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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Análise da macroturbulência do escoamento em escadas para peixes por bacias sucessivas

Sanagiotto, Daniela Guzzon January 2007 (has links)
Os mecanismos de transposição de peixes (MTP) são estruturas ou sistemas que possibilitam a migração da ictiofauna entre as partes de jusante/montante/jusante de uma barragem. As escadas para peixes representam um dos tipos de MTP mais conhecidos no mundo e apresentam diversas configurações geométricas. A escolha do tipo de escada deve atender às características natatórias dos peixes selecionados para transporem o obstáculo. Para algumas espécies, como o salmão, já se conhecem geometrias adequadas, entretanto, para a maioria das espécies isto não ocorre e muitos projetos têm demonstrado desempenho insatisfatório. No Brasil, encontra-se uma imensa diversidade de espécies de peixes, cujas características natatórias diferem em muito das apresentadas pelos salmonídeos. Este fato, associado à crescente exigência da implantação de MTP nos barramentos, através de leis estaduais ambientais, torna necessária a definição de estruturas adequadas à ictiofauna brasileira. A validação dos critérios de projeto passa, obrigatoriamente, por estudos que avaliem as características hidráulicas das estruturas propostas e a interação do fluxo com os padrões natatórios da ictiofauna. O número de pesquisas relacionadas ao funcionamento hidráulico de escadas para peixes vem crescendo, entretanto ainda são insuficientes, não existindo um consenso sobre os critérios, seja para sua caracterização completa, seja para definir sobre quais parâmetros devem ser considerados. Os padrões de turbulência do escoamento em escadas para peixes, cujas características supõem-se relacionarem-se com o grau de aceitação ou rejeição das espécies, são praticamente desconhecidos. Neste trabalho realizou-se a caracterização hidráulica através do estudo experimental, de três tipos de escadas para peixes: (1) com ranhura vertical; (2) com descarregador de superfície e (3) com orifício de fundo. As estruturas foram construídas nos laboratórios do Instituto de Pesquisas Hidráulicas da Universidade Federal do Rio Grande do Sul – IPH/UFRGS e no Laboratório Nacional de Engenharia Civil – LNEC – Portugal. As seguintes medições foram realizadas: velocidades em três direções, em diferentes planos dos tanques, com velocímetros acústicos Doppler (ADV) e níveis de água da superfície livre com pontas linimétricas e réguas graduadas. Para a estrutura com ranhura vertical ainda foram medidas as pressões médias e suas flutuações, junto ao fundo do canal, com transdutores piezoresistivos. Para cada uma das estruturas realizaram-se ensaios com três descargas. Além de definidas as características médias do escoamento, os dados de velocidades, que passaram por um processo de aplicação de filtros sem substituição, possibilitaram a avaliação de parâmetros de turbulência, entre eles a energia cinética da turbulência, a intensidade da turbulência e as tensões de Reynolds. No modelo da escada para peixes com ranhuras verticais verificou-se que os parâmetros hidráulicos estão de acordo com estruturas similares da bibliografia, entre eles, coeficiente de descarga, vazão adimensional e coeficiente de cisalhamento. Os campos de pressão junto ao fundo refletem o comportamento da superfície livre do escoamento. Através do mapeamento das velocidades dentro do tanque da escada do tipo ranhura vertical, foi possível caracterizar as duas zonas de recirculação e a região do jato principal. Os máximos valores médios de velocidade encontram-se na seção da ranhura, não excedendo 1,00 m/s (no modelo). Além disso, foi possível reconhecer as regiões de maior energia cinética da turbulência que apresentaram valores de até 1000 cm2/s2 na região do jato principal, as quais coincidem com as zonas de maiores tensões de Reynolds da ordem de até 30 N/m2. A partir das velocidades médias e em função das velocidades de nado dos peixes obtidos na literatura, foi possível a identificação de locais que atuam como “barreiras” ao deslocamento de determinada espécie. A avaliação qualitativa do comportamento da trajetória dos peixes dentro dos tanques mostrou-se de acordo com a definição destas “barreiras” hidráulicas e com a avaliação do comportamento dos campos de energia cinética da turbulência e das tensões de Reynolds. No modelo da escada do tipo descarregador de superfície observaram-se as máximas velocidades médias sobre o descarregador, com valores de até 1,73 m/s. Verifica-se que na maior parte do tanque as velocidades médias não ultrapassam 40% da velocidade potencial. Foram encontrados valores de energia cinética da turbulência até 2000 cm2/s2, com valores na maior parte do tanque em torno de 200 cm2/s2. Quanto aos campos de tensões de Reynolds, têm-se, na maior parte do tanque, os valores entre −5 e 5 N/m2, sendo que na região do jato mergulhante, os valores chegam até 30 N/m2. Na escada com orifícios de fundo verificaram-se as maiores velocidades médias nos planos sob influência do fluxo principal proveniente do orifício. Não foi possível a medição da velocidade na seção da abertura, sendo que os valores medidos no tanque não ultrapassaram 50% da velocidade potencial. Os máximos valores de energia cinética da turbulência atingem até 2000 cm2/s2 junto ao fundo, enquanto na região central do tanque, o valor médio é um pouco inferior a 200 cm2/s2. Os valores de tensão de Reynolds encontram-se entre −30 e 30 N/m2, com a maioria das regiões entre −5 e 5 N/m2. Os valores máximos e médios de energia cinética da turbulência e tensões de Reynolds para os modelos com descarregador de superfície e com orifício de fundo encontram-se na mesma faixa. Isto indica que, sob o ponto de vista técnico, possivelmente o critério de escolha entre essas duas estruturas recai nas características da ictiofauna. A passagem com ranhura vertical permite a escolha da profundidade preferencial de nado. No entanto, nessa estrutura, verificase que as componentes médias e turbulentas, nas regiões de descanso, comparando-as com os valores máximos do jato principal, são superiores proporcionalmente, às observadas nas zonas de recirculação das outras duas estruturas. As informações biológicas disponíveis na literatura não permitem a definição de condições preferenciais em relação aos parâmetros de turbulência entre as estruturas aqui avaliadas. No entanto, as informações obtidas nesse trabalho indicam que a energia cinética da turbulência e as tensões de Reynolds podem ser indicativos da tolerância ou preferência dos peixes até certos níveis de turbulência. / Fish facilities are structures or systems that enable fish passage through dams or obstructions. Fishways represent one of the most common fish facilities types worldwide, presenting different geometries and designs. The choice and design of these structures must attend the fish swimming performance and biological characteristics. For some species, as salmon, there are defined designs that can be successfully applied, however, that does not occur for the majority of the species and many projects have showed unsatisfactory efficiency. In Brazil, there is an immense diversity of fish species, whose swimming characteristics are strongly different than the other known species like the salmons. This fact, associated with the increasing requirement of fish facilities implantation in dams, mainly through environmental State Laws, requires the definition of structures adapted to the Brazilian fish. The design criteria validation needs, necessarily, studies to evaluate hydraulic characteristics on structure proposals and the interaction of the flow with swimming abilities. The number of researches related to the hydraulic functioning of fishways is increasing, however they are still insufficient and there is not a consensus on the criteria, either for its complete characterization, either to define which parameters should be considered. The flow turbulence patterns in fishways, whose characteristics are assumed to be related with the degree of acceptance or rejection of the species, are practically unknown. In this study a hydraulic characterization was carried out through an experimental study, including three kinds of fishways: (1) with vertical slots; (2) with rectangular notches and (3) with bottom orifices. The facilities were set up in the Hydraulic Research Institute of the Federal University of Rio Grande do Sul (IPH/UFRGS) and in the National Laboratory of Civil Engineering – LNEC - Portugal. The following measurements were carried out: three-direction velocities, in a 3D-mesh in one pool of each structure, with Acoustic Doppler Velocimeters and water level of the free surface with a point gauge and scales. In the vertical slot fishway it was carried out complementary measurements of pressure in the bottom of the channel, with transducers. For each structure three discharges were tested. Besides defining the mean flow characteristics, the velocity time data, filtered (through a digital process) without substitution, allowed to analyze some turbulence parameters, as turbulence kinetic energy, turbulence intensity and Reynolds’ shear stresses. In the vertical slot fishway model it was verified that the hydraulic parameters are in agreement with similar structures of the literature, among them, discharge coefficient, adimensional discharge and friction factor. The bottom pressure field agrees with the behavior of the free-surface flow. Two recirculation zones and the area of the main jet were characterized through the velocities distribution inside the vertical slot fishway pool. The maximum mean velocity values were found in the slot section, not exceeding 1.00 m/s (in the model). Moreover, it was possible to recognize the areas with larger turbulence kinetic energy that presented values of up to 1000 cm²/s² in the main jet area, which correspond to the largest Reynolds’ shear stresses values of up to 30 N/m². Considering mean velocities data and fish swimming capabilities, it was possible to identify regions that are insurmountable by the fish. The qualitative approach of the fish trajectory inside the structure agrees with the insurmountable regions described through mean velocities and with the distribution of turbulence kinetic energy and Reynolds’ stresses. In the fishway model with rectangular notches, the maximum mean velocities were observed on the weir, with values of up to 1.73 m/s. In the major part of the pool, mean velocities do not surpass 40% of the potential velocity. Values up to 2000 cm²/s² for turbulence kinetic energy were found, with values in the major part of the pool close to 200 cm²/s². For Reynolds’ stresses, the major part of the structure works with values in the range of −5 and 5 N/m², and in the jet entrance pool region the values are of up to 30 N/m². In the fishway with bottom orifices the largest mean velocities were verified in the plans under influence of the main flow connecting consecutive orifices. The measurement of the velocities in the orifice section was not possible and the values measured in the pool did not exceed 50% of the potential velocity. The maximum values of turbulence kinetic energy reached up to 2000 cm²/s² close to the bottom channel, while in the central area of the pool, the mean value is lower than 200 cm2/s2. The values of Reynolds’ shear stresses are between −30 and 30 N/m2, with the major part between−5 and 5 N/m2. The maximum and mean values of turbulence kinetic energy and Reynolds’ stresses in the models with rectangular notches and with orifice are in the same range. It indicates that the choice between these two structures relapses in the fish swimming characteristics. The passage with vertical slot allows the choice of the swimming depth preference. However, in the resting areas of this structure, it is verified that the mean and turbulent components when compared with the maximum values of the main jet, are higher proportionally, to the ones observed in the recirculation zones of the other two structures. The biological information available in the literature does not allow the definition of preferential conditions in relation to the turbulence parameters among the structures here appraised. However, the information obtained in this work indicates that the turbulence kinetic energy and Reynolds’ shear stress can be indicatives of the tolerance or preference of the fish to certain turbulence levels.
42

A Novel Therapeutic Approach To Regulate CAREx8 Protein Expression Through E6-Conjugated Cell Penetrating Peptides

Compaleo, Jared D. 02 June 2023 (has links)
No description available.
43

Fractal grid-turbulence and its effects on a performance of a model of a hydrokinetic turbine

Mahfouth, Altayeb 04 January 2017 (has links)
This thesis focuses on generating real world turbulence levels in a water tunnel rotor test using fractal grids and characterizing the effect of the fractal grid generated-turbulence on the performance of hydrokinetic turbines. The research of this thesis is divided into three studies: one field study and two laboratory studies. The field study was conducted at the Canadian Hydro Kinetic Turbine Test Centre (CHTTC) on the Winnipeg River. An Acoustic Doppler Velocimeter (ADV) was used in the field study to collect flow measurements in the river. The laboratory studies were conducted at the University of Victoria (UVic) fluids research lab and the Sustainable Systems Design Lab (SSDL). In addition, the Particle Image Velocimetry (PIV) technique was used in the experiential studies to obtain quantitative information about the vector flow field along the test section, both upstream and downstream of the rotor’s plane. The first study is a field study aiming to provide real flow characteristics and turbulence properties at different depths from the free-surface to boundary layer region of a fast river current by conducting a field study in the Winnipeg River using ADV. A novel technique to deploy and control an ADV from free-surface to boundary layer in a fast-current channel is introduced in this work. Flow characteristics in the river, including mean flow velocities and turbulence intensity profiles are analyzed. The obtained results indicate that the maximum mean velocity occurs below the free-surface, suggesting that the mean velocity is independent of the channel depth. From the free-surface to half depth, it was found that changes in both the mean velocity and turbulence intensity are gradual. From mid-depth to the river bed, the mean velocity drops rapidly while the turbulence intensity increases at a fast rate. The turbulent intensity varied from 9% at the free-surface to around 17.5% near the river bed. The results of this study were used in the second lab study to help designing a fractal grid for a recirculating water flume tank. The goal was to modify the turbulence intensity in the water tunnel such that the generated turbulence was similar to that in the river at a location typical of a hydrokinetic device. The properties of fractal-generated turbulence were experimentally investigated by means of 2D Particle Image Velocimetry (PIV). The streamwise turbulent intensity profiles for different grids along the channel are presented. Additionally, visualization of the average and fluctuating flow fields are also presented. The results are in good agreement with results in literature. The third and final study investigated the power coefficient of a scale hydrokinetic turbine rotor in controlled turbulent flow (7.4 % TI), as well as in the low-turbulence smooth flow (0.5% TI) typical of lab scale testing. PIV was employed for capturing the velocity field. The results show that using realistic TI levels in the water tunnel significantly decrease the turbine’s power coefficient compared to smooth flow, highlighting the importance of considering this effect in future experimental campaigns. / Graduate
44

As constru??es adverbiais em mente: an?lise funcionalista e implica??es para o ensino de l?ngua materna

Vidal, Ros?ngela Maria Bessa 19 June 2009 (has links)
Made available in DSpace on 2014-12-17T15:07:07Z (GMT). No. of bitstreams: 1 RosangelaMBV.pdf: 716170 bytes, checksum: b171d43fe0eb6f6301e64e00b9a62b55 (MD5) Previous issue date: 2009-06-19 / This research aims at investigating the constructions with adverbials in ly, based on the view of contemporaneous linguistic functionalism, such as proposed by Giv?n, Hopper, Thompson, Traugott, Furtado da Cunha, as well as the cognitivist notion of language, through construction grammar support upon the patterns of Goldberg and the prototypes theory. The cognitive functional approach adopted here considers the change as a proper and inherent phenomenon of language and understands the linguistic phenomenon as resulting from effective use of language. Another aspect to be considered to the realization of this study is the fact that the formation adjective + ly is a word construction mechanism really productive, which generates interests on linguistic description. In a particular way, our leading objective is to exam the constructions with adverbials in ly in the context of language in use, in its oral and written forms, looking for to apprehend the meaning multiple manifestations forged in the use. Bearing this in mind, we worked with data from the Corpus Discurso & Gram?tica (Natal). There are, in the data, adverbs ended in ly that take the signification of mode, as foreseen in traditional models, but there are also other significations, for instance, the modalizador in its different manifestations. The results show that this adverb is a linguistic mark that carries in its constitution the multiss?mico and multifunctional character, which interferes extremely in the ordination of this category, assuming a position sometimes pre-verbal, sometimes post-verbal. Other aspect observed refers to the relationship between the adverb and the verb, with emphasis on the compatibility or restriction between them, option which is related to the semantic aspect. The data in analysis legitimate the use in different constructions with adverb ended in ly in various genres, as follows: personal experience narrative, retold narrative, local description, proceeding account, opinion account, both in oral as in written language / A presente pesquisa tem por objetivo investigar as constru??es com adverbiais em mente , sob o enfoque do funcionalismo ling??stico contempor?neo, tal como proposto por Giv?n, Hopper, Thompson, Traugott, Furtado da Cunha, bem como sob a no??o cognitivista da linguagem atrav?s do suporte da gram?tica de constru??o nos moldes de Goldberg e a teoria dos prot?tipos. A abordagem cognitivo-funcional aqui adotada considera a mudan?a como fen?meno pr?prio e inerente ?s l?nguas, al?m de entender o fen?meno ling??stico como resultante do uso efetivo da l?ngua. Outro aspecto a considerar para a realiza??o desta pesquisa ? o fato de a forma??o adjetivo + mente ser um mecanismo de constitui??o de palavras bastante produtivo, o que gera interesse na descri??o ling??stica. De forma particular, o objetivo norteador ? examinar as constru??es com adverbiais em mente no contexto da l?ngua em uso, na forma oral e escrita, buscando apreender as m?ltiplas manifesta??es de sentido forjadas no uso. Para este fim, lan?amos m?o de dados provenientes do Corpus Discurso & Gram?tica (Natal). Nos dados encontram-se adv?rbios terminados em mente que assumem a significa??o de modo, como previsto nos moldes tradicionais, mas tamb?m outras significa??es, como por exemplo o modalizador em suas diferentes manifesta??es. Os resultados alcan?ados demonstram que esse adv?rbio ? uma marca ling??stica que carrega em sua constitui??o o car?ter multiss?mico e o multifuncional, o que interfere sobremaneira na ordena??o dessa categoria, assumindo posi??o ora pr?-verbal, ora p?s-verbal. Outro aspecto observado refere-se ao relacionamento do adv?rbio com o verbo, com destaque para a compatibilidade ou a restri??o entre eles, op??o que se vincula ao aspecto sem?ntico. Os dados em an?lise legitimam o uso de diferentes constru??es com adv?rbio terminado em mente em diversos g?neros textuais, quais sejam a narrativa de experi?ncia pessoal, narrativa recontada, descri??o de local, relato de procedimento e relato de opini?o, tanto na l?ngua oral, quanto na escrita
45

Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality

Goka, Edward Anthony Chilongo January 2014 (has links)
Introduction: Epidemiological studies have indicated that 5-38% of influenza like illnesses (ILI) develop into severe disease due to, among others, factors such as; underlying chronic diseases, age, pregnancy, and viral mutations. There are suggestions that dual or multiple virus infections may affect disease severity. This study investigated the association between co-infection between influenza A viruses and other respiratory viruses and disease severity. Methodology: Datum for samples from North West England tested between January 2007 and June 2012 was analysed for patterns of co-infection between influenza A viruses and ten respiratory viruses. Risk of hospitalization to a general ward ICU or death in single versus mixed infections was assessed using multiple logistic regression models. Results: One or more viruses were identified in 37.8% (11,715/30,975) of samples, of which 10.4% (1,214) were mixed infections and 89.6% (10,501) were single infections. Among patients with influenza A(H1N1)pdm09, co-infections occurred in 4.7% (137⁄2,879) vs. 6.5% (59⁄902) in those with seasonal influenza A virus infection. In general, patients with mixed respiratory virus infections had a higher risk of admission to a general ward (OR: 1.43, 95% CI: 1.2 – 1.7, p = <0.0001) than those with a single infection. Co-infection between seasonal influenza A viruses and influenza B virus was associated with a significant increase in the risk of admission to ICU/ death (OR: 22.0, 95% CI: 2.21 – 219.8 p = 0.008). RSV/seasonal influenza A viruses co-infection also associated with increased risk but this was not statistically significant. For the pandemic influenza A(H1N1)pdm09 virus, RSV and AdV co-infection increased risk of hospitalization to a general ward, whereas Flu B increased risk of admission to ICU/ death, but none of these were statistically significant. Considering only single infections, RSV and hPIV1-3 increased risk of admission to a general ward (OR: 1.49, 95% CI: 1.28 – 1.73, p = <0.0001 and OR: 1.34, 95% CI: 1.003 – 1.8, p = 0.05) and admission to ICU/ death (OR: 1.5, 95% CI: 1.20 – 2.0, p = <0.0001 and OR: 1.60, 95% CI: 1.02 – 2.40, p = 0.04). Conclusion: Co-infection is a significant predictor of disease outcome; there is insufficient public health data on this subject as not all samples sent for investigation of respiratory virus infection are tested for all respiratory viruses. Integration of testing for respiratory viruses’ co-infections into routine clinical practice and R&D on integrated drugs and vaccines for influenza A&B, RSV, and AdV, and development of multi-target diagnostic tests is encouraged.

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