The creative destruction of existing industries as a consequence of discontinuous technological change is a central theme in the literature on industrial innovation and technological development. Established competence-based and market-based explanations of this phenomenon argue that incumbents are seriously challenged only by ‘competence-destroying’ or ‘disruptive’ innovations, which make their existing knowledge base or business models obsolete and leave them vulnerable to attacks from new entrants. This paper challenges these arguments. With detailed empirical analyses of the automotive and gas turbine industries, we demonstrate that these explanations overestimate the ability of new entrants to destroy and disrupt established industries and underestimate the capacity of incumbents to perceive the potential of new technologies and integrate them with existing capabilities. Moreover, we show how intense competition in the wake of technological discontinuities, driven entirely by incumbents, may instead result in late industry shakeouts. We develop and extend the notion of ‘creative accumulation’ as a way of conceptualizing the innovating capacity of the incumbents that appear to master such turbulence. Specifically, we argue that creative accumulation requires firms to handle a triple challenge of simultaneously (a) fine-tuning and evolving existing technologies at a rapid pace, (b) acquiring and developing new technologies and resources and (c) integrating novel and existing knowledge into superior products and solutions. / Knowledge Integration and Innovation in Transnational Enterprise

Cervix cancer affects women of all ages and causes significant morbidity and mortality. Locally advanced disease is curable with radiotherapy (RT) in about 50% of patients, although often at the expense of serious side effects. In order to improve the therapeutic ratio of tumour control versus normal tissue toxicity, conformal intensity-modulated radiotherapy (IMRT) is being investigated. However, inter- and intra-fractional motion of cervix cancer can contribute to both geographical miss of the target and overdosing of surrounding normal tissues, particularly in the setting of conformal IMRT with steep dose gradients. Defining the target volume accurately and understanding the dose consequence of these complex intra-pelvic organ dynamics during external beam radiotherapy forms the essential foundations for future treatment optimization and adaptation. This in turn will lead to improvements in tumour control and disease-free survival while minimising treatment toxicity.

Obstructive sleep apnea (OSA) severity is strongly associated with the degree of overnight peripharyngeal fluid accumulation. We hypothesized that intravenous fluid loading would cause upper airway (UA) narrowing or increase the frequency of apneas and hypopneas per hour of sleep (apnea-hypopnea index; AHI). We employed a controlled, randomized double-crossover experiment in 9 healthy men aged 23-46 years. In the control, subjects were administered approximately 80 ml of normal saline intravenously during sleep. In the intervention, subjects were administered approximately 1850 ml of saline during sleep while wearing compression stockings to localize fluid rostrally. The intervention induced nuchal fluid accumulation, resulting in an increase in neck circumference (+0.1 cm during control, +0.6 cm during intervention, P< 0.01 ) and a decrease in UA cross-sectional area (-0.08 cm2 during control, -0.43 cm2 during intervention, P = 0.023). Although the intervention did not increase the AHI (control AHI = 19.5, intervention AHI = 30.3, P = 0.249), the AHI during the intervention correlated with age (r = 0.8, P < 0.01). Thus, intravenous saline loading during sleep can narrow the UA, which in older men may induce or worsen OSA. Further studies are needed to test this hypothesis.

Cervix cancer affects women of all ages and causes significant morbidity and mortality. Locally advanced disease is curable with radiotherapy (RT) in about 50% of patients, although often at the expense of serious side effects. In order to improve the therapeutic ratio of tumour control versus normal tissue toxicity, conformal intensity-modulated radiotherapy (IMRT) is being investigated. However, inter- and intra-fractional motion of cervix cancer can contribute to both geographical miss of the target and overdosing of surrounding normal tissues, particularly in the setting of conformal IMRT with steep dose gradients. Defining the target volume accurately and understanding the dose consequence of these complex intra-pelvic organ dynamics during external beam radiotherapy forms the essential foundations for future treatment optimization and adaptation. This in turn will lead to improvements in tumour control and disease-free survival while minimising treatment toxicity.

Obstructive sleep apnea (OSA) severity is strongly associated with the degree of overnight peripharyngeal fluid accumulation. We hypothesized that intravenous fluid loading would cause upper airway (UA) narrowing or increase the frequency of apneas and hypopneas per hour of sleep (apnea-hypopnea index; AHI). We employed a controlled, randomized double-crossover experiment in 9 healthy men aged 23-46 years. In the control, subjects were administered approximately 80 ml of normal saline intravenously during sleep. In the intervention, subjects were administered approximately 1850 ml of saline during sleep while wearing compression stockings to localize fluid rostrally. The intervention induced nuchal fluid accumulation, resulting in an increase in neck circumference (+0.1 cm during control, +0.6 cm during intervention, P< 0.01 ) and a decrease in UA cross-sectional area (-0.08 cm2 during control, -0.43 cm2 during intervention, P = 0.023). Although the intervention did not increase the AHI (control AHI = 19.5, intervention AHI = 30.3, P = 0.249), the AHI during the intervention correlated with age (r = 0.8, P < 0.01). Thus, intravenous saline loading during sleep can narrow the UA, which in older men may induce or worsen OSA. Further studies are needed to test this hypothesis.

This dissertation evaluates the empirical relation between the value-added tax (VAT) and the level of aggregate consumption. Furthermore, it develops a theoretical framework and an empirical analysis to study the impact of the VAT, as a form of taxing consumption, on capital accumulation, productivity growth, and overall economic growth. While recent theoretical work shows that the VAT may boost capital accumulation and growth by encouraging more savings, we find that the net impact of consumption taxes on growth and its sources is theoretically ambiguous, and depends on the interaction between utility parameters, the interest rate, and the tax structure. Moreover, we develop a theoretical model to study the tax design problem in order to rationalize the observed variation in effective VAT rates over time in our sample. This framework considers both equity and efficiency as important factors determining optimal tax structure, and we identify conditions under which taxes could be evolving or constant over time. Empirically, we use a panel of 15 European Union countries and employ the recently developed GMM dynamic panel techniques. After controlling for the potential biases associated with persistence, endogeneity, simultaneity, measurement error, omitted variables, and unobserved country-specific effects, we find that (i) the VAT exerts a negative impact on the level of aggregate consumption, (ii) the VAT affects physical capital accumulation positively, which feeds through to overall GDP growth, and (iii) productivity growth seems to be a less relevant channel for the VAT to influence economic growth.

Hydrological models have been developed to estimate snow accumulation, snowmelt and snowmelt runoff on the Canadian Prairies; however, their proper scale of application is unknown in the Prairie environment. The first objective of this thesis is to examine the proper scale for pre-melt snow accumulation as snow water equivalent (SWE) and snowmelt in a Prairie first order basin. Spatially distributed and spatially aggregated approaches were used to calculate SWE and snowmelt at St. Denis National Wildlife Area (SDNWA). Both approaches used models with similar physics, but differed in the model scale at which calculations were carried out. The simulated pre-melt SWE, cumulative seasonal SWE, and daily snowmelt from the two modelling approaches were compared to field observations of pre-melt SWE, cumulative seasonal SWE, and daily snowmelt; comparisons of areal cumulative seasonal SWE, areal snowmelt, snowmelt duration, and snow-covered area were also conducted between two modelling approaches. Results from these comparisons showed that both approaches had reasonable and similar accuracy in estimation of SWE and snowmelt. The spatially aggregated approach was more computationally efficient and was selected as a modelling scale for small-sized prairie basins. <p>Another objective of this thesis is to derive a snow hydrology model for the Canadian Prairies. Physically-based hydrological models were assembled in the Cold Regions Hydrological Model Platform (CRHM) using the aggregated approach. Tests of pre-melt SWE and surface snowmelt runoff were conducted at two basins in Saskatchewan Creighton Tributary of Bad Lake and Wetland 109, St. Denis. Results showed that the snow hydrology model had a reasonable capability to simulate SWE and snowmelt runoff to the stream and wetland. <p>Droughts are natural hazards that develop frequently on the Canadian Prairies. Analyzing the impact of drought on hydrological processes and water supply is another objective of this thesis. Synthetic drought scenarios were proposed for the Creighton Tributary of Bad Lake and the corresponding impacts on the snowmelt runoff-related processes were examined. Results indicated that wind redistribution of snow was very sensitive to drought conditions, sublimation of blowing snow and snow-covered period were sensitive to drought, but winter evaporation and infiltration did not show strong trend. The results also showed that drought conditions had magnified effects on the snowmelt runoff and could cause cessation of streamflow. Also, the impacts of the recent 1999-2005 drought on the snowmelt hydrology were investigated at St. Denis. Results illustrated that three-years (1999-2002) of severe winter drought were followed by a normal year (2002-03) and then a two-year (2003-05) recovery period, and then returning to normal (2005-06). Results showed that both snowfall and rainfall during hydrological winter were consistently low for severe drought and surface snowmelt runoff was very much lower during severe drought, about 45-65 mm less compared to that in the normal periods.

The dissertation develops the concept of repurposing as a means for thinking with activists and the issues they confront. It moves alongside pirate television collective insu^tv as they draw on a variety of histories, traditions and technological resources for their practices. Repurposing functions on multiple levels and at multiple scales, from the recycling of materials and spaces to the harnessing and relaying of encounters and events within an ever-expanding field of social relations. When seen as a way of connecting activist groups and communities, the repurposing of media contributes to strengthening an often fragmented and conflicted activist field. Indeed, insu^tv’s use of information and technology brings to the fore the value of media activism for the creation of social assemblages in which the “media” literally mediates between individuals and among individuals and their environment, instituting and developing an ontogenetic relation (Simondon, 1989). Yet, rather than simply making sense of insu^tv’s practices, the concept of repurposing also provokes a discussion regarding the ethics of connection. For insu^tv, this connective ethics can be understood as a set of rules and principles that facilitate the evaluation of actions, communication, and thought according to an immanent mode of collective existence (Deleuze, 1988; Simondon, 1989). For the author, herself a member of insu^tv and an academic researcher, this immanent position helps challenge traditional models of knowing and envisioning social change and instead proposes alternatives that attend to the singularity and relation among new political movements, and to the political potential of research methods that focus on process and fold activism into academia. The methodology is inspired by the militant research methods of the Italian Autonomia movement (conricerca or inchiesta), as developed and performed by activists themselves. While attending to the complexity of social struggles, the concept of repurposing enables an approach to research and experimentation as modes of sociability, where these modes are themselves repurposed through an ethics of connection. This line informs the relation between ethics and subjectivation, as well as between ethics and micropolitics, facilitating the emergence of new modes of political action through the repurposing of the social field itself.

The dissertation develops the concept of repurposing as a means for thinking with activists and the issues they confront. It moves alongside pirate television collective insu^tv as they draw on a variety of histories, traditions and technological resources for their practices. Repurposing functions on multiple levels and at multiple scales, from the recycling of materials and spaces to the harnessing and relaying of encounters and events within an ever-expanding field of social relations. When seen as a way of connecting activist groups and communities, the repurposing of media contributes to strengthening an often fragmented and conflicted activist field. Indeed, insu^tv’s use of information and technology brings to the fore the value of media activism for the creation of social assemblages in which the “media” literally mediates between individuals and among individuals and their environment, instituting and developing an ontogenetic relation (Simondon, 1989). Yet, rather than simply making sense of insu^tv’s practices, the concept of repurposing also provokes a discussion regarding the ethics of connection. For insu^tv, this connective ethics can be understood as a set of rules and principles that facilitate the evaluation of actions, communication, and thought according to an immanent mode of collective existence (Deleuze, 1988; Simondon, 1989). For the author, herself a member of insu^tv and an academic researcher, this immanent position helps challenge traditional models of knowing and envisioning social change and instead proposes alternatives that attend to the singularity and relation among new political movements, and to the political potential of research methods that focus on process and fold activism into academia. The methodology is inspired by the militant research methods of the Italian Autonomia movement (conricerca or inchiesta), as developed and performed by activists themselves. While attending to the complexity of social struggles, the concept of repurposing enables an approach to research and experimentation as modes of sociability, where these modes are themselves repurposed through an ethics of connection. This line informs the relation between ethics and subjectivation, as well as between ethics and micropolitics, facilitating the emergence of new modes of political action through the repurposing of the social field itself.

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