Orientador: Marco Antonio Tecchio / Resumo: O trabalho teve como objetivo avaliar o potencial produtivo das videiras, além de determinar o conteúdo de ácidos orgânicos, açúcares, compostos bioativos e a atividade antioxidante em uvas e sucos de uva de cultivares Vitis labrusca e híbridas cultivadas sobre diferentes portaenxertos sob condições tropicais na região Noroeste do Sudeste do Brasil. O experimento foi realizado em vinhedo do Instituto Agronômico, em Votuporanga, Estado de São Paulo. Foram avaliadas as cultivares Isabel Precoce, BRS Carmem, BRS Cora e IAC 138-22 ‘Máximo’ enxertadas sobre os portaenxertos IAC 766 ‘Campinas e IAC 572 ‘Jales’. As características produtivas das videiras foram avaliadas em dois ciclos produtivos (2017/2018). Os resultados mostraram que as cultivares BRS Carmem, BRS Cora e Isabel Precoce foram significativamente mais produtivas em relação à IAC 138-22 ‘Máximo’. A uva ‘Isabel Precoce’ apresentou características físico-químicas que atendem os padrões de sólidos solúveis e acidez exigidos pela legislação, o que pode representar uma grande vantagem ao produtor na busca de diferentes cultivares para blends em processamento de suco de uva. Em relação aos portaenxertos, o IAC 766 ‘Campinas’ proporcionou maior produtividade às copas, maior número de cachos por plantas, além de maior massa fresca do cacho. Ocorreu correlação positiva entre o conteúdo fenólico, antocianinas e atividades antioxidantes para as cultivares analisadas. Maiores teores de antocianinas e compostos fenólicos foram obti... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The aim of this study consisted of evaluating yield potential of grapevines, besides of determining content of organic acids, sugars, bioactive compounds and antioxidant activity in grapes and grape juices of the cultivars Vitis labrusca and hybrid cultivars grafted on different rootstock under tropical conditions in northwestern of the Southeast region of Brazil. The experiment was conducted in the Instituto Agronômico’s vineyards at Votuporanga, São Paulo state. The cultivars assessed were Isabel Precoce, BRS Carmem, BRS Cora and IAC 138-22 ‘Máximo’, grafted in the rootstocks IAC 766 ‘Campinas’ and IAC 572 ‘Jales’. The highest yields were observed in the cultivars BRS Carmem, BRS Cora and Isabel Precoce that were statistically superior compared to IAC 138-22 ‘Máximo’. Physiochemical characteristics of the grape Isabel Precoce has attended standards of the Brazilian legislation for soluble solids concentration and titratable acidity, which can be an advantage to producers seeking different cultivars for grape juice blends. Regarding rootstocks, the highest yields, number of clusters per vine and highest dry weight of the cluster were obtained using ‘IAC 766’. A positive correlation between phenolics content, anthocyanins and antioxidants activities was observed in all cultivars. Higher content of anthocyanins and phenolic compounds were obtained in grapes of the cultivar IAC 138-22 ‘Máximo’ and greater antioxidant activity was found in grapes of the cultivars BRS Cora when a... (Complete abstract click electronic access below) / Mestre

8. Abstract The fruit of the European elder, Sambucus nigra L., is used in therapy as a drug Sambuci fructus for its diaphoretic, diuretic and laxative effects. Cultivars of European elder are being studied for the use in the food industry and pharmacy. The fruit contains especially large amount of anthocyanins and flavonoids that are known for their antioxidant activity. The aim of this work is to measure the antioxidant activity of the drug Sambuci fructus and of the fruit of the European elder cultivars Samdal, Mammut, Sambo, Sambu, Sampo, Bohatka, Haschberg, Weihenstephan, Allesö, and Samyl. An extract containing anthocyanins was obtained from fruit by a process based on extraction of frozen material with acidified water at high temperature, followed by separation with polymer non-ionogenic polystyrene-divinylbenzene sorbent. The content of anthocyanins in the extracts was determined spectrophotometrically using a modified pH-differential method. The absorbance was measured along the range of 350 - 600 nm. The content of the anthocyanins was quantified in units of mg of cyanidin 3-glucoside in 1 ml of extract. The content ranged from 0.33 - 2.76 mg cyanidin 3-glucoside/ml of extract. The highest content was in the extract from the fruit of the cultivar Samdal and the lowest was of the cultivar Mammut....

<p>U ovoj studiji su predstavljeni rezultati taksonomskog, fitogeografskog i ekolo&scaron;kog istraživanja urbane flore Novog Sada sa posebnim osvrtom na uče&scaron;će alohtonih vrsta, i&scaron;čezlih i ugroženih taksona i prirodne resurse lekovitog bilja. Sprovedene taksonomske analize su komparativno rađene na ukupnoj urbanoj flori (850) i flori ruderalnih stani&scaron;ta (344) Novog Sada. Zabeleženi su i&scaron;čezli i ugroženi biljni taksoni na teritoriji grada Novog Sada. Ukupno 79 vrsta se smatra da je nestalo sa područja grada Novog Sada do<br />dana&scaron;njeg period,a &scaron;to je 8,04% od ukupnog broja vrsta. Utvrđeno je&nbsp; 115 (12,85%) vrsta koje su ugrožene na području grada Novog Sada. Od ukupno 895 vrsta ruderalne flore invazivne vrste&nbsp; su zastupljene sa 74 predstavnika (8,25%). Analizom ukupne flore evidentirano je 123 lekovitih biljaka. Iz ukupne flore izdvojene su biljke sa etarskim uljem, alkaloidima, fenolima i vitaminima koje koristi zvanična medicina. Od ukupnog broja taksona, izdvojeno je 23 medonosne biljke, 25 krmnih biljaka, 60 ukrasnih vrsta, 35 industrijskih, 68 alergijskih biljaka i 7 vrsta koje vezuju tlo. Analizom odabranih biljnih organa invazivnih vrsta&nbsp; (<em>Solidago gigantea, Iva xanthifolia, Amorpha futicosa, Fallopia<br />japonica i Ailanthus altissima</em>)&nbsp; utvrđen je ukupni sadržaj fenola i flavonoida.<br />Najveći sadržaj analiziranih ukupnih sekundarnih biomolekula (fenola i flavonoida) je utvrđen u&nbsp;<em> Fallopia japonica, Ailanthus altissima&nbsp; i&nbsp; Amorpha fruticosa</em>.&nbsp; Antiradikalsko delovanje&nbsp; ispitivanih ekstrakata je utvrđeno na nivou neutralizacije reaktivnih kiseoničnih vrsta (OH, NO i DPPH radikala). Antiradikalsko delovanje na nivou neutralizacije&nbsp; OH radikala odnosno najsnažnije &bdquo;skevindžer&ldquo; delovanje ispoljeno je od strane ekstrakta lista <em>Fallopia japonica</em>&nbsp; (IC50=10,89 &mu;g/ml)&nbsp; dok je ne&scaron;to manju aktivnost pokazala&nbsp;cvast pomenute vrste (IC50=14,87 &mu;g/ml).</p> / null / <p>Results of taxonomy, phitogeogrphical and ecological analysis of ruderal flora of Novi Sad with special attention in alien species and medicinal plant as natural resorces of&nbsp; ruderal flora are presented in this Thesis. Floristic review involving, taxonomy,&nbsp; phitogeographical and ecological analysis of total (895) and ruderal flora (344) of Novi Sad. Extincted (79) and endangered (115) species were recorded in the urban flora of Novi Sad. Invasive species (74) were recorded in total flora (8,25 %).<br />Analysis&nbsp; of the total urban flora of Novi Sad as potential natural resorces recorded 123 medicinal herbs (32 alien and 91 native), 23 nectar and polen rich plants, 25 forage crops, 60 ornamental, 35 plants for industrial use, 68 allergic i 7 soil errosion control plants.<br />The analysis of sampled plant organs of invasive species (Solidago gigantea, Iva xanthifolia, Amorpha futicosa, Fallopia japonica i Ailanthus altissima) were determined total phenolic compounds and flavonoids. Antioxidant activity of plant extracts&nbsp; was determined at the level of neutralizing reactive oxygenspecies (OH,&nbsp; NO and DPPH radicals). The Content of total phenolics and flavonoids were determinated in&nbsp; Fallopia japonica, Ailanthus altissima&nbsp; and Amorpha fruticosa. The best values of OH radical&nbsp; neutralization indicated leaves of&nbsp; Fallopia japonica&nbsp; (IC50=10,89 &mu;g/ml) and flowers (IC50=14,87 &mu;g/ml).</p>

Global food and nutritional insecurities, public health challenges of diet-linked non-communicable chronic diseases (NCDs), and rapid climate change-linked agricultural production challenges are interconnected and require urgent attention. Therefore, to address these complex and interconnected challenges, it is essential to advance robust and resilient strategies based on sustainable agricultural production practices, wider integration of nutritionally-balanced plant-based foods in the diet, improvement of human health-targeted nutritional qualities, post-harvest preservation qualities and food processing optimization. Therefore, food plants that are climate resilient and rich source of human health protective nutritional bioactives, such as sweet potato are ideal dietary targets for advancing global food and nutritional security solutions, while also addressing emerging NCD-linked health challenges. Sweet potatoes are rich source of stress protective phenolic bioactives with dual functional benefits relevant for resilience to climate change and countering diet-linked NCD challenges. However, the phenolic bioactive compounds and associated health protective functionalities of sweet potatoes vary widely between different flesh color and cultivars, due to different pre-harvest production practices, post-harvest storage conditions, and with different food processing strategies. Therefore, the aim of this dissertation was to screen sweet potato cultivars of different flesh color (off-white, orange, purple) and optimizing different food processing strategies based on optimum phenolic bioactive-linked antioxidant, anti-diabetic and anti-hypertensive properties using metabolically-targeted in vitro assay models. Overall, high soluble phenolic-linked antioxidant activity was observed in purple-fleshed cultivar, while high type 2 diabetes relevant anti-hyperglycemic and anti-hypertensive properties were observed in orange and white-fleshed sweet potatoes. Additionally, improvement in stability and retention of phenolic bioactives and associated functionalities were present in bio-transformed sweet potatoes after fermentation with beneficial lactic acid bacteria (LAB). Furthermore, food processing (deep-frying, baking, steaming, and boiling) optimization studies revealed optimum food processing conditions (cooking temperature, cooking time, and sweet potato sample size) based on higher retention of phenolics and associated antioxidant and anti-hyperglycemic functionalities. We also advanced metabolically-driven elicitation strategy based on the conceptual foundation of dual functional benefits of phenolic compounds to improve wound-healing in bruised potato tubers through stimulation of redox-linked pathway (pentose phosphate pathway) regulation associated with stress-protective phenolic biosynthesis and antioxidant enzyme responses.

>Magister Scientiae - MSc / Drought is a major stress that affects the productivity of plants across the globe. The consequences of drought are posed to continue reducing agricultural productivity as world climate changes. This makes it imperative to improve tolerance of staple food crops to drought. Under drought stress, reactive oxygen species (ROS) accumulate, which may lead to oxidative damage of DNA, proteins and lipids.

In this thesis was determinated selected chemical and nutritional parameters in the wild elderberry and 17 cultivated varieties of elderberry. The fruits was provided by the Research and Breeding Institute of Pomology Holovousy Ltd. The theoretical part deals describes elderberry, chemical composition of elderberry, especially biological active substances and its using not only food industry. Closer attention has been focused on effect of saccharides, anthocyanins and methods of their determination, specially determination by HPLC. The experimental part describes the various methods of determination of selected chemical and nutritional parameters. Total dry matter, content of total polyphenolic compounds, monomeric anthocyanin pigment and antioxidant activity was defined in all varieties of elderberry fruits. For some varieties was defined total soluble dry matter, content of organic acids and saccharides by various methods. In the end was compared the values from different methods varieties.

Stamen from Paeonia ostii 'Fengdan Bai' and Paeonia rockii is rich in phenolic compounds and popularly used as tea materials with various pharmaceutical functions. In order to investigate whether stamen from other tree peony cultivars could be used as a natural antioxidant, the quality of stamen from thirty-five cultivars collected from the same garden was evaluated based on their phenolic composition and content by high-performance liquid chromatography analysis and in vitro antioxidant properties coupled with comprehensive chemometrics analysis. The results revealed that phenolic contents and antioxidant capacities of tree peony stamen were unique and cultivar dependent. Stamen from 'Zi Erqiao' exhibited the highest total phenolic and flavonol content, and strongest antioxidant activities, while that of 'Fengdan Bai' and P. rockii were at below-average levels among test samples. Further, thirty-seven cultivars of tree peony were divided into three major groups with a significant difference in total metabolites content and antioxidant properties, which were mainly contributed by six phytochemical compounds. Among these, naringin and benzoylpaeoniflorin were found to be critical chemical markers for the identification of tree peony stamen with high quality by chemometric analysis. Moreover, correlation analysis suggested that stamen from the earlier flowering cultivars with the hidden pistil, double petal, shorter thrum, more carpel and volume were possibly of higher quality. Together, cultivars with stamen enriched in phenolics and antioxidants properties, and their relevant critical phenotypic and phytochemical traits were screened out. This study would benefit the rapid identification of tree peony stamen with high quality and provide a valuable reference for its development and utilization as functional foods and pharmaceutical resources.

<p>Upotrebom 50% etanola i 50% acetona kao ekstragensa izvr&scaron;ena je ekstrakcija delova ploda kestena: srž ploda, braon spoljna kora ploda, crvena unutra&scaron;nja kora ploda, ceo plod (bez ježevica), kao i drveta: li&scaron;će, resa, ježevice, stara i mlada kora stabla. Ispitivani su pitomi kesten, lovranski marun i kalemljeni italijanski marun. Nakon određivanja prinosa suvog ekstrakta, primenom standardnih spektrofotometrijskih metoda određen je sadržaj fenolnih jedinjenja, flavonoida i kondenzovanih tanina. Iako je primenom 50% acetona kao ekstragensa dobijen veći prinos fenolnih materija, flavonoida i kondenzovanih tanina, za proizvodnju ekstrakata se preporučuje 50% etanol kao ekstragens, jer obezbeđuje sasvim zadovoljavajuće rezultate, a prihvatljiviji je sa aspekta znatno niže toksičnosti.<br />Ekstrakt lista lovranskog maruna i rese pitomog kestena roda 2007. godine &scaron;tite eritrocite od hemolize izazvane H₂O₂.<br />Glavne komponente hidrolizata nakon metanolizacije ekstrakata su dimetil estar dehidrodigalne kiseline i metil estar dilaktona elaginske i valoneinske kiseline. Kvantitativnom LC/MS i HPLC/DAD analizom najveći sadržaj elagitanina je utvrđen za ekstrakt ježevica (170,6 mg/g ekstrakta).<br />Izv&scaron;eno je ispitivanje antioksidativne aktivnosti ekstrakata u odnosu na 1,1-difenil-2-pikrilhidrazil (DPPH), hidroksi (^&bull;OH) i superoksidni anjon (^&bull;O₂^-) radikale. Kapacitet ekstrakata za transformaciju organskih hidrofilnih radikala, ispitan kao sposobnost redukcije spin probe Tempon je najveći za ekstrakt rese pitomog kestena (A = 18,1%), dok ekstrakti lista pitomog kestena i mlade kore drveta ispoljavaju slabu aktivnost. Ispitivanje protektivnog delovanja ekstrakata u odnosu na UV zračenje određeno je kao sposobnost uklanjanja ^&bull;OH i ^&bull;O₂^- radikala nastalih nakon zračenja. Ekstrakti koji ispoljavaju pozitivne, ali relativno niske RI vrednosti za proizvodnju obe vrste radikala ^&bull;OH i ^&bull;O₂^- su spoljna braon kora lovranskog maruna, resa sa kalemljenog italijanskog maruna i list lovranskog maruna. Negativne RI vrednosti dobijene za ostale ekstrakte ukazuju na prooksidativnu aktivnost u vodenom rastvoru izloženom UV zračenju. Ekstrakti rese, lista i ježevica ispoljavaju aktivnost u cilju preveniranja/otklanjanja lipidne peroksidacije membrane eritrocita.<br />Ispitivanjem<em> in vitro</em> antioksidativne aktivnosti primenom MTT testa je utvrđeno da ekstrakti rese i ježevica pitomog kestena i lista lovranskog maruna imaju izuzetno visoku antioksidativnu aktivnost u ćeliji. Naročito je povoljna činjenica da deluju u niskim koncentracijama (0,02 mg/ml). Antimikrobna aktivnost ekstrakata <em>C. sativa </em>određena je u odnosu na (G+) bakterije: <em>S. aureus, S. lutea, B. cereus, L. lactis ssp. lactis, M. pyrogenes var. albus</em>, kao i na (G-) bakterije: <em>P. mirabilis i S. typhimurium</em>. Značajnu antimikrobnu aktivnost daju ekstrakti kore drveta, ježevica i spoljne braon kore ploda. Ekstrakti srži ploda i celog ploda nisu ispoljili antimikrobnu aktivnost. Postoji značajna i jako značajna korelacija između antimikrobne aktivnosti ekstrakata, kao i antimikrobne i antioksidativne aktivnosti u odnosu na superoksid anjon radikale. Ekstrakti lista, ježevica, spoljne braon i unutra&scaron;nje crvene kore ploda, kao i kore drveta <em>C. sativa</em> Mill. dobijeni primenom 50% etanola kao ekstragensa predstavljaju značajan izvor komponenata sa farmakolo&scaron;kim delovanjem u cilju smanjenja nivoa oksidativnog stresa, poseduju visok kapacitet sprečavanja lipidne peroksidacije, deluju u pravcu preveniranja/otklanjanja lipidne peroksidacije i za&scaron;tite membrane eritrocita, imaju visoku <em>in vitro</em> antioksidativnu aktivnost, a ispoljavaju i značajnu antimikrobnu aktivnost.</p> / <p>Parts of chestnut such as: seeds (without spiny burs), peeled chestnut, red internal seed coat and brown seed coat, as well as parts of the trees: leaf, catkin, spiny burs, young and old chestnut bark have been extracted by 50% ethanol and 50% acetone as an extragent. Three cultivars of <em>Castanea sativa</em> Mill.: sweet chestnut, Lovran&#39;s marrone and grafted Italian marrone were examined. After determination of the yield of dry extract, the content of total phenolic compounds, flavonoids and condensed tannins are determined by application of standard spectrophotometrics methods. Although, the highest content of total phenolics, flavonoids and condensed tannins are obtained by 50% acetone as extragents, for production of extracts 50% ethanol is more suitable, regards much lower toxicity.<br />Extracts of the leaf of Lovran&#39;s marrone and catkin of sweet chestnut native in 2007, protect erythrocytes from hemolysis provoked by H₂O₂.<br />Dehydrodigallic acid dimethyl ester, ellagic acid and valoneic acid dilactone methyl ester are the main compounds in all hydrolysates after methanolisation. The highest content of ellagitannin was detected in extract of spiny burs (170.6 mg/g extract), by application of quantitative LC/MS and HPLC/DAD analysis.<br />The examination of antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (^&bull;OH) and superoxide (^&bull;O2^-) radicals have been done. Capacity of extracts for removal of organic, hydrophilic radicals, exanimate as potential of reduction of spin probe Tempon is highest in extract of catkin of sweet chestnut (A = 18.1%), while extracts of catkin, leaf and spiny burs almost have no antioxidative activity. The evaluation of UV-protective activity of extracts is determinated as capacity for removal of ^&bull;OH and O₂^- radicals generated after irradiation. Extracts which showed positive, but relative low RI values for production of both radical species, OH and ^&bull;O₂ radicals, are brown seed coat of Lovran&#39;s marrone, catkin of grafted Italian marrone and leaf of Lovran&#39;s marrone. Negative RI values obtained for other extracts show that these have prooxidative activity in aqueous solution exposed to UV radiation. Extracts of catkin, leaf and spiny burs expressed activity to prevent/remove lipid peroxidation in the membrane of erythrocytes.<br />Examination of antioxidant activity <em>in vitro</em> by application of MTT test have been detected especially high antioxidant activity of extracts of catkin, spiny bur of sweet chestnut and leaf of Lovran&rsquo;s marrone in the cell. Particularly is favorable that extracts acting in low concentration (0.02 mg/ml). Antimicrobial activity of extracts of <em>C. sativa</em> was determinated against Gram-positive bacteria:<em> S. aureus, S. lutea, B. cereus, L. lactis ssp. lactis, M. pyrogenes var. albus</em>, as well as Gram-negative bacteria: <em>P. mirabilis and S. typhimurium</em>. The significant antimicrobial activity shows extracts of bark, spiny burs and brown seed coat. Extracts of peeled chestnut and seeds didn&rsquo;t show any antimicrobial activity. The very significant and significant correlation existed between antimicrobial activity of extracts, as well as antimicrobial activity and scavenging of^&bull;O2^- radical. Extracts of leaf, spiny burs, brown seed coat and red internal seed coat, as well as bark of <em>C. sativa</em> Mill. produced by 50% ethanol as extragent represent important resource of components with pharmacological activity in reducing level of oxidative stress, possess high activity to prevent/remove lipid peroxidation and protection of the membrane of erythrocytes, have high<em> in vitro</em> antioxidant activity, and also express significant antimicrobial activity.</p>

Drug Sambuci nigrae flos - Sambuci nigrae flos is obtained from the wild plants. The drug is primarily used to help reduce the symptoms of colds and flu. Elder flower provides antioxidant, anti-inflammatory, anticancer and diuretic effects. The main substances are flavonoids and hydroxycinnamic acid. Elderflowers from bred cultivars are not used to obtain drug so far. The aim of this work was to determine antioxidant acitivitiy of extracts of eldeflower cultivars. Cultivars ′Albida′, ′Allesö′, ′Aurea′, ′Bohatka′, ′Dana′, ′Haschberg′, ′Heidegg 13′, ′Juicy′, ′Korsør′, ′Mammut′, ′Pregarten′, ′Riese aus Voßloch′, ′Sambo′, ′Sambu′, ′Samdal′, ′Sampo′, ′Samyl′, ′Tulbing′ and ′Weinhenstephan′ were analyzed. Antioxidant activity was measured spectrophotometrically using DPPH ((2,2-diphenyl-1-picrylhydrazyl) radical method. Results of antioxidant activity were expressed as IC50 (concentration required for 50% reduction of the DPPH radical). The measured values are in the range 0.0419 - 0.0772 mg/ml. Cultivars 'Heidegg 13', 'Albida', 'Tulbing' showed the highest antioxidant activity, whereas the lowest activity was found in 'Pregarten','Korsør' and 'Allesö' clutivars.

Os inibidores da enzima acetilcolinesterase constituem o principal tratamento da doença de Alzheimer e fontes de substâncias naturais com potencial anticolinesterásico vêm sendo amplamente estudadas. Dentre os frutos com benefícios para a saúde, a romã é evidenciada como excelente fonte de compostos antioxidantes, sendo que maior parte dos compostos se concentram em sua casca. Com base nisso, o objetivo desta pesquisa foi buscar novas substâncias naturais com potencial anticolinesterásico, através da avaliação de extratos de casca de romã. Quatro extratos com diferentes concentrações de etanol foram analisados quanto à atividade antioxidante, quantidade de compostos fenólicos, taninos e atividade anticolinesterásica. Do presente estudo foi constatado que a casca da romã apresentou elevada capacidade antioxidante, independente da concentração do solvente de extração empregado. O extrato formulado com 80% de etanol se destacou perante os demais pelo seu poder de inibição da acetilcolinesterase. Houve correlação negativa entre a atividade anticolinesterásica e a atividade antioxidante dos extratos. A atomização do extrato não acarretou mudanças em sua atividade anticolinesterásica e nem na sua capacidade antioxidante. Da mesma forma, a adição das micropartículas a um suco elaborado a partir de um preparado em pó não modificou suas características sensoriais. Diante do exposto, a elaboração de micropartículas de extrato de casca de romã constitui alternativa viável para a incorporação em diversos produtos, com a finalidade de prevenir ou reduzir risco da doença de Alzheimer. / The acetylcholinesterase inhibitors are the primary treatment of Alzheimer\'s disease and sources of natural substances with potential anticholinesterase have been widely studied. Among the fruits with health benefits, the pomegranate is evidenced as an excellent source of antioxidant compounds, and most compounds are concentrated in its peel. Based on this, the objective of this research was to find new substances with potential anticholinesterase, through the evaluation of pomegranate peel extracts. Four extracts with different concentrations of ethanol were analyzed for their antioxidant activity, amount of phenolic compounds, tannins and anticholinesterase activity. From this study it was found that pomegranate peel showed high antioxidant capacity, independent of the concentration of the solvent extraction employed. The extract formulated with 80% ethanol in relation to other stood out by his power of acetylcholinesterase inhibition. There was a negative correlation between acetylcholinesterase activity and antioxidant activity of the extracts. Microencapsulation of extract did not cause changes in their anticholinesterase activity and antioxidant capacity. The same way, the addition of microcapsules to a powder preparation for refreshment not changed their sensory characteristics. Given the above, the preparation of microcapsules of pomegranate peel extract is a viable alternative for incorporation into various products, in order to prevent or reduce risk of Alzheimer\'s disease.