Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The present work describes a methodology of controlled synthesis of block copolymers by one-pot reactions involving simultaneous RAFT and ROP processes mediated by a bifunctional compound which acts as a chain transfer agent (CTA) for the RAFT process and co-initiator of the ROP process. Reactions involving the RAFT of Styrene (St) and the ROP of ε-Caprolactone (ε-CL) were performed to obtain PS-b-PCL diblock copolymers. The catalysts Sn(Oct)2 and diphenyl phosphate (DPP) were evaluated in the ROP process. Diphenyl phosphate is the most appropriate for this kind of reaction, since Sn(Oct)2 proved to be avid when interacted with CTA, interfering antagonistically in the radical equilibrium of the RAFT process. The reactions were always controlled when DPP was used as a ROP catalyst, wherein copolymers with narrow molar mass distribution were obtained in the end. This methodology was employed in the synthesis of other linear and graft amphiphilic block copolymers, proving to be an excellent alternative for this purpose. Thermoresponsive copolymers based on Poly(oligo(ethylene glycol)methyl ether methacrylate) (POEGMA) and pH responsive based on Poly(acrylic acid) (PAA) were obtained. The physicochemical properties of the copolymers were investigated in solid state as well as in solution, and the results are in total agreement with values reported in the literature. / Este trabalho descreve uma metodologia de síntese controlada de copolímeros em bloco por reações one-pot envolvendo processos RAFT e ROP simultâneos, mediados por um composto bifuncional que atua como agente de transferência de cadeia (CTA) para o processo RAFT e co-iniciador do processo ROP. Reações envolvendo a RAFT do estireno (St) e a ROP da ε-Caprolactona (ε-CL) foram realizadas para obter copolímeros dibloco PS-b-PCL. Os catalisadores Sn(Oct)2 e difenil fosfato (DPP) foram avaliados, sendo o último o mais apropriado para este tipo de reação, uma vez que Sn(Oct)2 mostrou-se ávido por interações com o CTA, interferindo antagonicamente no equilíbrio de radicais do processo RAFT. As reações mantiveram o caráter controlado quando DPP foi usado como catalisador ROP, sendo que ao final, copolímeros com estreita distribuição de massa molar foram obtidos. Esta metodologia foi empregada na síntese de outros copolímeros em bloco anfifílicos lineares e enxertados, se mostrando uma excelente alternativa para este propósito. Copolímeros termoresponsivos à base de Poli(metacrilato de poli(etilenoglicol)metil éter) (POEGMA) e pH responsivos à base de Poli(ácido acrílico) (PAA) foram obtidos. As propriedades físico-químicas dos copolímeros foram investigadas em estado sólido e em solução, e os resultados estão em plena concordância com valores relatados na literatura.

This diploma thesis focuses on strategic documents concerning the development of Zlín's region and their mutual compatibility. As first the theoretical part is concentrated on a general definition of regional policy and also Czech regional policy. Next, there are described individual strategic documents on the national and regional level and their mutual relations. In the practical part the thesis deals with particular documents of Zlín's region, i.e. Program for development of the Zlín's region territory, Development strategy of Zlín's region, Regional innovation strategy and above all Regional operational program NUTS II Middle Moravia. For each document there is described its vision and targets and there are indicated relations to other documents. The main part is focused on the Regional operational program NUTS II Middle Moravia and its relations to the other discussed strategic documents of Zlín's region based on its priorities and targets that are demonstrated through schemes. Finally, there is an evaluation of ability of ROP NUTS II Middle Moravia to fulfil priorities of Zlín's region.

The master‘s thesis is focused on financing of non-profit organization project. There are particular concepts of financing and appreciation mentioned. The possibility of getting funds from EU is also one of the solutions for financing the project. Submitter of the project is the Technical High School Karvina. The subject of the project is revitalization of a sports stadium to comply with the highest standards.

This theses is focused on the European Union and EU funds. Description of structural policy and its history, with a focus on structural and cohesion funds. Furthermore, attention is focused on the subsidy received from the ROP southeast. In summary is given a new programming framework 2014-2020. The practical part of the thesis was to describe, analyze and evaluate the project co-financed by EU structural funds. The project was implemented within the ROP SE and tackle integrated transport in the region Breclav.

Les travaux présentés dans ce manuscrit ont porté sur l'élaboration de nouveaux copolymères dibloc amphiphiles (poly(ε-caprolactone)-b-poly(méthacrylate d'oligo(éthylène glycol) méthyl éther) biodégradables, thermostimulables et susceptibles d'être employés dans des applications respectueuses de l'environnement comme le traitement des eaux contaminées. La particularité de ces copolymères provient d'une part de la différence de solubilité des deux blocs et d'autre part de l'association d'un bloc hydrophobe biodégradable à un bloc thermostimulable hydrophile. Les propriétés de ces copolymères en milieu aqueux ont ainsi été évaluées en fonction de la température. Ces composés ont été obtenus par la combinaison de deux techniques de polymérisation contrôlée en utilisant un amorceur difonctionnel. Pour cela, deux stratégies ont été testées : i) la polymérisation par ouverture de cycle (POC) de l'ε-caprolactone à partir d'un macro-amorceur de poly(méthacrylate d'oligo(éthylène glycol) méthyl éther) à terminaison OH après avoir mis au point les conditions expérimentales de la POC en comparant plusieurs catalyseurs. ii) par polymérisation radicalaire par transfert d'atome (ATRP) du méthacrylate d'oligo(éthylène glycol) amorcée à partir d'une poly(ε-caprolactone) à extrémité bromée. Les températures critiques inférieures de solubilité (LCST) de ces copolymères ont été déterminées par UV visible. Leurs comportements micellaires ont été étudiés par mesures HPPS / The development of new biodegradable diblock copolymers poly(ε-caprolactone)-b-poly[oligo(ethylene glycol)methyl ether methacrylate], which could be used in environmental friendly applications such as treatment of contaminated water has been the main goal of this work. For the preparation these copolymers, the ring-opening polymerization (ROP) and the Atom Transfer Radical Polymerization (ATRP) were combined by using a bifunctional initiator. The two-step route for the synthesis of these copolymers was using either ATRP or ROP as first step and the other polymerization secondly. Each polymerization was studied carefully in order to control the macromolecular parameters of the copolymers. On the one hand, the ATRP of methacrylates bearing oligo(ethylene glycol) was carried out by using poly(ε-caprolactone) with bromide end-group as macroinitiator. On the other hand, the ring opening polymerization of ε-caprolactone was initiated by the hydroxyl end-group of the poly[oligo(ethylene glycol)methyl ether methacrylate], using tin octoate, tin tetrakis(phenylethynyl) or bismuth triflate as catalysts. The Low Critical Solution Temperature (LCST) of these amphiphilic diblock copolymers in aqueous medium have been determined by UV-visible spectroscopy. Their micellar behaviors were also studied by measuring size by HPPS

Although very low birth weight preterm (VLBW) infants with grade 3,4 retinopathy of prematurity (ROP) are at high risk for unfavorable visual outcomes, the middle school vision motor integration (VMI) skills and cognitive outcome scores of these children remain largely unknown. Data for 323 very VLBW survivors of the Multicenter Randomized Indomethacin IVH Prevention Trial (BW 600 1250 g) were analyzed to test the hypothesis that grades 3, 4 ROP would be an important predictor of cognitive and VMI skills. 3 subgroups were evaluated: ROP negative (N = 163), ROP grades 1,2 (N = 137) and ROP grades 3,4 (N = 23) were evaluated prospectively at 12 years of age with a neurocognitive battery. High-resolution volumetric MRI scans were quantified for 40 of the study subjects, and occipital brain volumes were correlated with Beery VMI scores. Children with ROP 3-4 had [arrow up - increased] vision impairment and lower test scores. Whole brain volumes were significantly less for children with any grade of ROP (p = 0.02), occipital white matter volumes tended to be less for the same study subjects (p = 0.08) and both total occipital brain volumes and occipital white matter volumes were significantly correlated with Beery VMI scores (r=0.610, p = 0.009 and r = 0.652, p =0.005, respectively). Prematurely-born children with a history of grade 3-4 ROP continue to have [arrow up - increased] vision impairment, special needs and lower performance on cognitive, language and visual motor integration scores at age 12 years. Both whole occipital brain volumes and occipital white matter volumes were predictive of VMI scores for children with ROP. (supp by NS 27116)

BURDÍKOVÁ, H. Ex-post evaluation of non-investment projects in the field of tourism promotion financed from ROP South-East. Thesis. Brno, 2015. This thesis is concerned with evaluation in conditions of EU Cohesion Policy. The subjects of evaluation are non-investment projects financed from the Regional Operational Programme South-East, whose implementation falls within the programming period 2007-2013. It was selected a sample of five projects, which are focused on the development and promotion of tourism in the South Moravian Region and the Region Vysočina. The theoretical part is devoted to literature review, which focuses firstly on the general definition of regional policy, its specific application in the European Union and the Czech Republic. After putting in this necessary context, it is proceeded to explain the concept of evaluation, especially the difference between program and project evaluation and detailed description of subsequent (ex-post) evaluation. The conclusion of this part is determination of procedure of ex-post evaluation, which the author observes in practical part of the thesis. This part is devoted to a brief description of selected projects and the establishment of evaluation questions, together with its own indicator system. Quantitative analysis of the data is done in consideration of the goals of the thesis, which is assessment of cost-effectiveness of projects through cost-utility method CEA. Its conclusions are complemented and explained using information from qualitative analysis - individual interviews with representatives of the grant recipients. The results of this analysis are used to answer a set of evaluation questions and also to perform comparisons using the benchmarking method. In the last part of the thesis are formulated suggestions and recommendations for improving cost-effectiveness and quality of the examined projects for the grant recipients and the managing authority of the operational program.

This thesis is focusing on corruption and misuse of financial funds from European Union. It primarily analyses Regional Operation Programme North-West (ROP Severozápad), which ended with massive corruption affair. The affair lead to the suspension of payments from the European Union, change of assignment of projects in the next programme period, but also opened the question of current trends in corruption in the Czech Republic. The main aim of the thesis was to identify the most dangerous spots that lead to misuse of European funds, connect the corruption affair with current corruption trends in the Czech Republic and suggest basic activities that could prevent the misuse of European subsidies in the future. The aim was achieved via analysis of the operation programme, that ran through the years 2007-2013. It was discovered, that the system was purpose-built so that the local politicians could manipulate with the order of winning projects and thus unfairly distribute the financial funds from the European Union.

The main aim of this thesis is a description of possibilities for obtaining the financial supports for small and medium-sized entrepreneurs and entreprises. The description allow from possibilities of regional programmes which are created by The European Union. The thesis explaining contens and conditions of regional programmes and means and main steps for creating the feasibility study clearly according to the structure and conditions of the particular programme from the order of programmes of The European Union.

Return Oriented Programming (ROP) is the de-facto technique used to exploit most of today’s native-code vulnerabilities hiding in old and newly developed software alike. By reusing bits and pieces of already existing code (gadgets), ROP can be used to bypass the ever-present Write ⊕ eXecute (W⊕X) security feature, which enforces memory to only be marked as either executable or writable; never both at the same time. Even with its widespread use, crafting more advanced ROP-chains is mostly left as a manual task. This paper attempts to explore the viability of automating ROP-chain generation by leveraging genetic programming (GP), and describes the implementation and design of the ROP-compiler GENROP in this endeavour. We introduce a novel approach to adapt GP to work within the environment of ROP, which attempts to guide the algorithm and preemptively remove pathways which are known ahead of time to be unable to generate a solution. GENROP is tested by attempting to generate a working payload against a number of binaries, and is then evaluated based on success rate and payload size when compared to angrop (another ROP-compiler). The results show that the algorithm is able to generate functioning payloads in most of the tested cases, although it does perform worse than angrop. This can partly be explained by the fact that GENROP uses gadget definitions generated by angrop, which reduces the potential viability of the ROP-compiler, as more unwieldy but potentially usable gadgets are not available. Additionally, it was found that extensively guiding the algorithm has negative consequences in terms of solution diversity. Relying on faster execution times and more iterations might produce better results. Further work is required to assess whether or not generating ROP-chains using genetic programming is a viable approach.