This diploma thesis deals with an optimization of hydrostatic slide of the large-portal gantry machine FRU (TOS Kuřim). First part of the thesis concerns with an analysis of the current practice in hydrostatic guides in the field of heavy gantry machines, an usage of alternative materials for a construction of carrying parts of machines, and possibilities of current simulation methods. Aim of the second part of this thesis is a brief clarification of the principle of mathematical optimization, and creation of general methodology of construction optimization by means of system analysis. Optimization calculations were processed by ANSYS Workbench 11.0. There is achieved adjusted and optimized design of the hydrostatic slide as the result of the thesis. Moreover, the comparison of key deformations was added. Created methodology is applicable in both an area of construction of gantry machines, and a wide spectrum of construction fields.

This master's thesis deals with proposals for solutions to increase the stiffness of the slide for CNC horizontal boring standing in order to optimize the design of the slide. Selected problem was solved by sensitivity analysis using desegin of experiment in conditions of linear regression analysis. Data for the sensitivity analysis were obtained by using computational modeling using finite element method. The solution provides a view of the degree of influence on the deformation of the examined elements of the slide. Based on these results were selected elements with the greatest influence and created three ideological designs for improvement. Of these designs, was chose an optimal variant by PATTERN method acoording on the technical, economic and technical-economic aspect. This work offers a new look for the innovating the design to increase rigidity.

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Colorectal cancer is one of the most prevalent malignancies globally and recently introduced digital pathology enables the use of machine learning as an aid for fast diagnostics. This project aimed to develop a deep neural network model to specifically identify and differentiate dysplasia in the epithelium of colorectal polyps and was posed as a binary classification problem. The available dataset consisted of 80 whole slide images of different H&E-stained polyp sections, which were parted info smaller patches, annotated by a pathologist. The best performing model was a pre-trained ResNet-18 utilising a weighted sampler, weight decay and augmentation during fine tuning. Reaching an area under precision-recall curve of 0.9989 and 97.41% accuracy on previously unseen data, the model’s performance was determined to underperform compared to the task’s intra-observer variability and be in alignment with the inter-observer variability. Final model made publicly available at https://github.com/stinabr/classification-of-colorectal-polyps.

This thesis deals with the construction of drives for self-supporting gates. The main parts from which the drive is folded are not discussed here. In addition, the main points of load are solved which arise on the self-supporting gate and it´s contact with the guiding, carrying carts and movement elements. And here is explained what needs to be taken care of by the drive to accommodate the loads, which all aggravate the movement of the structure. in the work are also presented the load types of load calculations by which the drive parameters can be checked for suitability for the application.

This thesis deals with designing of C axis for interchangeable heads for milling machining centres with horizontal spindle centre of the slide type. Itâs divided into three parts, whereas the first part contains theoretical introduction to the problematic. The second part deals with systematic analysis of the topic and choosing the right variant for elaboration. The last part forms construction design of the chosen variant, which contains notes on the solution proce-dure, calculations and visualization in form of 3D models.

In this thesis analysis and inovation of electric machines for cars is discused. There are described principles of basics DC and AC electric machines. In detail this thesis deals with small electric machines used in cars. At least, electro motor for wiper is investigated and possibilities of its inovation in different ways are also mantioned.

This diploma thesis deals with the design and construction of a three-axis CNC machine primarily designed for PCB drilling and production of front panels for various electronic devices. All three axes are driven by stepper motors NEMA 23 which are connected to stepper motor drivers L6470. Processor STM32F407 is used to control the whole machine. The wiring is completed by a LCD display with touchscreen which is used to communicate with user. Data for drilling can be entering manually or via USB inerface. Part of this thesis is the selection of a suitable construction and components, assembling equipment, wiring design of electronic circuits and writing the code to control the machine. Finally, the parameters of the designed device have been measured.

Im Zuge der kontinuierlichen Weiterentwicklung von Verarbeitungs- und Verpackungsmaschinen werden immer höhere Anforderungen an die für den Gütertransfer eingesetzte Fördertechnik gestellt. Neben der erhöhten Förderleistung sind zudem ein schmiermittelfreier Betrieb sowie eine hundertprozentige Verfügbarkeit gefordert. Durch die zunehmende Leistungssteigerung kommt es zu hohen Beanspruchungen, die bei falscher Auslegung zu mechanischem oder thermischem Versagen der Kunststoff-Bauteile im Fördersystem führen können. Während das mechanische Versagen mit den aktuellen Dimensionierungen vermieden werden kann, gibt es bezüglich des thermischen Versagens keine hinreichend genaue Auslegungsvorschrift. Die vorliegende Arbeit befasst sich mit der thermischen Analyse von Gleitketten-Fördersystemen sowie den darin eingesetzten thermoplastischen Kunststoff-Kunststoff-Gleitpaarungen. Diesbezüglich werden die Gleitkontakte eines Gleitkettenförderers und deren Belastungen analysiert. Durch Abstraktion des Kette–Schiene-Systems wird ein semi-analytisches Berechnungsmodell zur Abschätzung der Reibtemperatur entwickelt, welches mittels experimenteller Untersuchungen auf einem Tribo-Prüfstand und an einem Fördersystem verifiziert wird. Aus den Untersuchungsergebnissen konnte ein thermisches Auslegungskriterium für Kunststoff-Kunststoff-Gleitpaarungen abgeleitet werden, welches sowohl auf Gleitketten-Förderer als auch perspektivisch auf ähnliche tribologische Systeme übertragen werden kann. / In the course of the continuous enhancements of processing and packaging machines, higher demands are set on conveying technology used for transferring goods. In addition to an increased delivery rate, a lubricant-free operation as well as a hundred percent availability are claimed. Increasing performance leads to high stresses that can result to mechanical or thermal failure of plastic components in the conveying system, if incorrectly designed. While mechanical failure can be avoided with up to date dimensioning, there is no sufficiently precise dimensioning criterion in regard to thermal failure. The present thesis is concerning with the thermal analysis of sliding chain conveyor systems as well as the thermoplastic plastic-plastic sliding pairs used therein. In this regard, the sliding contacts of a sliding chain conveyor and their loads are analyzed. By abstraction of the chain–rail system, a semi-analytical model for estimating the frictional temperature is developed, which is verified by experimental studies on a tribo test bench and a conveyor system. From the study results, a thermal dimensioning criterion for plastic plastic pairings could be derived, which can be applied to sliding chain conveyor as well as perspectivly similar tribological systems.

With a flat slide valve concept, when compared to conventional piston spool valves, reduced leakage and increased service life could be achieved. In order to achieve a reduction of leakage flows and guarantee the adjustability of the valves at the same time, a correct design of the pressure compensation is essential. The magnitude of force depends on both the operating point of the valve and the position of the slider. Due to the design of the flat slide valve, it is possible to use ceramic semi-finished products for the main stage, which consist of control plates and a slide plate. The geometries are simple enough to be inexpensively manufactured with sufficient accuracy, using a ceramic pre-product using laser cutting technology. This article introduces the concept of the flat slide valve for a proportional 4/3-way valve. The design of the valve, including the design of the metallic main stage is presented. This includes the design of the flow channels, which have to be suitable for ceramic materials. Furthermore the design of the actuator and hydraulic circuit for testing is presented. With the shown design, the function of a 4/3-way valve, known from piston spool valves, can be implemented with a linear behavior between slide plate deflection and opening flow cross section.