HIV/Aids Relative Survival and Mean Residual Life Analysis BY XINJIAN ZHANG Under the Direction of Gengsheng (Jeff) Qin and Ruiguang (Rick) Song ABSTRACT Generalized linear models with Poisson error were applied to investigate HIV/AIDS relative survival. Relative excess risk for death within 3 years after HIV/AIDS diagnosis was significantly higher for non-Hispanic blacks, American Indians and Hispanics compared with Whites. Excess hazard for death was also higher in men injection drug users compared with men who have sex with men (MSM). The relative excess hazard of old HIV/AIDS patients is significantly higher compared with younger patients. When CD4 increased, the relative excess hazard decreased; while with the increase of HIV viral load, the relative excess hazard decreased. This is the first study to use national wide data to examine the significance of HIV viral load as a determinant risk factor of disease progression after HIV infection; The mean residual lie needs to be further analyzed. INDEX WORDS: Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS), Survival, Mean residual life (MRL).

This thesis explores the association between a response variable and various regressors in dairy cattle breeding data using the various survival models in general and the partially linear single index survival model (PLSISM) in particular. In this study calf survival data and culling data were used. The calf survival data contains the following information: survival time, birth weight, weaning weight, calving ease score, average daily gain, number of disease incidences and serum total protein content. The culling data include, survival time, herd size variation, production level (milk, fat and protein), type of supervision, body condition score and age at first calving. Both data sets contain herd, year and season of calving and were analyzed using the various survival models. The Weibull model, however, was used for detailed analyses of the data sets. The nonparametric vector of PLSISM includes body weight, total serum protein and average daily gain for calf survival data and age at first calving, fat production and body condition core for culling data. The parametric vector of PLSISM consists of the rest of the covariates. The results show that the estimates of the parametric component are similar in the two models (Weibull and PLSISM). However, the estimates of the nonparametric component differ from parametric analysis. This difference may be attributed largely to the nonlinearity of the estimated function indicating the standard linear survival model does not adequately describe the underlying association between the response variable and the various covariates in this study. This is the first implementation and application of this complex model, PLSISM, with large real censored data.

This work explored features of canine mast cell tumours (MCT) to improve prognosis and to discover potential therapeutic targets. Subcutaneous MCT - a subset of these tumours arising in the subcutis - are usually grouped with cutaneous MCT, but there is evidence that they may be clinically different. The first objective was to develop a grading scheme for subcutaneous MCT. Over 300 canine subcutaneous MCT were evaluated retrospectively and parameters were correlated with clinical outcomes, making this the largest retrospective survival study of these tumours to date. The results of the study showed that the majority of subcutaneous MCT had excellent outcomes and key prognostic markers were identified (mitotic index, surgical margins and degree of infiltration). A subset of the subcutaneous MCT from the retrospective study was further evaluated to assess the cellular localization of KIT - a receptor tyrosine kinase (RTK) which is dysregulated and constitutively activated in some cutaneous MCT - as well as Ki67, a proliferation marker. In addition, evaluation of mutations of c-KIT, the gene for KIT, was determined for each MCT. Cytoplasmic KIT localization and high Ki67 values were predictive of decreased survival time and time to local reoccurrence, but no c-KIT mutations were detected. The majority of canine MCT do not appear to depend solely upon KIT for tumour progression and few other RTK targets have been studied in canine MCT. Based on evidence that vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR) - may play a role in the progression of canine MCT; the expression and distribution of these RTK were evaluated. The results showed that canine MCT have unique expression profiles and activity of KIT, VEGFR2 and PDGFR. Two novel mast cell tumour cell lines were generated and used to assess signalling of KIT and VEGFR2 in vitro. Stimulatory and inhibitory responses were assessed and found to be different in both cell lines. Both had autophosphorylated VEGFR2 and an autocrine VEGF/VEGFR2 signalling pathway existed for both cell lines. These findings are unique and the first that identify autocrine VEGF signalling as a possible survival mechanism for canine MCT. / Pet Trust Foundation, Ontario Veterinary College

The literature review on immigrant’s self-employment activities has limited the debate around the leading factors to this type of activity. Much research on the subject has tried to answer the question ‘what are the determinant characteristics to become self-employed?’ In addressing that question researchers have focused on the relative value of the block mobility thesis and the ethnic enclave theory. This focus created a research gap; researchers have ignored how self-employment may be used by immigrants as an alternative or complementary strategy for accessing a new labour market. Using the Longitudinal Immigration Database, this research explores, using survival regression analysis, the extent to which immigrants adopt different labour market strategies following their admission to Canada. More specifically, it examines their rate of access to labour market activities, the length of time they stay in specific type of labour market activities and the determinant factors for such events. The findings of this research demonstrate that 27 per cent of the economic immigrants, who were admitted to Canada between 1990 and 2008, are likely to rely on paid and self-employment activities simultaneously over time. This finding reinforces the need to analyse self-employment activity as a concurrent activity to paid employment. The regression analysis results on the concurrent activities imply that immigrants admitted under the self-employed category are more inclined, than the other economic immigrants, to rely on the two types of activities when integrating into the Canadian labour market. The findings of this thesis indicated that the traditional theories on self-employment activities are inadequate to explain concurrent self-employment activities and paid employment activities. There is a need to develop contemporary theories around this new concept of concurrent labour market activities that would take into consideration self-employment and employment theories as well as immigrants’ adaptive integration capacity.

Microorganisms have developed ways to preserve cellular functions under low temperature conditions using a variety of biochemical adaptations including the modification of ice formation. In order to conduct a limited survey of microbial ice-associating strategies, a bacterial community associated with frost-exposed leaves was assessed by the construction of a 16S rDNA library, followed by the characterization of some isolates. Fifteen different species were identified based on their 16S rDNA. Among these, Pseudomonas syringae J6 had ice nucleation activity (INA), which promoted ice formation close to 0ºC, whereas Erwinia billingiae, Flavobacterium sp. and Sphingobacterium kitahiroshimense inhibited the recrystallization of small ice crystals at temperatures close to melting. The Erwinia billingiae isolate showed adhesive and swarming behaviour, which can be associated with biofilm formation. Visualization using negative staining, transmission electron microscopy and scanning electron microscopy confirmed the presence of flagella in addition to the presence of slimy biofilm architecture in these Erwina billingiae cultures. Subsequent purification of the extracellular polymeric substance followed by mass spectrometry allowed the identification of a putative outer membrane protein A, which may be involved in the protection of this bacterium to freeze-thaw cycles. To further explore bacterial ice nucleation activity, an ice nucleation protein was cloned from Pseudomonas borealis, a bacterium originating from tundra soil, using degenerative PCR and chromosome walking. The sequence of the putative ice nucleation protein gene (inaPb) was cloned and expressed in Escherichia coli, and its identification was confirmed in the recombinant cells. Although the INPPb was more divergent than other plant-related bacterial INPs, it retained the highly conserved, repetitive core region. The protein may fold so that it has two flat faces, one for protein-protein interactions and the other for ice binding. Expression of the INPPb coding region fused to jelly fish green fluorescent protein showed a temperature-dependent polarized distribution of the recombinant protein in E. coli. In summary, results from this thesis suggests that low temperature survival may be associated with a number of ice-associating adaptations including the presence of biofilm formation in Erwina billingiae amongst other bacteria, INA in P. borealis and INA-expressing recombinant E. coli. / Thesis (Ph.D, Biology) -- Queen's University, 2010-01-27 11:47:02.385

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No description available.

Service screening with mammography was implemented in Northern Sweden between 1989 and 1998, covering 190,000 women aged 40-74 years constituting the target population in the area. The aim of this thesis was the evaluation of mammography screening in Northern Sweden with special focus on selected screening performance indicators and on the disease outcome. We analysed interval cancer (IC) incidence and episode sensitivity in the Norrbotten Mammography Screening Programme (NMSP) for the period 1989-2002. An overall IC rate at 1.1/1000 and IC rate ratio at 38% was found and epsiode sensitivity was estimated at 62-73%, in concert with reference values of the European guidelines. Radiological classification of the IC cases in three rounds of the NMSP showed that true, occult, missed and minimal signs IC, were present in 48%, 10%, 14% and 28% of the cases. We analysed early death from breast cancer (n=342) in Northern Sweden during the first five years of mammography service screening. Most fatal cases were advanced and incurable on diagnosis. In a few screen-detected cases with favourable prognostic factors the fatal outcome was unexpected. We estimated breast cancer survival by detection mode in 5120 women with breast cancer. We found a significantly favourable survival among IC cases compared to cases among uninvited. We studied breast cancer mortality in relation to mammography screening. Our findings indicated a long-term reduction of breast cancer mortality by 26-30% among women invited to screening and by 31-35% among women screened compared to not screened. We conclude from our evaluation of the mammography screening in Northern Sweden that women benefited from this public health intervention in form of improved survival and reduced mortality.

The first year of life is one of the main survival bottlenecks for many fish species. Individual traits affecting survival can be morphological, physiological or behavioural. Body size, growth rate and activity have all been found to affect fitness in different organisms. However, the effects of these traits on fitness in natural conditions and for underyearlings are poorly investigated. In this study we attempted to induce compensatory growth in laboratory conditions in natural populations of brown trout fry (Salmo trutta). It was performed by exposing the fry to a period of restricted resources followed by a period of refeeding. Two behavioural trials were conducted on each individual where activity level was scored. All fish were subsequently released in their native stream and recaptured after a month to check for survival. We found that high individual activity level in an open field context increased the probability of survival under natural conditions. The importance of body size for survival decreased over time, and thus, with fish size. Full compensation was detected in body condition, while only partly compensation in weight and no compensation in length were detected during the experimental periods. Our results suggest that a brown trout fry’s individual activity level is repeatable and can be an important trait for selection in nature. The instable interactions between activity and life-history traits indicate environmental effects on these interactions. Furthermore, if body size is not the only trait affecting survival, compensation in body structures may not be a fast response to increase fitness after a period of growth depression.

Šiame magistro darbe yra pateikiamas įmonės išgyvenamumą prognozuojantis Kokso proporcingųjų rizikų modelis. Pirmoje dalyje yra pateikiama trumpa modelių, susijusių su įmonių bankrotais ar nemokumu, apžvalga. Taip pat yra pristatomi balansinių ataskaitų ir įmonių finansų teoriniai pagrindai, įvairūs finansiniai rodikliai (įmonės pelnas/nuostolis, įsipareigojimai, turtas ir kt.) bei santykiniai finansiniai rodikliai (įmonės bendras skolos rodiklis, grynojo pelningumo koeficientas ir kt.). Be to, pateikiami išgyvenamumo analizės ir Kokso proporcingųjų rizikų modelio teoriniai pagrindai. Antroje darbo dalyje pateikiami empiriniai skaičiavimai. Čia parenkami statistiškai reikšmingi finansiniai ir santykiniai finansiniai rodikliai, įtakojantys įmonės gyvavimo trukmę, sudaromas bei tiriamas Kokso regresijos modelis, kuris vertina įmonės tikimybę išgyventi po tam tikro laiko. Ekonometrinė analizė atliekama naudojant SPSS, MS Excel ir SAS programinę įrangą. / This Master thesis develops survival of company prediction Cox proportional hazards model using the statistical methodology of Survival analysis. In the first part the short review of literature about models related with company’s bankruptcy, failure or financial distress is presented. Also the background of financial statement analysis, corporate finance, various financial variables (company’s profit/loss, liabilities, asset and other) and financial ratios (debt ratio, total asset turnover and other) are clarified. Furthermore, the theoretical background of Survival analysis and Cox proportional hazards model are presented. In the following part empirical computations are introduced. There are selected financial variables and financial ratios, which influence company’s survival and are statistically significant. Moreover, Cox regression model for estimating the probability of company’s survival after particular time is presented. Econometric analysis is performed using SPSS, MS Excel and SAS software.