Thesis (M.A.)--Guo li Taiwan shi fan da xue, 1980. / Cover title. Reproduced from ms. copy. Includes bibliographical references (p. 139-147).

Thesis (M.A.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 46-49).

Thesis (M.A.)--Si li Dongwu da xue, 1982. / Errata slip inserted. Includes bibliographical references (p. 265-274).

Thesis (Ph. D.)--University of Washington. / Bibliography: l. 242-251.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (leaves 122-127). Also available in electronic version.

"Guo li Taiwan shi fan da xue guo wen yan jiu suo shuo shi lun wen" / Reproduced from handwritten copy. Cover title. 880-06 Bibliography : p. 148-151.

abstract: ABSTRACT This dissertation examines the history of the early medieval city Ye 鄴 and its place in the literary tradition. Ye was the powerbase of the warlord Cao Cao 曹操 (155–220) and the birthplace of the Jian’an 建安 literature. It was also the capital city of the Later Zhao 後趙 (319–349), the Former Yan 前燕 (337–370), the Eastern Wei 東魏 (534–550), and the Northern Qi 北齊 (550–577). Through a contextualized close reading of a variety of literary and historical texts, including poems, prose, scholar notes, and local gazetteers, this study shows how Ye, destroyed in 580, continued to live on in various forms of representation and material remains, and continued to evolve as an imagined space that held multiple interpretations. The interpretations are represented in works that treat the heroic enterprise of Cao Cao in founding the city, the double-sided poems that collapsed celebration and themes of carpé diem in the Jian'an era, and in tropes of sorrow and lamentation on the glories, or ruins, of the city that had passed its life in a brilliant flash, and then was lost to time and text. Ye’s most iconic structure, the Bronze Bird Terrace, developed a distinct terrace-scape, a nearly mythical space where poets tangled with questions of sorrow, consciousness after death, and lamentation for women forced to serve their lord long after his demise. The last material vestiges of the city, its tiles which were shaped into inkstones, created a discourse in the Song and Yuan periods of heavy censure of Cao Cao's exercise of power and his supposed eventual failure of ambition and retreat to concern over meaningless material possessions. Over the years, these representations have seen in Ye a fertile ground, either experienced or imagined, where questions about political rise and fall and about the meaning of human life could be raised and partially answered. This dissertation looks closely at the ambivalent attitudes of writers through the ages about, and at their sometimes ambiguous representation of, the status and meaning of that ancient city. / Dissertation/Thesis / Doctoral Dissertation East Asian Languages and Civilizations 2016

Jedes Jahr treten weltweit über zehn Millionen Fälle von Tuberkulose (TB) auf. Die Weltgesundheitsorganisation (WHO) schätzt, dass ein Drittel der Weltbevölkerung mit dem Erreger Mycobacterium tuberculosis (Mtb) infiziert ist. Bei fünf bis zehn Prozent aller latent Infizierten bricht Tuberkulose im Laufe des Lebens aus. Dennoch sind bereits 100 Jahre seit der Entdeckung von Mtb vergangen, ohne dass die entscheidenden Faktoren für den unterschiedlichen Infektionsverlauf bekannt wären. In dieser Arbeit untersuche ich die unterschiedlichen Reaktionen auf eine Tuberkuloseinfektion in verschiedenen Wirten. In meinem ersten Ansatz habe ich öffentlich zugängliche Transkriptom-Datensätze von Tuberkulosepatienten und gesunden Probanden ausgewertet. Mit Hilfe der Gensatzanreicherungs-Analyse (eng. Gene Set Enrichment Analysis, GSEA) habe ich die Transkriptionsprofile von Tuberkulosepatienten betrachtet. Das besondere Augenmerk lag hierbei auf der Interferon (IFN)-Signalkaskade, die für den Krankheitsverlauf von besonderer Bedeutung ist. In dieser Arbeit zeige ich zunächst, dass Patienten ohne eine IFN-Signatur in der untersuchten Kohorte vorkommen und widme mich im Anschluss der Frage, ob diese Patienten einen anderen Phänotypus haben als jene mit einer starken IFN-Antwort. Indem ich nur Patienten ohne IFN-Antwort betrachte, werden Mechanismen deutlich, die allen Patientengruppen gemein sind, aber vorher von der starken IFN-Signatur überlagert wurden. Ich belege in dieser Arbeit, dass eine starke IFN-Regulation auch mit einer ausgeprägten Lungenpathologie in Tuberkulosepatienten einhergeht. Passend hierzu weisen auch gesunde Probanden nach Verabreichung des Impfstoffs FLUAD® einen erhöhten Blutwert IFN-induzierter Zytokine auf. Mit Hilfe maschinellen Lernens konnte ich Transkriptomsignaturen der Patienten mit bzw. ohne IFN-Antwort identifizieren und vergleichen. Im zweiten Ansatz widme ich mich den unterschiedlichen Transkriptionsantworten auf Mtb-Infektionen in humanen Kohorten und zwei verschiedenen Mausmodellen. Der humanen und der murinen Immunantwort auf Infektionen unterliegen gravierende Unterschiede. Trotzdem sind einige Elemente des Immunsystems in beiden Arten konserviert. In dieser Arbeit präsentiere ich einen neuen Ansatz der Datenintegration, der die Identifizierung von übereinstimmenden und nicht übereinstimmenden Regulationselementen der Genexpression in heterogenen Datensätzen ermöglicht. Die Analyse basiert auf öffentlich zugänglichen sowie de-novo-generierten Datensätzen, zu denen ich durch wissenschaftliche Kollaborationen meiner Kollegen in der Abteilung Immunologie sowie der zentralen Einheit Microarray des Max-Planck-Instituts für Infektionsbiologie, Zugang erhalten habe. Des Weiteren liegt ein Schwerpunkt auf der vergleichenden Analyse humaner und muriner Transkriptionsantworten auf Tuberkulose in Vollblut und Makrophagen. Die erhaltenen Ergebnisse weisen auf einen signifikanten Unterschied in der Regulierung der angeborenen sowie der erworbenen Immunität in Mensch und Maus als Reaktion auf eine Mtb-Infektion hin. In dieser Arbeit charakterisiere ich die unterschiedliche Regulierung von T-Zell bezogenen Genen, die mit unterschiedlich ausgeprägten Phänotypen bei stark oder schwach TB-anfälligen Mausstämmen korrespondiert. Darüber hinaus habe ich den 21. Tag nach einer Tuberkuloseinfektion in Mäusen als Zeitpunkt ermittelt, der die Transkriptionsantworten in den untersuchten humanen Kohorten am besten widerspiegelt. Die angewandten Ansätze erleichtern die Auswahl des am besten geeigneten Tiermodells für die Erforschung der humanen Immunantwort auf eine ausgewählte Krankheit und liefern die Basis für ein besseres Verständnis der unterschiedlichen Krankheitsverläufe in Mtb-infizierten Patienten. / Over 10 million tuberculosis (TB) cases are being reported annually and the World Health Organization (WHO) estimates that up to the 1/3 of the world population is infected with Mycobacterium tuberculosis (Mtb). Between 5 and 10% of the latently infected individuals develop TB during their lifetime. Yet, despite over 100 years of research since Mtb has been identified, we are not able to define all the factors which are responsible for the different infection outcomes in the hosts. In this thesis I investigate the variability in the response to TB presented by different hosts. In one approach, I collect publicly available transcriptomic datasets from TB patients and healthy donors. Using Gene Set Enrichment Analysis (GSEA) I examine transcriptional profiles of individuals with TB. In particular, focus is brought to interferon (IFN) signaling which has been previously described as crucial for the disease outcome. I show that patients lacking IFN signature are present in the studied cohorts and investigate whether these patients present different phenotype than patients with strong regulation of IFN responses. Moreover, by focusing on patients lacking IFN response I try to unearth mechanisms present in all patient groups but dominated by the signal of IFN response. I show that strong regulation of IFN genes is related to severe pathology in the lungs of TB patients and that it is reflected by the levels of IFN-inducible cytokines in blood of healthy volunteers after vaccination with FLUAD® vaccine. Using Machine Learning (ML) methods, I identify and compare transcriptomic signatures of the patients presenting and lacking the IFN response. In the second approach I study the differences in the transcriptional responses to Mtb infection in human cohorts and two different mouse models. The immunity in infection, inflammation and malignancy differs markedly in man and mouse. Nevertheless, there are elements of immune system which have been conserved between the species. I propose a novel data integration approach which identifies concordant and discordant elements of gene expression regulation in heterologous datasets. The analysis is based on publicly available as well as novel experimental data acquired thanks to collaboration with my colleagues from the Department of Immunology and Microarray Core Facility of Max Planck Institute for Infection Biology (MPIIB). Additionally, I focus on the comparison of human and murine transcriptional responses to TB in whole blood (WB) and in macrophages. The results indicate profound differences between regulation of innate and adaptive immunity in man and mouse upon Mtb infection. I characterize differential regulation of T-cell related genes corresponding to the differences in phenotype between TB high and low susceptible mouse strains and identify the time point of 21 days p.i. of mice as best reflection of transcriptional responses in the studied human cohorts. The implemented approaches facilitate the choice of an appropriate animal model for studies of the human immune response to a particular disease and provide the basis for better understanding of differences in the outcomes of Mtb infection in individual hosts.

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2003. / Includes bibliographical references (leaves 83-89). / This thesis seeks to examine the extent of the role that the Industrial Technology Research Institute (ITRI) played in Taiwan's high-technological development and whether developing countries of today can promote such development by creating similar institutional arrangements. Literature on innovation systems was reviewed, particularly national innovation systems and the role of R&D institutions within these. Taiwan's recent economic success, deemed attributable to economic and institutional reforms in recent decades, was also studied. In depth analysis was carried out of its leading high-technological research institute, ITRI, which bridges the gap between industry and academia. Although the case of Taiwan is sometimes presented as a unique example of industrial success of an SME-based state, this thesis argues that this success was possible because the research and development process had a large institute at its core. One way of creating such a research scale is by merging existing institutes, a process that would result in more efficient use of capital and human resources. The case of high-technological development in Pakistan is briefly assessed in order to gauge how its existing institutions structure could be amended to allow such changes to be made. The study concludes with the following three main points: (i) scale is an important factor: Taiwan's SME-based industry was able to succeed because of a large research institute at its core; (ii) in developing countries, governments decide which form of high-technology to pursue and when; thus, timing and choice of sector are important; and (iii) political leadership was seen to be important in the case of Taiwan's development in high-technology, and can play a key role in developing countries of today. / by Fareeha Yasmin Iqbal. / M.C.P.

ABSTRACT The effect of the urban landscape development influenced by the urban architecture movement through the means of participation during the evaluation process of the Yuan-Ye Building Landscape Award, sponsored by the Kaohsiung Judicious Creative Architecture Association is presented. The optimum resolutions of the public issues and policies through applying the mechanism of the participation of the public during the judging process have made the Award distinct from the others. In the process, the Award has implemented the following steps to accomplish the objectives: applying the resource control from top down with a communication channel from bottom up, creating a new type of workgroup among the sponsors, professionals, and the public through participation of working with and learning from each other, forming of informal team to reduce miscommunications between the fields, conducting community meetings and revising questionnaire to modify participation strategy to seek urban space issues and to set the judging criteria, and, finally, offering realistic solutions to resolve the actual urban space issues. To act on a theory as a study method, the Award, through the participants¡¦ comments of different roles to the situations and environments in the evaluation process while maintaining a comprehensive recordation, has developed a model of execution with suggested steps. In the process of action, with the complexity of the model and the growing number of participants and societies, the scale and the influenced range expanded gradually. In order to clear the situations, the report divided the system into two stages, the development stage and the fulfillment stage. Each stage has different steps with different events. The events such as the milestone of the event, the cooperation of the government, the reaction of the professionals and the expected result, all will interact on each other causing different effects to the whole operation. The feedback of the action can be extended to analysis the mechanism and interact of the model. The suggestion of improvement can be supplied to provide helpful information for the future reference. Key words¡GArchitecture¡BYuan-Ye Award ¡BUrban landscape development¡BParticipation.