Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / Este estudo experimental verificou a eficÃcia do uso de um lacre plÃstico no fechamento do coto distal do cÃlon sigmÃide comparando com sutura manual em plano Ãnico, contÃnuo e extramucoso utilizando fio de polipropileno. Foram utilizados 30 animais (Canis familiaris) fÃmeas, pesando entre 8,0 e 18,0 kg, clinicamente sadios, oriundos do canil da Prefeitura Municipal de Teresina, PiauÃ. Foram distribuÃdos em dois grupos de 15 animais; submetidos a laparotomia com secÃÃo do cÃlon sigmÃide, com fechamento do coto distal com sutura cotÃnua e extramucosa com fio de polipropileno ( Grupo I â Controle) e fechamento do coto distal com lacre plÃstico ( Grupo II- Estudo ). Todos os animais de ambos os grupos foram submetidos à anastomose colo-retal, tÃrmino lateral e avaliados no trans e pÃs-operatÃrio imediato por mÃdico veterinÃrio, sendo a alimentaÃÃo à base de raÃÃo padrÃo e Ãgua, ad libitum, instituÃda quando se observou evacuaÃÃo. Todos os animais foram submetidos à eutanÃsia no 21 DPO apÃs anestesia venosa com Cloridrato de Cetamina e aplicaÃÃo de cloreto de potÃssio 20% via endovenosa ; realizou-se nova laparotomia e avaliaÃÃo da anastomose colo-retal, correspondendo o cÃto distal do sigmÃide ,este segmento foi submetido a teste de rompimento de sutura. Estatisticamente foi realizado teste estatÃstico de VariÃncia aplicando-se o Teste SNK e confirmado com teste Qui-quadrado. Durante realizaÃÃo do teste de tensÃo, ocorreu rompimento do fechamento do coto cÃlico distal em quatro animais de cada grupo, nÃo havendo diferenÃa significativa entre os grupos (p>0.05). O tempo operatÃrio mÃdio foi 27,7 min. E 24,7 min., nos Grupos I e II respectivamente, nÃo havendo diferenÃa estatisticamente significante entre os dois grupos (p=0,09). A pressÃo mÃdia de ruptura foi 145,0mmHg e 195,0mmHg nos Grupos I e II respectivamente, nÃo havendo diferenÃa estatisticamente significante entre eles (p=0,057). O fechamento do cÃlon distal com lacre apresentou a mesma seguranÃa e eficÃcia do fechamento com fio polipropileno 3-0. / The objective of this experimental study was to compare the efficacy of two techniques of distal sigmoid stump closure: plastic zip-tie versus manual, running extramucosal single-layer suture with polypropylene thread. The study included 30 clinically healthy female dogs (Canis familiaris) weighing 8−18 kg supplied by the local municipal dog pound (Teresina, PiauÃ). The animals were distributed in two groups of 15 animals each and submitted to laparotomy, colon resection and closure of the distal sigmoid stump with either running extramucosal suture using 3-0 propylene thread (Group I) or a plastic zip-tie (Group II). All animals were submitted to latero-terminal colorectal anastomosis and were evaluated transoperatively and immediately after surgery by a veterinarian. Standard chow and water was provided ad libitum once evacuation had been observed. On the 21st postoperative day the animals were anesthetized with Cloridrate Cetamina i.v. and euthanized with 20% potassium chloride i.v. A second laparotomy was performed to evaluate the colorectal anastomosis and submit the sigmoid stump to a wound disruption test. Findings were submitted to variance analysis, followed by the Student-Newman-Keuls test and the Chi-square test for confirmation. Wound disruption occurred in four animals from each group, with no statistically significant difference between the groups (p>0.05). The average time of surgery was 27.7 min (Group I) and 24.7 min (Group II), with no statistically significant difference between the groups (p=0.09). The average disruption pressure was 145.0 mmHg (Group I) and 195.0 mmHg (Group II), with no statistically significant difference between the groups (p=0.057). Closure of the sigmoid stump may be as safely performed with plastic zip-tie as with conventional continuous suture using 3-0 polypropylene thread.

With the aim of better understanding the history of ocean closure and suturing between India and Asia, we conducted a geologic investigation of a siliciclastic matrix tectonic melange within the western Yarlung suture zone of southern Tibet (Lopu Range region, similar to 50 km northwest of Saga). The siliciclastic matrix melange includes abundant blocks of ocean plate stratigraphy and sparse blocks of sandstone. Metapelite and metabasite blocks in the melange exhibit lower greenschist fades mineral assemblages, indicating that they were not deeply subducted. We obtained detrital zircon U-Pb geochronologic and sandstone petrographic data from sandstone blocks in the melange and sandstone beds from Tethyan Himalayan strata exposed to the south of the suture. The sandstones from both units are all similar in U-Pb detrital zircon age spectra and petrography to the nearby Tethyan Cretaceous-Paleocene Sangdanlin section, which records the earliest appearance (at similar to 59 Ma) of arc-affinity strata deposited conformably on Indian-affinity strata. Two Paleocene sandstones, one of which is a schistose block incorporated in the siliciclastic matrix melange, yielded indistinguishable maximum depositional ages of similar to 59 Ma. Mesozoic Asian-affinity sandstone blocks previously documented in the siliciclastic matrix melange 200-500 km along strike to the east are notably absent in the Lopu Range region. We documented a gradational transition in structural style from the block-in-matrix melange in the northeast to the south-vergent Tethyan thrust belt in the southwest. Blocks of Tethyan Himalayan strata increase in size and the volumetric proportion of matrix decreases from northeast to southwest. We conclude that no arc-affinity sandstone blocks were incorporated into the subduction complex until India-Asia collision at similar to 59 Ma when the Xigaze forearc basin became overfilled and Tethyan Himalayan strata entered the trench. As collision progressed, there was a gradual transition in structural style from block-in-matrix melange formation to imbricate-style thrust belt formation. (C) 2017 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved.

Patients with pes planovalgus deformity often have coexisting spring ligament pathology. A primary repair of the ligament may fail during weightbearing due to chronic degeneration of the ligamentous tissue. Augmentation with a suture tape has been suggested to strengthen the repair. Limited data exist regarding flatfoot reconstruction with augmented spring ligament repair using a suture tape. This is a review of 57 consecutive patients who had flatfoot reconstruction with concomitant spring ligament augmented repair between July 2014 and August 2017. Weightbearing radiographic parameters were obtained preoperatively and compared to radiographs at an average time of 62 ± 46.5 (range 20-220) weeks postoperative. Significant improvements were seen in the radiographic parameters evaluated. Five patients had subsequent operations including one deep infection, 2 hardware removals remote to the spring ligament augmentation, 1 ankle arthrodesis, and 1 triple arthrodesis. Concomitant spring ligament repair augmented with a suture tape was a safe procedure that contributed to radiographic correction in a consecutive series of 57 patients undergoing flatfoot deformity correction.

Indiana University-Purdue University Indianapolis (IUPUI) / Background: Suture expansion is a very important clinical approach to correct maxillary width deficiency, but it has a high potential for treatment relapse. Accelerating bone formation and mineralization in the midpalatal suture during suture expansion is beneficial in preventing relapse of the arch width and reducing the retention period. Pyk2 is tyrosine kinase which has been shown to mediate signaling pathways that are involved in the process of bone remodeling. Pyk2 knock-out (KO) mice have augmented bone formation and increased bone mass, suggesting that therapeutic strategies that inhibit Pyk2 may be useful to enhance bone remodeling and prevent suture relapse during suture expansion. Objectives: To determine if Pyk2-deficiency affects midpalatal suture bone mass and bone remodeling with or without suture expansion in mice. Methods: Thirty-six Pyk2-KO and thirty-six wild type (WT) 6 week-old male mice were randomly assigned into three groups: receiving no expansion force (0 g), 10 g or 20 g force of rapid maxillary expansion for 14 days. Half of the mice in each group were used for histology analysis; the other half was assigned for fluorescence analysis. Suture width, maxilla width and bone volume/tissue volume around suture bone edges were measured using micro-CT. Histological analyses of osteoclasts (tartrate resistant acid phosphatase, TRAP), osteoblasts (alkaline phosphatase, ALP) and chondrocytes (alcian blue) were performed. Results: The BV/TV ratio was significantly higher in Pyk2-KO control mice compared to WT control mice. Suture expansion in WT and Pyk2-KO mice led to an increase in bone marrow spaces around the suture edge and significantly reduced BV/TV. Expansion also led to a significant increase in suture width, suture fibrous area, osteoclast number, cartilage area and hypertrophic chondrocyte number. However, BV/TV in Pyk2-KO mice was significantly higher than in WT mice at both the 10 g and 20 g force levels. In addition, Pyk2-KO exhibited reduced suture width, maxilla width, fibrous area and osteoclast number per bone surface (OC.S/BS) compared to WT mice under expansion forces. Cartilage area and hypertrophic chondrocyte number were increased by force but were independent of mouse genotypes. Conclusion: Pyk2-KO mice have higher BV/TV and narrower suture width compared to WT mice, which may be due to decreased osteoclast activity. The higher BV/TV of the midpalatal sutures of Pyk2-KO mice following suture expansion may suggest the presence of a more stable suture that has a reduced potential for relapse. Therapeutic strategies to inhibit Pyk2 during RME may be beneficial in increasing bone mass and preventing relapse of the suture.

No description available.

Les ophiolites de Saga et de Sangsang affleurent à l'ouest de la portion centrale de la ceinture ophiolitique de la Zone de Suture du Yarlung Zangbo (ZSYZ) au Tibet. Ces massifs semblent appartenir à un segment de zone de suprasubduction océanique tel que postulé pour les autres ophiolites de la portion Est de la ZSYZ. La chimie des roches mantelliques de ces deux massifs est toutefois très contrastée l'une de l'autre (fertile vs. réfractaire) et aussi lorsque comparée aux autres ophiolites de la ZSYZ, suggérant des histoires pétrogénétiques distinctes. Les relations de terrain et la géochimie indiquent que les ophiolites de Saga et de Sangsang ont été formées dans une configuration complexe arc - bassin arrière-arc où au moins deux plans de subduction intra-océaniques ont été actifs. Ces résultats permettent de mieux comprendre la morphologie de la zone de convergence avant les épisodes de collision qui ont mené à la configuration actuelle de la zone de suture.

The structural lineament mapping of southern India along withgeological, geochronological datasets help in redefining the Precambrian crustal blocks.The newly proposed Kumta and Mercara suture zones welding Archean crustal blocks in western peninsular India offer critical insights into the crustal evolution of Gondwana. The Kumta suturemainly consists of schistose rocks including quartz-phengite, garnet-biotite, chlorite, fuchsite and marble, whereas the Mercara suture contains mylonitic quartzo-feldspathic gneiss, garnet-kyanite-sillimanite gneiss, calc-silicate granulite and metagabbro. Metamorphic pressure-temperature estimations (Kumta suture: 11-18 kbar at 790-550oC; Mercara suture: 13 kbar at 825oC) suggest that, the sediments have undergone subduction to greater depths. The K-Ar age of biotite, phengite and U-Pb dating of zircon yields consistent metamorphic age of 1100-1400 Ma. In situ zircon 176Lu/177Hf isotope analysis shows wide range of εHf (t) values indicating the protolith sediments were derived from Paleo-Neoarchean juvenile crust that mixed with recycled older crust. The Bondla ultramafic-gabbro complex, northwest of the Kumta suture contains basalt, dolerite, gabbro, serpentinite, chromitite, peridotite and chromian spinel chemistry suggests evolution in a supra-subduction zone arc tectonic setting.The Sirsi shelf towards east of the Kumta suture, contains weakly deformed sedimentary rocks (limestone, shale, banded iron formations, greywacke, sandstone and quartzite) unconformable on relatively high-grade ca. 2571 Ma gneisses of the Dharwar craton. The Karwar block to the west is composed of weakly metamorphosedca. 3200 Ma tonalite-trondhjemite-granodiorite (TTG) with enclaves of amphibolite. In situ zircon 176Lu/177Hf isotope analysis and whole-rock 143Nd/144Nd isotopic analysis of TTGs show positive εHf and εNd values indicating ca. 3200 Ma juvenile crust. The Coorg block consists of ca. 3200 Ma charnockite, mafic granulites, hornblende-biotite gneiss, garnet-hornblende gabbro and anorthosite.In situ zircon 176Lu/177Hf isotope analysis indicates source as mixture of juvenile crust and older recycled crustal materials. Synthesis of the above results with published data suggests that Kumta and Mercara suture zones incorporate Paleoarchean to Mesoproterozoic sedimentssubjected to high-pressure metamorphism in the late Mesoproterozoic. Metamorphic P-T estimations of mafic granulite and U-Pb zircon geochronology of pelitic gneisses from Betsimisaraka suture zone, Madagascar suggests the rocks were underwent metamorphism at c. 24 kbar and c. 780°C during Mesoproterozoic suturing of Antongil-Masora blocks with the Antananarivo block.From the integration of above results with the new geophysical results and published data Mesoproterozoic Kumta-Mercara suture is interpreted as eastern extension of the Mesoproterozoic Betsimisaraka suture of Madagascar into western India.

The elucidation of the geologic processes that led to the creation of the Tibetan Plateau, a large area of thick crust and high elevation, is a fundamental question in geology. This study provides new data and insight on the geologic history of central Tibet in the Jurassic and Cretaceous, prior to the Indo-Asian collision, as well as the Gondwanan history of the Lhasa and Qiangtang terranes of the plateau. This investigation is centered on the Bangong suture zone near the town of Amdo and I present new geochronology, thermochronology, thermobarometry and structural data of the Amdo basement, an exposure of high-grade gneisses and intrusive granitoids. Using a range of thermochronometers, I show there were two periods of cooling, one in the Middle-Late Jurassic after high-grade metamorphism and a second in the Early Cretaceous. I attribute Middle-Late Jurassic metamorphism, magmatism, and initial cooling of the Amdo basement to arc related tectonism that resulted in tectonic or sedimentary burial of the magmatic arc. I propose that a second period of cooling, nonmarine, clastic sedimment deposition and thrust faulting in the Early Cretaceous is related to the Lhasa-Qiangtang collision. The thermochronology reveals limited denudation between the Cretaceous and the present, indicating the existence of thickened crust when India collided with Asia in the early Tertiary. U-Pb geochronology of the orthogneisses and detrital zircon geochronology of metasedimentary rocks suggests that the Lhasa and Qiangtang terrane were located farther west along Gondwanan's northern margin than most reconstructions depict.

Craniosynostosis is a disorder characterized by the premature fusing of cranial sutures in an infant. Premature closure of these sutures can lead to detrimental consequences on the development of a child. The two broad categories of craniosynostosis are classified as syndromic and nonsyndromic. Nonsyndromic craniosynostosis involves only the fusion of one or more sutures, whereas syndromic craniosynostosis involves other abnormalities throughout the body of the affected individual. Two of the families analyzed in this study were of the syndromic nature, and known FGFR mutations were discovered. However, phenotypical features documented in association with these mutations differed from our individuals. Two families affected with nonsyndromic sagittal synostosis were also analyzed. Within one of these families, three candidate mutations were identified as possible disease causing mutations. These mutations were found in the genes ITGAV, SLC30A9, and BAMBI. Here we analyze the function of these proteins and determine the significance of the role they may play in nonsyndromic craniosynostosis.

As lesões traumáticas do membros que resultam em secções tendíneas são problemas comuns na clínica equina. Estas lesões podem ser tratadas de forma conservativa ou cirúrgica. Diversas complicações tem sido associadas às técnicas cirúrgicas, como ruptura do fio de sutura, ruptura do coto tendíneo suturado, infecções da ferida, entre outros. O objetivo do presente trabalho foi avaliar biomecanicamente a combinação entre os padrões de sutura locking loop duplo e locking loop simples com sutura de epitendão, com os fios de sutura polipropileno e poliglactina 910, ambos de número 2, visando estipular a melhor combinação entre as variáveis quando aplicadas ao tendão flexor digital profundo de equinos. Os corpos de prova foram submetidos a ensaios mecânicos de tração, onde determinaram-se valores de força mínima, força máxima e pico de força durante o afastamento de 3 milímetros entre os cotos suturados, além do afastamento observado entre os cotos durante o pico máximo de força. Quando avaliada a força máxima, observaram-se maiores valores (p0,05) nos grupos onde foi utilizado o padrão locking loop simples com sutura de epitendão, e também quando a sutura foi realizada com polipropileno. Para a força mínima, o padrão simples também se mostrou superior, não havendo diferença significativa quando variaram-se os fios de sutura. Quando avaliado o pico de força, as suturas duplas foram superiores, não havendo diferença estatística quando comparadas com a sutura simples realizada com polipropileno. Os padrões duplos permitiram maior afastamento que os padrões simples com sutura de epitendão. O padrão locking loop simples, com sutura de epitendão, atinge maiores valores de força enquanto o afastamento é de até 3 milímetros. Quando realizado com polipropileno, este padrão suporta maior carga do que quando realizado com poliglactina. / The traumatic lesions of the limbs that result in tendon sections are common problems in equine medicine. These lesions can be treated with clinical or surgical procedures. Several complications, as rupture of the suture material, rupture of the tendon extremity and wound infection have been associated with the technique. The objective of this study was evaluate biomechanically the locking loop suture and the locking loop with epitendon suture, when performed with polypropylene and polyglactin 910 suture material, number 2, looking for the best combination between the variables when applied to equine deep digital flexor tendon. The specimens was submitted to a strain test. Values of minimum strength, maximum strength and force peak were measured during 3 millimeters of separation between the tendon extremities, and the gap was observed between the tendon extremities during the maximum peak force. During maximum strength evaluation, the higher values (p0,05) were observed in groups which were used simple locking loop pattern associated with epitendon suture, and also when the suture was performed with polypropylene. For the minimum strength, the simple pattern was also better, showing no significant difference between the types of suture material. When the peak force was measured, the double sutures were better, and there was no statistic variation when compared with the suture performed with polypropilene in a simple pattern. The double patterns allowed higher separation than the simple patterns associated with epitendon suture. The simple locking loop pattern, with epitendon suture, reaches higher values of strength when there is 3 millimeters of separation. When performed with polypropylene, this pattern supports higher load than when performed with polyglactin.