La compréhension des effets cérébraux sous-tendant l’impact de la stimulation magnétique transcrânienne répétée (rTMS) est un a priori nécessaire à la connaissance de la prise en charge thérapeutique des patients bénéficiant de ces traitements. A posteriori, elle permet en plus de comprendre les processus physiopathologiques responsables des symptômes cliniques propres aux troubles mentaux. Nous nous sommes ici intéressés aux effets de la rTMS sur le cerveau des patients souffrant de schizophrénie (SZ), au travers des deux principes fondamentaux du fonctionnement cérébral que sont la ségrégation et l’intégration fonctionnelle. En premier lieu, nous avons analysé l’effet de la rTMS visant le cortex préfrontal médian (CPM) sur le principe de ségrégation fonctionnelle chez des SZ avec trouble de la cognition sociale. Pour ce faire nous avons développé un paradigme d’imagerie par résonance magnétique fonctionnelle (IRMf) écologique et novateur de cognition sociale. Un prérequis aux études longitudinales en IRMf est la reproductibilité du signal d’activation. Nous avons alors démontré la fiabilité de notre paradigme entre deux sessions, puis à l’aide de ce paradigme, nous avons étudié l’effet de la rTMS sur la ségrégation à partir de la variation du signal BOLD et des taux de N-AcetylAspartate et de glutamate. Puis nous avons étudié l’impact de la rTMS ciblant le sillon temporal supérieur gauche (STSg) sur les hallucinations auditivo-verbales (AVH) en termes de connectivité fonctionnelle statique (intégration fonctionnelle). Nous avons ainsi mis en évidence l’effet bénéfique de la rTMS sur le trouble de cognition sociale et sur les AVH. En outre, quand la rTMS cible le STSg, il ne semble pas avoir d’effet sur la connectivité fonctionnelle statique du réseau cérébral du langage observé. Cependant, focalisé au niveau du CPM, elle permettrait d’augmenter la concentration de N-acétylaspartate des SZ. L’absence d’effet de la rTMS illustrerait plutôt des profils d’organisation cérébrale différents des SZ, et ce par des variabilités interindividuelles, suggérant qu’il serait à l’avenir bénéfique de déterminer les caractéristiques optimales de la stimulation sur une base individuelle afin de mieux moduler les processus anormaux du cerveau dans les schizophrénies. / The understanding of the brain effects underlying the impact of repeated transcranial magnetic stimulation (rTMS) is a necessary a priori necessary concerning patients treatments. A posteriori, it also helps to understand the pathophysiological processes responsible for the clinical symptoms of mental disorders. Hither, we are interested in the effects of rTMS on the brain of patients with schizophrenia (SZ), through the two fundamental principles of cerebral functioning: segregation and functional integration. First, we have analyzed the effect of rTMS on the medial prefrontal cortex (MPFC) according to functional segregation in SZ with social cognition disorder. To do this we have developed an ecological and innovative social cognition paradigm for functional magnetic resonance imaging (fMRI). A prerequisite for longitudinal studies in fMRI is the reproducibility of the activation signal, we have then demonstrated the reliability of our paradigm between two sessions. Using this paradigm, we have studied the effect of rTMS on segregation from the variation of the BOLD signal and the levels of N-Acetyl Aspartate and glutamate. Then, we studied the impact of rTMS targeting the left temporal sulcus (STS) on auditory-verbal hallucinations (AVH) in terms of functional connectivity (functional integration). We have thus demonstrated the beneficial effect of rTMS on social cognition disorder and on AVH. Moreover, when the rTMS targets the STS, it does not seem to have an effect on the static functional connectivity within the listening language network. However, focused on the MPFC, it would increase the N-acetylaspartate concentration of SZ. The absence of the effect of the rTMS would rather illustrate different brain organization patterns of the SZ, due to inter-individual variability, suggesting that it would be in the future beneficial to determine optimal characteristics of stimulation on an individual basis in order to best modulate abnormal processes of the brain in schizophrenias.

The evolutionary success of our species is bound to our sociality—the tendency to engage in and benefit from social interactions. On a conceptual level, this sociality has been parsed into two facets, namely the proclivity to like and seek social interactions (social motivation) as well as the cognitive abilities needed to coordinate with others socially (social cognition). While numerous studies have assessed social motivation and social cognition in young children, our current understanding of both facets is still far from conclusive. First, the exact ontogeny of social motivation and cognition remains largely unclear. Second, the degree to which either facet of sociality is shaped by cultural input remains poorly understood. Finally, interindividual variation in social motivation and cognition has yet to be examined, without which we can neither understand the construct validity of either facet, nor their potential interplay. In this dissertation, I present three studies addressing these issues by focusing on developmental, cross-cultural, and interindividual variation in three phenomena previously linked to sociality: Overimitation and collaboration as indicators of social motivation, as well as Theory of Mind as a proxy for social cognition. In the first study I assessed whether children’s overimitation would be shaped by age, culture, and the social presence of an adult model. I found that children across three diverse populations showed more overimitation with age and selectively in the presence of the model. I also documented cross-cultural variation in children’s overimitation. On an individual level, children’s overimitation did not predict their tendency to reengage a co-player in a collaborative activity. In study 2, I found children’s overimitation to vary systematically between two populations utilizing a procedure with reduced cognitive task demands. Here, age did not predict children’s overimitation and variation across populations was only observed in how much, but not whether, children would overimitate. In study 3, I documented systematic variation in children’s social motivation for collaboration as well as their Theory of Mind across three populations and across the age range tested. On an individual level, indicators of social motivation were ontogenetically linked and predicted children’s Theory of Mind. In the general discussion, I propose an integrative model of social motivation and cognition to embed and expand the current findings. Accordingly, the interplay of socialization goals and practices, social motivation, and social cognition builds the foundation for children’s social learning within social interactions.

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第12979号 / 論医博第2105号 / 新制||医||1012(附属図書館) / 32449 / (主査)教授 髙橋 良輔, 教授 佐藤 俊哉, 教授 渡邉 大 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

No description available.

No description available.

Theory of Mind (ToM) is the ability to infer mental states of others and this skill relies on a distributed network of brain regions. A brain region that has been traditionally disregarded in relation to non-motor functions is the cerebellum. Here, we leveraged large-scale multimodal neuroimaging data to elucidate the structural and functional role of the cerebellum in ToM. We used functional activations to determine whether the cerebellum has a domain-general or domain-specific functional role. We found that the cerebellum is organized in a domain-specific way. We used effective connectivity and probabilistic tractography to map the cerebello-cerebral ToM network. We found a left cerebellar effective and structural lateralization, with more and stronger effective connections from the left cerebellar hemisphere to the contralateral cerebral ToM areas and greater cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) streamline counts from and to the left cerebellum. Lastly, we examined the relationship between CTC and CPC white matter and ToM speed and accuracy but found no correlation. Our study provides novel insights to the network organization of the cerebellum, an overlooked brain structure, and ToM, one of humans’ most essential abilities to navigate the social world. / Psychology

Individuals with Traumatic Brain Injury (TBI) exhibit impaired performance on social cognition and theory of mind (ToM) measures, like the Video Social Inference Test (VSIT). The frontal lobe, being the primary region involved in higher level cognitive functions mediates the neural mechanisms involved in social cognition and ToM abilities, according to studies on brain and behaviour. The goal of this study was to examine if individuals with TBI who did not damage their frontal lobe would perform differently on the VSIT than individuals with TBI who did. This study was a secondary analysis of documented imaging data and VSIT scores obtained from 51 adults with moderate-to-severe TBI (23 females). A comparison was made between scores obtained on the VSIT between participants with and without frontal lobe lesions. The results indicated that there was no significant difference between the two groups, in other words, site of lesion in participants with TBI did not predict performance on the VSIT. The results suggest that while the VSIT may yield critical information about social cognition, it is not sensitive to individual site of lesion. There is evidence that aspects of social cognition are impaired in this clinical population, however, most research in this area is obstructed by the complex nature of TBI neuropathology in addition to small heterogenous samples involved in studies. Further research in this area is required in order to reveal and enhance our understanding of social cognition deficits following TBI. Keywords: social cognition, traumatic brain injury, theory of mind, frontal lobe lesions, video social inference test / Thesis / Master of Science (MSc)

Although the 14th Amendment of the U.S. Constitution grants American citizenship to any person born or naturalized in this country, subjective perceptions of who belongs in the country are driven by default assumptions that the prototypical American is White. This belief that Whites are somehow more American than members of other ethnic groups lies in sharp contrast to the widespread endorsement of multiculturalism in everyday life. Two studies provide evidence that these race-based beliefs about the prototypical American can produce discriminatory behavior against ethnic minorities in domains where patriotism is relevant, but not in domains where patriotism is irrelevant. Study 1 demonstrated that the more participants believe that the prototypical American is White, the less willing they are to hire highly qualified Asian Americans in national security jobs where patriotism is essential. Additionally, this effect was partially mediated by doubts about Asian Americans’ loyalty to thee country. Study 2 replicated and extended these findings by demonstrating that the more participants believe that the prototypical American is White, the less willing they are to hire highly qualified Asian Americans in national security jobs, but not in private business jobs where patriotism is irrelevant. Together, these studies demonstrate how race-based beliefs about the prototypical American can lead to discriminatory behavior against ethnic minorities, particularly in domains where national loyalty is important.

Domesticated species possess certain cognitive abilities that allow them to thrive in an environment with regular human interaction, and these interactions contribute to the overall human-animal relationship. Studying the human-animal relationship allows us to better understand how domesticated animals perceive and navigate their environment, which can then be used to improve their welfare. In chickens, this relationship is poorly understood, and further research would provide insight into the welfare needs of this animal. Here we show breed differences in the interspecific sociocognitive abilities of Gallus gallus, where the domesticated White Leghorn interacted more with a familiar human than the red junglefowl, and both the domesticated White Leghorn and the red junglefowl breed that had been selected for low fear of humans were habituated to human presence. This study sheds light on the effect of domestication on social cognition in chickens and begins to describe the human-chicken relationship.

Thesis advisor: Katherine McAuliffe / Thesis advisor: Angela Johnston / Human cooperation is unparalleled in the natural world and is a defining feature of human social life—it shapes nearly every social interaction we experience, from geopolitical conflict, to collective bargaining, to team collaboration. However, cooperation also presents a challenge—it is often personally costly or risky to cooperate. How are humans able to overcome these costs and risks in favor of the interest of the group? To address this question, it is important to investigate the cognitive abilities that allow us to successfully cooperate with others. One important ability for cooperation is mentalizing—the ability to represent other agents’ beliefs, knowledge, desires, and intentions. The ability to think about other agents’ minds in order to predict how they will behave (e.g., whether they will cooperate or free-ride) is an important component of our own cooperative behavior, particularly in the context of coordination—a type of cooperative interaction where cooperation is mutually beneficial but risky. I test the idea that our ability to represent the beliefs of others plays a critical role in successful cooperation. Studies 1 and 2 examine one cognitive ability for representing others’ knowledge—common knowledge—that underlies cooperation by reducing uncertainty about others’ cooperative behavior. Studies 3 and 4 investigate how we make inferences about others’ beliefs from how they behave and how that influences our own cooperative behavior in the context of social norms. Studies 2 and 4 take a developmental approach to investigate how early emerging mentalizing is for cooperative behavior to better understand how foundational it is in social cognition. Altogether, the results of these studies suggest that the ability to represent other agents’ beliefs in order to predict their behavior plays a fundamental role in supporting successful cooperation. / Thesis (PhD) — Boston College, 2023. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Psychology.