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Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatmentBrunello, Nicoletta, den Boer, Johan A., Judd, Lewis L., Kasper, Siegfried, Kelsey, Jeffrey E., Lader, Malcolm, Lecrubier, Yves, Lepine, Jean-Pierre, Lydiard, R. B., Mendlewicz, Julien, Montgomery, Stuart A., Racagni, Giorgio, Stein, Murray B., Wittchen, Hans-Ulrich 24 April 2013 (has links) (PDF)
Social phobia is a common disorder associated with significant psychosocial impairment, representing a substantial public health problem largely determined by the high prevalence, and the lifelong chronicity. Social phobia starts in early childhood or adolescence and is often comorbid with depression, other anxiety disorders, alcohol and substance abuse or eating disorders. This cascade of comorbidity, usually secondary to social phobia, increases the disability associated with the condition. The possibility that social phobia may be a trigger for later developing comorbid disorders directs attention to the need for early effective treatment as a preventive measure.
The most recent drug class to be investigated for the psychopharmacological treatment of social phobia is the SSRI group for which there is growing support. The other drug classes that have been evaluated are monoamine oxidase inhibitors (MAOIs), benzodiazepines, and beta-blockers. The SSRIs represent a new and attractive therapeutic choice for patients with generalized social phobia. Recently the first, large scale, placebo-controlled study to assess the efficacy of drug treatment in generalized social phobia has been completed with paroxetine. Paroxetine was more effective in reducing the symptoms than placebo and was well tolerated. Many now regard SSRIs as the drugs of choice in social phobia because of their effectiveness and because they avoid the problems of treatment with benzodiazepines or classical MAOIs.
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Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatmentBrunello, Nicoletta, den Boer, Johan A., Judd, Lewis L., Kasper, Siegfried, Kelsey, Jeffrey E., Lader, Malcolm, Lecrubier, Yves, Lepine, Jean-Pierre, Lydiard, R. B., Mendlewicz, Julien, Montgomery, Stuart A., Racagni, Giorgio, Stein, Murray B., Wittchen, Hans-Ulrich January 2000 (has links)
Social phobia is a common disorder associated with significant psychosocial impairment, representing a substantial public health problem largely determined by the high prevalence, and the lifelong chronicity. Social phobia starts in early childhood or adolescence and is often comorbid with depression, other anxiety disorders, alcohol and substance abuse or eating disorders. This cascade of comorbidity, usually secondary to social phobia, increases the disability associated with the condition. The possibility that social phobia may be a trigger for later developing comorbid disorders directs attention to the need for early effective treatment as a preventive measure.
The most recent drug class to be investigated for the psychopharmacological treatment of social phobia is the SSRI group for which there is growing support. The other drug classes that have been evaluated are monoamine oxidase inhibitors (MAOIs), benzodiazepines, and beta-blockers. The SSRIs represent a new and attractive therapeutic choice for patients with generalized social phobia. Recently the first, large scale, placebo-controlled study to assess the efficacy of drug treatment in generalized social phobia has been completed with paroxetine. Paroxetine was more effective in reducing the symptoms than placebo and was well tolerated. Many now regard SSRIs as the drugs of choice in social phobia because of their effectiveness and because they avoid the problems of treatment with benzodiazepines or classical MAOIs.
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Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for PsychopharmacologyBaldwin, David S., Anderson, Ian M., Nutt, David J., Allgulander, Christer, Bandelow, Borwin, den Boer, Johan A., Christmas, David M., Davies, Simon, Fineberg, Naomi, Lidbetter, Nicky, Malizia, Andrea, McCrone, Paul, Nabarro, Daniel, O’Neill, Catherine, Scott, Jan, van der Wee, Nic, Wittchen, Hans-Ulrich 17 September 2019 (has links)
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute treatment, longer-term treatment, combination treatment, and further approaches for patients who have not responded to first-line interventions. A consensus meeting involving international experts in anxiety disorders reviewed the main subject areas and considered the strength of supporting evidence and its clinical implications. The guidelines are based on available evidence, were constructed after extensive feedback from participants, and are presented as recommendations to aid clinical decision-making in primary, secondary and tertiary medical care. They may also serve as a source of information for patients, their carers, and medicines management and formulary committees.
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