Rats were trained to discriminate an injection of cocaine, 5.0 mg/kg, from an injection of saline, using a two-lever choice paradigm: one lever was correct after cocaine injection, the other lever was correct after a saline injection. After training, cocaine and methamphetamine were generalized to the cocaine lever, but phenethylamine (PEA) was only partially generalized. Cocaine was injected every 8 hrs, 20.0 mg/kg, and the discriminability of 5.0 mg/kg was tested every other day. Redetermination of the cocaine generalization curve after 6 days of chronic administration showed a shift to the right, from an ED50 of 4.1 mg/kg in the pre-chronic condition to 10.0 mg/kg. Tolerance did not develop to the behavioral effects of cocaine, measured by time to the first reinforcement and response rate. There was cross-tolerance to methamphetamine; however, no evidence for cross-tolerance to PEA was obtained. Following the acquisition of tolerance, chronic administration of cocaine was terminated, and the discriminability of 5.0 mg/kg was tested every other day for loss of tolerance. After 8 days the ED50 returned to 5.0 mg/kg.

No description available.

Diversity is an inevitable condition of modern societies, in which individuals come into contact with one another with various backgrounds; such as, race, ethnicity, nationality, sexual orientation, religion, and ideology. My dissertation answers three questions: what are the individual characteristics that influence social tolerance of people?’ What are the important things (education level, economic condition, gender, religiosity, etc.) that hold people in a society together as well as influence them positively or negatively to report social tolerance toward religiously different, racially different, sexually different (homosexuals), and nationally (immigrants) different people? From there, I am also trying to answer, if any, the impact of social intolerance on people’s overall well-being? And finally, I am attempting to explore the impact of the socio-historical developments in three societies (United States, Turkey, and South Africa) on social intolerance attitudes (racism, homophobia, xenophobia, and religious intolerance) of people? Previous studies on tolerance have used samples from either one country or a few countries from a continent. As a result, it remained unclear why some characteristics were significantly associated with social tolerance. Using the World Values Survey, I analyze the association between reporting social tolerance within individual and country level contexts. Additionally, using a historical comparative analysis approach, I explore societal factors that influence people to report social tolerance toward racially different, immigrants/foreign workers, homosexuals, and religiously different people in the United States, Turkey, and South Africa. In my multi-level logistic regression analyses, I find that as educational attainment of individuals’ increases, they are more likely to be socially tolerant toward racially different, immigrant/foreign workers, homosexuals, and those who practice a different religion. Schooling plays the most important role on whether individuals will be socially tolerant or intolerant. At the country level, I find that those who live in highly corrupted countries tend to report lower levels of social tolerance for all dimensions. My findings show that there is a connection between social tolerance, as a type of negative emotion, and individuals health outcomes. Also, my findings show that as social intolerance increases the likelihood of reporting good and very good health and mental well-being decreases.

No description available.

No description available.

LD2668 .T4 1942 M42 / Master of Science

Master of Science / Department of Agronomy / Kraig L. Roozeboom / Due to decreased availability of irrigation water in central and western Kansas and an increase in water restrictions, producers are looking for more efficient ways to use available irrigation water. Drought-tolerant technologies have become popular in hybrids for stress-prone environments across central and western Kansas and are marketed for their ability to produce greater grain yields with less water. The objective of this research was to understand how DT and non-DT corn hybrids respond in a wide range of environmental conditions in terms of soil water status change, canopy indicators of stress, dry matter partitioning, and grain yield. Soil water status change, yield, and canopy response characteristics of two DT hybrids, and one non-DT hybrid were compared at five locations over two years in rain-fed, semi-irrigated, or fully irrigated regimes making a total of 18 environments. Field experiments were established in 2014 and 2015 near Topeka, Scandia, Hutchinson, Garden City, and Tribune, KS. Two corn hybrids with different approaches drought tolerance (Pioneer 1151 AQUAmax, bred drought tolerance and Croplan 6000 DroughtGard, bred drought tolerance plus transgenic drought tolerance), and one hybrid with no specific drought tolerance characteristics but with proven performance in favorable environments (Croplan 6274) were used in the experiment. Soil moisture content (measured using a neutron moisture meter), canopy temperature, ear leaf temperature, and chlorophyll content were measured at tasseling (VT), milk or dough (R3-R4), and physiological maturity (R6) developmental stages. Grain yield was at all 18 environments, and biomass production was estimated at 14 of the environments. Hybrid plasticity of yield results show the response for Croplan 6000DG and Pioneer 1151AM differed, but Croplan 6274 was the same as both other hybrids at the 0.10 alpha level. Yields of all hybrids remained comparable in most environments, but as environment yields increased beyond 200 bu acˉ¹, Croplan 6000DG lagged behind Pioneer 1151AM. Hybrid harvest index plasticity shoed that all hybrids had the same response to environment in harvest index. Although, not statistically significant, when an environment supported favorable harvest index values greater than 0.40, it’s observed that Croplan 6000DG does have an improvement in harvest index relative to the Pioneer 1151AM and Croplan 6274.

The purpose of this study was to determine the relationship between the overall changes in concentration of plasma pyridoxal 5'-phosphate (PLP), red blood cell PLP (rbc PLP) and plasma glucose during an oral glucose tolerance test (OGTT) in persons with diabetes mellitus (DM), and to test the hypothesis that the decrease in plasma PLP concentration that occurs with increasing plasma glucose would be explained by a subsequent increase in rbc PLP concentration. A second objective was to compare the distribution of PLP between the red blood cell and the plasma (as measured by the rbc PLP/ plasma PLP ratio) in persons with diabetes to the distribution in non-diabetic controls. The third objective was to measure fasting plasma alkaline phosphatase (AP) activity, and to compare it to fasting plasma PLP concentrations, fasting rbc PLP concentrations, and the rbc PLP/plasma PLP ratio. The purpose of this third objective was to test the hypothesis that an increased plasma AP activity in persons with DM would be associated with decreased plasma PLP and increased rbc PLP concentrations. The study included 8 persons (3F; 5M) with insulin dependent diabetes mellitus (IDDM), 9 persons (5F; 4M) with non-insulin dependent diabetes mellitus (NIDDM) and 18 healthy control individuals (9F; 9M). All subjects were given a 75 gm oral D-glucose dose, and blood was drawn at 0 (fasting), 30, 60 and 120 minutes after the glucose load. Plasma glucose, PLP, insulin, and rbc PLP concentrations were measured at all time points during the OGTT. Fasting plasma alkaline phosphatase (AP) activity, percent glycosylated hemoglobin (%GlyHb), and the ratio between fasting rbc PLP and fasting plasma PLP were also determined. In general, females with DM were in poorer diabetic control as compared to males with DM. Mean fasting glucose levels, %GlyHb and body mass index (BMI) were highest in females with DM as compared to all other groups, and fasting insulin was nearly 2x higher in females with NIDDM as compared to males with NIDDM. There was an overall decrease in plasma PLP during the OGTT with increasing plasma glucose, which agrees with results from other studies. The overall decrease in plasma PLP (as measured by the negative, cumulative area under the curve: -AUC plp) was significantly correlated with the overall increase in plasma glucose (as measured by the positive, cumulative area under the curve: +AUC glu) for all study groups. The relationship was stronger in all males, and control females as compared to females with diabetes (p< 0.001 vs. p< 0.01, respectively). This difference was in part explained by lower mean fasting PLP levels in females with DM (19.3 nmol/L), as compared to males with DM (47.2nmol/L) and male and female controls (35.4 nmol/L and 34.0 nmol/L, respectively). The changes in rbc PLP during the OGTT were minimal, and did not significantly correlate with the increase in plasma glucose or the decrease in plasma PLP. Thus, the acute drop in plasma PLP concentration that occurred during the OGTT was not explained by a subsequent increase in rbc PLP concentration, as had been hypothesized. However, the higher than normal % glycosylated hemoglobin levels along with elevated rbc PLP concentrations in persons with diabetes as compared to controls suggests that chronically elevated blood glucose can contribute to increased rbc PLP concentrations. This was the first study to date that has measured rbc PLP in persons with diabetes mellitus. Rbc PLP values for persons with DM were 20-40% greater than respective control values at all time points during the OGTT. These differences between mean rbc PLP in persons with DM as compared to control groups were all statistically significant (p< 0.05) with the exception of the difference in the mean fasting rbc PLP value for females with NIDDM as compared to controls. The mean values ± standard deviations (SD) for fasting rbc PLP (nmol/L) were as follows: Females-IDDM, 49.5 ± 6.5; NIDDM, 39.3 ± 4.9; controls, 31.4 ± 9.0; Males-IDDM, 37.8 ± 10.9; NIDDM, 45.6 ± 12.3; controls, 28.3 ± 4.4. The ratio of fasting rbc PLP concentration to fasting plasma PLP concentration was 2-3x higher in females with DM as compared to control females and all male groups. Females with IDDM had a ratio of 3.2, and the ratio for females with NIDDM was 2.2. The ratios for all male groups, and control females were approximately 1:1, with a range of 0.8-1.2. The mean fasting plasma AP activity was within the normal range for all study groups. However, females with DM had higher AP activity (0.543 μkat/L) as compared to female controls and males with DM (0.408 μkat/L, .425 μkat/L, respectively p<0.05). There were no significant differences in mean fasting plasma AP activity between any male group (range 0.390-0.465 μkat/L). These results suggest that increased plasma glucose levels, increased AP activity, and overall poor glycemic control contribute to decreased plasma PLP concentrations, increased rbc PLP concentrations, and possibly to changes in the PLP distribution within the body. / Graduation date: 1994

No description available.

No description available.