)structure cérébrale, et de l'activité électrique néocorticale. Nos données démontrent l'existence de plusieurs altérations à ces différents niveaux, parfois transitoirement à des stades spécifiques. De plus, les enregistrements néocorticaux mettent en évidence des anomalies de divers types liées au sommeil lent. Nos résultats indiquent également un rôle de GluN2A dans la communication vocale, dans l'organisation de la microstructure cérébrale, et dans la maturation des activités d’ondes lentes. Ces données suggèrent que les souris KO Grin2a représentent un modèle fiable pour appréhender les mécanismes physiopathologiques associés à l’EAS et leur séquence temporelle. / NMDA receptors (NMDARs) are cation channels that are gated by glutamate - the major excitatory neurotransmitter of the central nervous system. NMDARs participate in brain development, synaptic plasticity, learning, memory and high cognitive functions. Pathogenic variants in the GRIN2A gene, which encodes the GluN2A subunit of the NMDARs, can cause a group of childhood focal epilepsies and epileptic encephalopathies with speech and language dysfunction, known as the epilepsy-aphasia spectrum (EAS). Features shared in common by EAS disorders include age-dependent epileptiform activity activated in sleep associated with speech, neuropsychological and behavioral deficits that may persist in adulthood. In order to start in deciphering the early events possibly associated with the dysfunctioning of GluN2A-containing NMDARs, we have explored the corresponding Grin2a knock-out (KO) mouse model. That consisted in looking for early alterations of vocal communication, of brain (micro)structure, and of neocortical electrical activity. Our data demonstrated the existence of several alterations at those various levels. Some alterations were transient only, being detected at selective stages; also, neocortical recordings pointed for sleep-related anomalies of various types. Our data also indicated a role for GluN2A-containing NMDA receptors in vocal communication, fine organization of brain microstructure, and proper maturation of slow wave activity in sleep. Altogether, our data suggest that the Grin2a KO mice represent a reliable model to further elucidate the pathophysiological mechanisms associated with the disorders of EAS and their temporal sequences.

Die Dissertation hat eine umfassende Betrachtung der aktuellen urheberrechtlichen Probleme des Tonträgersamplings zum Ziel. Sie teilt sich in einen zivil- und einen strafrechtlichen Teil. Der zivilrechtliche Teil der Untersuchung zeigt, inwieweit durch unautorisiertes Tonträgersampling die Vervielfältigungsrechte des Urhebers, des Interpreten sowie des Tonträgerherstellers verletzt werden können. Im Bereich der Rechte des Urhebers liegen die Schwerpunkte der Bearbeitung in der Frage der Schutzfähigkeit von Werkteilen, in der Anwendung der Regelung zur freien Benutzung gemäß § 24 Abs. 1 UrhG sowie in der Erörterung der für das Sampling relevanten urheberrechtlichen Schranken, insbesondere des Zitatrechts. Im Bereich der Rechte des Tonträgerherstellers sowie des ausübenden Künstlers werden schwerpunktmäßig die Schutzfähigkeit von Teilen der jeweiligen Leistung behandelt sowie die Frage einer möglichen analogen Anwendung der Regelung zur freien Benutzung gemäß § 24 Abs. 2 UrhG erörtert. Hierbei wird ein Überblick über die in der Lehre und der Rechtsprechung vertretenen Ansichten gegeben und ausführlich auf das zum Fall „Metall auf Metall“ im Jahr 2016 ergangene Urteil des Bundesverfassungsgerichts eingegangen. Der strafrechtliche Teil der Arbeit fragt danach, inwieweit unautorisiertes Sampling auch strafrechtliche Folgen haben kann. Schwerpunkte des strafrechtlichen Teils bilden die Erörterung der für das Sampling relevanten Straftatbestände des UrhG sowie die Behandlung der für das Sampling relevanten Irrtumskonstellationen nach der Irrtumsdogmatik des Strafgesetzbuches. / The purpose of this dissertation is to conduct a comprehensive investigation into current copyright issues associated with the sampling of audio recordings. The study is divided into two sections, one dealing with civil law and the other with criminal law. The section dedicated to civil law seeks to demonstrate to what extent unauthorised sound recording sampling represents a violation of the reproduction rights of the creator, the practising musical artist and the sound recording manufacturer. In terms of the rights of the creator, the main focus of the processing lies in the question of the protectability of work pieces used, the application of regulations determining free use pursuant to Section 24 paragraph 1 of the German Copyright Law, and the consideration of copyright limitations relevant to the sampling process, in particular quotation rights. In terms of the rights of the sound recording manufacturer as well as those of the practising artist, principal considerations are the protectability of parts of the respective performance and the question of a possible analogous application of regulations determining free use pursuant to Section 24 paragraph 2 of the German Copyright Law. In this regard, an overview of the views held in academia and jurisprudence will be provided as well as an extensive analysis of the judgment reached by the Bundesverfassungsgericht (German Federal Constitutional Court) in the 2016 case of “Metall auf Metall” (“Metal on Metal”). The section on criminal law addresses the question as to what extent sampling may result in penal consequences. The focus of the section on criminal law comprises the discussion of the respective copyright offences relevant to sampling, as well as the handling of the respective error framework relevant to sampling and pursuant to the doctrine of error in the German Criminal Code.

Les systèmes de réalité virtuelle interactifs combinent des représentations visuelle, sonore et haptique, afin de simuler de manière immersive l'exploration d'un monde tridimensionnel représenté depuis le point de vue d'un observateur contrôlé en temps réel par l'utilisateur. La plupart des travaux effectués dans ce domaine ont historiquement port'e sur les aspects visuels (par exemple des méthodes d'affichage interactif de modèles 3D complexes ou de simulation réaliste et efficace de l'éclairage) et relativement peu de travaux ont été consacrés 'a la simulation de sources sonores virtuelles 'également dénommée auralisation. Il est pourtant certain que la simulation sonore est un facteur clé dans la production d'environnements de synthèse, la perception sonore s'ajoutant à la perception visuelle pour produire une interaction plus naturelle. En particulier, les effets sonores spatialisés, dont la direction de provenance est fidèlement reproduite aux oreilles de l'auditeur, sont particulièrement importants pour localiser les objets, séparer de multiples signaux sonores simultanés et donner des indices sur les caractéristiques spatiales de l'environnement (taille, matériaux, etc.). La plupart des systèmes de réalité virtuelle immersifs, des simulateurs les plus complexes aux jeux vidéo destin'es au grand public mettent aujourd'hui en œuvre des algorithmes de synthèse et spatialisation des sons qui permettent d'améliorer la navigation et d'accroître le réalisme et la sensation de présence de l'utilisateur dans l'environnement de synthèse. Comme la synthèse d'image dont elle est l'équivalent auditif, l'auralisation, appel'ee aussi rendu sonore, est un vaste sujet 'a la croisée de multiples disciplines : informatique, acoustique et 'électroacoustique, traitement du signal, musique, calcul géométrique mais également psycho-acoustique et perception audio-visuelle. Elle regroupe trois problématiques principales: synthèse et contrôle interactif de sons, simulation des effets de propagation du son dans l'environnement et enfin, perception et restitution spatiale aux oreilles de l'auditeur. Historiquement, ces trois problématiques émergent de travaux en acoustique architecturale, acoustique musicale et psycho-acoustique. Toutefois une différence fondamentale entre rendu sonore pour la réalité virtuelle et acoustique réside dans l'interaction multimodale et dans l'efficacité des algorithmes devant être mis en œuvre pour des applications interactives. Ces aspects importants contribuent 'a en faire un domaine 'a part qui prend une importance croissante, tant dans le milieu de l'acoustique que dans celui de la synthèse d'image/réalité virtuelle.

Video based remote sensing techniques are well suited to collect spatially resolved wave images in the surf zone with breaking waves and dynamic bathymetric changes. An advanced video-based depth inversion method is developed to remotely survey bathymetry in the surf zone. The present method involves image processing of original wave image sequences, wave property estimation based on linear feature extraction from the processed image sequences, and is combined with a nonlinear depth inversion model. The original wave image sequences are processed through video image frame differencing and directional low-pass filtering schemes to remove wave-breaking-induced foam noise having high frequencies in the surf zone. The features of individual crest trajectories are extracted from the processed and rectified image sequences, i.e. processed image cross-shore timestacks, by tracking pixels of high intensity within an interrogation window of a Radon-transform-based line-detection algorithm. The wave celerity is computed using space-time information of the extracted trajectories of individual wave crests in the cross-shore timestack domain. The presented retrieval of nearshore bathymetry from video image sequences is based on a nonlinear depth inversion using the nonlinear shallow water wave theory. The nonlinear wave amplitude dispersion effects at the breaker points are determined by combining the nonlinear shallow water celerity equation with a wave breaker criterion, thereby computing water depths iteratively from the celerity measured from the video data. The water depths estimated at the breaker points present initial bathymetric anchor points. Bathymetric profiles in the surf zone are inverted by calculating wave heights dissipated after wave breaking with a wave dissipation model and wave heights shoaled before wave breaking with a wave shoaling model. The continuous wave amplitude dispersion effects are subtracted from the measured celerity profiles, resulting in nearshore bathymetric profiles. The nonlinear depth inversion derived bathymetric estimates from nearshore imagery match the measured values with a biased mean depth error of about +0.06m in the depth range of 0.1 to 3m. In addition, the wave height estimates by the depth inversion model are comparable to the in-situ measured wave heights with a biased mean wave height error of about +0.14m. The present depth inversion method based on optical remote-sensing supports coastal management, navigation, and amphibious operations.

Voices of Our Forefathers (2008) is a participatory video that was made with a group of Khwe Bushmen in Platfontein in the Northern Cape. It is unique not only for its inclusion of the Khwe subjects in the production process, but also for its unique representation of them. It portrays them from historical as well as modern perspectives. This research explores how a group of Khwe youth – the research participants – engaged and negotiated their encounter with the Voices of Our Forefathers (2008). It does this within the context of participatory communication for development and participatory video. It draws on theories of empowerment, reception and representation. A qualitative methodology was employed with in-depth interviews comprising the main data collection method, and thematic analysis and semiotics being the main data analysis methods. Thematic analysis was aided through the use of a software programme, Nvivo 8. The research explores research participants’ responses to Voices of Our Forefathers and critically examines articulations of empowerment. Most of the research participants felt empowered because VOOF (2008) incorporated the Khwe in the production process, particularly in terms of how they wanted to be represented. The Khwe Bushmen’s participation in their representation resulted in a range of nuanced interpretations and responses to VOOF (2008), which included discussions on rethinking their identities, learning new skills, fostering a sense of ownership of the film and the use of their language (Khwedam) in The Voices of Our Forefathers. It is argued, however, that although the research participants may have expressed that they are empowered, this needs to be understood and critically examined with respect to the larger contexts within which Bushmen, in general, live, which may or may not affect their senses of and the realities of their empowerment. Finally, it is argued that VOOF (2008) needs to be understood as a part of an on-going process in participatory communication for development. It might not have provided research participants with the necessary resources to completely transform their lives; it did, however, contribute to changing how they perceive themselves, which, according to Freirean theory, is a necessary step in empowering oneself. / Thesis (M.A.)-University of KwaZulu-Natal, Durban, 2011.

Worldwide research regarding the movement patterns, heart rate recordings and work–to–rest ratios of rugby union referees is very limited. It is therefore very important to extend research regarding this topic. The first objective of this dissertation was to determine the frequency, duration and intensity of movement patterns and work–to–rest ratio of different refereeing panels of South African Rugby Union referees during match–refereeing at the National Club Rugby Championship in Stellenbosch during 2007. The second objective was to compare the two halves of the match with regard to the frequency, duration and intensity of the different movement patterns and the work–to–rest ratios of various of SARU referees during match–refereeing at the National Club Rugby Championship in Stellenbosch during 2007. The South African Rugby Union referees were monitored during match–refereeing by means of video and heart rate recordings for a total of 16 matches within a week tournament. The frequency and duration of the different movement patterns during both halves of the matches were analysed using a Dartfish TeamPro analysis software package. Heart rates were recorded during the matches to determine the movement pattern intensities of the referees for the duration of each match using a Suunto Team pack heart rate monitoring system. The work–to–rest ratios were determined by comparing the time (in seconds) spent working (lateral movements and sprinting) to the time spent resting (standing still, walking and jogging). The results revealed a moderate practical significant difference (d=0.51) between the mean frequency of jogging movement patterns for the different refereeing panels. A moderate practical significant difference was also found between the mean duration of jogging (d=0.43) and sprinting (d=0.43) movement patterns of different refereeing panels. The mean intensity of the movement patterns by the different refereeing panels showed large practical significant differences between the anaerobic threshold (d=3.68) and sub–threshold (d=1.36) levels and a moderate practical significant difference for the maximal heart rate zones (d=0.43). Both the provincial and contender panel referees had work–to–rest ratios of 1:4 during match–refereeing. In comparing the two halves of rugby match–refereeing, a large practical significant difference was found between the mean frequency of movement pattern values for standing still (d=2.53), walking (d=2.50), jogging (d=2.42), lateral movements (d=2.86) and sprinting (d=1.31) as well as for mean duration of movement pattern values for standing still (d=2.05), lateral movements (d=0.76) and sprinting (d=0.77). Large practical significant difference were found between the time spent in the maximal threshold (d=2.07), anaerobic threshold (d=0.92) and sub–threshold (d=7.90) heart rate zones measured during the two halves of match–refereeing. Average work–to–rest ratios of 1:3.5 and 1:5 were found for the first and second halves of rugby match–refereeing, respectively. The information gained regarding the activity profile of SARU referees could be used to determine the influence of rugby refereeing experience on the movement patterns and work–to–rest ratio of rugby referees. It can also provide information for constructing specific training programmes and drills in the development of rugby match–required fitness standards for referees. A key component of a rugby union referee’s game is positioning. Being in the right place at the right time is vital. The results of this study suggest that movements associated with positioning ? namely standing still, walking and lateral movements are the major components of the game of referees’ movement during match–refereeing. However, further research is required on this topic of research. / Thesis (M.A. (Sport Science))--North-West University, Potchefstroom Campus, 2012.