Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-05-31T18:35:47Z No. of bitstreams: 2 Dissertação - Aroldo Vieira de Moraes Filho - 2013.pdf: 777889 bytes, checksum: ff3a609fe7af52fcc55701fe96a8d450 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-01T11:20:13Z (GMT) No. of bitstreams: 2 Dissertação - Aroldo Vieira de Moraes Filho - 2013.pdf: 777889 bytes, checksum: ff3a609fe7af52fcc55701fe96a8d450 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-06-01T11:20:14Z (GMT). No. of bitstreams: 2 Dissertação - Aroldo Vieira de Moraes Filho - 2013.pdf: 777889 bytes, checksum: ff3a609fe7af52fcc55701fe96a8d450 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2013-02-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / The antiretroviral drugs appeared to prevent the multiplying HIV virus in the body, reducing its virulence, but not eliminate it from infected cells. These drugs increase the length and the quality of life of AIDS patients. In this context, Efavirenz (EFV) is non-nucleoside reverse transcriptase inhibitors. The Tenofovir Disoproxil Fumarate (TDF), oral prodrug of tenofovir, is analogue of adenosine 5 'monophosphate, belonging to the class of nucleotide reverse transcriptase inhibitors. These drugs act on the mechanisms of HIV replication by inhibiting the action of reverse transcriptase and thus preventing viral DNA synthesis. In order to assess the toxic and toxic-genetic potential of EFV and TDF, the present study used the Test for Detection of Somatic Mutation and Recombination (SMART) in Drosophila melanogaster. 3rd stage larvae originating from standard cross (ST) between males mwh and females flr³, were treated with solution of EFV and TDF and distilled water (negative control), for approximately 48 hours (chronic treatment) until they reach the pupal stage. These strains are carriers of specific gene markers, located on the left arm of chromosome 3, which allow you to monitor events related to mutation, mitotic recombination and chromosome aberrations. The statistical diagnosis was obtained by conditional binomial test. In this work, the results demonstrated that the EFV was toxic in high concentrations, but showed no induction of toxic genetic events. Inversely, the TDF showed no toxicity at the concentrations tested, but was showed induction of toxic genetic events at all concentrations, with a prevalence of recombinogenic events. Then, it is essential to analyze constantly the effects risk/benefit of isolated drugs and identify toxic and toxic genetic activity of each drug in order to ensure the quality of life for patients who use monotherapies and offers support for investigations with therapies that use combinations of antiretroviral drugs. / Os medicamentos antirretrovirais surgiram para impedir a multiplicação do vírus HIV no organismo, reduzindo a sua virulência, porém sem eliminá-lo das células infectadas. Estes medicamentos aumentaram o tempo e a qualidade de vida dos pacientes com AIDS. Dentro deste contexto, o Efavirenz (EFV) é inibidor da transcriptase reversa não-análogo de nucleosídeo. O Fumarato de Tenofovir Desoproxila (TDF), pró-fármaco oral de tenofovir, é análogo da adenosina 5`-monofosfato, pertencente à classe de inibidores da transcriptase reversa análogos de nucleotídeos. Estes fármacos atuam nos mecanismos de replicação do HIV, inibindo a ação da transcriptase reversa e, consequentemente, impedindo a síntese de DNA viral. Com o intuito de avaliar o potencial tóxico e tóxico genético do EFV e do TDF, utilizou-se o Teste para Detecção de Mutação e Recombinação Somática (SMART) em Drosophila melanogaster. Larvas de 3º estágio oriundas do Cruzamento Padrão (ST – standard cross) entre machos mwh e fêmeas flr³, foram tratadas com soluções de EFV e TDF, assim como com água destilada (controle negativo), por aproximadamente 48 h (tratamento crônico), isto é, até atingirem o estágio de pupa. Essas linhagens são portadoras de genes marcadores específicos, localizados no braço esquerdo do cromossomo 3, que permitem monitorar eventos relacionados com mutação gênica, aberrações cromossômicas e recombinação mitótica. O diagnóstico estatístico foi obtido pelo teste binomial condicional. Os resultados demonstraram que o EFV foi tóxico em altas concentrações, mas não induziu eventos tóxico genéticos. Inversamente, o TDF não apresentou toxicidade nas concentrações testadas, porém apresentou indução de efeitos tóxico genéticos em todas as concentrações, com prevalência dos eventos recombinogênicos. Então, torna-se fundamental analisar constantemente o risco/benefício de medicamentos isolados e identificar a atividade tóxica e tóxico-genética de cada fármaco com o intuito de assegurar qualidade de vida aos pacientes que fazem uso de monoterapias e oferecer suporte para as investigações com as terapias que utilizam combinações de antirretrovirais.

Determinar quais são os aparelhos eletrônicos de uma residência que possuem maior influência na conta de luz não é tarefa trivial. As Redes de Sensores Sem Fios (RSSF) auxiliam os usuários nessa tarefa, permitindo descobrir se há algum tipo de desperdício no ambiente monitorado e assim, auxiliá-los a fazer as devidas correções. Por isso, é fundamental usar nas smart grids métodos que detectam novidades, também conhecido como anomalias , de forma individual e autônoma, para os usuários quando algo anômalo surge no consumo de energia dos equipamentos eletrônicos. Tais anomalias podem surgir, por exemplo, quando um equipamento consome energia acima do esperado, o que pode indicar um defeito. Nesse contexto, este trabalho propõe um método inteligente, nomeado como Novelty Detection Power Meter (NodePM), para detectar as novidades no consumo de energia dos equipamentos eletrônicos monitorados por uma smart grid. O NodePM detecta as novidades considerando a entropia de cada equipamento monitorado, a qual é calculada com base em um modelo de cadeia de markov que é gerado através de um algoritmo de aprendizado de máquina. Para tanto, o NodePM é integrado a uma plataforma de monitoramento remoto de consumo de energia, que consiste de uma RSSF associada a uma aplicação em nuvem. Para validar o desempenho do NodePM foram feitos experimentos utilizando a análise de variância e testes paramétricos e não-paramétricos. Os resultados de tais experimentos, obtidos mediante a análise estatística, evidenciou a viabilidade do NodePM na plataforma desenvolvida / It is not a simple task to determine which pieces of elevtronic equipment have the greatest influence on the electricity bill. The Wireless Sensor Networks (WSN) assist users in this task, allowing to discover if there is any type of a waste in a monitored environment and thus, help them to take proper actions. Hence, it is of crucial importance to use intelligent methods in the smart grids for a novelty detection and to inform the users in an individual and autonomous way when some anomaly has occurred in the energy consumption of electronic equipment. These anomalies can arise, for instance, when a piece of equipment consumes more energy than expected. In this context, we propose an intelligent method, named the Novelty Detection Power Meter (NodePM), to detect the novelties in the energy consumption of electonic equipment monitored by a smart grid. The NodePM detects the novelties considering the entropy of each device monitored, which is calculed based on a Markov chain model that is generated through a machine learning algorithm. For this end, the NodePM is integrated into a platform for the remote monitoring of energy consumption, which consists of a WSN associated with a cloud application. To validate the performance of the NodePM, experiments were done using analysis of variance and parametric and non-parametric tests. The result of these tests, which were obtained from a statistical analysis, provided evidence of the feasibility of the NodePM in the platform that was developed

This master thesis maps contemporary situation linked to the Industry 4.0 topic and sets it into connections and define its relations. The first part is dedicated to describing the beginning and nature of Industry 4.0. Next part shows main national initiatives of several countries. In the other part of thesis there is specific description of terms connected to this concept. Next part is about evaluating benefits, risks and restrictions. After that there is description of present use on market. The last part sums some predictions about Industry 4.0.

Emerging Software Defined Networking (SDN) technology has provided excellent flexibility to large-scale networks in terms of control, management, security, and maintenance. On the other hand, recent years witnessed a tremendous growth of the critical infrastructure networks, namely the Smart-Grid, in terms of its underlying communication infrastructure. Such large local networks requires significant effort in terms of network management and security. We explore the potential utilization of the SDN technology over the Smart Grid communication architecture. Specifically, we introduce three novel SDN deployment scenarios in local networks of Smart Grid. Moreover, we also investigate the pertinent security aspects with each deployment scenario along with possible solutions. On the other hand, we conducted experiments by using actual Smart Grid communication data to assess the recovery performance of the proposed SDN-based system. The results show that SDN is a viable technology for the Smart Grid communications with almost negligible delays in switching to backup wireless links.

The goal of the thesis is to provide investors and established businesses insights into the evolving concept of Internet of Things in the context of a business opportunity. First, the thesis provides comprehensive overview of the IoT concept, its historical development and relevant concepts similar to IoT including its definition and explanation. Second, the thesis discusses IoT as a disruptive technology with implications for general business strategy, current business models, value chains and competitive landscape. Third, it describes overwhelming opportunities for IoT application in various business fields and processes bringing added value to its stakeholders. Visionary concepts and applicable use cases are identified. Finally, the thesis analyses IoT market perception from both customer and business perspective based on quantitative and qualitative data researched. The research is focused mainly on customer awareness and value perception of IoT products as well as major drivers and challenges of the IoT market from business players' perspective. Such analytical insights identify major patterns and dynamism of the IoT market.

The goal of the Master´s thesis is to map the actual situation of transformation of power energy sector to smart grid, find answers to some of the major questions concerning the implementation of smart metering systems, evaluate societal and economic costs and benefits, evaluate trends in legislation, compare the situation in Slovakia with other peer countries from the European Union, and create a follow-up recommendations for Slovakia based on this assessment. The thesis includes detailed critical analysis of the CBA, originally created for Slovakia, using benchmarking with countries with a different calculation approach. The used methodology in this work is a research of available resources, qualitative research of case studies, break-down of the CBA, and expert research through interviewing. The outcome is evaluation of economic and societal contributions of smart metering systems and mapping the process and state of the implementation.

In my thesis I have been working theory bases of smart power, while trying to apply this theory to the foreign policy of Brazil. Theoretical and practical part of the thesis is based on three pillars: soft power, economic power and military might. The paper attempts to answer the question: What are the sources of brazilian power? Wha instruments are these sources turned to? How effectively can Brazil persuade another international actor about its interests or does it rely on coercive power? In trying to answer these questions, I focused mainly on the identification of the most important foreign policy actions in Brazil, which define its current position on the international scene. The application of smart power theory on Brazil's foreign policy is performed through the analysis of the Brazilian operations in peacekeeping mission in Haiti since 2004. The situation in Haiti is an unprecedented challenge for Brazil, under which it can draw on soft power, economic power and military resources.

In this diploma thesis I dealt with proposal of optimization security algorithms calculations, that will be implemented on smartcards. This project is based on knowledge of modular arithmetic, that is used in many encryption like public keys, digital signatures and has function. The result of this project is a design of changes for accelerate the security algorithms calculations.

This diploma thesis deals with the modelling of the piezoelectric composite material using the finite element method. The thesis is divided into three parts. Research study is done in the first part. It focuses on the possibility of use of the piezoelectric layers as sensors. The second part concerns the homogenization of MFC (macro fiber composite). Material and piezoelectric parameters are obtained by modelling elementary structural cell under different loading conditions. Determined characteristics are verified with experimental data. The third part proposes the design of the experimental device, which allows the simulation of the rotor excitation by rotating unbalance. Excitation responses of MFCs placed in specific locations are calculated using FEA model of the device. The conclusion includes the description of the suitability to vibration measurement on the device.

The thesis deals with PLC technology and issues with Smart Metering. In the theoretical part, a principle of technology's functionality and its advantages and disadvantages were described. In the experimental part methodology of data concentrator and electric meters was designed. In addition, extensive testing set according to capturing of DLMS communication, link quality influencing, reading registers of meters were realized. In the second experimental part limits of communications between broadband BPL modems were detected by the power line communication hardware channel emulator. Measurement of throughput, latency, frame loss passed off according to RCF 2544, RFC 6349 recommendation and according to the methodology of TCP Throughput In the last part, two laboratory exercises were created, first one deals with Smart Metering system and communication between the data concentrator and electric meters and the second one deals with communication among broadband BPL modems not only for Smart Metering purposes.