Consumption of similar biological medicinal products (biosimilars) in the Czech Republic Author: Kristýna Vlachová Supervisor: PharmDr. Pavel Horký, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Biological treatment is a modern alternative to chemotherapeutics especially in patients with difficult-to-treat diseases of autoimmune origin, as well as patients with other diseases. Biosimilars are biological medicinal products similar to the original biologics. They are increasingly used in a wide range of indications. A new biosimilar drug is registered every year, as soon as the patent protection of the original biologics expires. The assumption is that the consumption of biosimilars and biologists in the Czech Republic will increase. The question is to what extent it will increase and what is the market share of biosimilars. Objective: The aim of the diploma thesis was to analyze the consumption of biosimilar epoetin, adalimumab, infliximab and etanercept in the Czech Republic in 2010-2020. Methods: A retrospective analysis of the consumption of biosimilars epoetin, adalimumab, infliximab and etanercept was performed from 1. 1. 2010 to 31. 12. 2020. The selection of specific biosimilars was made on the basis of their wide...

abstract: In recent years, the rise in social media usage both vertically in terms of the number of users by platform and horizontally in terms of the number of platforms per user has led to data explosion. User-generated social media content provides an excellent opportunity to mine data of interest and to build resourceful applications. The rise in the number of healthcare-related social media platforms and the volume of healthcare knowledge available online in the last decade has resulted in increased social media usage for personal healthcare. In the United States, nearly ninety percent of adults, in the age group 50-75, have used social media to seek and share health information. Motivated by the growth of social media usage, this thesis focuses on healthcare-related applications, study various challenges posed by social media data, and address them through novel and effective machine learning algorithms. The major challenges for effectively and efficiently mining social media data to build functional applications include: (1) Data reliability and acceptance: most social media data (especially in the context of healthcare-related social media) is not regulated and little has been studied on the benefits of healthcare-specific social media; (2) Data heterogeneity: social media data is generated by users with both demographic and geographic diversity; (3) Model transparency and trustworthiness: most existing machine learning models for addressing heterogeneity are considered as black box models, not many providing explanations for why they do what they do to trust them. In response to these challenges, three main research directions have been investigated in this thesis: (1) Analyzing social media influence on healthcare: to study the real world impact of social media as a source to offer or seek support for patients with chronic health conditions; (2) Learning from task heterogeneity: to propose various models and algorithms that are adaptable to new social media platforms and robust to dynamic social media data, specifically on modeling user behaviors, identifying similar actors across platforms, and adapting black box models to a specific learning scenario; (3) Explaining heterogeneous models: to interpret predictive models in the presence of task heterogeneity. In this thesis, novel algorithms with theoretical analysis from various aspects (e.g., time complexity, convergence properties) have been proposed. The effectiveness and efficiency of the proposed algorithms is demonstrated by comparison with state-of-the-art methods and relevant case studies. / Dissertation/Thesis / Doctoral Dissertation Computer Science 2019

explains the reasons behind Boko Haram's unconventional tactic of kidnapping uses abductees as 'human bombs' Boko Haram's unconventional Kidnapping for at Boko Haram's martyrdom concept must have failed Overall, this dissertation concludes that Boko Haram's Kidnapping

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20154号 / 理博第4239号 / 新制||理||1610(附属図書館) / 京都大学大学院理学研究科数学・数理解析専攻 / (主査)教授 坂上 貴之, 教授 上田 哲生, 教授 國府 寛司 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

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The thesis consists of four main chapters. The first chapter includes an introduction to inhomogeneous self-similar sets and measures. In particular, we show that these sets and measures are natural generalizations of the well known self-similar sets and measures. We then investigate the structure of these sets and measures. In the second chapter we study various fractal dimensions (Hausdorff, packing and box dimensions) of inhomogeneous self-similar sets and compare our results with the well-known results for (ordinary) self-similar sets. In the third chapter we investigate the L {q} spectra and the Renyi dimensions of inhomogeneous self-similar measures and prove that new multifractal phenomena, not exhibited by (ordinary) self-similar measures, appear in the inhomogeneous case. Namely, we show that inhomogeneous self-similar measures may have phase transitions which is in sharp contrast to the behaviour of the L {q} spectra of (ordinary) self-similar measures satisfying the Open Set Condition. Then we study the significantly more difficult problem of computing the multifractal spectra of inhomogeneous self-similar measures. We show that the multifractal spectra of inhomogeneous self-similar measures may be non-concave which is again in sharp contrast to the behaviour of the multifractal spectra of (ordinary) self-similar measures satisfying the Open Set Condition. Then we present a number of applications of our results. Many of them are related to the notoriously difficult problem of computing (or simply obtaining non-trivial bounds) for the multifractal spectra of self-similar measures not satisfying the Open Set Condition. More precisely, we will show that our results provide a systematic approach to obtain non-trivial bounds (and in some cases even exact values) for the multifractal spectra of several large and interesting classes of self-similar measures not satisfying the Open Set Condition. In the fourth chapter we investigate the asymptotic behaviour of the Fourier transforms of inhomogeneous self-similar measures and again we present a number of applications of our results, in particular to non-linear self-similar measures.

We introduce methods to cope with self-similar sets when we do not assume any separation condition. For a self-similar set K ⊆ ℝᵈ we establish a similarity dimension-like formula for Hausdorff dimension regardless of any separation condition. By the application of this result we deduce that the Hausdorff measure and Hausdorff content of K are equal, which implies that K is Ahlfors regular if and only if Hᵗ (K) > 0 where t = dim[sub]H K. We further show that if t = dim[sub]H K < 1 then Hᵗ (K) > 0 is also equivalent to the weak separation property. Regarding Hausdorff dimension, we give a dimension approximation method that provides a tool to generalise results on non-overlapping self-similar sets to overlapping self-similar sets. We investigate how the Hausdorff dimension and measure of a self-similar set K ⊆ ℝᵈ behave under linear mappings. This depends on the nature of the group T generated by the orthogonal parts of the defining maps of K. We show that if T is finite then every linear image of K is a graph directed attractor and there exists at least one projection of K such that the dimension drops under projection. In general, with no restrictions on T we establish that Hᵗ (L ∘ O(K)) = Hᵗ (L(K)) for every element O of the closure of T , where L is a linear map and t = dim[sub]H K. We also prove that for disjoint subsets A and B of K we have that Hᵗ (L(A) ∩ L(B)) = 0. Hochman and Shmerkin showed that if T is dense in SO(d; ℝ) and the strong separation condition is satisfied then dim[sub]H (g(K)) = min {dim[sub]H K; l} for every continuously differentiable map g of rank l. We deduce the same result without any separation condition and we generalize a result of Eroğlu by obtaining that Hᵗ (g(K)) = 0. We show that for the attractor (K1, … ,Kq) of a graph directed iterated function system, for each 1 ≤ j ≤ q and ε > 0 there exists a self-similar set K ⊆ Kj that satisfies the strong separation condition and dim[sub]H Kj - ε < dim[sub]H K. We show that we can further assume convenient conditions on the orthogonal parts and similarity ratios of the defining similarities of K. Using this property we obtain results on a range of topics including on dimensions of projections, intersections, distance sets and sums and products of sets. We study the situations where the Hausdorff measure and Hausdorff content of a set are equal in the critical dimension. Our main result here shows that this equality holds for any subset of a set corresponding to a nontrivial cylinder of an irreducible subshift of finite type, and thus also for any self-similar or graph directed self-similar set, regardless of separation conditions. The main tool in the proof is an exhaustion lemma for Hausdorff measure based on the Vitali's Covering Theorem. We also give several examples showing that one cannot hope for the equality to hold in general if one moves in a number of the natural directions away from `self-similar'. Finally we consider an analogous version of the problem for packing measure. In this case we need the strong separation condition and can only prove that the packing measure and δ-approximate packing pre-measure coincide for sufficiently small δ > 0.

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