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The prognosis of cancer patients suffering from solid tumors significantly depends on the developmental stage of the tumor. For cervix carcinoma the prognosis is better for compact shapes than for diffusive shapes since the latter may already indicate invasion, the stage in tumor progression that precedes the formation of metastases. In this paper, we present methods for describing and evaluating tumor objects and their surfaces based on topological and geometric properties. For geometry, statistics of the binary object's distance transform are used to evaluate the tumor's invasion front. In addition, a simple compactness measure is adapted to 3D images and presented to compare different types of tumor samples. As a topological measure, the Betti numbers are calculated of voxelized tumor objects based on a medial axis transform. We further illustrate how these geometric and topological properties can be used for a quantitative comparison of histological material and single-cell-based tumor growth simulations.

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<p>Digital fringe projection (DFP) methods are commonly used to obtain high-accuracy shape measurements of opaque, diffusely-reflective objects. While some objects may have constant texture across its surface, this is not true for all; many measured objects may have high-contrast texture caused by edges of dark- and light-colored sections of the object. In these high-contrast areas, a phase artifact has been consistently observed, which in turn creates a specific measurement error that is sometimes referred to as ``discontinuity-induced measurement artifacts" (DMA). Our study indicated that this error is most likely caused by camera defocusing, which produces a Gaussian point spread function (PSF) that is convoluted across every captured image, thus creating an phase artifact shaped like a Gaussian function. Based on this finding, this thesis outlines a method for removing this error via Gaussian curve fitting on the affected regions. These regions can be found by locating large spikes in the image intensity gradient, which directly correspond to the edge of the phase artifact, and then using a weighted least squared method to fit a Gaussian function to the affected area. We propose to use this error removal method in two ways: first, to remove errors on a checkerboard calibration target in order to increase calibration accuracy; and second, to directly remove errors in high-contrast areas in order to decrease shape measurement error. Experimental results demonstrate that the proposed method succeeds in decreasing calibration error for a checkerboard calibration target by as much as 12\%. Shape measurement experiments were not only conducted across simple, flat boards, but also more complex surfaces, such as that of a coffee mug. This thesis will show that this measurement error can be significantly decreased for both simple and complex surfaces.</p>

<div>With robots expanding their applications in more and more scenarios, practical problems from different scenarios are challenging current 3D measurement techniques. For instance, infrastructure inspection robots need large-scale and high-spatial-resolution 3D data for crack and defect detection, medical robots need 3D data well registered with temperature information, and warehouse robots need multi-resolution 3D shape measurement to adapt to different tasks. In the past decades, a lot of progress has been made in improving the performance of 3D shape measurement methods. Yet, measurement scale and speed and the fusion of multiple modalities of 3D shape measurement techniques remain vital aspects to be improved for robots to have a more complete perception of the real scene. In this dissertation, we will focus on the digital fringe projection technique, which usually can achieve high-accuracy 3D data, and expand the capability of that technique to complicated robot applications by 1) extending the measurement scale, 2) registering with multi-modal information, and 3) improving the measurement speed of the digital fringe projection technique.</div><div><br></div><div>The measurement scale of the digital fringe projection technique mainly focused on a small scale, from several centimeters to tens of centimeters, due to the lack of a flexible and convenient calibration method for a large-scale digital fringe projection system. In this study, we first developed a flexible and convenient large-scale calibration method and then extended the measurement scale of the digital fringe projection technique to several meters. The meter scale is needed in many large-scale robot applications, including large infrastructure inspection. Our proposed method includes two steps: 1) accurately calibrate intrinsics (i.e., focal lengths and principal points) with a small calibration board at close range where both the camera and projector are out of focus, and 2) calibrate the extrinsic parameters (translation and rotation) from camera to projector with the assistance of a low-accuracy large-scale 3D sensor (e.g., Microsoft Kinect). The two-step strategy avoids fabricating a large and accurate calibration target, which is usually expensive and inconvenient for doing pose adjustments. With a small calibration board and a low-cost 3D sensor, we calibrated a large-scale 3D shape measurement system with a FOV of (1120 x 1900 x 1000) mm^3 and verified the correctness of our method.</div><div><br></div><div> Multi-modal information is required in applications such as medical robots, which may need both to capture the 3D geometry of objects and to monitor their temperature. To allow robots to have a more complete perception of the scene, we further developed a hardware system that can achieve real-time 3D geometry and temperature measurement. Specifically, we proposed a holistic approach to calibrate both a structured light system and a thermal camera under exactly the same world coordinate system, even though these two sensors do not share the same wavelength; and a computational framework to determine the sub-pixel corresponding temperature for each 3D point, as well as to discard those occluded points. Since the thermal 2D imaging and 3D visible imaging systems do not share the same spectrum of light, they can perform sensing simultaneously in real time. We developed a hardware system that achieved real-time 3D geometry and temperature measurement at 26Hz with 768 x 960 points per frame.</div><div><br></div><div> In dynamic applications, where the measured object or the 3D sensor could be in motion, the measurement speed will become an important factor to be considered. Previously, people projected additional fringe patterns for absolute phase unwrapping, which slowed down the measurement speed. To achieve higher measurement speed, we developed a method to unwrap a phase pixel by pixel by solely using geometric constraints of the structured light system without requiring additional image acquisition. Specifically, an artificial absolute phase map $\Phi_{min}$, at a given virtual depth plane $z = z_{min}$, is created from geometric constraints of the calibrated structured light system, such that the wrapped phase can be pixel-by-pixel unwrapped by referring to $\Phi_{min}$. Since $\Phi_{min}$ is defined in the projector space, the unwrapped phase obtained from this method is an absolute phase for each pixel. Experimental results demonstrate the success of this proposed novel absolute-phase unwrapping method. However, the geometric constraint-based phase unwrapping method using a virtual plane is constrained in a certain depth range. The depth range limitations cause difficulties in two measurement scenarios: measuring an object with larger depth variation, and measuring a dynamic object that could move beyond the depth range. To address the problem of depth limitation, we further propose to take advantage of an additional 3D scanner and use additional external information to extend the maximum measurement range of the pixel-wise phase unwrapping method. The additional 3D scanner can provide a more detailed reference phase map $\Phi_{ref}$ to assist us to do absolute phase unwrapping without the depth constraint. Experiments demonstrate that our method, assisted by an additional 3D scanner, can work for a large depth range, and the maximum speed of the low-cost 3D scanner is not necessarily an upper bound of the speed of the structured light system. Assisted by Kinect V2, our structured light system achieved 53Hz with a resolution 1600 x 1000 pixels when we measured dynamic objects that were moving in a large depth range.</div><div><br></div><div> In summary, we significantly advanced the 3D shape measurement technology for robots to have a more complete perception of the scene by enhancing the digital fringe projection technique in measurement scale (space domain), speed (time domain), and fusion with other modality information. This research can potentially enable robots to have a better understanding of the scene for more complicated tasks, and broadly impact many other academic studies and industrial practices.</div>

Structured Light Illumination (SLI) is the process where spatially varied patterns are projected onto a 3-D surface and based on the distortion by the surface topology, phase information can be calculated and a 3D model constructed. Phase Measuring Profilometry (PMP) is a particular type of SLI that requires three or more patterns temporarily multiplexed. High speed PMP attempts to scan moving objects whose motion is small so as to have little impact on the 3-D model. Given that practically all machine vision cameras and high speed cameras employ a Field Programmable Gate Array (FPGA) interface directly to the image sensors, the opportunity exists to do the processing on camera. This thesis focuses on the design, implementation, testing, and evaluation of a camera-projector system to implement a PMP dual-frequency scheme for 3-D shape measurement on a single FPGA chip. The processor architecture is implemented and tested using the Xilinx Spartan 3 FPGA chip on an Opal Kelly development board. The hardware is described using VHDL and Verilog Hardware Description Languages (HDLs).

In-situ 3-D shape measurements with submicron shape uncertainty of fast rotating objects in a cutting lathe are expected, which can be achieved by simultaneous distance and velocity measurements. Conventional tactile methods, coordinate measurement machines, only support ex-situ measurements. Optical measurement techniques such as triangulation and conoscopic holography offer only the distance, so that the absolute diameter cannot be retrieved directly. In comparison, laser Doppler distance sensors (P-LDD sensor) enable simultaneous and in-situ distance and velocity measurements for monitoring the cutting process in a lathe. In order to achieve shape measurement uncertainties below 1 µm, a P-LDD sensor with a dual camera based scattered light detection has been investigated. Coherent fiber bundles (CFB) are employed to forward the scattered light towards cameras. This enables a compact and passive sensor head in the future. Compared with a photo detector based sensor, the dual camera based sensor allows to decrease the measurement uncertainty by the order of one magnitude. As a result, the total shape uncertainty of absolute 3-D shape measurements can be reduced to about 100 nm.

Temperature drifts, tool deterioration, unknown vibrations as well as spindle play are major effects which decrease the achievable precision of computerized numerically controlled (CNC) lathes and lead to shape deviations between the processed work pieces. Since currently no measurement system exist for fast, precise and insitu 3d shape monitoring with keyhole access, much effort has to be made to simulate and compensate these effects. Therefore we introduce an optical interferometric sensor for absolute 3d shape measurements, which was integrated into a working lathe. According to the spindle rotational speed, a measurement rate of 2,500 Hz was achieved. In-situ absolute shape, surface profile and vibration measurements are presented. While thermal drifts of the sensor led to errors of several µm for the absolute shape, reference measurements with a coordinate machine show, that the surface profile could be measured with an uncertainty below one micron. Additionally, the spindle play of 0.8 µm was measured with the sensor.

La technique de reconstruction de forme par lumière structurée (ou projection de motifs) permet d’acquérir la topographie d’une surface objet avec une précision et un échantillonnage de points dense, de manière strictement non invasive. Pour ces raisons, elle fait depuis plusieurs années l’objet d’un fort intérêt. Les travaux présentés ici ont pour objectif d’adapter cette technique aux conditions sévères des expériences de physique des chocs : aspect monocoup, grande brièveté des phénomènes, diversité des échelles d’observation (de quelques millimètres au décimètre). Pour répondre à ces exigences, nous proposons de réaliser un dispositif autour d’un système d’imagerie rapide par éclairage laser nanoseconde, présentant des performances éprouvées et bien adaptées. La première partie des travaux s’intéresse à analyser les phénomènes prépondérants pour la qualité des images. Nous montrons quels sont les contributeurs principaux à la dégradation des signaux, et une technique efficace de lissage du speckle par fibrage est présentée. La deuxième partie donne une formulation projective de la reconstruction de forme ; celle-ci est rigoureuse, ne nécessitant pas de travailler dans l’approximation de faible perspective, ou de contraindre la géométrie de l’instrument. Un protocole d’étalonnage étendant la technique DLT (Direct Linear Transformation) aux systèmes à lumière structurée est proposé. Le modèle permet aussi, pour une expérience donnée, de prédire les performances de l’instrument par l’évaluation a priori des incertitudes de reconstruction. Nous montrons comment elles dépendent des paramètres du positionnement des sous-ensembles et de la forme-même de l’objet. Une démarche d’optimisation de la configuration de l’instrument pour une reconstruction donnée est introduite. La profondeur de champ limitant le champ objet minimal observable, la troisième partie propose de l’étendre par codage pupillaire : une démarche de conception originale est exposée. L’optimisation des composants est réalisée par algorithme génétique, sur la base de critères et de métriques définis dans l’espace de Fourier. Afin d’illustrer les performances de cette approche, un masque binaire annulaire a été conçu, réalisé et testé expérimentalement. Il corrige des défauts de mise au point très significatifs (Ψ≥±40 radians) sans impératif de filtrage de l’image. Nous montrons aussi que ce procédé donne accès à des composants tolérant des défauts de mise au point extrêmes (Ψ≈±100 radians , après filtrage). La dernière partie présente une validation expérimentale de l’instrument dans différents régimes, et à différentes échelles. Il a notamment été mis en œuvre sur l’installation LULI2000, où il a permis de mesurer dynamiquement la déformation et la fragmentation d’un matériau à base de carbone (champs millimétriques). Nous présentons également les mesures obtenues sous sollicitation pyrotechnique sur un revêtement de cuivre cylindrique de dimensions décimétriques. L’apparition et la croissance rapide de déformations radiales submillimétriques est mesurée à la surface du revêtement. / A Structured Light System (SLS) is an efficient means to measure a surface topography, as it features both high accuracy and dense spatial sampling in a strict non-invasive way. For these reasons, it became in the past years a technique of reference. The aim of the PhD is to bring this technique to the field of shock physics. Experiments involving shocks are indeed very specific: they only allow single-shot acquisition of extremely short phenomena occurring under a large range of spatial extensions (from a few mm to decimeters). In order to address these difficulties, we have envisioned the use of a well-known high-speed technique: pulsed laser illumination. The first part of the work deals with the evaluation of the key-parameters that have to be taken into account if one wants to get sharp acquisitions. The extensive study demonstrates that speckle effect and depth of field limitation are of particular importance. In this part, we provide an effective way to smooth speckle in nanosecond regime, leaving 14% of residual contrast. Second part introduces an original projective formulation for object-points reconstruction. This geometric approach is rigorous; it doesn’t involve any weak-perspective assumptions or geometric constraints (like camera-projector crossing of optical axis in object space). From this formulation, a calibration procedure is derived; we demonstrate that calibrating any structured-light system can be done by extending the Direct Linear Transformation (DLT) photogrammetric approach to SLS. Finally, we demonstrate that reconstruction uncertainties can be derived from the proposed model in an a priori manner; the accuracy of the reconstruction depends both on the configuration of the instrument and on the object shape itself. We finally introduce a procedure for optimizing the configuration of the instrument in order to lower the uncertainties for a given object. Since depth of field puts a limitation on the lowest measurable field extension, the third part focuses on extending it through pupil coding. We present an original way of designing phase components, based on criteria and metrics defined in Fourier space. The design of a binary annular phase mask is exhibited theoretically and experimentally. This one tolerates a defocus as high as Ψ≥±40 radians, without the need for image processing. We also demonstrate that masks designed with our method can restore extremely high defoci (Ψ≈±100 radians) after processing, hence extending depth of focus by amounts unseen yet. Finally, the fourth part exhibits experimental measurements obtained with the setup in different high-speed regimes and for different scales. It was embedded on LULI2000 high energy laser facility, and allowed measurements of the deformation and dynamic fragmentation of a sample of carbon. Finally, sub-millimetric deformations measured in ultra-high speed regime, on a cylinder of copper under pyrotechnic solicitation are presented.