Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-04-25T14:57:15Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) lais_matos_oliveira.pdf: 1897599 bytes, checksum: f8cca6f71386c22ad68bc755f7803402 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2017-05-16T19:49:29Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) lais_matos_oliveira.pdf: 1897599 bytes, checksum: f8cca6f71386c22ad68bc755f7803402 (MD5) / Made available in DSpace on 2017-05-16T19:49:29Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) lais_matos_oliveira.pdf: 1897599 bytes, checksum: f8cca6f71386c22ad68bc755f7803402 (MD5) Previous issue date: 2016 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Objetivou-se com este estudo avaliar as caracter?sticas fisiol?gicas de diferentes grupos gen?ticos mantidos no cerrado. Foram avaliados 48 bovinos de corte criados em sistema precoce para abate aos 24 meses, sendo seis machos e seis f?meas de cada grupo gen?tico (Nelore, ? Nelore x ?Caracu, ? Caracu x ? Nelore, ? Angus x ? Nelore x ?Caracu). Os par?metros fisiol?gicos taxa de suda??o (TS), frequ?ncia card?aca (FC), frequ?ncia respirat?ria (FR), temperatura retal (TR), temperatura da superf?cie corporal (TSC) foram obtidos entre 07:00 e 12:00h. Foram avaliados o comprimento, n?mero de pelos por unidade de ?rea, densidade de massa dos pelos e di?metro m?dio dos pelos. A colora??o do pelo e pele foram avaliadas por meio da Tabela Padr?o e do color?metro MniScan XE Plus. O delineamento experimental foi o inteiramente casualizado em esquema fatorial com seis repeti??es. Foi utilizado o procedimento GLM do SAS, adotando-se para compara??o de m?dias o teste t com n?vel de signific?ncia de 5%. O NEL apresentou maior FR seguido pelo ?NCAR. A FC foi maior no ver?o. A TS foi maior no ver?o em rela??o ao outono. A TR foi maior no ?NCAR, seguido pelo ?CAR, sendo a menor TR observada no NEL e TRI. Houve correla??o positiva entre a temperatura do olho e a temperatura retal. Os pelos do dorso e garupa foram mais compridos no outono, e, em rela??o ao sexo, maiores nas f?meas. O comprimento dos pelos na garupa foi maior no TRI, seguido pelo ?CAR, NEL e ?NCAR. O di?metro dos pelo do dorso foi maior para o ?NCAR, seguido pelo ?CAR, TRI e NEL. O n?mero de pelos na garupa foi maior n?mero no ver?o. Os pelos do dorso foram mais inclinados no ?NCAR, seguidos pelo ?CAR, NEL e TRI. No ver?o, os pelos do dorso permaneceram mais inclinados, e, em rela??o ao sexo, os machos tiveram maior inclina??o no dorso e garupa. A densidade dos pelos no dorso e garupa foi maior no outono. Os pelos da garupa foram mais densos no ?NCAR, seguidos do ?CAR, TRI e NEL. A EC no dorso foi maior no TRI, seguida pelo NEL, ?CAR e ?NCAR. Entre os sexos a EC foi maior nas f?meas. A EC na garupa foi maior no TRI, seguida pelo ?CAR, NEL e ?NCAR. Os pelos tanto do dorso quanto da garupa foram mais claros no NEL. Os pelos mais escuros no dorso foram observados no TRI e na garupa no ?CAR. O grupo gen?tico que demonstrou maior adapta??o ? cria??o no Cerrado foi o NEL seguido do ?NCAR. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Zootecnia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2016. / The objective with this study was to evaluate the physiological characteristics of different genetic groups maintained in the savannah. Thirty-eight beef cattle raised in a system to be slaughter at 24 months of age were evaluated, with six males and six females of each genetic group (Nellore; ? Nellore x ? Caracu; ? Caracu x ? Nellore; and ? Angus x ? Nellore x ? Caracu). Sweating rate (SR), heart rate (HR), respiratory rate (RR), rectal temperature (RT) and body surface temperature (BST) were obtained between 07:00 and 12:00. Length, number of furs per unit area, mass density of the fur, and the average furs diameter were assessed. Fur and skin coloring were evaluated using the Standard Table and the MniScan XE Plus colorimeter. The experimental design was the completely randomized in a factorial scheme with six replicates. The GLM procedure of SAS was used, adopting the t test for mean comparison with significance level of 5%. The NEL presented higher RR followed by ? NCAR. The HR was higher in the summer. The SR was greater in the summer compared with the autumn. The RT was higher in the ?NCAR, followed by ?CAR, with the lower RT observed in NEL and TRI. There was a positive correlation between eye temperature and rectal temperature. The furs of the dorsum and rump were longer in the autumn, and, in relation to sex, larger in females. The fur length on the rump was longer in TRI, followed by ?CAR, NEL and ?NCAR. The fur diameter on the dorsum was larger for ?NCAR, followed by ?CAR, TRI and NEL. The number of furs on the rump was higher in the summer. The furs on the dorsum were more inclined in ?NCAR, followed by ?CAR, NEL, and TRI. In the summer, the furs on the dorsum remained more leaned, and, in relation to sex, the males have a higher inclination on the dorsum and rump. Fur density on the dorsum and rump was higher in autumn. The furs of the rump were denser in ?NCAR, followed by ?CAR, TRI, and NEL. The EC on the dorsum was higher in TRI, followed by NEL, ? CAR, and ?NCAR. Among the sexes, the EC was higher in females. The EC on the rump was higher in TRI, followed by ? CAR, NEL and ?NCAR. The furs on both dorsum and rump were clearer in the NEL. The darker furs on the dorsum were observed on TRI and on the rump on ? CAR. The genetic group that demonstrated the greatest adaptation to the raising in the savannah was NEL followed by ?NCAR.

Introdução: A hiperidrose primária consiste em uma sudorese excessiva em regiões limitadas do corpo. A simpatectomia torácica videotoracoscópica é um dos tratamentos propostos para a hiperidrose primária palmar, aliando alto sucesso terapêutico com baixo risco. A fisiopatologia da hiperidrose primária ainda não está totalmente esclarecida. Objetivos: Analisar as características morfométricas dos gânglios simpáticos torácicos (G3), removidos cirurgicamente de pacientes portadores de hiperidrose palmar. Como controle foram utilizados os gânglios simpáticos, removidos no mesmo nível (G3), de pacientes doadores de órgãos por morte encefálica, sabidamente sem hiperidrose. Foram estudadas a estereologia e a apoptose celular e as fibras do sistema colágeno /elastina da matriz extracelular. Métodos: Estudo transversal, no qual foram incluídos 40 gânglios simpáticos torácicos (G3) removidos do hemitórax esquerdo, provenientes de pacientes com hiperidrose palmar (Grupo I), submetidos à simpatectomia videotoracoscópica, e 14 gânglios simpáticos de pacientes controle sabidamente sem hiperidrose (Grupo II), removidos por esternotomia mediana. Resultados: Em relação ao sexo, a proporção de mulheres e homens foi de 30:10, no Grupo I, e 7:7 no Grupo II, com p = 0,103. A idade no Grupo I, variou de 10 a 42 anos, com uma média de 23,73 (+ 7,51) e no Grupo II variou de 17 a 68 anos, com uma média de 37,57 (+ 16,65) , apresentando um p = 0,009. A média das células ganglionares nos pacientes do Grupo I foi de 14,25 (+ 3,81) e no Grupo II foi de 10,65 (+ 4,93) com p = 0,007. A média das células ganglionares coradas pela caspase (apoptose) no Grupo I foi de 2,37 (+ 0,79) e no Grupo II foi de 0,77 (+ 0,28) com p < 0,001. A mediana da área de colágeno corada pelo Picrosírius no Grupo I foi de 0,80 IQ (0,08-1,87) e no Grupo II foi de 2,36 IQ (0,49-5,98) com p = 0,061. Conclusões: Os pacientes portadores de hiperidrose primária palmar apresentam um maior número de células ganglionares no gânglio simpático, em relação aos do grupo controle. Há um número maior de células ganglionares simpáticas em apoptose na hiperidrose. Os pacientes portadores de hiperidrose apresentam menos colágeno no gânglio simpático / Introduction: Primary hyperhidrosis consists of excessive sweating in small areas of the body. The video-assisted thoracic sympathectomy is one of the suggested treatments for primary palmar hyperhidrosis, which combines high therapeutic success with low risk. The pathophysiology of primary hyperhidrosis is not fully understood yet. Objectives: Analyzing the morphometric characteristics of the thoracic sympathetic ganglion (G3) surgically removed from patients with palmar hyperhidrosis. The sympathetic ganglion removed at the same level (G3) from patients who are organ donors after brain death and who did not have hyperhidrosis were used as control. Stereology and cellular apoptosis, as well as the fibers of the collagen/elastin system of the extracellular matrix were subjected to scrutiny. Methods: Cross-sectional study, which included 40 thoracic sympathetic ganglion (G3) removed from the left hemithorax of patients who have palmar hyperhidrosis (Group I) and underwent video-assisted thoracoscopic sympathectomy, and also 14 sympathetic ganglion from control patients who did not have hyperhidrosis (Group II), which were removed with median sternotomy. Results: In regards to gender , the proportion of women to men was 30:10 in Group I and 7:7 in Group II, with p = 0.103. The age Group I ranged from 10 to 42 years, with an average of 23.73 (+ 7.51) years and in Group II, from to 17 to 68 years, with an average of 37.57 (+ 16.65) years, with p = 0.009. The average of ganglion cells in Group I was 14.25 (+ 3.81) and in Group II, 10.65 (+ 4.93) with p = 0.007. The average ganglion cells stained by Caspase (apoptosis) in Group I was 2.37 (+0.79) and in Group II, 0.77 (+ 0.28) with p = 0.001. The median collagen area by Picrosirius in Group I was 0.80 IQ (0.08-1.87) and in Group II, 2.36 IQ (0.49-5.98) with p = 0.061. Conclusions: Patients with primary palmar hyperhidrosis have an increased number of ganglion cells in the sympathetic ganglion in comparison to the control group. There are a higher number of sympathetic ganglion cells in apoptosis in hyperhidrosis. Patients with hyperhidrosis have less collagen in sympathetic ganglion

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

Si la sueur fraîchement émise par le corps humain est inodore, la dégradation de celle-ci par la flore bactérienne cutanée produit des composés volatils malodorants, responsables des odeurs de transpiration. Les odeurs de transpiration apparaissent également sur les vêtements au cours de leur utilisation, particulièrement sur les textiles réalisés en fibres synthétiques. Ce travail a pour but d’améliorer la compréhension du phénomène d’émanation d’odeurs en étudiant l’effet du sujet testé, l’effet de la flore bactérienne et l’effet du textile sur les émissions de composés volatils malodorants.L’intérêt de ce travail réside dans l’approche globale de la problématique des odeurs de transpiration et dans la diversité des méthodes de mesure mises en place, tant dans l’étude de la flore microbiologique que dans les méthodes de mesures des composés odorants émis.Dans un premier temps, le dénombrement simultané de la flore bactérienne sur la peau et sur le vêtement a été réalisé sur un échantillon de 15 sujets à l’issue d’un exercice physique. Cette expérimentation a permis d’évaluer le taux de transfert bactérien moyen lors d’une activité sportive et d’étudier son rôle dans l’émission d’odeurs. Ensuite, afin d’affiner ces résultats, une méthode basée sur la biologie moléculaire a été mise en place pour réaliser le suivi qualitatif de la stabilité de la flore commensale axillaire d’un sujet pendant 3 mois. Le transfert bactérien spécifique entre la peau du testeur et le vêtement a été étudié pour 4 matières textiles sélectionnées (dont le coton et le PET). Ceci a permis de déterminer le rôle du transfert bactérien spécifique dans l’émission des odeurs à partir de textile.Enfin, le dernier chapitre est consacré à l’étude de l’émission de composés volatils et odorants à l’aide de mesures olfactives et d’un nez électronique au cours du temps par 8 composants textiles sélectionnés. Après traitement statistique par analyse en composante principale et étude détaillée des mesures, 9 composés chimiques ont été identifiés comme indicateurs d’un comportement textile malodorant. Ces derniers pourraient être utilisés dans la mise en place d’une méthode ciblée de mesure physico-chimique des mauvaises odeurs.Ce travail a permis de déterminer l’impact de chacun des facteurs sujet, flore bactérienne et textile dans l’émission d’odeurs. En outre, ce travail ouvre des perspectives sur l’étude des contaminations bactériennes par contact, mais également dans l’étude des odeurs, sur les phénomènes de désorption de molécules volatiles à partir de différentes matrices textiles et sur les solutions pouvant être envisagées pour limiter les émissions odorantes à partir de textiles. / Fresh human sweat is odorless. Odoriferous volatile compounds are produced by the metabolism of bacteria living on the skin, generating strong malodor. Sweaty body odors do also appear on clothes during use, and especially on synthetic fabrics. The aim of this document is to improve understanding of odor emission by investigating subject effect, microbiota effect and fabric effect on the emission of odoriferous volatile compounds.Odors of perspiration are hereby globally approached with a wide use of methods and experimental devices, for microbial flora study as well as for odoriferous volatile compounds emission study.First, microflora enumeration has been simultaneously processed on the skin and on the fabric after exercise for 15 subjects. This experiment allowed an evaluation of the average bacterial transfer yield during physical activity and the beginning of the investigation of its effect on odor emission.A molecular biology methodology has then been developed in order to refine these results. Monitoring of qualitative composition of the microbiota has been performed to study the stability of the armpit’s ecosystem on a subject during 3 months. Specific microbial transfer from subject’s skin to clothe has been performed for 4 textile fabrics (including cotton and PET). This leaded to characterize the effect of specific bacterial transfer on odor emission from fabric.The last chapter is dedicated to the study of the emission of odoriferous volatile compounds over time using olfactory measurements and electronic nose for 8 selected fabrics. Principal component analysis targeted 9 chemical compounds that have been selected as malodorous behavior indicators for a given fabric. Those 9 compounds could be used for setting up a fitted physicochemical method of malodor.To conclude, this study helped to understand the effect of 3 factors in odor perception from a fabric after sport : subject, microbial flora and fabric. Perspectives have been charted on contact microbial contamination, but also on odor, and especially on desorption of odoriferous volatile molecules from a textile or knitted matrix. The solutions that could be used to limit malodorous emission from fabrics have also been discussed.