When stimuli processing time varies in an oddball paradigm, the latency of the P300 will vary across trials. In an oddball task requiring difficult response selections, as the variation of stimuli processing time increases, so does the variation of the P300 latency, causing latency jitters in the measurement. Averaging the P300 across different trials without adjusting this latency jitter will lead to diminished P300 amplitude, resulting in inaccurate conclusions from the data. Verleger et al. (2014) reported a diminished P300 amplitude in a difficult oddball task that required subjects to make response selections among stimuli that are difficult to distinguish, but his work did not correct for any latency jitter observed within his sample. The current study replicated the easy and hard oddball tasks conducted in Verleger et al.. Raw ERPs obtained from 16 subjects indicated a successful replication of the study. An examination of the behavioral data showed that there was substantial variation in the P300 during the hard oddball tasks, and a latency jitter correction was applied in the analysis. Results indicated that there was a significant increase in the amplitude of P300 after latency jitter correction, and that this P300 amplitude did not differ significantly between easy and hard oddball tasks. These results suggest that difficult decision requirement does not reduce the amplitude of the P300, and that latency jitter should be accounted for when analyzing data from tasks involving a difficult decision requirement.

The current study used event-related potentials (ERPs) to investigate how motivational salience in the form of expectation violation influences spatial attention. The medial frontal negativity (MFN) ERP indexes expected value, being negative to unexpected punishments and positive to unexpected rewards. The P1 and N1 ERPs index spatial attention, being larger to stimuli in attended locations. This design attached motivational value to locations by making one visual hemifield economically rewarding (greater probability of a rewarding outcome) and the other punishing (greater probability of a punishing outcome). Keypresses to a dot probe following a reward-signifying stimulus were awarded money if correct, and penalized following a punishment-signifying stimulus if incorrect. We predicted that salience would be attached to visual hemifield, thus the MFN would be most negative to punishing outcomes in the rewarding hemifield and most positive to rewarding outcomes in the punishing hemifield. We also predicted that attention would be allocated to a location where expectation was violated, thus the P1 and N1 ERPs would be larger and RTs (reaction times) faster to dot probes appearing in the same side as an outcome that violated expected value. In a sample of 36 participants, there were no significant effects on the MFN, although the means were in the predicted direction, suggesting a lack of power. Contrary to our hypothesis, keypresses were slower, P1 smaller, and N1 larger to probes opposite the location where an expectation violation occurred. This suggested that expectation violation did not direct attention to a particular location, but produced general interference.

Class of 2015 Abstract / Objectives: To compare provider acceptance rates of medication therapy management (MTM) interventions initiated by a MTM center for potential drug-related problems in 2012. Interventions included cost-savings to patients, adherence to clinical guidelines, medication adherence, and safety initiatives. Methods: This retrospective cross-sectional project measured the provider acceptance rates of MTM interventions for Medicare Part D beneficiaries. Intervention count and acceptance rates were analyzed from the center’s MTM software and database that utilizes prescription claims analysis post-intervention to determine intervention success. A chi-square test was used to assess the statistical significance between the interventions. An alpha level of 0.5 was determined a-priori. This was a quality improvement project, and Institutional Review Board approved this project as exempt status. Results: The total percent of recommendations accepted was 35% (159,795 out of 455,898). The rate of acceptance was highest for safety interventions (51%), followed by cost (35%), adherence (12%), and guidelines (8%). The acceptance rates for the four intervention types were statistically different from each other (p-value <0.0001). Within each intervention type, the most frequently accepted interventions were: removal of medications from the Beer’s Criteria (8% of safety related changes); changes from a brand name, non-oral medication like eye drops and nasal sprays, to a generic within the same class (15% of cost-saving related changes); improved adherence to hypertension and diabetic medications (29% of adherence related changes); and adding an antihypertensive agent to diabetic patients (62% of clinical guideline related changes). Conclusions: Safety initiatives had the highest acceptance percentage of all four intervention types. Approving more safety interventions with medication use may reduce the risk of morbidity and mortality. Pharmacists providing MTM services may want to increase focus on drug safety as providers are accepting more safety interventions. More research is needed to determine why providers approve the other recommendations at lower rates.

Class of 2016 Abstract / Objectives: To compare health-related quality of life (HRQoL) among stroke survivors by gender and race/ethnicity to identify gender and racial/ethnic disparities. Methods: This study adopted a retrospective cross-sectional research design utilizing data from the 2013 Behavioral Risk Factor Surveillance System (BRFSS), a state-based telephone survey administered to noninstitutionalized United States citizens. Inclusion criteria for this project were adults aged 50 or older who: participated in the 2013 BRFSS survey; indicated they had ever been told by a provider that they had experienced a stroke (of any type); and reported data on seven questions aimed to assess HRQoL (general, physical, and mental health; life satisfaction; emotional support; activity limitations; and sleep quality). Chi square tests and logistic regression models were used to compare HRQoL responses by gender and race/ethnicity. Results: In the 2013 BRFSS database 20,391 of 491,773 respondents reported experiencing stroke. Of those, 16,561 met the inclusion criteria. The majority were female (61.1%) and identified their race/ethnicity as white (78.6%). Logistic regression analysis revealed females were more likely than males to report worse outcomes across the following three HRQoL domains: activity limitations (AOR=0.752, 95% CI 0.617-0.918); mental health (AOR=1.398, 95% CI: 1.110-1.761); and general health (AOR=0.764, 95% CI: 0.588-0.993). Minority populations (African American, Hispanic, and Other) were more likely to report activity limitations (AOR=0.766, 95%CI: 0.614-0.955) and fair/poor general health (AOR=1.837, 95%CI: 1.324-2.549). Conclusions: Analysis identified gender and racial/ethnic disparities in HRQoL indicators among stroke survivors. Females and minority populations were more likely to report poorer outcomes.

Magister Scientiae (Physiotherapy) - MSc(Physio) / Lack of adherence to the correct working conditions exposes workers to ergonomics-related hazards and eventually work-related musculoskeletal disorders (WRMDs) which are estimated at 160 million per year globally. Literature shows that with modernization by use of computers, administrators are exposed to prolonged sitting and long working hours which predisposes them to ergonomic hazards. Low back pain and neck pain are the leading work-related musculoskeletal disorders with a lifetime prevalence of 70 - 80% and 50 - 60% respectively.Both low back pain and neck pain have a multifactorial aetiology that includes work-related and individual related factors. Lack of reporting of work-related injuries has led to paucity of statistical literature with regards to work-related low back pain and neck pain, especially in the developing countries. The aim of this study was to determine the prevalence of ergonomics related low back pain and neck pain, and describe the effect of a knowledge-based ergonomic intervention among administrators in Aga Khan University Hospital, Nairobi (AKUH, N). A mixed method design was used in this study using a survey and two focus group discussions(FGD). A self-administered questionnaire that is in four sections was administered to 208 participants. The questionnaire sought the prevalence of musculoskeletal disorders, the knowledge of participants with regards to low back pain and neck pain as well as the work-related and individual risk factors related to the same. The dissemination of the study results involved a one hour knowledge-based ergonomic session given to all interested participants, based on the information from the survey. Two FGD with purposive selection of eight participants were held to explore their experience on the value of the information provided.The statistical package for social sciences (SPSS) version 20 was used to capture and analyze the quantitative data. Descriptive statistics was used to summarize the study findings in the form of means, frequencies, standard deviations and percentages. Inferential statistics (chi-square) was used to test the associations between different categorical variables (p<0.05). For the qualitative data, the tape recorded interviews were transcribed verbatim, field notes typed, sorting and arranging data was done and themes were generated. Thematic content analysis was used to generate the themes. The aim of the study, confidentiality and the participants‘ freedom to withdraw from the study were explained. Informed consent was also obtained before the survey and FGD and referral was made where necessary. The findings of the current study revealed that the study participants were knowledgeable about ergonomics-related low back pain and neck pain however this knowledge was not directly translated into behaviour. Low back pain (LBP) had the highest twelve month prevalence at 75.5% followed by neck pain at 67.8%, and LBP showed significant associations at p< 0.05 with some work-related and individual risk factors. The results of the FGDs showed that most participants had positive behavioural and attitudinal change post the knowledge-based ergonomic intervention despite the challenges they met in implementing the behavioural change. These results therefore show the need for continual education about ergonomics to create awareness on the predisposing factors to work-related LBP and neck pain, hence promoting a healthier quality of life amongst employees through adherence to healthy work behavioural practice.

This research is an exploratory study, examining how people feel about HIV/AIDS and their reaction towards a person who tested HIV positive. The purpose of the study was to explore factors contributing to the stigma associated with HIV/AIDS in Mamelodi and Atteridgeville. Thirty fieldworkers interviewed a convenient sample of 1077 respondents from different ethnic groups, gender, educational level, marital status and age groups and found that respondents tend to stigmatising persons with HIV/AIDS. This research uses both quantitative and qualitative methods as a research approach. The two methodologies were used with the intention of making some contribution to the methodology of social psychological HIV/AIDS studies. The questionnaire was employed as a quantitative instrument with a view to identify the respondents’ views. The questionnaire consists of five (5) sections: Personal information, health related questions, an HIV knowledge scale consisting of 16 questions and two HIV stigma scales used to assess personal and perceived community stigma. The level of personal stigma attached to HIV/AIDS was found to be lower than the level of stigma perceived in the community. This indicates that people perceive a collective stigma in the community that is negative, blaming, judging and restrictive towards interaction with people with HIV/AIDS. The perception of highly stigmatising attitudes in the community was shared by all sub-groups in the study. Only 22% of people surveyed would be scared or felt uncomfortable sending their child to school with children living with AIDS. Almost 42% of respondents believe that people who were exposed to AIDS through sex got what they deserved. In general, research shows that knowledge of HIV is quite high (95%). / Dissertation (MA (Research Psychology))--University of Pretoria, 2008. / Psychology / unrestricted

Consuming alcohol may lead to negative consequences, such as aggression, violence or drunkdriving. However, not all adolescents who consume alcohol engage in negative behaviors.The purpose of this study was to examine the role of gender and impulsivity as risk factors forengagement in negative conducts after alcohol intoxication. The sample of this studycomprised 1,002 Swedish adolescent students between 12 and 16 years of age (52% boys). Students filled in self-report questionnaire at two time points (T1 and T2), once a year. Aftercontrolling for previous levels of negative consequences of alcohol consumption, as well asfor drinking habits at T1, the result showed that impulsivity had an impact on adolescent’salcohol-related consequences after intoxication. Also, boys showed a higher tendency toreport negative consequences after alcohol intoxication compared to girls. All in all, thislongitudinal study shed new light on the personality aspects that make adolescents more likelyto engage in negative conducts after alcohol consumption.

Located in the middle part of the Baltic, the island of Gotland underwent major environmental changes, associated with different stages of the development of the basin during the Holocene, and therefore represents a promising location for shore-displacement studies. This thesis is focused on a palaeohydrological evolution of the Lina Mire, central eastern part of Gotland, in the Middle Holocene and aims to reconstruct the timing and environment of the Littorina transgression. The research is based on a multi-proxy approach and carried out, applying lithostratigraphical, biostratigraphical (diatom analysis) and geochemical methods (XRF, organic and carbonate content) along with radiocarbon dating. The initiation of the Littorina transgression was constrained at 8.5 ka cal BP, however, probably proceeded by a hiatus. A two-folded pattern oft he maximum sub-phases is suggested. Acquired results fit well with previous studies on areas with the similar rate of apparent land uplift, suggesting an average rate of 2 mm/yr for the last 2.8 ka. / I Tjelvars fotspår

Traumatic brain injuries (TBI) are one of the leading causes of disability worldwide (Zitnay, 2008), yet one of the least understood neurological conditions (Duncan, 2005). Research has examined short-term deficits; however, less focus has been on the consequences of multiple concussions. Previous electroencephalography (EEG) concussion research has examined the N200 and P300 human event-related potential (ERP) components, yielding inconclusive results (Duncan, Kosmidis & Mirsky, 2005). An ERP component not as frequently examined is the reward positivity, generated by the anterior cingulate cortex (ACC), a region which experiences increased anatomical stress following injury. In this study, 51 students from the University of Victoria took a ‘Concussion Survey’ to determine participant history and groups; no history of concussion, a single injury or multiple injuries (2+). Participants performed an oddball and decision-making task while EEG data was collected. No significant differences were found between groups for the N200, P300 or reward positivity peak latencies or amplitudes. Both concussion groups yielded attenuated peak amplitudes, but no differences existed between the group with a single concussion versus multiple. Unexpectedly, N200 and reward positivity peak latencies were greater in the group with single injuries, compared to those with a history of multiple concussions. This study adds to a continuous line of inconclusive research on the N200 and P300, suggesting minimal cognitive deficits result from concussive injuries. Furthermore, no noticeable differences were observed between groups with a single versus multiple injuries. While the ACC is located in a region of increased stress following TBI, functional deficits impacting the reward positivity may not be as significant as previously hypothesized. Results may be impacted by confounding variables, including not reliably being able to account for time since injury, injury severity and differences in gender dispersion of participants. With concussions on the rise, continued research, particularly longitudinally and within-subjects is critical for the advancement of both TBI prevention and management. / Graduate

Age-related macular degeneration (AMD) is the leading cause of blindness inAmerica. The fact that AMD wreaks most of the damage in the center of the retina raises the question of whether light, integrated over long periods, is more concentrated in the macula. A method, based on eye-tracking, was developed to measure the distribution of light in the retina under natural viewing conditions. The hypothesis was that integrated over time, retinal illumination peaked in the macula. Additionally a possible relationship between age and retinal illumination was investigated. The eye tracker superimposed the subject’s gaze position on a video recorded by a scene camera. Five informed subjects were employed in feasibility tests, and 58 naïve subjects participated in 5 phases. In phase 1 the subjects viewed a gray-scale image. In phase 2, they observed a sequence of photographic images. In phase 3 they viewed a video. In phase 4, they worked on a computer; in phase 5, the subjects walked around freely. The informed subjects were instructed to gaze at bright objects in the field of view and then at dark objects. Naïve subjects were allowed to gaze freely for all phases. Using the subject’s gaze coordinates, and the video provided by the scene camera, the cumulative light distribution on the retina was calculated for ~15° around the fovea. As expected for control subjects, cumulative retinal light distributions peaked and dipped in the fovea when they gazed at bright or dark objects respectively. The light distribution maps obtained from the naïve subjects presented a tendency to peak in the macula for phases 1, 2, and 3, a consistent tendency in phase 4 and a variable tendency in phase 5. The feasibility of using an eye-tracker system to measure the distribution of light in the retina was demonstrated, thus helping to understand the role played by light exposure in the etiology of AMD. Results showed that a tendency for light to peak in the macula is a characteristic of some individuals and of certain tasks. In these situations, risk of AMD could be increased. No significant difference was observed based on age.