Combination inhaled corticosteroids (ICs) are the primary treatment prescribed for patients with asthma; however, voice problems are also associated with ICs. In this study, 32 rabbits were assigned randomly to one of five experimental groups: baseline, induction, induction control, reversibility, and reversibility control. The baseline group received no treatment and larynges were obtained following quarantine. Rabbits belonging to experimental groups received IC treatment twice a day until trained raters noted visible vocal fold changes during endoscopy, which was performed every 2 weeks. When changes were observed, animals were euthanized, and the larynges were harvested from the experimental induction group and the corresponding control group. The remaining rabbits entered a withdrawal phase wherein ICs were discontinued, and endoscopy was performed every 2 weeks until visual-perceptual ratings indicated a return to baseline. Subsequently, all excised larynges underwent benchtop phonation trials to acquire aerodynamic data relating to vocal fold functioning at phonation onset. Analysis included 17 rabbits from the previous phase of the study and showed an increase in phonation threshold pressure (PTP) and phonation threshold flow (PTF) following IC use compared to the control groups. Rabbits in the experimental withdrawal group showed lower PTP and PTF compared to the induction group, but still greater values than the control groups. These results indicate IC-related adverse vocal effects may decrease after treatment is withdrawn but might not reverse completely. These findings indicate a trend toward recovery when ICs are withdrawn but lay critical groundwork for future studies involving asthma management and IC-driven voice disorders.

While the idea of critical break rate of water distribution pipeline (defined as the break rate after which it is no longer economical to continuously repair) has been accepted in the literature and among the practicing engineers, the formula to obtain the critical break rate has remained elusive. In this dissertation, an equation for identifying the threshold break rate of a pipe is developed. The threshold break rate equation gives a rule of thumb for pipe replacement decision. Input parameters to obtain the threshold break rate of a pipe are repair and replacement costs, interest rate, and the length of the pipe. In addition, a methodology that enables the use of threshold break rate with the failure intensity and hazard functions is developed. The methodology is drawn by considering the relationships of the definitions of the threshold break rate with intensity and hazard functions in the context of a repairable system's failure process modeling. As a result, the newly developed threshold break rate equation can be coupled with any appropriate intensity and hazard function to obtain economically optimal replacement time of a pipe. Also, practical usage of the threshold break rate is demonstrated with a number of numerical examples. Design aids in the form of charts and tables are provided. The threshold break rate can be easily obtained either graphically or with the aid of the tables. The methodology that links the threshold break rate and failure rate (intensity and hazard) functions is extended to accommodate stress multiplying environmental factors in the form of the proportional intensity and hazards model. The two models consist of an age dependent failure rate function and a covariate structure. They are applied to a case study area pipe system to obtain optimal replacement times for individual pipes in the system. As a result, important hazard characteristics of water distribution pipes are drawn, and implications on the optimal replacement analysis are discussed. A pipe break prediction model is also developed in this research. The model spans the space between the linear and exponential break trends. The model is applied to the case study area pipe system with various cost options. The results from this analysis are discussed in terms of practical implementation of the replacement strategies. / Ph. D.

Threshold leak sizes and leak rates were calculated for a number of liquid food products exhibiting a wide range of surface tension and viscosity values. From this data, one can see that mathematically, under typical pressure differentials generated in food packages (less than or equal to ±34.5 kPa), a leak will never start through a 2 μm defect. The calculated leak rates were compared to calculated evaporation rates. The evaporation rate exceeds the leak rate at lower sized microholes (2, and 5 μm diameter) under typical pressure differentials found in food packages. If the liquid, typically aqueous in food products, is evaporating off faster than the leak itself, then there will be solids left behind that could effectively plug the leak. The critical leak size is the size micro-defect that allows microbial penetration into the package. The critical leak size of air-filled defects was found to be 7 μm at all pressures tested. This size is considerably important to food packagers because this is when sterility of the package is lost. Previous leak studies have shown that the critical leak size for liquid-filled defects coincide with the threshold leak size and pressure. If this is in fact true, then air-filled defects should exhibit a larger critical leak size than the liquid-filled defects. In this study, air-filled defects were examined. A bioaerosol exposure chamber was used to test micro-defects, nickel microtubes of known diameters 2, 5, 7, 10, 20, and 50 μm hydraulic diameters, against pressure differentials of 0, -6.9, -13.8, and -34.5 kPa. / Master of Science

This thesis is an investigation of architectural elements and lighting conditions that reinforce a journey. From the initial encounter to the presence of the sanctuary, a Presbyterian church has been constructed in downtown Blacksburg to instrumentally govern an interaction between congregation and form. / Master of Architecture

The architectural opportunity to develop the sound and light lock of a performance venue as a space that engages and prepares the audience for a performance is one that is sadly missing from most halls. I have explored the development of this threshold as a true architectural space, one that enhances the overall experience for the audience members. And by introducing a parametric process into the architectural and acoustic development, have proposed a unique process for the design of concert halls. From physical model building to analysis by computer simulation, digital technology has undoubtedly advanced the realm of acoustic prediction. But common computer prediction programs that exist today are still essentially digitized applications of the analog model building process. Being: construct a model, analyze, make adjustments and repeat until the desired results are achieved. By implementing a parametric approach to model building it allows for design changes and the significance of those changes to be recognized in real time, an invaluable tool in the development of a sound-sensitive space. Utilizing the 3D software Rhinoceros and its scripting plug-in Grasshopper, it becomes possible to easily visualize crucial first-order reflections relative to surfaces that can be controlled and manipulated in very precise ways. This software is becoming more popular amongst architects and designers, and the prediction process will be an extension of this software into the field of acoustics. By using software already in the design vernacular, there is a seamless transition between design and analysis, making for a more cohesive project / Master of Architecture

Innovative nano-scale devices have been developed to enhance future circuit design to overcome physical barriers hindering complementary metal-oxide semiconductor (CMOS) technology. Among the emerging nanodevices, resonant tunneling diodes (RTDs) have demonstrated promising electronic features due to their high speed switching capability and functional versatility. Great circuit functionality can be achieved through integrating heterostructure field-effect transistors (HFETs) in conjunction with RTDs to modulate effective negative differential resistance (NDR). However, RTDs are intrinsically suitable for implementing threshold logic rather than Boolean logic which has dominated CMOS technology in the past. To fully take advantage of such emerging nanotechnology, efficient design methodologies and design automation tools for threshold logic therefore become essential. In this thesis, we first propose novel programmable logic elements (PLEs) implemented in threshold gates (TGs) and multi-threshold threshold gates (MTTGs) by exploring RTD/ HFET monostable-bistable transition logic element (MOBILE) principles. Our three-input PLE can be configured through five control bits to realize all the three-variable logic functions, which is, to the best of our knowledge, the first single RTD-based structure that provides complete logic implementation. It is also a more efficient reconfigurable circuit element than a general look-up table which requires eight configuration bits for three-variable functions. We further extend the design concept to construct a more versatile four-input PLE. A comprehensive comparison of three- and four-input PLEs provides an insightful view of design tradeoffs between performance and area. We present the mathematical proof of PLE's logic completeness based on Shannon Expansion, as well as the HSPICE simulation results of the programmable and primitive RTD/HFET gates that we have designed. An efficient control bit generating algorithm is developed by using a special encoding scheme to implement any given logic function. In addition, we propose novel techniques of formulating a given threshold logic in conjunctive normal form (CNF) that facilitates efficient SAT-based equivalence checking for threshold logic networks. Three different strategies of CNF generation from threshold logic representations are implemented. Experimental results based on MCNC benchmarks are presented as a complete comparison. Our hybrid algorithm, which takes into account input symmetry as well as input weight order of threshold gates, can efficiently generate CNF formulas in terms of both SAT solving time and CNF generating time. / Master of Science

The Book of Exodus in the Old Testament recounts the liberation and salvation of an oppressed people and their subsequent journey to and arrival at the Promised Land. In the Christian Church, this journey continues in the lives of believers. The spiritual journey begins with salvation, continues with a repeated process of suffering and redemption, and terminates with an awakening to a better understanding of God.<p> The spiritual journey made concrete is the concern of this project. The Christian life, grossly simplified, is a passage from one place to another. The believer is constantly passing through the threshold from this life to the next, from an old, limited understanding of the divine to a new understanding.<p> In the Catholic Church, this process of passage is ritualized in the journey of the believer to the church each Sunday. Upon entering the church building, the believer passes from the secular and mundane to the sacred and holy.<p> Where does the secular end and the sacred begin? How does one delimit a boundary between the two? How does one cross the threshold from the profane to the sacred? That is the focus of this project. / Master of Architecture

Field-based liquefaction evaluation procedures include the stress-based, strain-based, and energybased based approaches. The existence of a volumetric threshold shear strain, γtv, under which there is no development of excess pore pressures, and the unique relationship between pore pressure ratio and cyclic shear strain, γc, make a compelling argument for using a strain-based approach. However, the cyclic strain approach has not yet been standardized for field evaluations. The primary objective of this thesis is to use published databases of 415 shear-wave velocity and 230 Standard Penetration Test liquefaction field case histories to investigate the performance of the cyclic strain approach for the evaluation of initial liquefaction relative to the cyclic stress approach. Additionally, the concept of the γtv is expressed in terms of the peak ground surface acceleration and defined as the threshold amax. Computing (amax)t could provide a fast and simple evaluation for initial liquefaction, where no liquefaction is expected for a minimum computed (amax)t determined from the case histories. The variant of the strain-based procedure proposed herein avoids the direct need for laboratory cyclic testing by employing pore pressure generation models that are functions of cyclic shear strain, number of equivalent cycles, and relative density to predict initial liquefaction. The results from the proposed procedure are compared with those of the stress-based approach to determine which better matches the field observations of the case histories. It was found that the cyclic strain approach resulted in 70% to 77% correct predictions. In contrast, the cyclic stress approach yielded 87% to 90% correct predictions. The reasons why the predictions were not always correct with the cyclic strain approach are due to inherent limitations of the cyclic strain approach. Most significantly, an inherent and potentially fatal limitation of the strain-based procedure is it ignoring the softening of the soil stiffness due to excess pore pressure in representing the earthquake loading in terms of γc and neqγ. / Master of Science / Earthquakes can cause heavy damage when they occur. One of the ways in which this happens is when the earthquake shaking causes the soil to behave like a liquid. This is the phenomenon known as liquefaction. An example of liquefaction is a person sinking in quicksand. Relating this to earthquakes, liquefaction can be thought of as a building sinking in quicksand that formed as a consequence of earthquake shaking. Destructive cases of liquefaction have been reported in almost all major earthquakes. When cases of liquefaction are properly documented, they can provide information that will help engineers and scientists assess the efficacy of existing liquefaction evaluation procedures and/or to develop new procedures. There are different methods to evaluate the occurrence of liquefaction, with the cyclic stress approach being the most widely used. This study assesses the efficacy of an alternative approach to see if it yields better predictions of liquefaction triggering than the cyclic stress approach. The approach under consideration is called the cyclic strain approach. To examine the effectiveness of the cyclic strain approach, sites that experienced liquefaction in the past were analyzed to see if the predictions made with the approach matched the past field observations. Due to potential shortcomings in implementing the strain based procedure, as well as inherent limitations of the procedure, the strain-based procedure yielded predictions that were inferior to the more widely used stress-based procedure.

The objective of this study was to evaluate effects of extracorporeal shockwave therapy (ESWT) on spinal mechanical nociceptive threshold (MNT) and multifidus muscle cross-sectional area (CSA) in horses with thoracolumbar pain. We hypothesized that ESWT would increase MNT and multifidus CSA. Twelve horses with thoracolumbar pain were included. Prior to treatment, each thoracolumbar spine was radiographed to document existing pathology. Horses received 3 ESWT treatments, 2 weeks apart (days 0, 14, 28). Palpation scores were documented (days 0, 45, 65) and ultrasonographic CSA of left and right multifidus was recorded at T12, T14, T16, T18, L3 and L5 (days 0, 45, 65). MNT was measured at T12, T14, T16, T18, L3 and L5 every 7 days (day 0-56). Change in MNT in 10/12 horses was significant at each timepoint compared to day 0 (P<0.05). MNT increased at all timepoints at 6 sites in 2/12, at 5 sites in 3/12, at 4 sites in 4/12 and at 1 site in 1/12 (P<0.05). MNT average percent increase from day 0-56 was 64% for T12-T18 and 29% for L3-L5. There was no statistical difference in MNT from day 35-56 (P=0.25). A bimodal analgesic trend was observed following ESWT. Degree of radiographic change was not associated with response to treatment and no significant change in multifidus CSA was observed. In conclusion, 3 treatments of ESWT 2 weeks apart raised MNT over a 56-day period in horses with back pain, but did not influence change in CSA of the multifidus. / Master of Science / Back pain in the horse is a frequently diagnosed and treated cause of back stiffness, lameness, poor performance and/or avoidance behavior under saddle. Treatment is focused on reducing pain and inflammation and on strengthening and promoting proper muscle development to maintain long term results. Recently, rehabilitation of the deep spinal stabilizer multifidus muscle, particularly with regard to increased cross-sectional area (CSA), has become a focus of targeted physiotherapy. Assessment of the degree of pain is subjective due to individual interpretation and palpation technique. In an attempt to standardize quantification of pain, pressure algometry has become a validated, objective and repeatable measure of axial skeleton mechanical nociceptive threshold (MNT), which is defined as the minimum pressure required to induce a pain response. Although many treatment options for back pain exist, there is limited research documenting the efficacy of these treatments in horses. Extracorporeal shockwave therapy (ESWT), which consists of focused, high velocity acoustic waves, is one type of non-invasive, well-tolerated treatment for back pain. Despite its popularity, there is no research documenting the effects of ESWT on equine spinal MNT or multifidus muscle CSA. This is the first study to document the effects of ESWT on spinal MNT and multifidus muscle CSA in horses with back pain. We hope that the results of this study will help guide treatment decisions for horses with back pain.

Deterioration of bridge decks is an ongoing problem faced by transportation agencies across the country. In past decades, Non-Destructive Evaluation (NDE) techniques, capable of detecting various deteriorations types, e.g., cracking, delamination and reinforcing steel corrosion, have emerged. These techniques generate large amounts of data representing different underlying physics, (decibels for ground penetrating radar and volts for half-cell potential), making data interpretation and comparison difficult for bridge owners and practitioners. The deterioration threshold, or the transition between healthy and deteriorated areas, is essential in understanding NDE data. However, this threshold is determined empirically in former research and engineering practice. In the present research, a probability-based method is proposed to identify deterioration thresholds for specified confidence levels. NDE data measuring different underlying physics are transformed into a binary format by threshold values to compare and combine multiple NDE techniques for bridge deck assessment. The finite element method is also implemented to correlate bridge deck surface stresses with deteriorations measured by NDE techniques, and to study the causes on concrete bridge deck degradation. The general methodology developed in this study will be demonstrated on three bridges, i.e., Virginia, New Jersey and New York Pilot Bridges, which were studied under Federal Highway Administration (FHWA)'s Long-Term Bridge Performance (LTBP) Program. / Ph. D.