This thesis presents a study of W±Z diboson production with the ATLAS experiment at the LHC. The measurements are made using 20.3fb⁻¹ of data collected during proton-proton collisions produced at a centre-of-mass energy of √s = 8 TeV. Final states with three leptons and missing transverse energy are considered. The first study of the polarisation of the W boson in such events is presented. This study provides a cross-section independent method by which to study anomalous gauge boson couplings. The estimated sensitivity of this measurement to anomalous gauge boson couplings will therefore also be presented. Also discussed, are measurements of the W±Z production cross-section and limits on anomalous gauge boson couplings. Finally, a study is presented which assess the impact of extending the inner-detector tracker to |η| = 4.0. This was considered for the ATLAS upgrade program. The effect of such an extension was studied for multiple final states, including the W±Z inclusive and VBS analyses as well as the WWW triboson analysis.

The Standard Model (SM) is the fundamental theory describing elementary particles and their main interactions at typical energy scales at collider experiments, the electromagnetic, the weak, and the strong interactions. The more complex underlying structure describing the weak and the strong interactions in the SM compared to the electromagnetic interaction necessitates direct three-point and four-point interactions among the mediators of the weak and strong interactions, called gauge bosons. Such self-interactions do not exist for the gauge boson of the electromagnetic interaction, the photon. While the three-point interaction was studied in detail in earlier collider experiments, the four-point interaction is a fundamental prediction of the SM, which was not observed for the weak interaction when starting this study. One process, where both the three-point as well as the four-point interactions contribute is the scattering of electroweak gauge bosons W, Z, γ also referred to as vector boson scattering (VBS). In the SM, this scattering is mediated by gauge boson self-interactions, or via the exchange of a Higgs boson. The scattering contributions mediated by a Higgs boson are sensitive to the properties of the Higgs boson and the details of the mechanism in which the W and Z bosons acquire their masses, called electroweak symmetry breaking. At hadron colliders such as the Large Hadron Collider (LHC), VBS is observable in a final state with the decay products of two gauge bosons in combination with two jets. These jets have a distinct signature allowing for good suppression of backgrounds and consequently for studies of the complex final state despite the low cross-sections. The first evidence for a VBS process was presented based on the Run 1 dataset alone by the ATLAS collaboration in the WW → WW channel in the fully leptonic final state. The CMS collaboration published the first observation of VBS in the same channel using data from 2015 and 2016 of Run 2, which was later confirmed by the ATLAS collaboration with contributions by the author, e.g. in the modelling of WZ background processes and associated uncertainties. The second boson channel for which VBS was observed was the WZ/γ → WZ boson channel in the fully leptonic final state. This observation was published by the ATLAS collaboration with significant contributions by the author. The studied dataset was collected with the ATLAS detector at a centre-of-mass energy √s = 13 TeV during 2015 and 2016 of Run 2 of the LHC and amounts to an integrated luminosity of 36.1/fb. In this study, the dataset was re-analysed following the same overall approach but with improvements in several key aspects. A comprehensive overview of available setups for reliable simulations of the signal process is presented. In a modelling study of the available setups, modelling issues in the parton shower simulation of SHERPA and earlier versions of PYTHIA observed in earlier studies are confirmed. The best matrix-element accuracies in available setups are leading-order for the full VBS signal process and next-to-leading-order in the VBF approximation. For upcoming analyses, a leading-order calculation of the full process including an additional QCD emission merged with parton shower simulations is found to be most promising, before full next-to-leading order calculations become available for all boson channels in VBS. Additional emphasis is set on the modelling of backgrounds, mainly WZ diboson production in association with additional QCD emissions as well as the experimental background due to misidentified leptons. A data-driven approach is applied and studied in detail for a reliable estimate of the latter background. Significant improvements to the estimate, e.g. in the form of additional corrections, are found via dedicated tests of the self-consistency of the approach using simulations. Machine-learning algorithms in the form of Boosted-Decision-Trees (BDT) are trained and optimized for improved separation of the background and signal processes. Evidence for the signal process is found with a significance of 3.44 σ using the profile likelihood method in a binned maximum-likelihood fit. The fiducial cross-section is measured to be σ= 1.41 + 0.46 - 0.40(stat) + 0.38 - 0.28 (theo) ± 0.13 (sys) fb , which is in good agreement with the leading-order SM prediction of σ = 1.33 + 0.14 -0.15 fb.:1 Introduction 2 Theoretical Framework 3 Simulations and Modelling Studies 4 Experiment 5 Object and Event Selection 6 Background Estimation 7 Multi-variate Event Classification 8 Uncertainties 9 Cross-section Measurement 10 Conclusions & Outlook

Doctor of Philosophy / Department of Physics / Yurii Maravin / In this Dissertation I present a detailed study of ppbar->WZ production using fully leptonic decays of W and Z bosons with electrons and muons in the final state. Data used for the study were collected by the D0 detector at the Fermilab proton-antiproton collider with a center-of-mass energy of 1.96 TeV and correspond to 4.1 fb[surepscript]-1 of integrated luminosity. The most precise measurement of the WZ production cross section is obtained and found to be in a good agreement with the standard model prediction. I also present a search for new phenomena in the WZ production by investigating the coupling between W and Z bosons and by searching for new charged particles that can decay into WZ boson pair. No evidence for new physics is found, and the most stringent limits are set on the anomalous WWZ coupling parameters and masses of charged resonances. This result also sets the stringest limit on one of the possible sources of electroweak symmetry breaking, a low-scale Technicolor with a typical heavy techni-pion hypothesis.

Cette thèse présente la première mesure de production du W Z avec le détecteur CMS au LHC en utilisant les modes leptoniques. La réponse du calorimètre électromagnétique (ECAL) est étudiée par la mesure du pouvoir d'arrêt de muons dans le tungstate de plomb d'ECAL. Les électrons sont validés avec les premières données pour être utilisable dans toutes les analyses. Avec les données de rayons cosmiques, le pouvoir d'arrêt de muons traversants le tungstate de plomb du calorimètre électromagnétique a été mesuré pour une gamme d'impulsion 5-1000 GeV/c. Le résultat compatible avec l'attendu a permis de valider l'échelle d'énergie d'ECAL, déterminée auparavant avec un faisceau d'électrons de 120 GeV/c, dans la région du sub-GeV en accord avec 1.004+0.002-0.003(stat.) ±0.019(syst.). Les données des premières collisions de LHC ont permis la vérification des algorithmes de reconstruction des électrons, en particulier pour la détermination des pré-traces dans la partie la plus interne du trajectographe. Les algorithmes ont été optimisés, sur des électrons issus de désintégrations de bosons W et entièrement validés avec 14/pb de données environ. La mesure physique est la section efficace de production des bosons associés WZ dans les collisions proton-proton à √s =7TeV. La signature claire de la désintégration en leptons permet l'extraction efficace du signal et la réjection du bruit de fond, pour chaque canal considéré. Le premier évènement a été observé avec 36/pb de données. Avec 1.09/fb, la section de production de WZ a été mesurée pour la première fois à √s =7TeV σ(WZ) = 19.11+3.30-2.53(stat.)±1.10(syst.)±1.15(lumi.)pb et trouvée en accord avec la prédiction du Model Standard (18.57+0.75-0.58 pb NLO).

In this dissertation, we present a study of WZ production in proton-proton collisions at a center-of-mass energy of 7 TeV. The data analyzed was collected by the ATLAS detector and corresponds to an integrated luminosity of \(4.6 fb^{−1}\) provided by the Large Hadron Collider in 2011. We select WZ events in the fully leptonic decay mode with electrons, muons, and missing transverse energy in the final state. Events are required to have three isolated leptons with significant transverse momentum, a large missing transverse energy, a Z candidate reconstructed from two of the selected leptons, and a W candidate reconstructed from the missing transverse energy and third lepton. The major backgrounds to the WZ signal in the leptonic decay channel are Z+jets events, ZZ production, Z+photon events, and events with top quarks. We estimate the Z+jets and top quark background contributions from data and take the expected contribution for the other background processes from simulation. We observe 317 WZ candidates in data, with a background expectation of \(68\pm10\) events. The total production cross section is extracted from the selected sample using a maximum likelihood method and is determined to be \(19.0^{+1.4}_{-1.3} (stat) \pm0.9 (syst) \pm0.4 (lumi) pb\), which is consistent with the next-to-leading Standard Model prediction of \(17.6^{+1.1}_{-1.0} pb\). WZ production in the Standard Model includes a contribution from the WWZ triple gauge boson vertex. If new physics beyond the Standard Model exists and interacts with W and Z bosons, the coupling of the WWZ vertex could differ from the Standard Model prediction. We set limits on anomalous triple gauge boson couplings using the transverse momentum spectrum of Z bosons in the selected sample. We derive the 95% confidence interval for three model-independent anomalous triple gauge couplings using a frequentist approach and set the most stringent bounds to date on two of the three parameters. / Physics

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Krebserkrankungen sind das Resultat komplexer Vorgänge und Veränderungen. Eine wichtige Variable in der Initialisierung ist die Interaktion zwischen Genotyp und Umwelt. Da Magenkarzinome zu den wenigen Krebserkrankungen gehören, bei denen im letzten Jahrhundert ein deutlicher Rückgang in der Inzidenz beobachtet werden konnte (Becker 2006), stellt sich die Frage, ob es Unterschiede in der genetischen Ausstattung von historischen Tumorgenomen im Vergleich zu rezenten gibt. Als typisches Zielgen für Tumormutationen wurde das Tumorsuppressorgen p53 untersucht. Au¬ßerdem wurde Helicobacter pylori (H. pylori) als Risikofaktor für die Entstehung von Magenkarzinomen in den historischen Proben identifiziert. Insgesamt standen 51 Gewebeproben von Magenkarzinompatienten aus den Medizinhistori¬schen Museen Berlin und Zürich, dem Pathologisch-anatomischen Bundesmuseum Wien sowie der anatomischen Sammlung der Universität Tartu zur Verfügung. Bei 47 Proben handelte es sich nach histologischer Diagnose um Magenkarzinome. Die Proben sind zwischen 50 und 180 Jahre alt und wurden in Konservierungsflüssigkeiten unbekannter Zusammensetzung gelagert. Von 45% der Proben konnten vollständige Sequenzen der Exons 5 bis 8 des p53-Gens generiert werden. Es konnten Veränderungen im Mutationsspektrum und in der Lokalisation der Mutationen in den historischen Proben im Vergleich zu rezenten Tumormutationen festgestellt werden. Die Mutationsfrequenz betrug 52%. Insgesamt wurden zehn verschiedene Mutationsereignisse in p53 bei elf verschiedenen Proben detektiert, wobei drei Proben von zwei Mutationen betroffen waren. Zwei Mutationen führen direkt (Q144X) bzw. indirekt (S166fs) zu der Entstehung von Stoppcodons. Zu einem Verlust des p53-Proteins bei gleichzeitiger Akquirierung onkogener Funktionen kommt es durch die Hotspot-Mutation R248W (Wang & El-Deiry 2007). Zu einer Zunahme der Funktionsfähigkeit (gain-of-function) kommt es außerdem durch die Mutation K291E. Die Mutation E271K ist an einer splice site lokalisiert, so dass das Exon nicht in die mRNA übernommen werden kann. Die Konsequenzen der anderen Mutationsereignisse sind nicht eindeutig belegt, scheinen aber einen geringeren Einfluss auf die Funktionalität von p53 zu haben. Abweichend zu rezenten Magenkarzinomen konnte die Mutation M246K als Hotspot der historischen Proben identifiziert werden. Insgesamt waren nur vier historische Mutationen bisher aus rezentem Magenkarzinomgewebe beschrieben, davon die Mehrheit in Studien mit asiatischen Patienten. Die veränderten Mutationen der historischen Magenkarzinome können als Hinweis auf Veränderungen in den karzinogen wirkenden Einflussfaktoren dienen, etwa eine veränderte Lebens- und Ernährungsweise durch die Einführung von Kühlmöglichkeiten für Lebensmittel. Der Risikofaktor H. pylori konnte in 70% der Gewebeproben sicher nachgewiesen werden. Der Anteil der Träger des Virulenzfaktors cag betrug 44%. 73% der Proben mit p53-Mutation waren nachweislich mit H. pylori und davon wiederum 63% mit einem cag-positiven Stamm infiziert. Die Infektion ermöglicht eine Teilerklärung für die untypische Lokalisation der Mutationen, da H. pylori-induzierte Mutationen seltener an Magenkarzinom-Hotspots vorkommen (Murakami et al. 1999). Es konnten keine resistenztypischen Mutationen gegen das Antibiotikum Clarithromycin in den historischen Geweben identifiziert werden. Die vorliegende Arbeit konnte p53-Mutationen und das Bakterium H. pylori in den historischen Gewebeproben identifizieren. Ein verändertes Mutationsspektrum und die veränderte Lokalisation der Mutationen geben den Hinweis, dass sich die Einflüsse auf die Entstehung der Magenkarzinome im letzten Jahrhundert verändert haben.