The objective of this exploratory research was to investigate the interplay among emotion, risk perception, and situation awareness as potential risk factors within the health care domain. To accomplish this objective, a two-phase study approach was employed. In Phase I, a proof-of-concept testbed of the emotional interface concept, namely Wearable Avatar Risk Display (WARD), was tested as the primary communication medium to explore participants' emotional responses and risk choices under the influence of the validated International Affective Picture System (IAPS). Based on the lessons learned, a limited prototype of WARD was further refined and then implemented in a formative evaluation. The formative evaluation employed two medical students from the Edward Via Virginia College of Osteopathic Medicine (VCOM) to investigate their emotional response, risk perception, and situation awareness using the MicroSim InHospital under the influence of the validated film-based Mood Induction Procedures (MIPs). In Phase II, 32 new medical students from VCOM participated in 2 (intervention) x 2 (film) between-subjects study for addressing three research questions. Both quantitative and qualitative data were collected and analyzed. Results from Phase I indicated the need for MIPs, as well as shed light on the feasibility of employing anthropomorphic computer characters as intervention devices. Participants found anthropomorphic computer characters to be meaningful as virtual assistants in a team environment. The Facial Expression Coding System also indicated that participants experienced high levels of happiness/amusement when a happy and credible anthropomorphic computer character was introduced under angry emotional induction via MIPs. Physiological states results confirmed that participants' heart rate variability was affected significantly after the use of anthropomorphic computer characters, verifying that their utilization was potentially effective. The lessons I learned from the Phase I results led me to refine procedures and training/evaluation techniques, and to introduce anthropomorphic computer characters with minimal intrusiveness during the Phase II study. Findings from Phase II showed that one particular medical item, wiping contaminated spills, was found to be influenced by induced anger. Moreover, mixed support for using anthropomorphic computer characters and text interventions was also found for the medical and general risk perception ratings under induced anger. Sub-constructs within 3-D SART correlated with emotional responses and anthropomorphic computer character intervention. Two additional items, supply of attention and complexity of the situation, were also found to be influenced by anthropomorphic computer character intervention. Content analysis using the Word-Frequency List method resulted in positive responses for both anthropomorphic computer character and text interventions. Using Two-sample t tests, text based interventions led to a higher level of subjective happiness as measured by PANAS-X. Multiple regressions were also conducted and resulted in six equations for predicting the influence of emotion on situation awareness and medical based risk perception. / Ph. D.

This thesis presents the design, modeling, and development of adaptive robot hands that are capable of performing dexterous, in-hand manipulation. The robot hand comprises of anthropomorphic robotic fingers, which employ an adaptive actuation mechanism. The mechanism achieves both flexion/extension and adduction/abduction, on the finger's metacarpophalangeal joint, by using two actuators. Moment arm pulleys are employed to drive the tendon laterally, such that an amplification on the abduction motion occurs, while also maintaining the flexion motion. Particular emphasis has been given to the modeling and the analysis of the actuation mechanism. Also, a model for spatial motion is provided that relates the actuation modes with the finger motion and the tendon force with the finger characteristics. For the hand design, the use of differential mechanisms simplifies the actuation scheme, as we utilize only two actuators for four fingers, achieving affordable dexterity. A design optimization framework assess the results of hand anthropometry studies to derive key parameters for the bio-inspired actuation design. The model assumptions are evaluated with the finite element method. The proposed finger has been fabricated with the Hybrid Deposition Manufacturing technique and the actuation mechanism's efficiency has been validated with experiments that include the computation of the finger workspace, the assessment of the force exertion capabilities, the demonstration of the feasible motions, and the grasping and manipulation capabilities. Also, the hand design is fabricated with off-the-shelf materials and rapid prototyping techniques while its efficiency has been validated using an extensive set of experimental paradigms that involved the execution of grasping and in-hand manipulation tasks with everyday objects. / Master of Science / This thesis presents the design, modeling, and development of adaptive robot hands that are capable of performing selective interdigitation, robust grasping, and dexterous, in-hand manipulation. The robotic fingers employ an adaptive actuation mechanism. The design is minimal and the hand is capable of performing selective interdigitation, robust grasping, and dexterous, in-hand manipulation. Particular emphasis has been given to the modeling and the analysis of the actuation mechanism. For the hand design, the use of differential mechanisms simplifies the actuation scheme, as we utilize only two actuators for four fingers, achieving affordable dexterity. A design optimization framework assess the results of hand anthropometry studies to derive key parameters for the actuation design. The robotic fingers and the anthropomorphic hand were fabricated using off-the-self materials and additive manufacturing techniques. Several experiments were performed to validate the efficacy of the robot hand.

An under-body blast (UBB) refers to the use of a roadside explosive device to target a vehicle and its occupants. During Operation Iraqi Freedom, improvised explosive devices (IEDs) accounted for an estimated 63% of US fatalities. Furthermore, advancements in protective equipment, combat triage, and treatment have caused an increase in IED casualties surviving with debilitating injuries. Military vehicles have been common targets of IED attacks because of the potential to inflict multiple casualties. Anthropomorphic test devices (ATDs) are mechanical human surrogates designed to transfer loads and display kinematics similar to a human subject. ATDs have been used successfully by the automotive industry for decades to quantify human injury during an impact and assess safety measures. Currently the Hybrid III ATD is used in live-fire military vehicle assessments. However, the Hybrid III was designed for frontal impacts and demonstrated poor biofidelity in vertical loading experiments. To assess military vehicle safety and make informed improvements to vehicle design, a novel Anthropomorphic Test Device (ATD) was developed and optimized for vertical loading. ATDs, commonly referred to as crash dummies, are designed to estimate the risk of injuries to a human during an impact. The main objective of this study was to develop and validate a Finite Element (FE) model of the ATD lower limb. / Master of Science / An under-body blast (UBB) refers to the use of a roadside explosive device to target a vehicle and its occupants. During Operation Iraqi Freedom, improvised explosive devices (IEDs) accounted for an estimated 63% of US fatalities. Furthermore, advancements in protective equipment, combat triage, and treatment have caused an increase in IED casualties surviving with debilitating injuries. Military vehicles have been common targets of IED attacks because of the potential to inflict multiple casualties. Anthropomorphic test devices (ATDs) are mechanical human surrogates designed to transfer loads and display kinematics similar to a human subject. ATDs have been used successfully by the automotive industry for decades to quantify human injury during an impact and assess safety measures. Currently the Hybrid III ATD is used in live-fire military vehicle assessments. However, the Hybrid III was designed for frontal impacts and demonstrated poor biofidelity in vertical loading experiments. To assess military vehicle safety and make informed improvements to vehicle design, a novel Anthropomorphic Test Device (ATD) was developed and optimized for vertical loading. ATDs, commonly referred to as crash dummies, are designed to estimate the risk of injuries to a human during an impact. The main objective of this study was to develop and validate a Finite Element (FE) model of the ATD lower limb.

For over 30 years, the development and control of anthropomorphic robotic hands has been a highly popular sub-discipline in robotics research. Because the human hand is an extremely sophisticated system, both in its mechanical and sensory abilities, engineers have been fascinated with replicating these abilities in artificial systems. The applications of robotic hands typically fall under the categories of standalone testbed platforms, mostly to conduct research on manipulation, prosthetics, and robotic end effectors for larger systems. The teleoperation of robotic hands is another application with significant potential, where users can control a manipulator in real time to accomplish diverse tasks. In controlling a device that seeks to emulate the function of the human hand, it is intuitive to choose a human-machine interface (HMI) that will allow for the most intuitive control. Data gloves are the ideal HMI for this need, allowing a robotic hand to accurately mimic the human operator's natural movements. In this paper we present a combined review on the critical design aspects of data gloves and robotic hands. In literature, many of the proposed designs covering both these topical areas, robotic hand and data gloves, are cost prohibitive which limits their implementation for intended tasks. After reviewing the literature, new designs of robotic hand and data glove technology are also presented, introducing low cost solutions that can serve as accessible platforms for researchers, students, and engineers to further the development of teleoperative applications. / Master of Science / For over 30 years, the development and control of anthropomorphic robotic hands has been a highly popular sub-discipline in robotics research. Because the human hand is an extremely sophisticated system, both in its mechanical and sensory abilities, engineers have been fascinated with replicating these abilities in artificial systems. The applications of robotic hands typically fall under the categories of standalone testbed platforms, mostly to conduct research on manipulation, prosthetics, and robotic end effectors for larger systems. The teleoperation of robotic hands is another application with significant potential, where users can control a manipulator in real time to accomplish diverse tasks. In controlling a device that seeks to emulate the function of the human hand, it is intuitive to choose a human-machine interface (HMI) that will allow for the most intuitive control. Data gloves are the ideal HMI for this need, allowing a robotic hand to accurately mimic the human operator’s natural movements. In this paper we present a combined review on the critical design aspects of data gloves and robotic hands. In literature, many of the proposed designs covering both these topical areas, robotic hand and data gloves, are cost prohibitive which limits their implementation for intended tasks. After reviewing the literature, new designs of robotic hand and data glove technology are also presented, introducing low cost solutions that can serve as accessible platforms for researchers, students, and engineers to further the development of teleoperative applications.

This research deals with the phenomenon of anthropomorphic vessels between the 7th and the beginning of the 5th millennium BC in a vast area that includes the Italian peninsula with Sicily, Central Europe, the Balkans and the Near East. The survey concerned 927 specimens from 229 sites. The formal analysis of the artifacts belonging to the cultures attested between Mesopotamia and the Rhine river allowed to establish the times and vectors of diffusion of this tradition before its arrival in Italy, as well as to hypothesize the connections that have transmitted the tradition of the anthropomorphic vessel to the Neolithic farming communities in the south-east of southern Italy. The study of Italian finds has led to the recognition of four main areas affected by the phenomenon and has allowed us to define their styles. An important part of the study was the examination of the archaeological contexts of the finds, in order to understand the possible spheres of use. In particular, the research allowed us to highlight the frequent and widespread presence of the anthropomorphic vessel in waste pits together with a series of symbolic objects: a constant presence and therefore not random, which is a hint of deliberate deposition of selected materials. This circumstance suggests that the anthropomorphic vessel belongs to a set of objects of ritual use and that the Neolithic refuse pit, contrary to what is generally believed, should be interpreted also as places of performative activity.

La protonthérapie est une technique avancée de radiothérapie qui permet de délivrer une dose élevée à la tumeur, tout en épargnant au mieux les tissus sains environnants, grâce aux propriétés balistiques des protons. Cependant, des particules secondaires, principalement des neutrons, sont créées par les interactions nucléaires que les protons initient dans les composantes de la ligne et de la salle de traitement, ainsi que dans le patient. Ces neutrons secondaires conduisent à des doses indésirables déposées aux tissus sains situés à distance du volume cible, dont la conséquence pourrait être une augmentation du risque de développement de seconds cancers chez les patients traités et en particulier chez les enfants. Cette thèse a pour objectif d’évaluer par calcul les doses dues aux neutrons secondaires reçues par des patients de différents âges traités à l’Institut Curie- centre de protonthérapie d’Orsay (ICPO) par des faisceaux de protons de 178 MeV pour des tumeurs intracrâniennes. Les traitements sont réalisés dans la nouvelle salle de l’ICPO équipée d’un bras isocentrique IBA. Les composants de la ligne et de la salle de traitement ainsi que la source de protons ont été modélisés à l’aide du code de calcul Monte Carlo MCNPX. Le modèle obtenu a été validé par une série de comparaisons de calculs à des mesures expérimentales. Ces comparaisons ont concerné : a) les distributions de doses latérales et en profondeur du faisceau de protons primaire dans un fantôme d’eau, b) la spectrométrie des neutrons en une point de la salle, c) les équivalents de doses ambiants en différents points de la salle et d) les doses à distance du volume cible au sein d’un fantôme physique anthropomorhe. Des accords satisfaisants ont été obtenus entre les calculs et les mesures, permettant ainsi de considérer le modèle comme validé.Les fantômes hybrides-voxels de différents âges, développés par l’Université de Floride ont été ensuite introduits dans le modèle et des calculs de doses dues aux neutrons secondaires aux différents organes de ces fantômes ont été réalisés. Les doses diminuent lorsque la distance de l’organe au champ de traitement augmente et lorsque l’âge du patient augmente. Un patient de 1 an peut recevoir des doses deux fois plus élevées qu’un adulte. La dose maximale, égale à 16,5 mGy pour un traitement délivrant 54 Gy à la tumeur, est reçue, pour le fantôme de 1 an, par les glandes salivaires. Une incidence latérale (gauche ou droite) du faisceau de protons peut délivrer des doses deux fois plus élevées qu’une incidence supérieure (gauche ou droite), et quatre fois plus élevées qu’une incidence antéro-supérieure pour certains organes. Des doses équivalentes aux organes dues aux neutrons ont été aussi calculées. Les facteurs de pondération wR des neutrons varient entre 4 et 10, et les doses équivalentes atteignent au maximum 155 mSv au cours d’un traitement complet. / Proton therapy is an advanced radiation therapy technique that allows delivering high doses to the tumor while saving the healthy surrounding tissues due to the protons’ ballistic properties. However, secondary particles, especially neutrons, are created during protons’ nuclear reactions in the beam-line and the treatment room components, as well as inside the patient. Those secondary neutrons lead to unwanted dose deposition to the healthy tissues located at distance from the target, which may increase the secondary cancer risks to the patients, especially the pediatric ones. The aim of this work was to calculate the neutron secondary doses received by patients of different ages treated at the Institut Curie-centre de Protonthérapie d’Orsay (ICPO) for intracranial tumors, using a 178 MeV proton beam. The treatments are undertaken at the new ICPO room equipped with an IBA gantry. The treatment room and the beam-line components, as well as the proton source were modeled using the Monte Carlo code MCNPX. The obtained model was then validated by a series of comparisons between model calculations and experimental measurements. The comparisons concerned: a) depth and lateral proton dose distributions in a water phantom, b) neutron spectrometry at one position in the treatment room, c) ambient dose equivalents at different positions in the treatment room and d) secondary absorbed doses inside a physical anthropomorphic phantom. A general good agreement was found between calculations and measurements, thus our model was considered as validated. The University of Florida hybrid voxelized phantoms of different ages were introduced into the MCNPX validated model, and secondary neutron doses were calculated to many of these phantoms’ organs. The calculated doses were found to decrease as the organ’s distance to the treatment field increases and as the patient’s age increases. The secondary doses received by a one year-old patient may be two times higher than the doses received by an adult. A maximum dose of 16.5 mGy for a whole treatment delivering 54 Gy to the tumor was calculated to the salivary glands of a one year-old phantom. The calculated doses for a lateral proton beam incidence (left or right) may be, for some organs, two times higher than doses for an upper incidence (left or right) and four times higher than doses for an antero-superior incidence. Neutron equivalent doses were also calculated for some organs. The neutron weighting factors wR were found to vary between 4 and 10 and the equivalent doses for the considered organs reached at maximum 155 mSv during a whole treatment.

Este trabalho visa contribuir para redução do grau de rejeição de próteses para membros superiores, tornando-as mais funcionais e eficientes. Tais propósitos são almejados por meio do estudo centrado no desenvolvimento de uma plataforma eletrônica de controle e nos demais constituintes de uma prótese. Dentre eles estão os atuadores, sensores, mecanismos e o programa de gerenciamento, que integra todos os componentes para as ações da prótese. Para esse trabalho foi usado somente um dedo para a execução de todos os testes, sendo esse dedo compatível com o desenvolvimento de uma prótese antropomórfica multifunção. O paciente comanda as ações da prótese ao enviar suas decisões à ela por meio de sinal mioelétrico, mas as ações da mesma são executadas de forma inconsciente. Isto é possível devido ao programa de gerenciamento, que controla os movimentos antropomórficos a partir de trajetórias definidas e também pelas informações de sensações de força e temperatura para o paciente, realimentação proprioceptiva. / This work contributes to minimize the rejection level of upper limb prosthesis, keeping it more function and efficient. This achieved by the development of a control electronic platform and the others prosthesis components, like actuators, sensors, mechanisms and the management program, that integrate all the components to actions of prosthesis. In this work was used only one finger to perform of all tests, and this finger is compatible with the development of a multifunction anthropomorphic prosthesis. The user command comes from myoelectric signal, but the actions in the prosthesis are executed unconsciously. The management program control the anthropomorphic movements based on defined trajectory and create information of force and temperature sensation to the user, proprioceptive feedback.

In the thesis study, it is intended to design and manufacture an anthropomorphic robot head that can resemble human head/neck and eye movements. The designed robot head consists of a 4-DOF neck and a 4-DOF head. The head is composed of 3-DOF eyes and 1-DOF jaw. This work focuses on the head/neck and eyes therefore / the other free to move parts such as eyebrows, eyelids, ears etc. are not implemented. The general kinematic human modeling technique can be applied to facilitate the humanoid robotics design process since human anatomy can be represented as a sequence of rigid bodies connected by joints. In this study, we refer to the anthropometric data in determining the dimensions of all parts in order to have a robot head as human-like as possible. In addition, motion types, motion ranges and their velocities are considered. These factors are of great importance in imitating the human head movements as close as possible. It is intended that the developed humanoid robot head will be used as a research platform in studying fields such as / social interaction between human and robots, artificial intelligence and virtual reality. It will also be an experimental setup to conduct experiments for studying active vision systems.

abstract: Coronary computed tomography angiography (CTA) has a high negative predictive value for ruling out coronary artery disease with non-invasive evaluation of the coronary arteries. My work has attempted to provide metrics that could increase the positive predictive value of coronary CTA through the use of dual energy CTA imaging. After developing an algorithm for obtaining calcium scores from a CTA exam, a dual energy CTA exam was performed on patients at dose levels equivalent to levels for single energy CTA with a calcium scoring exam. Calcium Agatston scores obtained from the dual energy CTA exam were within ±11% of scores obtained with conventional calcium scoring exams. In the presence of highly attenuating coronary calcium plaques, the virtual non-calcium images obtained with dual energy CTA were able to successfully measure percent coronary stenosis within 5% of known stenosis values, which is not possible with single energy CTA images due to the presence of the calcium blooming artifact. After fabricating an anthropomorphic beating heart phantom with coronary plaques, characterization of soft plaque vulnerability to rupture or erosion was demonstrated with measurements of the distance from soft plaque to aortic ostium, percent stenosis, and percent lipid volume in soft plaque. A classification model was developed, with training data from the beating heart phantom and plaques, which utilized support vector machines to classify coronary soft plaque pixels as lipid or fibrous. Lipid versus fibrous classification with single energy CTA images exhibited a 17% error while dual energy CTA images in the classification model developed here only exhibited a 4% error. Combining the calcium blooming correction and the percent lipid volume methods developed in this work will provide physicians with metrics for increasing the positive predictive value of coronary CTA as well as expanding the use of coronary CTA to patients with highly attenuating calcium plaques. / Dissertation/Thesis / Ph.D. Bioengineering 2013

Este trabalho visa contribuir para redução do grau de rejeição de próteses para membros superiores, tornando-as mais funcionais e eficientes. Tais propósitos são almejados por meio do estudo centrado no desenvolvimento de uma plataforma eletrônica de controle e nos demais constituintes de uma prótese. Dentre eles estão os atuadores, sensores, mecanismos e o programa de gerenciamento, que integra todos os componentes para as ações da prótese. Para esse trabalho foi usado somente um dedo para a execução de todos os testes, sendo esse dedo compatível com o desenvolvimento de uma prótese antropomórfica multifunção. O paciente comanda as ações da prótese ao enviar suas decisões à ela por meio de sinal mioelétrico, mas as ações da mesma são executadas de forma inconsciente. Isto é possível devido ao programa de gerenciamento, que controla os movimentos antropomórficos a partir de trajetórias definidas e também pelas informações de sensações de força e temperatura para o paciente, realimentação proprioceptiva. / This work contributes to minimize the rejection level of upper limb prosthesis, keeping it more function and efficient. This achieved by the development of a control electronic platform and the others prosthesis components, like actuators, sensors, mechanisms and the management program, that integrate all the components to actions of prosthesis. In this work was used only one finger to perform of all tests, and this finger is compatible with the development of a multifunction anthropomorphic prosthesis. The user command comes from myoelectric signal, but the actions in the prosthesis are executed unconsciously. The management program control the anthropomorphic movements based on defined trajectory and create information of force and temperature sensation to the user, proprioceptive feedback.