Open and Shut Fiona M. Ryan Doctor of Musical Arts Graduate Department of Music University of Toronto 2013 Abstract “Open and Shut” is a short opera in two scenes composed with concert opera performances in mind; it could be performed with or without staging. There are five characters in this work. The protagonist is Bridget (Soprano). In the first scene Bridget encounters Martha (Soprano) and Rose (Mezzo Soprano), two fundamentalist Christians who are handing out religious pamphlets on the street. In the second scene Bridget meets her friends Frank (Tenor) and Paul (Baritone) in a café and tells them of her encounter with these two women (Martha and Rose); a heated discussion of religion ensues. Each character is represented by a distinctive style of music that fits with their personality and ideology. Martha's music and singing style is inspired by Baroque and Classical sacred music (well suited to a coloratura voice) to represent her traditional and authoritarian viewpoint: the instrumentation for her music is similar to a Baroque orchestra (strings, oboe, bassoon, and sometimes brass). Rose's music is inspired by traditional folk hymns and spirituals to represent both her traditional ideals and her earnest simplicity: her vocal lines feature repetition and gospel-inspired inflections, she is accompanied by textures featuring piano, bass, and flute. Frank is an opinionated, cynical atheist whose music is atonal (flexibly based on 12 tone procedures) and is filled with harsher chords and jagged melodies to represent his modern but rigid view; his vocal lines are often paired with cello. Paul is a hippie who supports people exploring spirituality, but is opposed to institutions; Paul's music is based on use of non-traditional modes and aleatoric principles with an emphasis on the interaction of percussion and voice. Bridget is caught between all of these worlds so her music is an intuitively composed fusion of tonal, modal, and atonal styles; Bridget's individuality is represented by a recognizable melodic theme (introduced at measure 41 and repeated throughout the piece by alto flute, viola, clarinet, and piano). Additionally, each scene starts with music inspired by the sounds of a city.

Open and Shut Fiona M. Ryan Doctor of Musical Arts Graduate Department of Music University of Toronto 2013 Abstract “Open and Shut” is a short opera in two scenes composed with concert opera performances in mind; it could be performed with or without staging. There are five characters in this work. The protagonist is Bridget (Soprano). In the first scene Bridget encounters Martha (Soprano) and Rose (Mezzo Soprano), two fundamentalist Christians who are handing out religious pamphlets on the street. In the second scene Bridget meets her friends Frank (Tenor) and Paul (Baritone) in a café and tells them of her encounter with these two women (Martha and Rose); a heated discussion of religion ensues. Each character is represented by a distinctive style of music that fits with their personality and ideology. Martha's music and singing style is inspired by Baroque and Classical sacred music (well suited to a coloratura voice) to represent her traditional and authoritarian viewpoint: the instrumentation for her music is similar to a Baroque orchestra (strings, oboe, bassoon, and sometimes brass). Rose's music is inspired by traditional folk hymns and spirituals to represent both her traditional ideals and her earnest simplicity: her vocal lines feature repetition and gospel-inspired inflections, she is accompanied by textures featuring piano, bass, and flute. Frank is an opinionated, cynical atheist whose music is atonal (flexibly based on 12 tone procedures) and is filled with harsher chords and jagged melodies to represent his modern but rigid view; his vocal lines are often paired with cello. Paul is a hippie who supports people exploring spirituality, but is opposed to institutions; Paul's music is based on use of non-traditional modes and aleatoric principles with an emphasis on the interaction of percussion and voice. Bridget is caught between all of these worlds so her music is an intuitively composed fusion of tonal, modal, and atonal styles; Bridget's individuality is represented by a recognizable melodic theme (introduced at measure 41 and repeated throughout the piece by alto flute, viola, clarinet, and piano). Additionally, each scene starts with music inspired by the sounds of a city.

Thesis (doctoral)--Universität, Marburg, 2003.

Marburg, Univ., Diss., 2009

Cette thèse propose une nouvelle approche de l’étude du phénomène d’introduction en bourse. Elle explore les déterminants (ex-ante) et les effets (expost sur la performance opérationnelle) de la cotation sur la place de Paris. Le positionnement théorique et le développement des hypothèses a été la première étape de la démarche. Deux hypothèses centrales expliquant le comportement de cotation émergent : celle du besoin de financement et celle du timing du marché. Pour vérifier empiriquement les hypothèses développées dans la première partie de la thèse, nous avons suivi dans la deuxième partie une démarche empirique en deux étapes : (1) estimer la probabilité d’introduction en bourse, par un modèle « Logit », en fonction des facteurs identifiés dans le développement théorique et (2) comparer les performances opérationnelles des sociétés introduites en bourse à celles des sociétés non introduites de mêmes caractéristiques ex-ante, par la méthode de l’appariement sur le score de propension et l’analyse de l’effet moyen du traitement sur les traités. Il en ressort que l’hypothèse du timing du marché est pertinente. Le déclin des performances opérationnelles des sociétés introduites sur les Second et le Nouveau marchés de la bourse de Paris, comparativement à un groupe témoin, est mis en évidence. Ce phénomène provient du choix d’une fenêtre d’opportunité pour s’introduire en bourse, ce moment coïncide avec un pic de performance (rentabilité économique et taux de marge économique) qui n’est pas maintenu après cotation. Par ailleurs, l’introduction en bourse qui a souvent lieu à l’occasion d’une forte croissance, s’accompagne d’une restructuration du bilan de l’entreprise qui se traduit par une baisse du taux d’endettement. / This thesis proposes a new approach of the study of initial public offerings (IPOs). It explores the ex-ante determinants and the ex-post effects (on the operating performance) of IPOs on the French stock market. In the first part of the dissertation, we have surveyed the literature on how and when firms go public. Two main hypotheses explain the behavior of firms that undergo an IPO: the need for financing and the market timing. To check these, we implement a two stage test: (1) using a logistic regression, we construct a model that predicts the likelihood of IPOs according to factors related to the firm itself and to the characteristics of its environment (industry affiliation and IPO’s activity) and (2) using the propensity score and the Average Treatment effect on the Treated methodology, we compare the operating performance of firms that go public (treated) with those that stay private (untreated). The results reveal that the timing of the going public decision is relevant. It seems that firms choose the appropriate window to go public, and that generally coincides with a peak of performance which is not maintained after the event. Consistent with prior share price based evidence, we find that the operating performance of French IPOs typically deteriorates over the first five post-listing years. In addition, firms appear to go public to improve their balance sheet after a period of high growth, in order to diminish the debt ratio.

Les travaux présentés dans cette thèse s'inscrivent dans le cadre de l"algorithmique et de la combinatoire du texte et s'appliquent à la bio-informatique. Plus particulièrement, ils concernent la localisation de motifs pondérés modélisés par des matrices score-position dans un texte non pondéré. Ces travaux sont appliqués au problème biologique de la recherche de sites de fixation de facteurs de transcription dans un génome. Cette application contribue à la compréhension de la régulation des gènes. Nous nous sommes attaqués à deux problèmes complémentaires, la recherche d'une seule matrice dans un texte puis la recherche simultanée d'un ensemble de matrices. Pour accélérer les algorithmes existant, nous nous sommes inspiré des algorithmes de recherche de motifs exacts connus pour leur efficacité. La différence est que les matrices score-position sont des motifs probabilistes, utilisant des fonctions de score. Nous devons donc intégrer la distribution de ces fonctions dans les algorithmes de recherche. Concernant le premier problème nous proposons une extension de l'algorithme de Knuth, Morris et Pratt qui repose sur un pré-traitement du motif pour optimiser le parcours le long du texte. Concernant le second problème nous avons utilisé une structure d'indexation afin de factoriser l'ensemble des matrices. Cette structure tire partie des distributions de scores associées à chaque matrice. Dans les deux cas, nous traitons en amont une partie des données de départ. Nous avons choisi de pré-traiter les matrices par rapport à l'application bio-informatique car les sites de fixation de facteurs de transcription sont des données relativement stables dans le temps. Ces algorithmes ont été mis en oeuvre dans un logiciel disponible en ligne appelé TFMscan. Ils ont fait l'objet d'une validation à grande échelle sur les bases de données de facteurs de transcription Jaspar et Transfac. / The work presented in this thesis is a part of the algorithmic and the combination of text and is apply to bio-informatic. More precisely, they relate to the location of grounds weighted modeled by position weIght matrices scoring in an unweighted text. This work is applied to the problem of biological research binding sites of transcription factors in a genome. This applrcation contributes to understanding the regulation of genes. We tackled two problems, find a single. matnx in a text and then the simultaneous search of a whole matrices. To accelerate existing algonthms, we have been inspired by exact research algorithms known for their effectiveness. The difference is that the dice are scoring position probabilistic grounds usmg. functions score. We must integrate the distribution of these functions in the search algonthms. Regardmg the first problem we proposed an extension of the Knuth. Morris and Pratt algorithm witch is based on a pre-treatment ta optimize route of ground along the text .Regarding the second problem we used an indexing structure in order to factor all matnces. ThIs structure uses distributions of scores associated to each matrix. ln both cases we are dea!mg with upstream part of baselines. We chose to pre-treat matrices in relation to the bio-mformatic application because the binding sites of transcription factors data are relatively stable over time. These algorithms have been implemented in a software available online called TFMscan. They have been validated on a large-scale bases data transcription factors Jaspar and Transfac .

OBJETIVO: Determinar la relación entre los resultados del test estresante y el Score de Apgar en gestaciones de 41 semanas a más atendidas en la Unidad de Embarazo Patológico del Hospital Nacional Daniel Alcides Carrión durante los años 2014 y 2015. METODOLOGÍA: Estudio de tipo observacional con diseño descriptivo correlacional, retrospectivo y de corte transversal, en el que se tuvo como muestra a 374 gestantes de 41 semanas a más que se han realizado el test estresante y que cumplían con los criterios de selección. En cuanto al análisis de los datos, para el análisis descriptivo de las variables cuantitativas se estimaron medidas de tendencia central (media) y medidas de dispersión (desviación estándar) y para las variables cualitativas (nominal) se estimaron frecuencias absolutas y porcentajes (frecuencias relativas). La relación de los resultados del test estresante y el score de Apgar (análisis inferencial) se realizó a través de la prueba Chi cuadrado (p<0.05, significativo). RESULTADOS: Las gestantes de 41 semanas a más tenían una edad promedio de 26 años, eran convivientes (62%) y con grado de instrucción secundaria (65.2%). Los resultados del test estresante fueron línea de base de 110-160 lpm (93.6%), variabilidad de 6-25 lpm (80.2%), aceleraciones presentes (87.2%), desaceleración variable (11.5%) y contracciones regulares (88.2%), cuya conclusión fue en su mayoría Negativo (95.7%). El 92.2% de los recién nacidos tuvo un score de Apgar al minuto de 7 a 10 y el 99.2% tuvo un Apgar a los 5 minutos de 7 a 10. Hubo relación significativa entre los resultados del test estresante y el Score de Apgar a los cinco minutos (p=0.000). CONCLUSIÓN: Existe relación entre los resultados del test estresante y el Score de Apgar a los cinco minutos en gestaciones de 41 semanas a más atendidas en la Unidad de Embarazo Patológico del Hospital Nacional Daniel Alcides Carrión durante los años 2014 y 2015. PALABRAS CLAVES: Test Estresante, Score de Apgar, Gestación, 41 semanas. / --- OBJECTIVE: Determine the relationship between stressful test results and Apgar Score in gestations of 41 weeks to more attended at the Pathological Pregnancy Unit of the National Hospital Daniel Alcides Carrión during the years 2014 and 2015. METHODOLOGY: Observational study with correlational, retrospective and crosssectional descriptive design, in which as shown was 41 weeks pregnant 374 more who have made the stressful test that met the selection criteria. As for the analysis of data for descriptive analysis of quantitative variables measures of central tendency (mean) and dispersion measures (standard deviation) and qualitative variables (nominal) were estimated absolute frequencies and percentages were estimated (relative frequencies). The relationship of stressful test results and Apgar score (inferential analysis) was performed using chi-square test (p <0.05, significant). RESULTS: 41 weeks pregnant more have an average age of 26 years were cohabiting (62%) and grade secondary education (65.2%). The results of the test were stressful baseline 110-160 bpm (93.6%), variability 6-25 lpm (80.2%), accelerations present (87.2%), variable deceleration (11.5%) and regular contractions (88.2%) whose conclusion was mostly negative (95.7%). 92.2% of newborns had an Apgar score of 7 to 10 minutes and 99.2% had an Apgar score at 5 minutes from 7 to 10. There was significant relationship between stressful test results and Apgar Score five minutes (p = 0.000). CONCLUSIONS: There is a relationship between stressful test results and Apgar Score in five minutes in gestations of 41 weeks to more attended at the Pathological Pregnancy Unit of the National Hospital Daniel Alcides Carrion during the years 2014 and 2015. KEYWORDS: Stressful Test, Apgar Score, pregnancy, 41 weeks. / Tesis

Anhand einer retrospektiven Kohorte von 299 Patienten mit hepatozellulärem Karzinom, die von 2005 – 2014 am Universitätsklinikum Würzburg behandelt wurden, erfolgte die Entwicklung eines Scores mit prognostischer Aussagekraft. Der Score enthält neben dem Zirrhose-Status die Laborparameter GOT, INR und Thrombozyten. Es erfolgte eine externe Validierung an einer prospektiven Patientenkohorte des Universitätsklinikums Wien. / Based on a retrospective cohort of 299 patients with hepatocellular carcinoma treated at the University Hospital of Würzburg from 2005 - 2014, a score with prognostic significance was developed. The score includes the laboratory parameters GOT, INR and platelets in addition to cirrhosis status. External validation was performed on a prospective cohort of patients at the University Hospital of Vienna.

Two hundred and nine beef carcasses (361 ± 53 kg) from crossbred, grain-finished cattle harvested in a commercial packing plant and evaluated for marbling score, core temperature (n=1), pH, shrinkage, color, and aerobic plate count (n=50) for 24, 48, 72, and 96 h under spray chilling. There were minimal changes in shrinkage among time points (-0.4 to 1.2%; P ≤ 0.002), pH (5.56 to 5.69; P ≤ 0.001), and APC (0.1 to 0.7 log; P ˂ 0.001). Marbling score values were converted to numeric values of 200 (Practically Devoid00) to 1100 (Abundant00). Carcasses with SM or greater marbling score at 24 h had a 34 to 60 points deduction after 96 h of spray chilling (P ≤ 0.042), the SL carcasses had an increase marbling score, from 442 to 469 points. Moreover, SL carcasses had a greater percentage of PUFA (P < 0.001).

No description available.