Q'eqchi' is one of many Mayan languages spoken in Guatemala, C.A. This study provides the first Tone Break and Indices (ToBI) transcription system (Silverman et al., 1992) labeling of Q'eqchi' within the Autosegmental-Metrical (AM) model of intonation (Liberman, 1975; Pierrehumbert, 1980; Ladd, 1996). As an exploratory study into the basic intonation patterns of the language, observations were made on a variety of phenomenon relating to the intonational structure and contour pattern of the language. Three native male speakers of Q'eqchi' each provided 75 spoken sentences designed to best observe the basic patterns of intonation in the language. Each spoken utterance was analyzed through the labeling of pitch accents, phrase accents, and boundary tones in accordance with ToBI transcription guidelines (Beckman & Hirschberg, 1994; Beckman & Elam, 1997). The study reinforces previous observation on the stress pattern in the language, identifies the pitch accents and boundary tones which best describe the behavior of the intonational contour of the Q'eqchi' speakers, and proves the existence of prosodic phrases which dictate the intonational patterns of speech. In addition, the different patterns observed in declarative, imperative, and interrogative sentences are exemplified and discussed along with other phenomenon observed in the spoken data.

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Yes / TOBI® is a recently marketed preservative and sulphate free tobramycin formulation approved by FDA for maintenance therapy for patient with cystic fibrosis. The performance of selected recent nebuliser delivery systems has been assessed using the developed method to determine the optimum combinations to deliver approved tobramycin inhaled solution (TOBI)®. A simple, sensitive and specific high performance liquid chromatographic method has been developed and used to quantitative determination of the aminoglycoside tobramycin following pre-column derivatisation with phenylisocyanate (PIC). The reaction time was 10 min at 80º C and the resulting derivative was stable for five days at room temperature. The quantitative performance of the assay was further improved by using another aminoglycoside (neomycin) as internal standard. The stable resulting PIC-tobramycin derivative was separated using a HPLC 5μm Columbus C18 column (150x4.60 mm i.d, Phenomenex). The mobile phase was consisted of acetonitrile-glacial acetic acid-water (450:5:545, v/v/v) and ultraviolet detection at (240 nm). The proposed method showed good validation data. The standard curve was linear (n=5) at seven different concentrations, ranging from 20 to 140μg/ml and the correlation coefficient (R2) of the regression line was 0.9995. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.86μg/ml and 2.62μg/ml, respectively. The relative standard deviation (RSD %) was less than 0.6% for intra-day assay (n=5) and 2.5% for inter-day assay (n=5). A number of nebuliser performance comparison studies have been demonstrated for aerosolise TOBI® to choice the optimum combination produces high repirable inhaled mass of tobramycin. The objective of this study was to evaluate the performance of recent nebuliser delivery systems to nebulise approved tobramycin inhaled solution (TOBI)®.

The objective of this research is to develop and design front-end analog circuits for Capacitive Micromachined Ultrasound Transducers (CMUTs) and optical grating MEMS microphone. This work is motivated by the fact that with micro-scaling, MEMS sense capacitance gets smaller in a CMUT array element for intravascular ultrasound imaging, which has dimensions of 70um x 70um and sub pico-farad capacitance. Smaller sensors lead to a lower active-to-parasitic ratio and thus, degrads sensitivity. Area and power requirements are also very stringent, such as the case of intravascular catheter implementations with CMOS-First CMUT fabrication approach. In this implementation, capacitive feedback charge amplifier is an alternative approach to resistive feedback amplifiers. Capacitive feedback charge amplifier provides high sensitivity, small area, low distortion and saving power. This approach of charge amplifiers is also suitable in capacitive microphones where it provides low power and high sensitivity. Another approach to overcome capacitive detection challenges is to implement optical detection. In the case of biomimetic microphone structure, optical detection overcomes capacitive detection's thermal noise issues. Also with micro-scaling, optical detection overcomes the increased parasitics without any sensitivity degradation, unlike capacitive detection. For hearing aids, along with sensitivity, battery life is another challenge. We propose the use of 1-bit front-end sigma-delta ADC for overall improved hearing aid power efficiency. Front-end interface based on envelope detection and synchronous detection schemes have also been designed. These interface circuits consume currents in microampere range from a 1.5V battery. Circuit techniques are used for maximizing linear range and signal handling with low supplies. The entire front end signal processing with Vertical Cavity Surface Emitting Laser (VCSEL) drivers, photodiodes, filters and detectors is implemented on a single chip in 0.35um CMOS process.