As estruturas lamelares de madeira foram introduzidas na Europa em 1908, no Brasil em 1922 e nos Estados Unidos em 1925. Foram muito empregadas entre as décadas de 20 e 60 para cobrirem ambientes que abrangessem grandes áreas como galpões industriais, ginásios, auditórios, pavilhões de exposição, garagens, depósitos, igrejas, salões de clube e outros. Estas estruturas são constituídas por elementos de barras denominados lamelas, que compõem uma malha losangular tridimensional em formato de abóbada. Este trabalho tem por finalidade a apresentação das recomendações de dimensionamento destas estruturas a partir da determinação dos esforços atuantes nas barras e deslocamentos dos nós, com base na atual norma brasileira NBR 7190:1997 - Projeto de estruturas de madeira. Para esta finalidade foi desenvolvido um abrangente estudo teórico e experimental a respeito do sistema estrutural e construtivo destas estruturas. Os resultados obtidos mostram a viabilidade técnica e econômica (racionalização do uso de materiais) na utilização destas estruturas para coberturas de médios a grandes vãos. / The wood segmental-lattice vaults were introduced in Europe in 1908, in Brazil in 1922 and in the United States in 1925. They were very used between the twenties and sixties for covering big areas as industrial sheds, gymnasiums, auditoriums, exposition pavilions, garages, storaged structures, churches, club salons and others. These structures are constituted by bar elements that are parts of a three dimensional quadrangular net, forming a vault. The purpose of this work is to present the design recommendations of these structures from the determination of the active efforts on the bars and nodal displacements, with basis on the Brazilian standard NBR 7190:1997 - Timber structures project and, for this purpose, was developed a broad theoretical and an experimental studies about the structural and constructive systems of these structures. The results show the technical and economic viabilities (rationalization in the use of materials) in using these structures for covering medium and long roof spans.

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第22837号 / 人健博第79号 / 新制||人健||6(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 岡 昌吾, 教授 藤井 康友, 教授 萩原 正敏 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DGAM

The aim of the diploma project is to find a method through which it will be possibleto classify the selected emotion from speech. At the beginning of the work deals with the description of the human body and their voice-generating operation. Furthermore, the text deals with the problem of the human voice into digital form.Great attention is paid to the parameters of the speech signal with an emphasis on describing the symptoms to help the selected emotion. The work deals with therecognition of emotions and a description of some of them. The main part is finding the best methods to reduce symptoms of segmental and suprasegmental speech utterances. The results of success was achieved by comparing the classification of selected emotions when using multiple methods and compare their results. The most important criterion in assessing the results ofthe reduction parameters of the speech signal, based on previous research in this area.

The Master Thesis describes knowlege in thrust bearings with solid segments. Contains analysis of thrust bearing used in NR/20SJ turbochargers. Further designs new thrust bearing with enhancement of load carrying capacity. The new thrust bearing and the old one are tested and compared.

Focal segmental glomerulosclerosis is one of the commonest cause of the nephrotic syndrome in adults patients. It is a damage of glomerulus characterized by leakage of proteins to urine and oedemas which usually develops into the end-stage renal disease within 10 years. Recently have been described familial forms of this disease which arise from injury to proteins making up filtration barrier of kidney. In 2005 non-selective ion channel TRPC6 was assigned among these proteins. In this thesis I focused on summarizing existing knowledge of the nephrotic syndrome, focal segmental glomerulosclerosis and involvement of TRPC6 in their origin. Second part of this work is devoted to the screening analysis of TRPC6 gene to discover possible mutations and polymorfisms in 47 patients with histologically proven focal segmental glomerulosclerosis or minimal change disease. The used methods were high resolution melting and direct sequencing. In the group of patients was detected no pathogenic mutation, only 2 known polymorfisms P15S and A404V and few changes which do not result in alteration of amino acid. So it seems TRPC6 gene mutations are a rare cause of the focal segmental glomerulosclerosis in adult patients in the Czech Republic.

Title: Structuring of plasma polymers: new methods for fabrication of nano-architectured thin films Author: Daniil Nikitin Department / Institute: Department of Macromolecular Physics/Charles University Supervisor of the doctoral thesis: Doc. Ing. Andrey Shukurov, PhD, Department of Macromolecular Physics/Charles University Abstract: The PhD thesis aims at the investigation of nanostructures based on plasma polymers. The main attention is paid to the combination of a gas aggregation cluster source with plasma-assisted vapor phase deposition for the fabrication of metal-polymer nanocomposites with bactericidal potential. Copper nanoparticles were incorporated into a biocompatible matrix of plasma polymerized poly(ethylene oxide) (ppPEO). The efficiency of such nanocomposite against multi-drug resistant bacteria was demonstrated. It was found that the segmental dynamics of the plasma polymer significantly changed in the presence of nanoparticles as revealed by the measurements of the dynamic glass transition temperature. The nanoscale confinement crucially influences the non-fouling properties of poly(ethylene oxide). A separate chapter is dedicated to the examination of the nanoparticle formation, growth and transport inside the source. Copper and silver nanoparticles were detected in situ in the gas phase...

Title: Structuring of plasma polymers: new methods for fabrication of nano-architectured thin films Author: Daniil Nikitin Department / Institute: Department of Macromolecular Physics/Charles University Supervisor of the doctoral thesis: Doc. Ing. Andrey Shukurov, PhD, Department of Macromolecular Physics/Charles University Abstract: The PhD thesis aims at the investigation of nanostructures based on plasma polymers. The main attention is paid to the combination of a gas aggregation cluster source with plasma-assisted vapor phase deposition for the fabrication of metal-polymer nanocomposites with bactericidal potential. Copper nanoparticles were incorporated into a biocompatible matrix of plasma polymerized poly(ethylene oxide) (ppPEO). The efficiency of such nanocomposite against multi-drug resistant bacteria was demonstrated. It was found that the segmental dynamics of the plasma polymer significantly changed in the presence of nanoparticles as revealed by the measurements of the dynamic glass transition temperature. The nanoscale confinement crucially influences the non-fouling properties of poly(ethylene oxide). A separate chapter is dedicated to the examination of the nanoparticle formation, growth and transport inside the source. Copper and silver nanoparticles were detected in situ in the gas phase...

While lumbar kinematics can be measured in vivo, most measurements are invasive (such as percutaneous bone pins), provide high doses of radiation (such as biplane fluoroscopy), or are taken with the patient in a static position (such as MRIs). Recent work suggests that lumbar kinematics can be determined by dynamic measurements of epidermal strain in the lower back. This work aims to develop and examine a method of examining lumbar kinematics via optoelectronic motion capture utilizing skin-mounted markers in the lumbar region. Two studies were performed. One study examined lumbar epidermal strain in 28 asymptomatic subjects during diagnostic movements, while the second study used fresh/frozen cadavers to compare segmental lumbar kinematics as measured by both an optoelectronic motion capture system utilizing skin-mounted markers and an electromagnetic motion capture system utilizing sensors mounted to percutaneous bone pins inserted into the spinous processes. In the first study, participants had a grid-like marker set adhered to their lower back. They were instructed to perform 17 diagnostic movements, with data from three trials of each exercise being captured. Data was analyzed in MATLAB to examine segmental lumbar kinematics. Analysis shows trends consistent with expected movement patterns for asymptomatic individuals with measurement values consistent with those found in previous studies. Trends of symmetry in motion for left versus right motions were observed, as well as a trend for the return motion in a movement to be faster than the outgoing motion. In the second study, three fresh/frozen cadavers were outfitted with electromagnetic motion tracking sensors mounted to bone pins which were placed in the spinous processes of L1-S2. Each cadaver also had a similar grid-like marker set of optical motion tracking markers adhered in the lumbar region. The cadavers were moved through 10 of the same diagnostic exercises with data from seven trials from each exercise being captured. Data was analyzed in MATLAB to compare the end range of motion as measured by the optical system to the same measurements by the electromagnetic system. End ROM values showed statistically different measurements for five of the twelve segment measurements compared. Data collected in this work contributes to the establishment of normative dynamic kinematics of the lumbar spine in the asymptomatic population. It also outlines the strengths and weaknesses of the methodology utilized.

La neurostimulation périphérique (en anglais transcutaneous electrical nerve stimulation ou TENS) est une modalité thérapeutique fréquemment utilisée en réadaptation pour diminuer la douleur. À ce jour, cependant, l’efficacité analgésique du TENS chez les aînés demeure peu documentée. La majorité des études effectuées jusqu’à présent ont été réalisées chez les jeunes adultes ou chez des populations d’âge hétérogènes. La présente étude, un essai croisé randomisé à double insu, avait pour objectif de documenter l’efficacité analgésique du TENS conventionnel et du TENS acupuncture chez les aînés et d’observer si la réponse analgésique de ces deux modalités de TENS entre les aînés et les jeunes adultes est différente. Quinze aînés et quinze jeunes adultes ont participé à l’étude. Les participants étaient évalués à trois occasions distinctes pour recevoir en alternance un TENS conventionnel, un TENS acupuncture et un TENS placebo. Une douleur expérimentale était créée à l’aide d’une thermode de type Peltier, appliquée au niveau de la colonne lombaire pendant deux minutes, période durant laquelle les participants devaient évaluer l’intensité de leur douleur avec une échelle visuelle analogue reliée à un ordinateur (CoVAS). Les mesures de douleur ont été prises avant, pendant et après l’application de chaque type de TENS. Chez les jeunes adultes, lorsque comparée au niveau de douleur initiale, une diminution significative de la douleur a été observée pendant et après l’application du TENS conventionnel et acupuncture. Le TENS conventionnel et acupuncture étaient supérieurs au traitement placebo (toutes les valeurs de p < 0,05). Cependant, chez les aînés, le TENS conventionnel et acupuncture n’ont pas permis de diminuer significativement la douleur. De plus, aucune modalité TENS ne se démarquait du traitement placebo (toutes les valeurs de p > 0,05). Bien que le TENS conventionnel et le TENS acupuncture soient efficaces chez les jeunes adultes, les présents résultats suggèrent que le TENS n’est pas la meilleure option de traitement pour diminuer la douleur chez les aînés, du moins lorsqu’il est utilisé seul (monothérapie). Des études futures, visant à déterminer des façons de bonifier l’effet du TENS chez les aînés, sont nécessaires.

Introduction : Cette étude vise à évaluer la stabilité de la chirurgie LeFort I multisegmentaire à moyen (fin du traitement orthodontique) et à long termes dans les trois plans de l'espace (transversal, antéro-postérieur et vertical). Matériel et méthodes : L'échantillon étudié est composé de 31 patients traités en clinique privée, ayant eu une chirurgie LeFort I multisegmentaire en deux, trois ou quatre morceaux, et ayant terminé leur traitement orthodontique. Parmi eux, 17 patients ayant terminé leur traitement orthodontique depuis plus de deux ans (moyenne de trois ans post-traitement) ont permis d'évaluer la stabilité de la procédure chirurgicale à long terme. La collecte des données a été réalisée sur des modèles et des radiographies céphalométriques latérales pris à des temps précis tout au long du traitement orthodontique, ainsi que pendant la période de contention. Concernant l'analyse statistique, des T-tests et des corrélations de Pearson ont été utilisés. Le test de Bland-Altman et le coefficient de corrélation intra-classe ont permis d'analyser les fiabilités intra-examinateur et inter-examinateurs. Résultats : Une récidive transverse significative, mais très faible cliniquement, est constatée aux niveaux prémolaires et molaires entre la chirurgie et la fin du traitement orthodontique. Elle est corrélée avec l’expansion totale réalisée. Cette récidive transverse est non significative suite au traitement orthodontique. Aucune corrélation statistiquement significative n'est mise en évidence entre le nombre de segments et la récidive transverse postchirurgicale. Une variation de certaines mesures antéro-postérieures et verticales statistiquement significative, mais faible cliniquement, est notée entre la chirurgie et la fin du traitement orthodontique (avancement et impaction postérieure). Pour les mesures antéro-postérieures et verticales, aucun changement n'est statistiquement significatif suite au traitement orthodontique. Conclusion : Pour l'échantillon étudié, la stabilité de l'ostéotomie de type LeFort I multisegmentaire est très bonne, dans les trois plans de l'espace étudiés. / Introduction : The aim of this study was to evaluate the medium and long term stability of segmented LeFort I surgery in all three planes of space (transverse, sagittal and vertical). Materials and methods : The sample consisted of 31 private practice patients that received a two, three, or four-piece segmented LeFort I surgery and who had finished their orthodontic treatment. Study models and cephalometric radiographs were analyzed before treatment, before surgery, after surgery, and at the end of the orthodontic treatment for the 31 patients as well as a minumum two years into retention for 17 patients (mean of 3 years post-treatment). T-tests and Pearson correlation tests were used. Intra and inter-examiner reliability were verified with Bland Altman and intraclass coefficient tests. Results : A statistically significant transverse relapse was seen at the premolars and molars between surgery and the end of orthodontic treatment, that has little clinical significance. The relapse is correlated with the effective expansion. There was no significant relapse after orthodontic treatment was completed. There was no correlation between the amount of relapse observed and the amount of segments. Statistically significant changes were measured in the post surgical phase for maxillary advancement and impaction cases, but were shown to be of limited clinical significance. After removal of fixed appliances, no significant changes were noted. Conclusion : Multisegmented Lefort I surgery appears to have good stability in all three planes of space in the studied sample.