Este trabalho visa dar uma contribuição para o aumento de eficiência no fluxo de projeto de sistemas integrados, especificamente na avaliação de desempenho da comunicação entre os seus blocos componentes. É proposto o uso de modelagem e simulação de hardware em alto nível, no nível de transações, denominado TLM, para aproveitar a redução de esforço e tempo que se pode oferecer ao projeto de sistemas integrados, diferentemente de enfoques convencionais em níveis mais baixos de descrição, como o nível de registradores (RTL). É proposta uma forma de análise do tráfego intrachip produzido na comunicação de elementos do sistema, visando-se o uso dos resultados obtidos para descrição de geradores de tráfego. A principal contribuição deste trabalho é a proposta da análise de séries de tráfego obtido durante simulação de plataformas de hardware descritas no nível TLM usando-se métodos estatísticos conhecidos da área de estudo de séries temporais. A análise permite ao projetista ter maior compreensão da natureza estatística do tráfego intrachip, denominada dependência de curta ou longa duração (SRD e LRD), para o posterior ajuste de modelos usados na geração de séries sintéticas que representem tal natureza. Os resultados da análise mostraram que o tráfego obtido por simulação TLM tem natureza similar em relação ao da do tráfego obtido por simulação num nível mais baixo de abstração, do tipo de precisão por ciclos, indicando que o tráfego TLM pode ser usado para a representação do tráfego intrachip. Outra contribuição deste trabalho é a proposta de ajuste de modelos paramétricos autossimilares usando-se a decomposição da série de tráfego original, tendo sido feita uma comparação dos resultados desta com o ajuste convencional feito a modelos sem decomposição. Estas contribuições foram agrupadas dentro de uma metodologia detalhada, apresentada neste documento, para a qual experimentos foram realizados. Os resultados a partir das séries sintéticas autossimilares geradas pelos modelos estimados, apresentaram semelhança nos indicadores de SRD e LRD em relação às séries originais TLM, mostrando ser favorável o uso futuro destas séries sintéticas na implementação de geradores de tráfego. / It is objective of this work to make a contribution to improve the efficiency of the integrated systems design flow, specifically on the evaluation of communication performance between component blocks. The use of high level hardware modeling and simulation, at the transaction level, known as TLM, is proposed, in order to take advantage of the reduction of effort and time for the integrated system design; that in contrast to the traditional approaches, which use lower hardware description level, such as register transfer level (RTL). A methodology to evaluate the intra-chip traffic produced by the communication between system elements is proposed. The main contribution of this work is the analysis of traffic time series obtained by simulation of hardware platforms modeled in TLM, using well-known statistical methods for time series analysis. The analysis allows the system developer to understand the statistical nature of the intra-chip traffic, also known as short and long range dependence (SRD and LRD), for later adjustment and accurate representation of the traffic nature in synthetic series. The analysis results have shown that traffic traces obtained by TLM simulation has similar statistical nature as the traffic traces obtained at lower abstraction level, as cycle accurate type, which indicates that TLM traffic could be used to represent intrachip traffic. Another contribution of this work is a fitting procedure to auto similar parametric models thought the decomposition of the original traffic, and its comparison to the results of the conventional fitting, when applied to models that are not decomposed. These contributions were grouped and included in the detailed methodology presented in this document, being a series of experiments carried out. The results related to self-similar synthetic series, obtained from the fitted models, have shown similarity to the SRD and LRD indicators of the original TLM series, what favors the use of synthetic series future for the implementation of traffic generators.

During the last decade, the enormous commercial explosion of the Internet has brought up the exhaustive use of Public Telephone Switched Network (PTSN) communication lines by computers (end-users) from all over the world. As a direct consequence of this explosion, a brand new research field, inside the context of the so-called Queuing Theory, has emerged. In fact, the actual dynamics of LAN/WAN data packets has revealed, statistically speaking, a very interesting hidden behavior. These traffic flows possess an intrinsical scale invariance property; this means that, whatever the observational time scale is, their statistical properties remains almost the same. This constitutes a core property of fractal processes. It is, by far, in sharp contrast with classical traffic assumptions, like those models based on Markovian rules. All measurements and results presented here were based on real LAN/WAN traffic traces gathered at ITA's gateway. Basically, this Thesis covers from how to identify the problem up to how to control it. Many statistical methods, to infer an unbiased and well-defined Hurst parameter are developed. Beside this, a mathematical formulism, to be used in our simulation studies, is presented. An open-loop Call Admission Control (CAC) scheme, based on that mathematical formulism is proposed. This CAC algorithm is confronted against the current ATM Forum's ABR service CAC close-loop algorithm. Furthermore, a pure stochastic simulation analysis of the proposed open-loop CAC algorithm, enhancing its advantages and drawbacks, is shown. From these simulation studies some new results have emerged. Finally, we can stand the following: the Internet explosion gave us the exceptional chance to have a real fractal queueing theory, such an issue has never seen before, however, under certain networking conditions, it can be reduced to the well-known classical Markovian-based queuing theory.

A implementação de medicamentos genéricos no Brasil e de programas e políticas para garantir o acesso da população a medicamentos com qualidade, segurança e eficácia resultaram em mais de 3.800 medicamentos genéricos de 445 fármacos registrados na Agência Nacional de Vigilância Sanitária (ANVISA) desde 1999. Os medicamentos genéricos comprovaram a sua equivalência terapêutica e, portanto, intercambialidade com seus respectivos medicamentos de referência por meio de estudos de bioequivalência. Em 2014, a ANVISA estendeu a intercambialidade aos medicamentos similares, aumentando o número de medicamentos intercambiáveis para cada medicamento de referência. As normas para prescrição e dispensação permitem apenas a substituição de medicamento de referência por seu medicamento genérico ou similar intercambiável e vice-versa. Entretanto, o que se observa na prática é a substituição entre medicamentos genéricos e similares de um mesmo fármaco, tanto na rede privada onde os descontos chegam até 90% do preço estabelecido para a venda, como na rede pública, em função da disponibilidade dos medicamentos, visto que as compras públicas se baseiam no menor preço ofertado pelos fabricantes. Entretanto, a bioequivalência e a intercambialidade entre os medicamentos genéricos ou similares de um mesmo referência não pode ser garantida pois os mesmos não foram testados entre si. A ausência de bioequivalência entre medicamentos substituídos pode provocar ineficácia terapêutica ou aparecimento de eventos adversos ou até mesmo intoxicação em pacientes. Consequentemente, podem ocorrer desperdício, gastos com tratamento de eventos adversos, abandono do tratamento e adoção de segunda linha de tratamentos. Este trabalho avaliou a bioequivalência entre os medicamentos genéricos e similares de um mesmo medicamento de referência por meio do método de metanálise, empregando dados de estudos de bioequivalência realizados para o registro de medicamentos genéricos e similares na ANVISA. Foram incluídos na análise estudos de aciclovir, amoxicilina, cefalexina, doxazosina, fenitoína, fluoxetina, levofloxacino e quetiapina. Os resultados demonstraram a ausência de bioequivalência entre a maioria dos medicamentos genéricos e similares contendo o mesmo fármaco. os resultados comprovam que medicamentos genéricos e similares de mesmo fármaco não são obrigatoriamente intercambiáveis e a substituição, principalmente para aqueles usados no tratamento de doenças crônicas, podem trazer graves consequências clínicas. Esta preocupação é aumentada para os fármacos com estreita faixa terapêutica e aqueles com alta variabilidade no processo de absorção. A adoção de uma lista de medicamentos não substituíveis, a exemplo de outros países, e o investimento na divulgação de informações sobre intercambialidade de medicamentos, tanto para profissionais de saúde como para a população, podem contribuir para a redução da substituição entre medicamentos não intercambiáveis, a promoção do uso racional dos medicamentos, a redução de gastos com medicamentos e tratamento de eventos adversos e o aumento da adesão do paciente ao tratamento. / The implementation of generic drugs in Brazil, as well as programs and policies to ensure access to medicines with quality, safety and efficacy to the overall population, resulted in more than 3,800 generic drug products of 445 drugs registered in the National Health Surveillance Agency (ANVISA) since 1999. Generic drug products proved their therapeutic equivalence in bioequivalence studies and, therefore, the interchangeability with their respective reference drug product. In 2014, ANVISA expanded the interchangeability to similar drug products, increasing the number of interchangeable drug products for each reference drug product. Regulations for the prescription and dispensation of medicine only allow the substitution of a reference drug product for a generic or an interchangeable similar drug product or vice versa. However, in practice, it appears that there is a substitution between generic and similar drug products of a same reference drug product in private pharmacy chains - where discounts reach up to 90% of the selling price - as well as in public pharmacy, depending on the medicine availability, because public purchases are based on the lower price offered by the manufacturers. Nevertheless, the bioequivalence and interchangeability between generic and similar drug products of the same reference drug product cannot be guaranteed because they haven\'t been evaluated. Lack of bioequivalence between substituted drug products may result in therapeutic ineffectiveness or the occurrence of adverse events and even to patient intoxication. As a consequence, there might be waste, expenses due to adverse events treatment, no adherence to the treatment or the adoption of second-line treatment. This study evaluated the bioequivalence between generic and similar drugs of the same reference drug product through a meta-analysis, using data from bioequivalence studies carried out for the registration of generic and similar drug products at ANVISA. The drugs included in the study were acyclovir, amoxicillin, cephalexin, doxazosin, phenytoin, fluoxetine, levofloxacin and quetiapine. Results showed lack of bioequivalence between most of the generic and similar drugs containing the same drug and prove that generic and similar drug products of the reference drug product are not necessarily interchangeable. Moreover, the substitution of drugs used for chronic illnesses could lead to serious clinical consequences. This concern increases for drugs with narrow therapeutic index and those with high variable absorption process. The adoption of a list of non-interchangeable medicines - like in other countries - and investment in the dissemination of information about interchangeability between drug products to health professionals and to the population may contribute to reduce the substitution of drugs which are not interchangeable, promote a rational use of medicines, the reduction of expenses with drugs and adverse effects treatment and to improve treatment adherence.

Made available in DSpace on 2016-04-27T16:58:52Z (GMT). No. of bitstreams: 1 Luis Manuel Peliz Marques Bica.pdf: 1767213 bytes, checksum: c7c588be6809bae8b1d9cd810c12b337 (MD5) Previous issue date: 2009-04-28 / Secretaria da Educação do Estado de São Paulo / The objective of this study was to investigate the visual and textual aspects of the theme function, in a general way, and of the similar function in particular, in textbooks of Mathematics for the 1st grade of Brazilian high school. Thus, we see which is the focus given to the conceptual development of the similar function, specially its graphical representation, and how are promoted as the joints between the algebraic parameters and their visual correspondings from the mathematical and visual points of view. In order to achieve our goals, we developed a set of criteria for research that led to carry out a qualitative analysis of three textbooks from 1st grade of high school, approved in 2005 by the National Books Program for the High School of the Ministry of Education and Culture. The research was based on the theory of Records of Semiotic Representation of Raymond Duval. The investigation criteria were as objective to indicate if the books provided a global concern expressed by Duval. In all the work we were always attentive to official recommendations, notably regarding to the contextualization and interdisciplinary of the concept of study. We also analyze the exercises of the books about similar function in order to check if they remained consistent with the expositive treatment, as well as they promoted conversion activities which show phenomena of congruence and non-congruence. The results showed that only two books, one more than the other, promoted global understanding and presented a diversity of records. These books also showed consistency between the theoretical text and the exercises, many of them contextualized. As far as the exercises, the research has shown that these books also had some exercises with non-congruence phenomena / O objetivo deste trabalho foi investigar os aspectos visuais e textuais do tema função de forma geral, e da função afim em particular, em livros didáticos de Matemática da 1ª série do Ensino Médio brasileiro. Para tanto, verificamos qual o enfoque dado ao desenvolvimento conceitual da função afim, em especial sua representação gráfica, e como são promovidas as articulações entre os parâmetros algébricos e seus correspondentes visuais dos pontos de vista matemático e visual. Para atingir nossos objetivos, desenvolvemos um conjunto de critérios de investigação que permitiram realizar uma análise qualitativa em três livros didáticos da 1ª série do Ensino Médio aprovados em 2005 pelo Programa Nacional de Livros para o Ensino Médio do Ministério de Educação e Cultura. A pesquisa foi fundamentada na teoria dos Registros de Representação Semiótica de Raymond Duval. Os critérios de investigação tiveram como objetivo indicar se os livros propiciavam a apreensão global defendida por Duval. Em todo o trabalho estivemos sempre atentos às recomendações oficiais, notadamente no que diz respeito à contextualização e interdisciplinaridade do conceito em estudo. Também analisamos os exercícios dos livros sobre função afim para verificar se mantinham coerência com o tratamento expositivo, bem como se promoviam atividades de conversão onde se manifestassem fenômenos de congruência e de não-congruência. Os resultados mostraram que apenas dois livros, um mais que o outro, promoviam a apreensão global e apresentavam diversidade de registros. Estes livros mostraram também coerência entre o texto teórico e os exercícios, muitos deles contextualizados. Quanto aos exercícios, a pesquisa mostrou que estes livros também apresentaram alguns exercícios com fenômenos de não-congruência

Made available in DSpace on 2017-07-10T17:11:46Z (GMT). No. of bitstreams: 1 DISSERTACAO Marcos Muller2.pdf: 3169941 bytes, checksum: 9c51b1da2e6c3f07726daa30c819efbb (MD5) Previous issue date: 2014-02-21 / Fundação Parque Tecnológico Itaipu / This work presents the use of clustering techniques in load curves for the similar days method for load forecasting, in order to obtain a reduced data to achieve a faster computational algorithm, while achieving similar or superior performance compared to those obtained by the traditional method that makes use of the original data set. The method allows to perform similar day load forecasting using short-term historical data from the consumption of electricity at consumers level, and related data, which allow tracing analogies to a future day. Conventional implementations of the method are used for comparison and validation. The scenario that provides the data for the studies, as well as the equipment, and data preprocessing stage, are presented. The methodology is validated using the cluster silhoute analysis. With the MAPE values was possible to verify the forecast, indicating superiority of the method based on clustered load curves. / Este trabalho apresenta a utilização de clusterização de curvas de carga do nível menos agregado para o método de dias similares, com o objetivo de obter conjuntos reduzidos de dados que imponham menores cargas computacionais ao algoritmo de previsão, e permitir ainda, desempenhos similares ou superiores quando comparados aos obtidos pelo método de dias similares que faz uso do conjunto original de dados. O método de dias similares permite realizar previsão de carga de curtíssimo prazo a partir de dados históricos de consumo de energia elétrica, além de dados correlatos, que permitem traçar analogias com um dia futuro. Implementações convencionais do mesmo método são utilizadas para comparação de resultados. O cenário que fornece os dados para os estudos, assim como os equipamentos empregados e a etapa de pré-processamento de dados são apresentadas. A análise de silhuetas de cluster foi empregada com o objetivo de validar os agrupamentos. Por meio do cálculo do MAPE foi possível verificar a assertividade das previsões, indicando superioridade daquela baseada nas curvas de carga clusterizadas.

La present Tesi Doctoral, titulada desenvolupament computacional de la semblançamolecular quàntica, tracta, fonamentalment, els aspectes de càlcul de mesures de semblançabasades en la comparació de funcions de densitat electrònica.El primer capítol, Semblança quàntica, és introductori. S'hi descriuen les funcions de densitat de probabilitat electrònica i llur significança en el marc de la mecànica quàntica. Se n'expliciten els aspectes essencials i les condicions matemàtiques a satisfer, cara a una millor comprensió dels models de densitat electrònica que es proposen. Hom presenta les densitats electròniques, mencionant els teoremes de Hohenberg i Kohn i esquematitzant la teoria de Bader, com magnituds fonamentals en la descripció de les molècules i en la comprensió de llurspropietats.En el capítol Models de densitats electròniques moleculars es presenten procediments computacionals originals per l'ajust de funcions densitat a models expandits en termes de gaussianes 1s centrades en els nuclis. Les restriccions físico-matemàtiques associades a lesdistribucions de probabilitat s'introdueixen de manera rigorosa, en el procediment anomenatAtomic Shell Approximation (ASA). Aquest procediment, implementat en el programa ASAC,parteix d'un espai funcional quasi complert, d'on se seleccionen variacionalment les funcions ocapes de l'expansió, d'acord als requisits de no negativitat. La qualitat d'aquestes densitats i de les mesures de semblança derivades es verifica abastament. Aquest model ASA s'estén arepresentacions dinàmiques, físicament més acurades, en quant que afectades per les vibracions nuclears, cara a una exploració de l'efecte de l'esmorteïment dels pics nuclears en les mesures de semblança molecular. La comparació de les densitats dinàmiques respecte les estàtiques evidencia un reordenament en les densitats dinàmiques, d'acord al que constituiria una manifestació del Principi quàntic de Le Chatelier. El procediment ASA, explícitament consistent amb les condicions de N-representabilitat, s'aplica també a la determinació directe de densitats electròniqueshidrogenoides, en un context de teoria del funcional de la densitat.El capítol Maximització global de la funció de semblança presenta algorismes originals per la determinació de la màxima sobreposició de les densitats electròniques moleculars. Les mesures de semblança molecular quàntica s'identifiquen amb el màxim solapament, de manera es mesuri la distància entre les molècules, independentment dels sistemes de referència on es defineixen les densitats electròniques. Partint de la solució global en el límit de densitats infinitament compactades en els nuclis, es proposen tres nivells de aproximació per l'exploraciósistemàtica, no estocàstica, de la funció de semblança, possibilitant la identificació eficient del màxim global, així com també dels diferents màxims locals. Es proposa també una parametrització original de les integrals de recobriment a través d'ajustos a funcions lorentzianes, en quant que tècnica d'acceleració computacional. En la pràctica de les relacions estructura-activitat, aquests avenços possibiliten la implementació eficient de mesures de semblança quantitatives, i, paral·lelament, proporcionen una metodologia totalment automàtica d'alineació molecular. El capítol Semblances d'àtoms en molècules descriu un algorisme de comparació dels àtoms de Bader, o regions tridimensionals delimitades per superfícies de flux zero de la funció de densitat electrònica. El caràcter quantitatiu d'aquestes semblances possibilita la mesura rigorosa de la noció química de transferibilitat d'àtoms i grups funcionals. Les superfícies de flux zero i elsalgorismes d'integració usats han estat publicats recentment i constitueixen l'aproximació mésacurada pel càlcul de les propietats atòmiques.Finalment, en el capítol Semblances en estructures cristal·lines hom proposa una definició original de semblança, específica per la comparació dels conceptes de suavitat o softness en la distribució de fonons associats a l'estructura cristal·lina. Aquests conceptes apareixen en estudis de superconductivitat a causa de la influència de les interaccions electró-fonó en les temperatures de transició a l'estat superconductor. En aplicar-se aquesta metodologia a l'anàlisi de sals de BEDT-TTF,s'evidencien correlacions estructurals entre sals superconductores i no superconductores, enconsonància amb les hipòtesis apuntades a la literatura sobre la rellevància de determinadesinteraccions.Conclouen aquesta tesi un apèndix que conté el programa ASAC, implementació de l'algorisme ASA, i un capítol final amb referències bibliogràfiques. / The present Doctoral Thesis, entitled Computational Development of Quantum Molecular Similarity, fundamentally deals on the calculation of similar-ity measures arising from the comparison of electron density functions.The first chapter, Quantum Similarity, is introductory. Electron probability functions are described, emphasizing their significance in Quantum Mechanics, and their mathematical constrains.In the chapter Models of molecular electron densities, original procedures to fit electron densities to 1s Gaussian expansions are presented. Mathematical constrains attached to probability distribution functions are explicitly considered,in the procedure named Atomic Shell Approximation (ASA). This procedure, im-plementedin the computer program ASAC, uses an initial, nearly complete func-tional space, from where functions or shells are variationally selected, according to the non-negativity requirements. The quality of these model densities and theaccuracy of the derived similarity measures are extensively verified. The ASA model is also extended to dynamic distributions, presumably a more physical rep-resentation of free molecule and ligand electron densities. The ASA procedure,explicitly consistent with the N-representability conditions, is adapted to the direct determination of hydrogenoid electron densities, in a context of the Density Func-tional Theory.The chapter Global Maximization of the Similarity Function describes original algorithms to determine the maximum overlap of two molecular electron densities. Similarity measures are identified with the maximum overlap in order tomeasure the distances among molecules, independently on the reference frame-.work where they are defined. Starting from the known global solution attached to hypothetical, infinitely compacted molecular electron densities, one proposes three levels of approach for an efficient scanning and global maximization of the non-deformed similarity function. Parametrazing overlap integrals through Lorentzian-likefunctions is also proposed to speed up computations. In the practice of structure-activity relationships, the presented advances provide an efficient implemen-tation of quantitative similarity measures, and, moreover, provide a new, com-pletely automatic methodology for molecular superposition and alignments.The chapter Similarities of atoms in molecules describes an algorithm for the comparison of Bader atoms. The accurate similarity measures obtained pro-vide a rigorous quantification of the degree of transferability of atoms and func-tional groups.Finally, in the chapter Similarities among crystalline structures, it is pro-posed a similarity definition for the comparison of crystalline structures regarding the concept of softness. This concept emerges from the BCS theory of supercon-ductivity.It appears related to the influence of electron-phonon interactions in the transition temperatures to the superconducting state. The application of this methodology in analyzing BEDT-TTF salts reveals a structural correlation among su-perconductors and non-superconductors, according to pointed hypothesis regard-ing the influence of some intermolecular interactions.The present Thesis concludes listing the ASAC code, implementation of the ASA algorithm, together with a chapter containing bibliographic references.

Recently there have been reports that certain physiological data seem to have the properties of long-range correlation and self-similarity. These two properties can be characterized by a long-range dependent parameter d, as well as a self-similar parameter H. In Peng et al (1995), the alteration of long-range correlations with life-threatening pathologies are studied by analyzing the heart rate data of different groups of subjects. The self-similarity properties of two well-known processes, namely the Fractional Brownian Motion (FBM) and the Fractional ARIMA (FARIMA), are of interest to see if it is suitable to be used to model the heart rate data in order to examine the health conditions of some patients. The Embedded Branching Process (EBP) method for estimating parameter $H$ and a goodness of fit test for examining the self-similarity of a process based on the EBP method are proposed in Jones and Shen (2004). In this work, the performance of the goodness of fit test are examined using simulated data from the FBM and FARIMA processes. A modification of the distribution of the test statistics under null hypothesis is proposed and has been modified to be more appropriate. Some simulation comparisons of different estimation methods of the parameter $H$ for some FARIMA processes are also presented and applied to heart rate data obtained from Kaohsiung Veterans General Hospital.

Die Berücksichtigung der flächenhaften bodenhydraulischen Variabilität gilt bei der Modellierung von Wasser- und Stofftransportprozessen als problematisch. Dies liegt vorrangig an ihrer Erfassung, die kosten- und zeitintensiv ist. Die vorliegende Arbeit untersucht verschiedene Messstrategien, die zur Abbildung der flächenhaften Bodenhydraulik mit wenigen, einfach zu bestimmenden und physikalisch begründeten Bodenparametern führen. Die Vorgehensweise erfolgt mit der Anwendung eines Ähnlichkeitskonzeptes, das die Böden in bodenhydraulisch ähnliche Klassen unterteilt. Innerhalb einer Klasse kann die Variabilität der Retentions- und hydraulischen Leitfähigkeitcharakteristik auf einen freien Parameter (Skalierungsparameter) reduziert werden. Die Analyse der Zusammenhänge zwischen Boden- und Skalierungsparametern führt letztendlich zu den geeigneten Parametern die eine flächenhafte Abbildung möglich machen. Diese Untersuchungen bilden die Grundlage für die weitere Entwicklung eines stochastischen Modellansatzes, der die Variabilität der Bodenhydraulik bei der Modellierung des Bodenwassertransportes im Feldmaßstab berücksichtigen kann. An Hand von drei Datensätzen unterschiedlicher Skalenausbreitung konnte dieses Konzept angewendet werden. Die Ergebnisse zeigen, dass die Beschreibung der hydraulischen Variabilität nur für die vertikale (Profil) nicht aber für die flächenhafte Ausbreitung mit einfachen Bodenparametern möglich ist. Mit einer ersten Modellanwendung konnte gezeigt werden, dass über die Variabilität der Bodenparameter Trockenrohdichte und Tongehalt auch die Variabilität der Bodenhydraulik und damit die Berechnung des Bodenfeuchteverlaufs am Standort darstellbar ist. / The consideration of the spatial variability of the unsaturated soil hydraulic characteristics still remains an unsolved problem in the modelling of the water and matter transport in the vadose zone. This can be mainly explained by the rather cumbersome measurement of this variability, which is both, time-consuming and cost-intensive. The presented thesis analyses various measurement strategies which aim at the description of the soil-hydraulic heterogeneity by a small number of proxy-parameters, which should be easily measurable and still have a soil-physical meaning. The developed approach uses a similarity concept, which groups soils into similar soil hydraulic classes. Within a class, the variability of the retention and hydraulic conductivity curves can be explained by a single parameter (scaling parameter). The analysis of the correlation between the soil parameters and the scaling parameters can eventually indicate which soil parameters can be used for describing the soil hydraulic variability in a given area. This investigation forms the basis for the further development of a stochastic model, which can integrate the soil-hydraulic variability in the modelling of the soil water transport. Three data sets, all covering different scales, were subsequently used in the application of the developed concept. The results show that depth development of the soil-hydraulic variability in a soil profile can be explained by a single soil parameter. Contrarily, the explanation of the horizontal variability of the soil-hydraulic properties was not possible with the given data sets. First model applications for a soil profile showed that including the variability of the soil parameters bulk density and clay fraction in the water transport simulations could describe the variability of the soil-hydraulic variability and thus, the dynamics of the soil water content at the investigated profile.

Σεισμικά γεγονότα τα οποία προέρχονται από σεισμικές πηγές των οποίων η απόσταση μεταξύ τους είναι πολύ μικρότερη από την απόσταση μέχρι τον κοντινότερο σταθμό καταγραφής, είναι γνωστά στη βιβλιογραφία σαν όμοια σεισμικά γεγονότα και αποτελούν αντικείμενο έρευνας εδώ και μια εικοσαετία. Η διαδικασία επαναπροσδιορισμού των υποκεντρικών παραμέτρων ή επανεντοπισμού όμοιων σεισμικών γεγονότων οδηγεί σε εκτιμήσεις των παραμέτρων που είναι συνήθως μεταξύ μίας και δύο τάξεων μεγέθους μικρότερου σφάλματος από τις αντίστοιχες των συνηθισμένων διαδικασιών εντοπισμού και επομένως, μπορεί εν δυνάμει να παράξει μια λεπτομερέστερη εικόνα της σεισμικότητας μιας περιοχής, από την οποία μπορεί στη συνέχεια να προκύψει η ακριβής χαρτογράφηση των ενεργών ρηγμάτων της. Πρόκειται για μια σύνθετη διαδικασία που μπορεί να αναλυθεί στα παρακάτω τρία βασικά βήματα: 1. Αναγνώριση ομάδων όμοιων σεισμικών γεγονότων. 2. Υπολογισμός διαφορών χρόνων άφιξης μεταξύ όμοιων σεισμικών γεγονότων. 3. Επίλυση προβλήματος αντιστροφής. Το πρώτο από τα παραπάνω βήματα είναι η αναγνώριση των λεγόμενων σεισμικών οικογενειών που υπάρχουν στον διαθέσιμο κατάλογο και έχει ξεχωριστή σημασία για την ολική επιτυχία της διαδικασίας. Μόνο εάν εξασφαλιστεί η ορθότητα της επίλυσης αυτού του προβλήματος τίθενται σε ισχύ οι προϋποθέσεις για την εφαρμογή της διαδικασίας και άρα έχει νόημα η γεωλογική ανάλυση που ακολουθεί. Είναι επίσης ένα πρόβλημα που απαντάται και σε άλλες γεωλογικές εφαρμογές, όπως είναι για παράδειγμα ο αυτόματος εντοπισμός του ρήγματος γένεσης ενός άγνωστου σεισμικού γεγονότος μέσω της σύγκρισής του με διαθέσιμες αντιπροσωπευτικές οικογένειες. Το πρόβλημα της αναγνώρισης είναι στην ουσία ένα πρόβλημα ταξινόμησης και ως εκ τούτου προϋποθέτει την επίλυση δύο σημαντικών επιμέρους υποπροβλημάτων. Συγκεκριμένα, αυτό της αντιστοίχισης των σεισμικών κυματομορφών (matching problem) και αυτό της κατηγοριοποίησής τους (clustering problem). Το πρώτο έχει να κάνει με τη σύγκριση όλων των δυνατών ζευγών σεισμογραμμάτων του καταλόγου ώστε να εντοπισθούν όλα τα όμοια ζεύγη, ενώ το δεύτερο αφορά την ομαδοποίηση των ομοίων σεισμογραμμάτων ώστε να προκύψουν οι σεισμικές οικογένειες. Στα πλαίσια αυτής της εργασίας, λαμβάνοντας υπόψη τις ιδιομορφίες που υπεισέρχονται στο παραπάνω πρόβλημα ταξινόμησης από τις ιδιαιτερότητες των σεισμογραμμάτων αλλά και την ιδιαίτερη φύση της εφαρμογής, προτείνουμε μια μέθοδο σύγκρισης που βασίζεται σε μια γενικευμένη μορφή του συντελεστή συσχέτισης και μια μέθοδο κατηγοριοποίησης βασισμένη σε γράφους, με στόχο την αποτελεσματική αλλά και αποδοτική επίλυσή του. / Seismic events that occur in a confined region, meaning that the distance separating the sources is very small compared to the distance between the sources and the recording station, are known in the literature as similar seismic events and have been under study for the past two decades. The re-estimation of the hypocenter parameters or the relocation of similar events gives an estimation error that is between one and two orders of magnitude lower that the one produced by the conventional location procedures. As a result, the application of this approach creates a much more detailed image of the seismicity of the region under study, from which the exact mapping of the active faults of the region can occur. The relocation procedure is in fact a complex procedure, consisting of three basic steps: 1. Identification of groups of similar seismic events. 2. Estimation of the arrival time differences between events of the same group. 3. Solution of the inverse problem. The first of the above steps, namely the identification of the seismic families of the given catalog plays an important role in the total success of the procedure, since only the correct solution of this problem can ensure that the requirements for the application of the procedure are met and therefore the geological analysis that is based on its outcome is meaningful. The problem is also encountered in other geological applications, such as the automatic location of the fault mechanism of an unknown event by comparison with available representative families. The problem of the identification of the seismic families is a classification problem and as such, requires the solution of two subproblems, namely the matching problem and the clustering problem. The object of the first one is the comparison of all the possible event pairs of the catalog with the purpose of locating all the existing similar pairs, while the second one is concerned with the grouping of the similar pairs into seismic families. In this work, taking into consideration the particularities that supersede the classification problem described above due to the special nature of the seismograms and also the specific requirements of the application, we propose a comparing method which is based on a generalized form of the correlation coefficient and a graph – based clustering technique, as an effective solution of the problem at hand.

Rättsutvecklingen går ständigt framåt och reglerna om fåmansföretag har ändrats successivt under åren. Innebörden av begreppet samma eller likartad verksamhet framgår inte tydligt av lagtexten eller förarbetena. Tolkningen av 57 kap. 4§ IL har därmed blivit föremål för prövning i ett flertal rättsfall av domstolen. Den 16 november 2012 fastställde HFD ett antal förhandsbesked från SRN. Innebörden av begreppet samma eller likartad verksamhet har utvidgats av HFD till att omfatta mer än vad som framgår av lagtextens ordalydelse. HFD har fastställt att överföring av verksamhet kan ske genom kapital och därmed kan två fåmansföretag som bedriver olika typer av verksamheter anses bedriva samma eller likartad verksamhet på grund av att kapital har förts över mellan fåmansföretagen. HFD har även fastställt att när ägaren är verksam i betydande omfattning i ett annat fåmansföretag än det han äger krävs det att ett ägarsamband föreligger mellan dessa fåmansföretag för att de ska anses bedriva samma eller likartad verksamhet. Ägarens andelar är kvalificerade under fem beskattningsår efter försäljningen av ett fåmansföretag och därmed blir det en övergångsperiod där reglerna om fåmansföretag fortfarande tillämpas. Frågan huruvida en tilläggsköpeskilling påverkar karenstiden har inte explicit prövats av HFD. När tilläggsköpeskillingen är hänförlig till den tidigare ägarens arbetsinsats som anställd efter försäljningen anser författarna att det implicit framgår av HFD:s avgöranden att karenstiden börjar löpa efter att köpeskillingen utgår och inte efter att en tilläggsköpeskilling utgår. Om tilläggsköpeskillingen istället utgår till kapitalförvaltningsföretaget och inte är hänförlig till den tidigare ägarens lön för arbetet efter försäljningen i företaget börjar karenstiden löpa efter att den sista tilläggsköpeskillingen har utgått. / The rules of close companies have continuously been developed and the rules have been changed successively over the years. The meaning of the concept “the same or similar ac- tivity” is not clearly expressed in the legislative text or the legislative history. The interpretation of 57 chapter 4§ Income Tax Act has therefore been the object of proceedings in several cases by the court. On the 16th of November 2012, the Supreme Administrative Court (SAC) settled a num- ber of rulings from the Swedish Tax Board (Skatterättsnämnden). The meaning of the concept “the same or similar activity” has been extended by the SAC to include more than what can be read from the legislative text. The SAC has settled that the transfer of activity can be made through capital and therefore two close companies engaging in different types of activities can be determined as engaging same or similar activities because capital has been transferred between the close companies. The SAC has also settled that when the owner is engaged in “significant quantities” in another close company, which he does not own, then it is required that an ownership relationship exists between these two close companies for them to be determined as engaging same or similar activity. The owner's shares are qualified for five tax years after the sale of a close company and therefore there will be a transition period where the rules for close companies still applies. The question whether an additional payment affects the qualifying period has not been explicitly tried by the SAC. When the additional payment is due to the previous owner's work performance as an employee after the sale, the authors claim that it can be implied from the SAC's rulings, that the qualifying period starts after the purchase price is paid and not after the additional payment is paid. However if the additional payment is paid to the asset management company and is not related to the previous owner’s salary after the sale of the company the qualifying period starts after the last additional payment has been paid.