<p>U doktorskoj disertaciji evaluirani su interkorelacioni rezultati odnosa ključnih fizičko-hemijskih parametara i katjona metala u površinskoj vodi Dunava, Tise (na po tri selektovana reprezentativna lokaliteta) i kanala Dunav-Tisa-Dunav (na dva lokaliteta). U<br />Kanalu Dunav-Tisa-Dunav praćene su i rezidualne katjonske koncentracije metala u sedimentu. Na osnovu podataka prisutnosti katjona metala u heterogenom sistemu tečno/čvrsto izračunate su po prvi put konstante podeonih procesa za ispitivane katjone metala. Primenom multivarijantnih statističkih metoda analizirani su korelacioni odnosi između ključnih fizičko-hemijskih parametara i koncentracionih nivoa rezidula katjona teških, lakih i semimetala. Faktorskom analizom (PCA) i klaster analizom sa dendogramima tumačeni, analizirani i diskutovani su dobijeni rezultati. Za optimalnog uočavanja korelacionih odnosa primenjeno je unapređeno rangiranje određenih skupova podataka (interkorelacije ključnih fizičko-hemijskih parametara i rezidua katjona metala) i grafički prikazanih Haseovih dijagrama primenom DART softvera (Decision Analysis by Ranking Techniques) za definisani model procene uticaja raspodele katjona toksičnih metala u heterogenom sistemu tečno/čvrsto na kvalitet površinskih voda.</p> / <p>In the doctoral thesis are evaluated inter correlational results of key physicochemical parameters and metal cations in surface water of Danube, Tisa (on three selected representative sampling points) and canal Danube-Tisa-Danube (on two sampling sites). In the canal Danube-Tisa-Danube are also followed residual metal cations concentrations in sediment. Based on metal cations presence data in heterogeneous system liquid/solid for the first time partitioning processes constants are calculated for<br />selected metal cations. Appling multivariate statistical methods correlations between key physicochemical parameters and concentration levels of residual heavy, light and semimetals cations are analysed. Using factorial analyse (PCA) and cluster analyse with dendograms obtained results were interpreted, analysed and discussed. For optimal comprehension of correlations, advanced method ranking of finite order sets is applied (inter correlations key physicochemical parameters and residual metal cations) and graphically shown Hasse diagrams obtained by DART software (Decision Analysis by Ranking Techniques) for defined impact assessment model of toxic metal cations partitioning in heterogeneous system liquid/solid for surface water quality.</p>

<p>&Scaron;irom sveta, karcinom bronha je i dalje vodeći po incidenci i mortalitetu, sa 2,1 milion novih slučajeva i predviđenih 1,8 smrtnih ishoda u 2018. godini. Karcinom bronha predstavlja skoro petinu (18,4%) svih smrtnih ishoda od karcinoma. Istraživanje je sprovedeno kao retrospektivna studija za period 2010-2016 godine. Svi podaci potrebni za sprovođenje ovog istraživanja direktno su prikupljeni iz zdravstvenog informacionog sistema i registra za karcinom bronha Instituta za plućne bolesti Vojvodine (IPBV), koji je referentna ustanova za pacijente sa karcinomom bronha za celu Autonomnu Pokrajinu Vojvodinu. Cilj rada je bio da se utvrdi uticaj demografskih i kliničko-patololo&scaron;kih karakteristika na ukupno vreme preživljavanja kod bolesnika sa karcinomom bronha, kao i da se izradi geoprostorna analiza incidencije i mortaliteta od karcinoma bronha na teritoriji Vojvodine. Podaci o broju novoobolelih i broju umrlih pacijenata potrebni za analizu incidencije i mortaliteta prikupljeni su od lokalnih Instituta za javno zdravlje za svaki od sedam okruga. Za potrebe analize overall survivall, survival rate ukupno je obuhvaćeno 8142 bolesnika lečenih u IPBV, od kojih je nakon provere uključujućih i isključujućih kriterijuma, u konačnu analizu u&scaron;lo njih 7540. Za potrebe analize incidencije i mortaliteta prikupljeni su podaci od lokalnih Instituta za javno zdravlje za svaki od sedam okruga i ukupno je uključeno 21915 pacijenata. Od ukupno 7540 bolesnika, bilo je 5456 (72,4%) mu&scaron;karaca i 2084 (27,6%) žena. Prosečna starost bolesnika iznosila je 63,4&plusmn;8,85 godina, Najveći broj bolesnika su bili pu&scaron;ači, njih 4911 (65,1%), biv&scaron;ih pu&scaron;ača je bilo 1995 (26,5%), dok je najmanje bilo nepu&scaron;ača, svega 634 (8,4%). Srednja vrednost indeksa paklo-godina (pack-years) iznosila je 50,57&plusmn;28,80. Posmatrano prema bračnom statusu, najvi&scaron;e bolesnika je bilo oženjeno/udato, njih 5348 (70,9%). Najveći broj bolesnika je ocenio svoj socioekonomski status kao osrednji, njih 4912 (65,1%). Broj bolesnika sa ECOG performans statusom 1 bio je 5679 (75,3%), njih 840 (11,1%) je imalo ECOG performans status 2, dok je ECOG performans status 0 imao 451 (6,0%) bolesnik. Najveći broj bolesnika bio je dijagnostikovan u IV stadijumu bolesti 3108 (41,2%), zatim u IIIB 1886 (25,0%), IIIA 1401 (18,6%), dok je u IA stadijumu dijagnostikovano najmanje bolesnika, njih 234 (3,1%). Najveći broj bolesnika imao je potvrđenu dijagnozu adenokarcinoma, njih 3342 (44,3%), zatim skvamoznog karcinoma 2472 (32,8%), mikrocelularnog karcinoma 1386 (18,4%). Od ukupnog broja bolesnika, tokom perioda praćenja preminulo je njih 6420 (85,1%), dok je 1120 (14,9%) bolesnika bilo živo. Prosečno vreme preživljavanja mu&scaron;karaca bilo je 17,116 meseci, a žena 23,193 meseca. Mu&scaron;karci oboleli od karcinoma bronha statistički značajno (p=0,000) kraće su živeli u odnosu na žene. Analiza kumulativnog preživljavanja bolesnika pokazala je da je postojala statistički značajna razlika u preživljavanju u odnosu na pol kod podtipova adenokarcinom (p=0,000), skvamozni karcinom (p=0,000) i mikrocelularni karcinom (p=0,001). Statistički značajna razlika u preživljavanju postojala je i u odnosu na starost, mesto stanovanja, tip tumora, stadijum bolesti, ECOG, pu&scaron;ački status i TNM stadijum bolesti (p=0,000). Ukupno jednogodi&scaron;nje preživljavanje obolelih od karcinoma bronha iznosilo je 32,5%, skvamoznog karcinoma 37,3%, adenokarcinoma 33,4% i mikrocelularnog karcinoma 20,9%. Ukupno trogodi&scaron;nje preživljavanje obolelih od karcinoma bronha iznosilo je 9,2%, skvamoznog karcinoma 10,8%, adenokarcinoma 10,7% i mikrocelularnog karcinoma 2,0%. Ukupno petogodi&scaron;nje preživljavanje obolelih od karcinoma bronha iznosilo je 5,0%, kod skvamoznog karcinoma 6,1%, adenokarcinoma 5,4% i mikrocelularnog karcinoma 1,3%. Ukupno jednogodi&scaron;nje preživljavanje obolelih od karcinoma bronha u 1A stadijumu iznosilo je 78,1%, u 1B stadijumu 73,2%, 2A stadijumu 70,4%, 2B stadijumu 52,1%, 3A stadijumu 42,3%, 3B stadijumu 28,3%, dok je u 4 stadijumu bolesti ukupno jednogodi&scaron;nje preživljavanje bilo 17,9%. Ukupno trogodi&scaron;nje preživljavanje obolelih od karcinoma bronha u 1A stadijumu iznosilo je 40,8%, u 1B stadijumu 37,5%, 2A stadijumu 31,2%, 2B stadijumu 21,6%, 3A stadijumu 9,7%, 3B stadijumu 5,5%, dok je u 4 stadijumu bolesti ukupno trogodi&scaron;nje preživljavanje bilo 2,9%. Ukupno petogodi&scaron;nje preživljavanje obolelih od karcinoma bronha u 1A stadijumu iznosilo je 32,1%, u 1B stadijumu 19,3%, 2A stadijumu 16,2%, 2B stadijumu 13,3%, 3A stadijumu 4,4%, 3B stadijumu 2,6%, dok je u 4 stadijumu bolesti ukupno petogodi&scaron;nje preživljavanje bilo 1,6%. Kao nezavisni prediktori preživljavanja izdvojeni su mu&scaron;ki pol, starost preko 60 godina, ECOG performans status veći od 2, pu&scaron;ačka navika, lo&scaron;iji socioekonomski status, stadijum IV bolesti, T4 status, M1b status i mikrokarcinom kao tip tumora (p=0,000). Incidencija karcinoma bronha za mu&scaron;karce iznosila je 118,9 na 100000 stanovnika, a za žene 43,3 na 100000 stanovnika. Standardizovana stopa incidencije karcinoma bronha za mu&scaron;karce iznosila je 65,4 na 100000 stanovnika, a za žene 21,7 na 100000 stanovnika. Prema okruzima je postojala statistički značajna razlika (p=0,001). Stopa mortaliteta od karcinoma bronha za mu&scaron;karce iznosila 125,1 na 100000 stanovnika, a za žene 43,8 na 100000 stanovnika. Standardizovana stopa mortaliteta od karcinoma bronha za mu&scaron;karce iznosila 67,6 na 100000 stanovnika, a za žene 20,9 na 100000 stanovnika. Prema okruzima je postojala statistički značajna razlika (p=0,001). Analizom prikupljenih podataka utvrđeno je da postoji statistički značajna razlika u ukupnom vremenu preživljavanja pacijenata sa dijagnostikovanim karcinomom bronha u odnosu na pol (p=0,000), starosnu dob (p=0,000), mesto stanovanja (p=0,014), pu&scaron;ački status (p=0,001), ECOG performans status (p=0,000) i socioekonosmski status (p=0,000). Postoji statistički značajna razlika u ukupnom vremenu preživljavanja pacijenata sa dijagnostikovanim karcinomom bronha u odsnosu na tip tumora (p=0,000), stadijum bolesti (p=0,000), T-deskriptor (p=0,000), N-deskriptor (p=0,000) i M-deskriptor (p=0,000). Utvrđeno je da ukupno jednogodi&scaron;nje preživljavanje obolelih od karcinoma bronha iznosi 32,5%, trogodi&scaron;nje preživljavanje obolelih od karcinoma bronha iznosi 9,2%, a petogodi&scaron;nje preživljavanje iznosi 5,0%. Utvrđeno je da su nezavisni prediktori preživljavanja mu&scaron;ki pol, starost preko 60 godina, ECOG performans status 2 i veći, pu&scaron;ačka navika, lo&scaron;iji socioekonomski status, stadijum IV bolesti, T4 status, M1b status i mikroculularni karcinom kao tip tumora. Urađena je analiza incidencije i mortaliteta od karcinoma bronha na teritoriji AP Vojvodine i utvrđeno je da postoje značajne regionalne razlike u incidenciji i mortalitetu od karcinoma bronha na teritoriji AP Vojvodine.</p> / <p>Worldwide, lung cancer remains the leading cause of cancer incidencije and mortality, with 2.1 million new lung cancer cases and 1.8 million deaths predicted in 2018. Methodology: For the purpose of this retrospective study we collected data of 21915 patients from seven Public Health Institutes, one for each district. This data was categorized by five-year age groups during 2010&ndash;2016. Survival analysis data of 8142 patients was collected from the Institute for Pulmonary Diseases of Vojvodina Hospital Information System and the Lung Cancer Registry. The primary objective was to determine the impact on overall survival by assessing demographic and clinical pathological characteristics in these patients. The secondary objective was to analyze the incidencije and mortality of lung cancer in the region of Vojvodina. Incidencije and mortality rates were directly age-standardized to the World and Europe Standard Population. A total of 7540 patients were eligible for the survival analysis, 5456 (72.4%) males and 2084 (27.6%) females. The average survival time, including all stages and cancer types was 17.1 months for men and 23.2 months for women (p = 0.000). There was statistically significant difference in survival time by gender in subtypes of adenocarcinoma (p = 0.000), squamous cell carcinoma (p= 0.000) and microcellular carcinoma (p = 0.001). Analysis showed significant difference in survival by age (p = 0.000), cancer type (p = 0.000), stage of the disease (p = 0.000), ECOG performance status (p = 0.000), smoking status (p = 0.001), TNM stage of disease (p = 0.000) and among districts (p = 0.014). Male gender (p = 0.000), age over 60 (p = 0.000), ECOG performance status 2 and greater (p = 0.000), smoking habit (p = 0.002), lower socioeconomic status (p = 0.000), stage IV of disease (p = 0.000) and small cell lung cancer as tumor type (p = 0.000) were identified as independent prognostic factors. One-year survival in 1A stage was 78.1%, in 1B stage 73.2%, 2A stage 70.4%, 2B stage 52.1%, 3A stage 42.3%, 3B stage 28.3 %, while in stage 4 was 17.9%. Three-year survival in 1A stage was 40.8%, in 1B stage 37.5%, 2A stage 31.2%, 2B stage 21.6%, 3A stage 9.7%, 3B stage 5.5 %, while in stage 4 was 2.9%. Five-year in 1A stage is 32.1%, in 1B stage 19.3%, 2A stage 16.2%, 2B stage 13.3%, 3A stage 4.4%, 3B stage 2.6 %, while in stage 4 was 1.6%. The incidencije rate was 118.9 per 100000 for males and 43.3 per 100000 for women. The standardized incidencije rate was 65.4 per 100000 for males and 21.7 per 100000 for females. There was a statistically significant difference by districts (p = 0.001). Mortality rate was 125.1 per 100000 for males and 43.8 per 100000 for females. The standardized mortality rate was 67.6 per 100000 for males and 20.9 per 100000 for females. There was also a statistically significant difference by district (p = 0.001). There was a statistically significant difference in overall survival by gender (p = 0.000), age (p = 0.000), place of residence (p = 0.014), smoking status (p = 0.001), ECOG performance status (p = 0.000), and socioeconomic status (p = 0.000). There was also a statistically significant difference in the overall survival by tumor type (p = 0.000), stage of disease (p = 0.000), T-descriptor (p = 0.000), N-descriptor (p = 0.000), and M-descriptor (p = 0.000). One-year survival rate was 32.5%, three-year survival was 9.2%, and five-year survival rate was 5.0%. Incidencije and mortality rates data were analyzed for the territory of Vojvodina, and it was found that there were significant regional differences.</p>

<p>Predmet&nbsp; istraživanja ove&nbsp; doktorske&nbsp; disertacije&nbsp; su srednje&nbsp; i&nbsp; gornje&nbsp; pleistocene&nbsp; lesno-paleozemlji&scaron;ne sekvence&nbsp; (LPS)&nbsp; u&nbsp; dolini&nbsp; Južne Morave&nbsp; na&nbsp; profilima&nbsp; ciglana&nbsp; u&nbsp; Stalaću i Belotincu.&nbsp; Ove&nbsp; LPC&nbsp; predstavljaju jedinstven&nbsp; kontinentalni&nbsp; arhiv&nbsp; paleoklimatskih&nbsp; i paleoekolo&scaron;kih promena&nbsp; tokom&nbsp; pleistocena&nbsp; u&nbsp; ovom&nbsp; delu&nbsp; Balkanskog&nbsp; poluostrva.&nbsp; Nakon detalʁnihterenskih istraživanjai uzorkovanja na pomenutim lesnim profilima, razmatrano je vi&scaron;e istraživačkihproblema.&nbsp; Izvr&scaron;eno&nbsp; jepedo- i lito-stratigrafsko opisivanje&nbsp; naoba profila.&nbsp; Na njima je&nbsp; zapaženo nekoliko&nbsp; metara&nbsp; moćnih glacijalnih&nbsp; lesnih&nbsp; horizonata&nbsp; i nekoliko&nbsp; interglacijalnih<br />pedokomleksa,&nbsp; koji&nbsp; se vizuelno&nbsp; jasno&nbsp; razlikuju.&nbsp; Izvr&scaron;ena&nbsp; je rekonstrukcija&nbsp; relʁefa na&nbsp; osnovu prostornih odnosa LPS. Ukupna deblʁinaanalizirananih LPS iznosi:&nbsp; u&nbsp; Stalaću&nbsp; približno20,5 m, gde&nbsp; je&nbsp; zapaženo po&nbsp; sedam&nbsp; pedokompleksa&nbsp; i&nbsp; lesnih&nbsp; horizonata,&nbsp; dok&nbsp; je&nbsp; deblʁina u&nbsp; Belotincu analiziranih LPS 8 m. Vrednosti magnetnog susceptibiliteta (MS)&nbsp; u&nbsp; Stalaćuukazuje da poreklo pra&scaron;kastog fluvijalnog materijala&nbsp; potiče&nbsp; izdva nezavisna izvora.&nbsp; Veće vrednosti&nbsp; MS prisutne&nbsp; su u materijalu koji&nbsp; potiče&nbsp; iz sliva Zapadne Morave. Dok manje vrednosti ukazuju da&nbsp; je poreklo materijala iz JužneMorave. U Belotincu manje vrednosti MS ukazuju da je poreklo materijala iz<br />sliva&nbsp; Južne Morave.&nbsp; Tumačenjem rezultata apsolutnog luminescentnog datiranja&nbsp; na oba profila ukazuju da&nbsp; su LPS nastajale tokom poslednjih ~ 350.000 godina u&nbsp; Stalaću i ~ 35.500 godina u Belotincu. Granulometrijski sastav LPS u Stalaću&nbsp; je&nbsp; sačinjen od pet različitih frakcija&nbsp; &lt; 2,0 &mu;m, 2,0-6,2&nbsp; &mu;m,&nbsp; 6,2-20,0&nbsp; &mu;m,&nbsp; 20,0-63,0&nbsp; &mu;mi&nbsp; &gt;63,0&nbsp; &mu;m.&nbsp; Dok,&nbsp; su u&nbsp; Belotincu&nbsp; najvi&scaron;e&nbsp; zastupljene krupne&nbsp; čestice od&nbsp; 51&nbsp; %&nbsp; do&nbsp; 66&nbsp; %&nbsp; i&nbsp; grube&nbsp; frakcije,&nbsp; koje&nbsp; ukazuju&nbsp; na&nbsp; neposrednu&nbsp; blizinu&nbsp; izvora porekla&nbsp; materijala.&nbsp; Boja&nbsp; LPS&nbsp; na&nbsp; profilima&nbsp; u&nbsp; Stalaću i&nbsp; Belotincu&nbsp; menja&nbsp; se i&nbsp; kovarira&nbsp; sa&nbsp; MS. Kolorimetrijski rezultati ukazuju, slično MS rezultatima, da lesni sedimenti potiču jednim delom iz&nbsp; Južne Morave,&nbsp; a&nbsp; drugim&nbsp; delom&nbsp; iz Zapadne&nbsp; Morave.&nbsp; Geohemijske&nbsp; analize&nbsp; ukazuju&nbsp; na dominantno&nbsp; silikatno&nbsp; raspadanje&nbsp; čestica,&nbsp; slično dunavskom&nbsp; lesu.&nbsp; Geohemijski&nbsp; sastav&nbsp; LPS Belotinc&nbsp; pokazuje&nbsp; da&nbsp; pedokompleks&nbsp; je&nbsp; obogaćen organskog&nbsp; ugljenika,&nbsp; dok&nbsp; su u&nbsp; lesnim slojevima&nbsp; primećene&nbsp; niže vrednosti&nbsp; organskog&nbsp; ugljenika.&nbsp; Generalno&nbsp; tumačenje svih&nbsp; rezultata ukazuje na dominantan mediteranski klimatski uticaj na LPS u srednjem pleistocenu, dok&nbsp; je u gornjem i mlađem pleistocenu bio dominantan uticaj kontinentalne klime.</p> / <p>The&nbsp; research&nbsp; subject&nbsp; of&nbsp; this&nbsp; dissertation&nbsp; are&nbsp; Middle&nbsp; and&nbsp; Upper&nbsp; Pleistocene&nbsp; loesspaleosol&nbsp; sequences&nbsp; (LPS)&nbsp; in&nbsp; the&nbsp; South&nbsp; Morava&nbsp; valley,&nbsp; at&nbsp; brickyards&rsquo; profiles&nbsp; in&nbsp; Stalac&nbsp; and Belotinac. These LPS represent a unique continental record of paleoclimate and paleoecological changes during Pleistocene in this part of the Balkan Peninsula. After detailed terrain researches and&nbsp; samplings&nbsp; at&nbsp; the&nbsp; two&nbsp; loess&nbsp; profiles,&nbsp; several&nbsp; research&nbsp; problems&nbsp; were&nbsp; discussed.&nbsp; Pedostratigraphic and litho-stratigraphic descriptions were done for both profiles. There were found several&nbsp; meters&nbsp; of&nbsp; powerful&nbsp; glacial&nbsp; loess&nbsp; horizons&nbsp; and&nbsp; several&nbsp; interglacial&nbsp; pedocomplexes&nbsp; that were visually distinctive. A relief reconstruction was carried out based on spatial LPS ratios. The total&nbsp; thickness&nbsp; of&nbsp; the&nbsp; analyzed&nbsp; LPS&nbsp; is:&nbsp; approximately&nbsp; 20.5&nbsp; m&nbsp; in&nbsp; Stalac,&nbsp; where&nbsp; seven pedocomplexes&nbsp; and&nbsp; seven&nbsp; horizons&nbsp; were&nbsp; observed,&nbsp; whereas&nbsp; thickness&nbsp; of&nbsp; analyzed&nbsp; LPS&nbsp; in Belotinac was 8 &nbsp; m. The magnetic susceptibility (MS) values in Stalacpoint at two independent sources of dusty fluvial materials. The higher MS values are observed in materials originating from the West Morava basin, while lower MS values indicate that materials originate from the South&nbsp; Morava&nbsp; basin.&nbsp; Interpretations&nbsp; of&nbsp; absolute&nbsp; luminescent&nbsp; dating&nbsp; results&nbsp; at&nbsp; both&nbsp; profiles indicate&nbsp; that&nbsp; the&nbsp; LPS&nbsp; were&nbsp; formed&nbsp; during&nbsp; last&nbsp; ~&nbsp; 350.000&nbsp; years&nbsp; in&nbsp; Stalac&nbsp; and&nbsp; ~&nbsp; 35.500&nbsp; in Belotinac. The LPS in Stalac is granulometrically consisted of five different fractions: &lt; 2.0 &mu;m, 2.0-6.2 &mu;m, 6.2-20.0&nbsp; &mu;m, 20.0-63.0&nbsp; &mu;mand &gt;63.0&nbsp; &mu;m. In Belotinac the most frequent particles are&nbsp; the&nbsp; large&nbsp; ones&nbsp; varying&nbsp; from&nbsp; 51%&nbsp; to&nbsp; 66%&nbsp; and&nbsp; rough&nbsp; fractions,&nbsp; which&nbsp; indicates&nbsp; that&nbsp; the material source was in its immediate proximity. The LPS colours both in Stalac and Belotinac covariate with the MS. Similarly to the MS results, the colorimetric results indicate that a part of the loess sediments originates from the South Morava, and the other part from the West Morava. Geochemical analyses point at a dominant silicate particle decomposition, which is similar to the Danube&nbsp; loess.&nbsp; Geochemical&nbsp; composition&nbsp; of&nbsp; BelotinacLPS&nbsp; shows&nbsp; an&nbsp; organic-carbon-enriched pedocomplex,&nbsp; while&nbsp; lower&nbsp; values&nbsp; of&nbsp; the&nbsp; organic&nbsp; carbon&nbsp; are&nbsp; observed&nbsp; in&nbsp; the&nbsp; loess&nbsp; layers.&nbsp; The general interpretation of the results points at dominant Mediterranean climate influence on the LPS&nbsp; in&nbsp; the&nbsp; Middle&nbsp; Pleistocene,&nbsp; while&nbsp; in&nbsp; the&nbsp; Upper&nbsp; and&nbsp; Younger&nbsp; Pleistocene&nbsp; a&nbsp; continental climate influence was dominant.</p>

<p>Ова докторска дисертација се бави проблемом мерења и детекције<br />асиметрије побуде торусног трансформатора прикљученог на нисконапонску<br />дистрибутивну мрежу. Анализом постојећих научних решења изведен је<br />закључак да иста испољавају висок ниво систематске грешке услед<br />флуктуације побудног напона трансформатора. Основни допринос тезе јесте<br />предложени нови интерполациони поступак за калибрацију сензора<br />асиметрије у нисконапонској дистрибутивној мрежи, који успешно редукује<br />наведену систематску грешку. Додатни допринос представља рачунарска<br />имплементација методе за рад у реалном времену.</p> / <p>Ova doktorska disertacija se bavi problemom merenja i detekcije<br />asimetrije pobude torusnog transformatora priključenog na niskonaponsku<br />distributivnu mrežu. Analizom postojećih naučnih rešenja izveden je<br />zaključak da ista ispoljavaju visok nivo sistematske greške usled<br />fluktuacije pobudnog napona transformatora. Osnovni doprinos teze jeste<br />predloženi novi interpolacioni postupak za kalibraciju senzora<br />asimetrije u niskonaponskoj distributivnoj mreži, koji uspešno redukuje<br />navedenu sistematsku grešku. Dodatni doprinos predstavlja računarska<br />implementacija metode za rad u realnom vremenu.</p> / <p>This PhD thesis addresses the problem of measurement and detection of the<br />excitation current asymmetry of a toroidal transformer connected to the low<br />voltage distribution network. By analyzing the existing scientific solutions, it<br />was concluded that they show a high level of systematic error due to the<br />fluctuation of the supply voltage of the transformer. The main contribution of<br />the thesis is the proposal of a new interpolation method for the calibration of<br />an asymmetry sensor connected to the low-voltage distribution network that<br />successfully reduces the systematic error. Computer implementation of the<br />method for work in real time represents an additional contribution.</p>

<p>Osolike muve predstavljaju veliku familiju dvokrilaca koja u ekosistemu ima važnu ulogu opra&scaron;ivača biljaka i razlaganja organske materije. One su takođe dobar indikator naru&scaron;enosti ekosistema.&nbsp; Stoga je poznavanje njihove taksonomije i<br />ekologije od izuzetnog značaja. Jedan od tri najbrojnija roda osolikih muva&nbsp; predstavlja rod <em>Eumerus</em>, čija revizija na Balkanskom poluostrvu je predmet ove disertacije. Balkansko poluostrvo predstavlja izuzetan centar raznovrsnosti živog<br />sveta, između ostalih familija i za osolike muve. Za rod<em> Eumerus</em>, ono je pored Srednje Azije i Južne Afrike, jedan od centara specijacije.Predstavnici roda Eumerus su uglavnom sitnije crne muve, ponekad sa crvenim trbuhom. Karakteri&scaron;u ih bele popra&scaron;ene&nbsp; trake na tergitima, dva reda trnova na metafemuru&nbsp; apikoventralno i uvučena gornja spolja&scaron;nja poprečna vena na&nbsp; krilu, često sa dva kratka ispusta na ispupčenoj strani, okrenuta ka spolja. Cilj ove disertacije bio je utvrđivanje tačnog broja&nbsp; vrsta na Balkanskom poluostrvu i razre&scaron;avanje njihove&nbsp; taksonomije. Kao rezultat, utvrđeno je 44 prisutne vrste na&nbsp; istraživanom području koje su na osnovu morfolo&scaron;ke sličnosti&nbsp; podeljene u deset grupa. Tri utvrđene vrste ne pripadaju&nbsp; nijednoj grupi. U toku ovog istraživanja otkriveno je 12 vrsta novih za nauku:<em> E. aurofinis, E. banaticus</em>, in litt., <em>E. <span id="cke_bm_182S" style="display: none;">&nbsp;</span><span id="cke_bm_185S" style="display: none;">&nbsp;</span>bicornis</em><span id="cke_bm_185E" style="display: none;">&nbsp;</span><span id="cke_bm_182E" style="display: none;">&nbsp;</span>, in<span id="cke_bm_183S" style="display: none;">&nbsp;</span> litt., <span id="cke_bm_186S" style="display: none;">&nbsp;</span><em>E. crassus</em><span id="cke_bm_186E" style="display: none;">&nbsp;</span>, <span id="cke_bm_187S" style="display: none;">&nbsp;</span><em>E. kar<span id="cke_bm_183E" style="display: none;">&nbsp;</span>yates</em><span id="cke_bm_187E" style="display: none;">&nbsp;</span>, in li<span id="cke_bm_188S" style="display: none;">&nbsp;</span>tt., <em>E. montanum</em>, <em>E.&nbsp;<span id="cke_bm_188E" style="display: none;">&nbsp;</span> montenegr<span id="cke_bm_184E" style="display: none;">&nbsp;</span>inus, E. <span id="cke_bm_189E" style="display: none;">&nbsp;</span>nigrorufus</em>, in litt.<em>, E. phaeacus</em>, in litt., <span id="cke_bm_202S" style="display: none;">&nbsp;</span><em>E. rubrum, E. tenuitarsis</em><span id="cke_bm_202E" style="display: none;">&nbsp;</span>, in litt. i<em> E. torsicus.</em> Geometrijska morfometrija krila je d<span id="cke_bm_203E" style="display: none;">&nbsp;</span>ala odlične rezultate za razdvajanje&nbsp; kriptičnih taksona u okviru roda <em>Eumerus,</em> primenjena na&nbsp; vrstama grupe minotaurus. Utvrđeni su najznačajniji morfolo&scaron;ki karakteri za razlikovanje vrsta. Jedan od veoma&nbsp; značajnih rezultata ove disertacije je ključ za identifikaciju&nbsp; vrsta roda<em> Eumerus</em> na Balkanskom poluostrvu. Na osnovu morfolo&scaron;ke analize donet je zaključak da tricolor grupa&nbsp; predstavlja morfolo&scaron;ki zasebnu taksonomsku celinu sa jasnim&nbsp; indicijama da je njen rang iznad grupe vrsta. Centre diverziteta&nbsp; vrsta roda <em>Eumerus</em> na istraživanom području predstavljaju, prema bogastvu vrsta grčka ostrva Lezbos i Krf i jugoistočni&nbsp; deo Crne Gore uključujući Skadarsko jezero. Na osnovu &Scaron;enonovog indeksa diverziteta, područja sa najvećim indeksom su sledeća: ostrva Hios, Lezbos i Krf, zatim Peloponez i veći&nbsp; deo Crne Gore.</p> / <p>Hoverflies represents a large family of Diptera that have in the ecosystem an important role of pollinators and decomposer of organic matter. They are also a good indicator of ecosystem disruption. Therefore, knowledge of their taxonomy and ecology is of great importance. One of the three most numerous genus of hoverflies is the genus<em> Eumerus</em>, whose revision in the Balkan Peninsula is the subject of this dissertation. The Balkan Peninsula is an exceptional center of biodiversity, for&nbsp; hoverflies among other families. For the genus&nbsp;<em> Eumerus</em>, Balkan Peninsula is next to&nbsp; Central Asia and South Africa, one of the centers of speciation. Representatives of the genus&nbsp; Eumerus&nbsp; are mostly small black flies, sometimes with red abdomen. They are characterized by white stripes on the tergites, two rows of spines on the metafemur apico-ventrally and recessed upper outer transverse wing vein. The aim of&nbsp; this dissertation was to determine the number of species on the Balkan&nbsp; Peninsula and to resolve their taxonomy. As a result, 44 species were identified in the investigated area, which are divided into ten groups based on the&nbsp; morphological similarity. The three species identified do not belong to any group. In the course of this study, 12 new species were discovered for the science:&nbsp; <em>E. aurofinis, E. banaticus,</em> in litt.,&nbsp; <em>E. bicornis</em>, in litt.,&nbsp;<em> E. crassus,&nbsp; E. karyates</em>, in litt.,&nbsp; <em>E. montanum,&nbsp; E. montenegrinus,&nbsp; E. nigrorufus,</em> in litt.,&nbsp; <em>E. phaeacus</em>, in litt.,&nbsp; <em>E. rubrum,</em> <em>E. tenuitarsis</em>, in litt. and&nbsp; <em>E. torsicus</em>. The geometric&nbsp; morphometry of the wings gave excellent results for the separation of cryptic taxons within the genus&nbsp; Eumerus, applied to the species of the&nbsp; minotaurus&nbsp; group. The most important morphological characters for differentiating species were determined. One of the very important results of this dissertation is the identification key for species of the genus&nbsp; <em>Eumerus&nbsp;</em> on the Balkan Peninsula. Based on morphological analysis, conclusion is that the tricolor&nbsp; group represents a morphologically separate taxonomic entity with clear indications that its rank is above a group of species. The centers of diversity of the genus&nbsp;<em> Eumerus</em>&nbsp; in the research area represent, according to the species richness of the Greek island of Lesbos and Corfu and the southeastern&nbsp; part of Montenegro including the Skadar Lake. Based on the Shannon&rsquo;s Diversity Index, the areas with the highest index are as follows: the islands of Hios, Lesbos and Corfu, then Peloponnese and most of Montenegro.</p>

<p>Predviđena istraživanja u ovoj doktorskoj disertaciji su usmerena u pravcu&nbsp;<br />modifikacije klasičnih metoda i postupaka za transformaciju karboksilne grupe&nbsp;<br />prirodnih i sintetičkih karboksilnih kiselina. Modifikacije su rađene novim,&nbsp;<br />savremenim, ekonomski i ekolo&scaron;ki opravdanim metodama rada u&nbsp;<br />mikrotalasnom reaktoru. Modifikovanim sintetskim postupcima u&nbsp;<br />mikrotalasnom reaktoru urađena je sinteza amida, hidroksamskih&nbsp; derivata,&nbsp;<br />kao i redukcija individualnih naftnih kiselina i&nbsp; sme&scaron;e&nbsp; prirodnih naftnih kiselina&nbsp;<br />&bdquo;Velebit&ldquo; do alkohola. Prirodne naftne kiseline kori&scaron;ćene u ovom radu su prvo&nbsp;<br />izolovane iz gasne frakcije (interval destilacije 168-290 &deg;C) vojvođanske nafte&nbsp;<br />&bdquo;Velebit&ldquo; a potom preči&scaron;ćene i razdvojene na uže frakcije na osnovu različite&nbsp;<br />kiselosti. Nakon toga, izvr&scaron;ena je njihova karakterizacija GC-MS-EI analizom&nbsp;<br />(čime je potvrđeno da dolazi do strukturne diferencijacije kiselina). U radu je&nbsp;<br />takođe ispitana biolo&scaron;ka aktivnost sintetizovanih derivata. Proučavan je uticaj&nbsp;<br />prirodnih naftnih kiselina &bdquo;Velebit&ldquo; i njenih derivata na rast&nbsp; pet sojeva&nbsp;<br />Pseudomonas sp., kao i uticaj odabranih sintetisanih jedinjenja na proliferaciju&nbsp;<br />četiri ćelijske linije humanih tumora pri čemu je kao kontrola služila jedna&nbsp;<br />zdrava humana ćelijska linija.</p> / <p>The investigation of this doctoral dissertation is directed toward the modification of the &nbsp;transformation of the carboxylic group of natural and synthetic carboxylic acids. The dissertation takes into consideration the classical methods and procedures of the reaction and modifies them using microwave reactor. The synthesis of amides, hydroxamic derivatives, as well as the reduction&nbsp; of individual petroleum acids and acid mixtures of natural oil &quot;Velebit&quot; to alcohol were achieved&nbsp; by the modifications made to the synthetic methods in the microwave reactor. The natural oil acids used within this study were first isolated from the gas fraction (distillation interval 168-290 &deg;C) of the Vojvodina&#39;s crude oil &quot;Velebit&quot;, and then purified and separated by the narrow fractions under the different acidity. After that, their characterisation was made by the GC-MS-EI analysis which confirmed that the structural differentiation of&nbsp;&nbsp; acids had been achieved. Also, the biological activity of the synthesized derivatives are analysed. The impact of natural petroleum acids &quot;Velebit&quot; and its derivatives on the growth of five strains of&nbsp; Pseudomonas&nbsp; sp. was studied, as well as the impact of selected synthesized compounds on the proliferation of four human tumor cell lines wherein one healthy human cell lines used as the control.</p>

<p>Klaster analiza ima dugu istoriju i mada se<br />primenjuje u mnogim oblastima i dalje ostaju<br />značajni izazovi. U disertaciji je prikazan uvod<br />u neglatki optimizacioni pristup u<br />klasterovanju, sa osvrtom na problem<br />klasterovanja velikih skupova podataka.<br />Međutim, ovi optimizacioni algoritmi bolje<br />funkcioni&scaron;u u radu sa neprekidnim podacima.<br />Jedan od glavnih izazova u klaster analizi je<br />rad sa velikim skupovima podataka sa<br />kategorijalnim i kombinovanim (numerički i<br />kategorijalni) tipovima promenljivih. Rad sa<br />velikim brojem instanci (objekata) i velikim<br />brojem dimenzija (promenljivih), može<br />predstavljati problem u klaster analizi, zbog<br />vremenske složenosti. Jedan od načina<br />re&scaron;avanja ovog problema je redukovanje broja<br />instanci, bez gubitka informacija.<br />Prvi cilj disertacije je bio upoređivanje<br />rezultata klasterovanja na celom skupu i<br />prostim slučajnim uzorcima sa kategorijalnim i<br />kombinovanim podacima, za različite veličine<br />uzorka i različit broj klastera. Nije utvrđena<br />značajna razlika (p&gt;0.05) u rezultatima<br />klasterovanja na uzorcima obima<br />0.03m,0.05m,0.1m,0.3m (gde je m obim<br />posmatranog skupa) i celom skupu.<br />Drugi cilj disertacije je bio konstrukcija<br />efikasnog postupka klasterovanja velikih<br />skupova podataka sa kategorijalnim i<br />kombinovanim tipovima promenljivih.<br />Predloženi postupak se sastoji iz sledećih<br />koraka: 1. klasterovanje na prostim slučajnim<br />uzorcima određene kardinalnosti; 2.<br />određivanje najboljeg klasterskog re&scaron;enja na<br />uzorku, primenom odgovarajućeg kriterijuma<br />validnosti; 3. dobijeni centri klastera iz ovog<br />uzorka služe za klasterovanje ostatka skupa.<br />Treći cilj disertacije predstavlja primenu<br />klaster analize u definisanju klastera<br />bihejvioralnih faktora rizika u populaciji<br />odraslog stanovni&scaron;tva Srbije, kao i analizu<br />sociodemografskih karakteristika dobijenih<br />klastera. Klaster analiza je primenjena na<br />velikom reprezentativnom uzorku odraslog<br />stanovni&scaron;tva Srbije, starosti 20 i vi&scaron;e godina.<br />Izdvojeno je pet jasno odvojenih klastera sa<br />karakterističnim kombinacijama bihejvioralnih<br />faktora rizika: Bez rizičnih faktora, &Scaron;tetna<br />upotreba alkohola i druge rizične navike,<br />Nepravilna ishrana i druge rizične navike,<br />Nedovoljna fizička aktivnost, Pu&scaron;enje. Rezultati<br />multinomnog logističkog regresionog modela<br />ukazuju da ispitanici koji nisu u braku, lo&scaron;ijeg<br />su materijalnog stanja, nižeg obrazovanja i žive<br />u Vojvodini imaju veću &scaron;ansu za prisustvo<br />vi&scaron;estrukih bihejvioralnih faktora rizika.</p> / <p>The cluster analysis has a long history and a<br />large number of clustering techniques have<br />been developed in many areas, however,<br />significant challenges still remain. In this<br />thesis we have provided a introduction to<br />nonsmooth optimization approach to clustering<br />with reference to clustering large datasets.<br />Nevertheless, these optimization clustering<br />algorithms work much better when a dataset<br />contains only vectors with continuous features.<br />One of the main challenges is clustering of large<br />datasets with categorical and mixed (numerical<br />and categorical) data. Clustering deals with a<br />large number of instances (objects) and a large<br />number of dimensions (variables) can be<br />problematic because of time complexity. One of<br />the ways to solve this problem is by reducing<br />the number of instances, without the loss of<br />information.<br />The first aim of this thesis was to compare<br />the results of cluster algorithms on the whole<br />dataset and on simple random samples with<br />categorical and mixed data, in terms of validity,<br />for different number of clusters and for<br />different sample sizes. There were no<br />significant differences (p&gt;0.05) between the<br />obtained results on the samples of the size of<br />0.03m,0.05m,0.1m,0.3m (where m is the size of<br />the dataset) and the whole dataset.<br />The second aim of this thesis was to<br />develop an efficient clustering procedure for<br />large datasets with categorical and mixed<br />(numeric and categorical) values. The proposed<br />procedure consists of the following steps: 1.<br />clustering on simple random samples of a given<br />cardinality; 2. finding the best cluster solution<br />on a sample (by appropriate validity measure);<br />3. using cluster centers from this sample for<br />clustering of the remaining data.<br />The third aim of this thesis was to<br />examine clustering of four lifestyle risk factors<br />and to examine the variation across different<br />socio-demographic groups in a Serbian adult<br />population. Cluster analysis was carried out on<br />a large representative sample of Serbian adults<br />aged 20 and over. We identified five<br />homogenous health behaviour clusters with<br />specific combination of risk factors: &#39;No Risk<br />Behaviours&#39;, &#39;Drinkers with Risk Behaviours&#39;,<br />&#39;Unhealthy diet with Risk Behaviours&#39;,<br />&#39;Smoking&#39;. Results of multinomial logistic<br />regression indicated that single adults, less<br />educated, with low socio-economic status and<br />living in the region of Vojvodina are most likely<br />to be a part of the clusters with a high-risk<br />profile.</p>

<p>Истраживање старења средства за влажење у реалним условима током 8-часовног радног времена у процесу офсет штампе је омогућило сагледавање критичних фактора деактивације средства за влажење и представља основ за праћење кинетике структурних и физичко-хемијских промена активних компоненти средства за влажење. Такође, истраживање обезбеђује и дефинисање могућих механизама хемијских процеса који условљавају пад активности присутних компоненти средства за влажење током процеса старења.</p> / <p>Istraživanje starenja sredstva za vlaženje u realnim uslovima tokom 8-časovnog radnog vremena u procesu ofset štampe je omogućilo sagledavanje kritičnih faktora deaktivacije sredstva za vlaženje i predstavlja osnov za praćenje kinetike strukturnih i fizičko-hemijskih promena aktivnih komponenti sredstva za vlaženje. Takođe, istraživanje obezbeđuje i definisanje mogućih mehanizama hemijskih procesa koji uslovljavaju pad aktivnosti prisutnih komponenti sredstva za vlaženje tokom procesa starenja.</p> / <p>The investigation of fountain solution aging in real condition during 8-hr<br />working shift of offset printing process allows an overview of the critical<br />factors of fountain solution deactivation and represents the basis for<br />monitoring the structural and physico-chemical changes of active<br />components of fountain solution. Also, the investigation defines the possible<br />mechanism of chemical processes which cause the decreasing of activity of<br />present components in fountain solution during aging process.</p>

<p>U ovom radu se proučava bogatstvo arheolo&scaron;kih lokaliteta sa teritorije dana&scaron;nje&nbsp;Republike Srbije sa aspekta razvoja hemijske proizvodnje, tj. materijalne kulture, koja je&nbsp;postignuta, za to doba, karakterističnom proizvodnjom metalne robe i građevinskog&nbsp;materijala. Uzorci koji su kori&scaron;ćeni, u većini slučajeva, nisu imali prethodni tretman ili su&nbsp;vađeni direktno iz leži&scaron;ta arheolo&scaron;kih nalaza, uz odobrenje lokalnih i regionalnih muzeja:&nbsp;&bdquo;Muzej Vojvodine&rdquo; u Novom Sadu, &bdquo;Zavičajni muzej&rdquo; u Rumi, &bdquo;Muzej Srema&rdquo; u Sremskoj&nbsp;Mitrovici, &bdquo;Muzej Viminacium&rdquo; kod Kostolca, &bdquo;Arheolo&scaron;ki muzej Đerdapa&rdquo; u Kladovu,&nbsp;Muzej &bdquo;Đerdap 2&rdquo; u Turn Severinu, Rumunija, &nbsp;&bdquo;Muzej Krajine&rdquo; u Negotinu, &bdquo;Narodni&nbsp;muzej&rdquo; u Zaječaru, &bdquo;Muzej Mediana&rdquo;, kraj Ni&scaron;a. Uzorci građevinskog materijala, opeke i&nbsp;vezivnog materijala potiču sa arheolo&scaron;kih lokaliteta: Mihajlovac-Klevora (<em>Clevora</em>), Trajanov&nbsp;most, Medijana (<em>Mediana</em>), Dijana <em>(Diana</em>), Najsus (<em>Naissus</em>), Feliks Romulijana <em>(Felix&nbsp;Romuliana</em>), Frateniza, &Scaron;arkamen, Hrtkovci i Viminacijum (<em>Viminacium</em>). Uzorci rimskih&nbsp;novčića su: iz perioda vladavine Flavia Julia Constantiusa, sa arheolo&scaron;kog lokaliteta Sirmium&nbsp;i drugih arheolo&scaron;kih lokaliteta dana&scaron;nje AP Vojvodine i sa arheolo&scaron;kih lokaliteta Istočne&nbsp;Srbije. Metode ispitivanja arheolo&scaron;kih uzoraka su: Mikroskopija, metalur&scaron;ki mikroskopi&nbsp;<em>Leitz</em>, <em>Orthoplan</em>, (x100) i <em>Carl Zeiss Jena</em> (x1000), gemolo&scaron;ki mikroskop <em>Konig electronic&nbsp;</em>(200X), skenirajući elektronski mikroskop (<em>Scanning electronic microscopy</em>, SEM), JEOL&nbsp;JSM-6460LV; Spektroskopske metode, Energetski disperzivni spektroskop (<em>Energy&nbsp;dispersive spectroscopy</em>), EDS Oxford Instrument; Rendgenska fluorometrija <em>(X-ray&nbsp;fluorescence </em>XRF), <em>Thermo Fisher,</em> NITON XL 3t-950.</p><p><em>Poglavlja u radu</em>: I Teorijski deo: Teorijski deo čine dva poglavlja: uvod i op&scaron;ti deo.&nbsp;<br />U prvom poglavlju su istaknuti razlozi i ciljevi odabira građevinskog materijala i metalnih&nbsp;novčića, kao polazna tačka istraživanja razvoja hemijske proizvodnje u doba &nbsp;antike na&nbsp;teritoriji dana&scaron;nje Srbije. Vojna inženjerija je bila inicijator razvoja tehnologije građevinskog&nbsp;materijala i metalnih novčića, dok je ostala hemijska proizvodnja bila na nivou zanatskih&nbsp;ve&scaron;tina. Drugo poglavlje čini pet tema: Op&scaron;i deo, Istorijske i dru&scaron;tvene prilike u doba antike u&nbsp;Rimu i na teritoriji Balkana, Istorijske i dru&scaron;tvene prilike u doba antike na teritoriji dana&scaron;nje&nbsp;Srbije, Proizvodnja opeke u doba &nbsp;antike i Metalurgija u doba antike na teritoriji dana&scaron;nje&nbsp;Srbije. II Metodologija istraživanja: Poglavlje Metodologija istraživanja obuhvata: Predmet&nbsp;istraživanja, Problem istraživanja, Cilj istraživanja, Zadatke istraživanja, Hipoteze. III &nbsp;<br />Ekspeimentalni deo: Eksperimentalni deo je podeljen u dve veće celine: Materijal i Metode.&nbsp;Celinu Materijal čini sedam odlomaka: Uzorkovanje materijala, Uzimanje uzoraka&nbsp;građevinskog materijala, Detekcija uzoraka građevinskog materijala vizuelnim putem,&nbsp;Kalupljenje uzoraka građevinskog materijala, Digitalna fotografija i optička mikroskopija&nbsp;uzoraka opeke, Detekcija metalnih novčića. Celinu Metode čini pet odlomaka: Terenska&nbsp;istraživanja, bibliografska, muzeolo&scaron;ka, arhivska i kartografska istraživanja, Lociranje&nbsp;arheolo&scaron;kih lokaliteta (geofizička merenja), Fotografije arheolo&scaron;kih lokaliteta, Hemijske&nbsp;analize građevinskog materijala (Skenirajuća elektronska mikroskopija <em>(Scanning electronic&nbsp;microscopy</em>, SEM); Energijsko disperziona spektroskopija (<em>Energy dispersive spectroscopy</em>,&nbsp;EDS)), Hemijske analize metalnog novca (Mikroskopska analiza metalnog novca;&nbsp;Rendgenska fluoroscentna analiza (<em>X-ray fluorescence analysis</em>, XRF) metalnog novca). IV&nbsp;Diskusija rezultata istraživanja: U diskusiji rezultata istraživanja su: Prikaz, Interpretacija&nbsp;rezultata analiza; Diskusija dobijenih rezultata; Uporedne analize podataka. V Zaključak: Na&nbsp;osnovu istraživanja, konstatovano je da je hemijska proizvodnja u kasnoj antici, bila&nbsp;usmerena: ka dobijanju kvalitetnog građevinskog materijala i prema razvijenoj metalurgiji u&nbsp;kovnicama metalnog novca. VI Prilog: Prilozima se prikazuju: biografski i bibliografski&nbsp;prikazi arheologa, istraživača arheolo&scaron;kih lokaliteta, deo karte rimskih puteva &bdquo;Tabula&nbsp;Peutingriana&rdquo;, odlomak iz Vitruviusovih knjiga, izgled novčića sa likovima rimskih&nbsp;imperatora koji su rođeni na tlu dana&scaron;nje Republike Srbije, rad kojim se dokazuje da je&nbsp;opeku, najče&scaron;će, proizvodila vojska, podaci o glini, kao osnovnoj sirovini za proizvodnju&nbsp;opeke, mineralni sastav zemlji&scaron;ta, odrednica hemijskog sastava građevinskog materijala,&nbsp;rezultati hemijske analize ručno pravljene opeke, kao i rezultati hemijske analize savremene&nbsp;opeke. VII Literatura: U ovom radu je navedeno 445 naslova.&nbsp;</p><p>Ova doktorska teza objedinjuje regije koje su istraživali poznati naučnici, tj. sve veće&nbsp;arheolo&scaron;ke lokalitete na teritoriji dana&scaron;nje Republike Srbije, tako &nbsp;da otvara put za dalja&nbsp;uporedna istraživanja i ispitivanja u hemiji, arheologiji, muzeologiji, arhitekturi, kao i&nbsp;poslovima restauracije, &scaron;to, do sada, nije u dovoljnoj meri učinjeno.&nbsp;</p> / <p>This paper examines the wealth of archaeological sites on the territory of present-day&nbsp;Republic Serbia in terms of the development of chemical production, material &nbsp;culture, which&nbsp;is achieved, for the time, the typical manufacture of metal goods, and building materials. The&nbsp;samples that were used, in most cases, they had no prior treatment or were extracted directly&nbsp;from the deposits of archaeological finds, with the approval of local and regional museum:&nbsp;&rdquo;The Museum of Vojvodina&rdquo; in Novi Sad, &rdquo;Heritage Museum&rdquo; in Ruma, &rdquo;The Museum of&nbsp;Srem&rdquo; in Sremska Mitrovica, &rdquo;Museum Viminacium&rdquo; near Kostolac, &rdquo;Archaeological&nbsp;Museum Đerdap&rdquo; in Kladovo, Museum &rdquo;Đerdap 2&rdquo; in Drobeta Turn-Severin, Romania,&nbsp;&rdquo;Museum of Krajina&rdquo; in Negotin, &rdquo;National Museum&rdquo; in Zaječar, Museum &rdquo;Mediana&rdquo;, near&nbsp;Ni&scaron;. Samples of building materials, bricks and connective material originating from&nbsp;archaeological sites: Mihajlovac-Clevora, Trajanʼs Bridge, Mediana, Diana, Naissus, Felix&nbsp;Romuliana, Frateniza, &Scaron;arkamen, Hrtkovci and Viminacium. Samples of Roman coins are&nbsp;from the &nbsp;reign of Constantius Julia Flavia, the archaeological site of Sirmium and other&nbsp;archaeological sites today Vojvodina and from archaeological sites in Eastern Serbia&nbsp;(Prahovo). Test methods for archaeological samples are: Microscopy, Metallurgical&nbsp;Microscopes Leitz, ORHTOPLAN (x100) and Carl Zeiss Jena (x1000) Gemmological Konig&nbsp;Electronic Microscope (200X), Scanning Electron Microscope (SEM), JEOL JSM-6460LV;&nbsp;Spectroscopic Methods, Energy Dispersive Spectrometer (EDS), Oxford Instrument; X-Ray&nbsp;Fluorometry (XRF ), Thermo Fisher, NITON XL 3t- 950th.&nbsp;</p><p>Chapters in the paper: I Theoretical part: The theoretical part consists of two chapters:&nbsp;introduction and general part. In the first chapter of the prominent causes and objectives of&nbsp;the selection of building materials and coins, as a starting point for research on the&nbsp;development of chemical production in ancient times on the territory of Serbia. Army Corps&nbsp;of Engineers was the initiator of the technology of building materials and coins, and other&nbsp;chemical production was at the level of craft skills. The second section consists of five topics:&nbsp;General part, historical and social conditions in ancient times in Rome and in the Balkans,&nbsp;historical and social conditions in ancient times on the territory of Serbia, Manufacture of&nbsp;bricks in ancient times and Metallurgy in ancient times on the territory of Serbia. II Research&nbsp;Methodology: Research Methodology Chapter includes: The research, research problem,&nbsp;research objectives, the tasks of research hypotheses. Ekspeimentalni part III: The&nbsp;experimental part is divided into two major parts: Materials and Methods. Whole material&nbsp;consists of seven sections: Sampling materials, sampling of construction materials, building&nbsp;materials detection patterns visually, molding samples of building materials, digital&nbsp;photography &nbsp;and optical microscopy samples of bricks, Detection coins. Whole methods&nbsp;consists of five sections: Field research, bibliographic, museum, archival research and&nbsp;mapping, locating archaeological sites (geophysical measurements), photos of archaeological&nbsp;sites, the chemical analysis of building materials Scanning Electron Microscopy (SEM),&nbsp;Energy-Dispersive Spectroscopy (EDS), the chemical analysis of coins (Microscopic&nbsp;Analysis; X-ray Fluorescence Analysis (XRF). IV Discussion of research results: In the&nbsp;discussion of the research results are: Preview, interpretation of the results of analysis;&nbsp;Discussion of the results obtained; Comparative analysis of the data. In Conclusion: Based on&nbsp;the research, it was found that the chemical production in late antiquity, was directed: in&nbsp;obtaining high-quality building materials to advanced metallurgy in the mints coins.&nbsp;Appendix VI: Articles are displayed: biographical and bibliographical representations of&nbsp;archaeologists, researchers archaeological sites, part of the map of Roman roads &bdquo;Tabula&nbsp;Peutingriana&rdquo; section of &nbsp;Vitruviusovʼs books, coins with the appearance of the characters of&nbsp;Roman emperors were born in the territory of present-day Republic of Serbia, the work of&nbsp;proving that the bricks, usually producing army, data on clay, which is the basic raw material&nbsp;for the production of bricks, the mineral content of the soil, the term chemical composition &nbsp;of&nbsp;building materials, the results of chemical analysis handmade bricks, and the results of&nbsp;chemical analysis of contemporary brick. VII Literature: In this study indicated 445 titles.&nbsp;</p><p>This doctoral thesis combines the region explored by famous scientists, ie. all major&nbsp;archaeological sites on the territory of the Republic of Serbia, so that it opens the way for&nbsp;further comparative research and studies in chemistry, archeology, museology, architecture&nbsp;and restoration operations, which, so far, has not &nbsp;been sufficiently done.</p>

<p>Tumorsko pupljenje (TP) u karcinomu je morfolo&scaron;ki fenomen koji predstavlja pojavu pojedinačnih ili malih grupa dediferentovanih tumorskih ćelija koje se na invazivnom frontu karcinoma odvajaju od glavne tumorske mase. Kod metastatskog kolorektalnog karcinoma (KRK) definitivno ne možemo odrediti pravi doprinos TP. Cilj je bio da se ispita terapijski patohistolo&scaron;ki odgovor na primenjeni hemioterapijski režim, prognostički i nezavisni negativni značaj TP , kao i korelacija TP i terapijskog odgovora histolo&scaron;ke regresije kod R0 reseciranih sinhronih i metahronih jetrenih metastaza KRK, koji su primali polihemioterapije po protokolu Folfox 4, sa i bez VEGF inhibitora &ndash; bevacizumaba (AV).&nbsp; Studija je prospektivno &ndash; retrospektivna i obuhvata 77 bolesnika oba pola, uzrasta preko 18 godina, sa patohistolo&scaron;ki verifikovanim jetrenim metastazama KRK, koji su operisani u Institutu za onkologiju Vojvodine u periodu od 1. maja 2007. do 1. juna 2017. godine. Od ukupno 120 bolesnika, njih 77 je ispunjavalo sledeće kriterijume: da je histolo&scaron;ki dokazan metastatski adenokarcinom kolorektuma sa R0 resekcijom i da su preoperativno dobijali HT sa biolo&scaron;kom terapijom ili bez nje. Bolesnike smo podelili u dve grupe: KRK &ndash; sinhrona metastatska bolest i KRK &ndash; metahrona metastatska bolest. Nakon selekcije bolesnika, rađena je mikroskopska analiza rutinskih histolo&scaron;kih i imunohistohemijskih preparata i određivana je gustina TP, histolo&scaron;ka regresija prema mTRG bodovanju komparirala se sa radiolo&scaron;kim odgovorom po RECIST-u. Događaji od interesa u kliničkom toku bolesti jesu progresija nakon hirur&scaron;kog zahvata jetrenih metastaza i ukupno preživljavanje u periodu od 24 meseca. Nema statistički značajne patohistolo&scaron;ke razlike u učestalosti lo&scaron;ijeg terapijskog odgovora (mTRG 3 &ndash; 5) u odnosu na bolji terapijski odgovor (mTRG 1, 2) između bolesnika sa sinhronom i metahronom metastatskom bole&scaron;ću KRK, koji su lečeni hemioterapijskim protokolom Folfox4: 13 (76,5%) vs. 13 (72,2%); p = 0,774. Kod bolesnika sa sinhronim metastazama KRK, lečenih hemioterapijskim protokolom Folfox 4, postoji statistički značajna razlika u učestalosti preživljavanja tokom dve godine, i to kod bolesnika sa malom u odnosu na one sa velikom gustinom TP: 10 (90,9%) vs. 5 (55,6%); p = 0,049. Kod tih bolesnika, lečenih hemioterapijskim protokolom Folfox4/AV, postoji statistički značajna razlika u učestalosti preživljavanja tokom dve godine, i to kod bolesnika sa malom u odnosu na one sa velikom gustinom TP: 9 (100%) vs. 6 (33,3%); p = 0,048. Kod bolesnika sa metahronim metastazama KRK lečenih hemioterapijskim protokolom Folfox4, sa i bez AV, nema statistički značajne razlike u učestalosti preživljavanja tokom dve godine u odnosu na gustinu TP. Kod bolesnika sa sinhronim i metahronim metastazama KRK nema statistički značajne razlike u učestalosti lo&scaron;ijeg histolo&scaron;kog odgovora na terapiju (mTRG 3 &ndash; 5) kod onih sa malom u odnosu na one sa velikom gustinom (TP): (8 (50%) vs. 15 (78,9%); p = 0,072 i TP: 8 (80%) vs. 13 (72,2%); p = 0,649). Kod bolesnika sa sinhronim metastazama KRK lečenih hemioterapijskim protokolom Folfox4, sa i bez AV, postoji statistički značajna razlika u učestalosti preživljavanja tokom dve godine u odnosu na gustinu TP. Takođe, kod tih bolesnika velika gustina TP je nezavistan negativan faktor prognoze u odnosu na date terapijske režime, &scaron;to se vidi u preživljavanju tokom dve godine.</p> / <p>Tumor budding (TB) in cancer is a morphological phenomenon representing the appearance of single or small groups of dedifferentiated tumor cells that separate from the main tumor mass on the invasive front of cancer. In metastatic colorectal cancer (MCC), the true contribution of TB cannot be determined. The aim was to investigate the therapeutic pathohistological response to the applied chemotherapy, the prognostic and independent negative significance of TB, as well as the correlation of TB and the therapeutic response of histological regression in R0 resectable synchronous and metachronous liver metastases of MCC receiving polychemotherapy according to the Folfox 4 protocol, with and without VEGF inhibitors - bevacizumab (AV). The research was conducted as a prospective &ndash; retrospective study that included 77 patients of both sex, over 18 years of age, with pathohistologically verified MCC liver metastases, who underwent surgery at the Institute of Oncology of Vojvodina from 1st May 2007 until 1st June 2017. From 120 patients, 77 patients met the following criteria: they had histologically proven metastatic colorectal adenocarcinoma with R0 resection and also received preoperative chemotherapy with or without biological therapy. The patients were divided into two groups: MCC - synchronous metastatic disease and MCC - metachronous metastatic disease. After the patient selection, microscopic analysis of routine histological and immunohistochemical preparations was performed, the density of TB was determined, and the histological regression according to mTRG scoring was compared with a radiologic response according to the RECIST. The events of interest in the clinical course of the disease were the progression of hepatic metastases after surgery and overall survival during 24 months. There is no statistically significant pathohistological difference in the incidence of worse therapeutic response (mTRG 3 - 5) compared to the better therapeutic response (mTRG 1, 2) between patients with synchronous and metachronous MCC who were treated with the Folfox4 chemotherapy protocol: 13 (76.5%) vs. 13 (72.2%); p = 0.774. In patients with synchronous MCC metastases treated with the Folfox 4 chemotherapy protocol, there was a statistically significant difference in the survival rates during two years particularly in patients with low versus high TB density: 10 (90.9%) vs. 5 (55.6%); p = 0.049. In those patients who were treated with the Folfox4 / AV chemotherapy protocol, there was a statistically significant difference in survival rates during two years particularly in patients with low TB density in reference to those with high: 9 (100%) vs. 6 (33.3%); p = 0.048. In patients with metachronous MCC metastases who were treated with the Folfox4 chemotherapy protocol, with and without AV, there was no statistically significant difference in survival rate during two years when referring to the TB density. In patients with synchronous and metachronous metastases, MCC has no statistically significant difference in the incidence of worse histological response to therapy (mTRG 3 - 5) in patients with low TB density versus the ones with high density (TB): (8 (50%) vs. 15 (78.9%); p = 0.072 and TP: 8 (80%) vs. 13 (72.2%); p = 0.649). In patients with synchronous MCC metastases who were treated with the Folfox4 chemotherapy protocol, with and without AV, there is a statistically significant difference in survival rates during a two-year follow up when referring to the TB density. Also, the high density of TB is an independent negative prognostic factor in these patients in reference to the given therapeutic regimens, as seen in the two-year survival rate.</p>