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Investigation of the Roles of Pseudouridine Synthases in Ribosome Biogenesis and Epitranscriptomic Gene RegulationJayalath, Kumudie 03 December 2021 (has links)
No description available.
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Elongation Factor P is required for clinically relevant phenotypes in <i>Acinetobacter baylyi </i>.Kostrevski, Dylan 03 May 2023 (has links)
No description available.
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Developmental Regulation of Translation in Parasitic FlatwormsHagerty, James Robert 01 September 2021 (has links)
No description available.
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The role of microRNAs, DNA methylation and translational control in regulation of sex specific gene expression in mouse liverHao, Pengying 09 October 2018 (has links)
Sex differences are widespread in both mouse and human liver, and are associated with sex differences in drug metabolism and liver pathophysiology. The secretory patterns of growth hormone (GH) is one of the major drivers of liver sex specificity, where intermittent and continuous secretion in male and female respectively lead to sex bias in the expression of more than 1000 genes in mouse liver, via a complex interplay of GH-responsive transcription factors and epigenetic mechanisms. This thesis explores three themes of molecular control in the regulation of liver sex differences: microRNAs, DNA methylation, and translational control. Studies herein identified two microRNAs, miR-1948-5p and miR-802-5p, whose expression is sex biased and regulated by GH and the
transcription factor STAT5b. Small RNA sequencing confirmed the sex specificity of these two microRNAs and identified an additional 18 sex-biased microRNAs. Computational and experimental characterization of miR-1948-5p and miR-802-5p confirmed their authenticity. In vivo inhibition of these microRNAs by locked nucleic acids indicated that miR-1948-5p and miR-802-5p played a functional role in repressing female-biased genes and male-biased genes, respectively. This thesis also investigated the impact of GH and STAT5b on liver DNA methylation profiles. Reduced representation bisulfite sequencing was performed on liver tissues from four mouse models that perturbed the GH and STAT5b axis. In the wildtype liver, sex biased demethylation was positively associated with sex biased chromatin opening and gene expression. Global hypermethylation was observed in livers of mice with lit/lit mutation resulting in GH deficiency or with hepatocyte-specific deletion of the STAT5ab locus. Strikingly, these hypermethylated loci were enriched for enhancer elements and STAT5b binding sites found in wild-type mouse liver. Hypophysectomy followed by GH replacement mouse models identified differentially methylated regions that were sex-biased and rapidly methylated and demethylated in response to GH stimulation. Finally, we used ribosome profiling to validate sex-biased protein translation and identify mechanisms of translational control. In sum, this body of work provides novel insights and broadens our understanding of the diverse molecular mechanisms underlying sexual dimorphism in the liver. / 2020-10-08T00:00:00Z
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RIBOSOME - mRNA INTERACTIONS THAT CONTRIBUTE TO RECOGNITION AND BINDING OF A 5’-TERMINAL AUG START CODONKrishnan, Karthik M. 30 June 2010 (has links)
No description available.
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Loss of tumor suppressor RPL5/RPL11 does not induce cell-cycle arrest, but impedes proliferation due to reduced ribosome content and translation capacity: Implications in Diamond Blackfan AnemiaTeng, Teng January 2013 (has links)
No description available.
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Coevolution of Ribosomes and The Translational Apparatus: The Structure and Function of Eukaryotic Ribosomal Protein uS7 from Yeast, Saccharomyces cerevisiae.Ghosh, Arnab 25 June 2015 (has links)
No description available.
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Novel Role of SEC23B as a Cancer Susceptibility Gene in Cowden Syndrome and Apparently Sporadic Thyroid CancerYehia, Lamis 02 February 2018 (has links)
No description available.
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Determining the mechanism of elongation factor P -dependent regulation of gene expressionElgamal, Sara January 2015 (has links)
No description available.
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Functional Studies of Transfer RNA Interactions in the RibosomeWalker, Sarah Elizabeth 10 September 2008 (has links)
No description available.
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