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Mon domaine de recherche est l'Interaction Homme-Machine. Mes travaux dans ce domaine s'organisent autour de deux axes. <br /><br />Le premier axe concerne la conception de systèmes interactifs pour la coordination, la communication et la collaboration entre individus. Je m'intéresse en particulier à la manière dont des moyens vidéo peuvent être utilisés pour permettre des échanges plus subtils (i.e. légers, nuancés, implicites) et plus informels (i.e. spontanés, opportuns) que ceux permis par les systèmes actuels.<br /><br />Le deuxième axe concerne la conception de nouvelles métaphores et techniques destinées à enrichir et simplifier l'interaction au quotidien avec les systèmes informatiques. Je m'intéresse plus particulièrement aux moyens de faire évoluer la métaphore du bureau sous-jacente à la gestion des données et des applications dans la plupart des systèmes actuels.<br /><br />Ce document présente les problématiques liées à ces deux axes de recherche, les travaux s'y rapportant auxquels j'ai participé depuis septembre 2001 et quelques perspectives ouvertes par ces travaux.

<p>När Windows Vista introducerades förändrades mappstrukturen för hur användarprofilen sparas jämfört med tidigare Windowsversioner såsom Windows XP. Denna rapport undersöker kompatibilitetsproblem med Roaming User Profiles mellan äldre och nyare versioner av operativsystemet. Syftet med rapporten var att utreda vilka problem som kan uppstå, vad det gäller Roaming User Profiles, vid en övergång från Windows XP till Windows Vista eller 7. Undersökningen genomfördes med hjälp av laborationer, litteratur och tester för att hitta problemen såväl som lösningar till dem. Resultatet visar att profiler skapade med Windows XP inte följer med till Windows Vista eller 7 utan det skapas sammanlagt två olika profiler, en för det äldre och en för det nyare operativsystemet. Ett skript som kopierar en användares filer från Windows XP till Vista/7 utformades därför. Slutligen presenterades en handlingsplan med olika alternativ vid en övergång från Windows XP till den nyare generationen av operativsystemen i Windowsfamiljen. Folder Redirection är en väl fungerande lösning dock går funktionaliteten som Roaming User Profiles erbjuder förlorad eftersom man endast får en uppmappning av bl.a. ”Mina Dokument” och ”Start Menu”.</p>

L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blocage stérique, constitue une nouvelle stratégie prometteuse pour réguler l'expression génétique. Ces ON peuvent mener au traitement de maladies comme la β-thalassémie, la dystrophie musculaire de Duchenne (DMD) ou les cancers. Cependant leur développement clinique requiert un système de délivrance efficace. Les peptides cationiques (CPPs) sont caractérisés par leur capacité à s'internaliser dans les cellules eucaryotes. Cependant leur efficacité à promouvoir la délivrance cytoplasmique et nucléaire des ON est limitée par leur séquestration dans des vésicules d'endocytose, ce qui est à l'origine de la dégradation du matériel internalisé. Nous avons contribué à l'étude du trafic intracellulaire et de l'activité dans un essai de correction d'épissage de plusieurs familles de CPPs capables de délivrer efficacement des analogues d'ON à des doses non toxiques et en absence d'agents endosomolytiques. Nos études mécanistiques indiquent que ces constructions (covalentes ou non covalentes) CPP-ON sont endocytées par la voie clathrine, que la ségrégation dans les endosomes reste une limitation et qu'il existe une bonne corrélation entre leur activité biologique et leur capacité à déstabiliser les membranes endosomales. / The use of antisense oligonucleotides PMO or PNA to correct splicing errors by steric- block represents a new promising therapeutic strategy. These ONs lead to the treatment of diseases such as β-thalassemia, Duchenne muscular dystrophy (DMD) or cancers. However their functional success requires efficient delivery. Cationic cell penetrating peptides (CPPs) are characterized by their ability to be internalized in eukaryotic cells. However their efficiency in promoting cytoplasmic and nuclear delivery of ON has been hampered by endocytic sequestration and subsequent degradation of internalized material in endocytic vesicles, which is responsible for the degradation of internalized material. We have contributed to the study of intracellular trafficking and activity (using splicing correction assay) of several families of CPPs capable of delivering effective analogs ON at nontoxic doses and in the absence of agents endosomolytic. Our mechanistic studies indicate that these constructs (covalent or noncovalent) CPP-ON are internalized through clathrin, that segregation in endosomes remains a limitation and that there is good correlation between biological activity and their ability to destabilize endosomal membranes.

När Windows Vista introducerades förändrades mappstrukturen för hur användarprofilen sparas jämfört med tidigare Windowsversioner såsom Windows XP. Denna rapport undersöker kompatibilitetsproblem med Roaming User Profiles mellan äldre och nyare versioner av operativsystemet. Syftet med rapporten var att utreda vilka problem som kan uppstå, vad det gäller Roaming User Profiles, vid en övergång från Windows XP till Windows Vista eller 7. Undersökningen genomfördes med hjälp av laborationer, litteratur och tester för att hitta problemen såväl som lösningar till dem. Resultatet visar att profiler skapade med Windows XP inte följer med till Windows Vista eller 7 utan det skapas sammanlagt två olika profiler, en för det äldre och en för det nyare operativsystemet. Ett skript som kopierar en användares filer från Windows XP till Vista/7 utformades därför. Slutligen presenterades en handlingsplan med olika alternativ vid en övergång från Windows XP till den nyare generationen av operativsystemen i Windowsfamiljen. Folder Redirection är en väl fungerande lösning dock går funktionaliteten som Roaming User Profiles erbjuder förlorad eftersom man endast får en uppmappning av bl.a. ”Mina Dokument” och ”Start Menu”.

Various anomalous effects that emerge when the interfaces between media are involved in sound-matter or light-matter interactions are studied. The three specific systems examined are a fluid channel between elastic metal plates, a linear chain of metallic perforated cylindrical shells in air, and a metal-dielectric slab with the interfaces treated as finite regions of smoothly changing material properties. The scattering of acoustic signals on the first two is predicted to be accompanied by the effects of redirection and splitting of sound. In the third system, which supports the propagation of surface plasmons, it is discovered that the transition region introduces a nonradiative decay mechanism which adds to the plasmon dissipation. The analytical results are supported with numerical simulations. The outlined phenomena provide the ideas and implications for applications involving manipulation of sound or excitation of surface plasmons.

Cost efficient operation and maintenance strategies are crucial for reducing cost of wind energy. Since the regime change from feed-in tariffs to an auction-based bidding system for capacity in most European wind projects, levelized cost of energy is challenged constantly. Therefore, new technologies such as new controllers are developed to improve operation and to increase profit. Previous research studies demonstrated the advantage of increased power output of wake redirection control. However, understanding and quantifying the impact of wind farm control technologies on operation and maintenance strategies is inevitable to evaluate the economic feasibility of such new technologies. Thus, an event-based O&amp;M simulation tool has been developed. Besides general modules, such as the wind turbine model, the weather forecasting model and a model for simulating corrective and planned maintenance, the developed tool also takes wake effects into account. This allows considering different power productions for each individual turbine and a failure rate distribution within the wind farm which is based on altering loads on the different components. Both aspects are driven by changes in operation when applying a new controller technology. Exemplarily, the economic feasibility of a closed-loop active wake steering control has been analysed. Main achievements of this study are the possibility to quantify the impact of the active wake steering control on O&amp;M related KPIs. Results show that additional loads caused by applying yaw-misalignment and redirecting wake, lead to an increase in OPEX. However, the achieved energy production gain and thus related additional revenue exceeds additional cost in the case study. Nonetheless, the study reveals that the profitability of the controller is highly dependent on the electricity price which can be acquired during the wind farm’s lifetime.

Made available in DSpace on 2016-06-02T19:06:15Z (GMT). No. of bitstreams: 1 6215.pdf: 2705931 bytes, checksum: f13134b07bf961a0e166ae8f6fdc0bf0 (MD5) Previous issue date: 2014-02-27 / Financiadora de Estudos e Projetos / During the last decade, the advent of large scale processing and the need for rapid modification of computational structures have increased the popularity of Cloud Computing, particularly the Infrastructure as a Service model. Several companies have invested in infrastructure to become providers of this kind of service, whether for general public or only to supply their own business needs. This has increased the number of virtualized datacenters across the world and created a growing interest in interoperability between different providers. However, due to the lack of technology standardization, and to limitations in the current network s architecture, this interoperability is still an issue. Based on this, this research project presents an OpenFlow based network flow redirection architecture to support service continuity during the migration of applications between different IaaS providers. The tests performed show the applicability of the proposed architecture in a real network environment, having control only of the network edges, and without setting up any specific hardware. / Durante a ultima década, o advento do processamento em larga escala e a necessidade de rápida modificação de estruturas computacionais fez com que a computação em nuvem se popularizasse, em particular na forma de aprovisionamento de Infraestrutura como Serviço. Diversas companhias investiram em infraestrutura para se tornarem provedores desse tipo de serviço, seja para o publico ou para proverem recursos para seus próprios negócios. Isto aumentou o numero de centros de dados virtualizados e gerou o interesse na interoperabilidade entre os diferentes provedores. Entretanto, devido a falta de padronização de tecnologias, e devido a limitações na arquitetura das redes atuais, essa interoperabilidade ainda e um assunto em aberto. Com base nisso, o presente trabalho apresenta uma arquitetura de redirecionamento de fluxos de rede baseada em OpenFlow para o suporte a continuidade de serviço durante a migração de aplicações entre diferentes provedores de IaaS. Os testes realizados comprovam sua aplicabilidade em um cenário real, controlando apenas as bordas da rede, e sem a instalação de nenhum hardware específico.