For a launch vehicle, the Navigation System is responsible for determining the vehicle state and providing state and state derived information for Guidance and Controls. The accuracy required of the Navigation System by the vehicle is dependent upon the vehicle, vehicle mission, and other consideration, such as impact foot print. NASAs Ares I launch vehicle and SLS are examples of launch vehicles with are/where to employ inertial navigation systems. For an inertial navigation system, the navigation system accuracy is defined by the inertial instrument errors to a degree determined by the method of estimating the initial navigation state. Utilization of GPS aiding greatly reduces the accuracy required in inertial hardware to meet the same accuracy at orbit insertion. For a launch vehicle with lunar bound payload, the navigation accuracy can have large implications on propellant required to correct for state errors during trans-lunar injection.

The purpose of this study was to investigate whether water protection areas with nearby shooting ranges could be polluted by lead from ammunition or not. The goal was to make a risk assessment of the hazard for human health and the environment. The risk assessment leads to a classification of the shooting ranges. The work of the inventory was done according to the method developed by the Swedish Environmental Protection Agency, called “Methodology for Inventory of Polluted Areas”. The report contains two types of studies: one literature study and one practical study where interviews were conducted along with a visit to one of the shooting ranges. The results show that one shooting range was considered to be of high risk to the environment because of the high activity that accumulated several tons of lead and the shooting range’s nearness to a water treatment plant. The other two shooting ranges were smaller and not too close to a drinking water source. Therefore the risks were moderate. Conclusions drawn from this report is that water protection areas within nearby shooting ranges are exposed to potential pollution from lead, but the risks aren’t immediate. Probably will time play an important role to prevent lead spreading to the ground water. Because of its attributes, lead has low mobility under normal conditions.  The vertical transport in the ground is considered slow and it could take hundreds of years before it reaches ground water.

This thesis developed a linear shaped charge (LSC) separation mechanism capable of severing the interstage skin for first stage separation of the Ares I launch vehicle. The derived LSC design solution was found using available data on Explosive Technology’s Jetcord LSC and from National Aeronautics and Space Administration (NASA) Marshall Space Flight Center’s (MSFC) desired characteristics. Mechanism components are designed after Minuteman III’s separation mechanism for first stage separation and NASA MSFC’s desired characteristics. Mechanism severance is verified through the use of the numerical method capability smoothed particle hydrodynamics that the hydrocode Autodyn offers. Three simulations are conducted to determine feasibility: the first of only the LSC exploding, to numerically validate the explosion process; the second of the LSC penetrating the target, to numerically validate the penetration process and failure mechanisms; and the last of the entire mechanism, to obtain information about the explosion, penetration, failure, and debris generated.

Dans les milieux astrophysiques explosifs tels que les novae ou les sursauts X, la densité d'hydrogène et la température sont suffisamment grandes pour que le temps entre deux réactions impliquant un proton soit plus court que le temps de vie de certains ions radioactifs. La connaissance de la section efficace des réactions de capture d’un proton par un ion radioactif est un des ingrédients important permettant la modélisation de tels milieux. Dans ce travail, un nouveau dispositif expérimental permettant d'étudier la force de résonance de réactions (p,gamma) en cinématique inverse est présenté. Ce dispositif, baptisé ARES (Astrophysical REcoil Separator), a été d’abord caractérisé à l'aide de l'étude de la réaction 19F(p,gamma)20Ne et plus particulièrement de la mesure de la force de la résonance bien connue à 635 keV au dessus du seuil 19F+p. De plus, la simulation de cette expérience est en accord avec les mesures effectuées. Une première mesure de force de résonance d'une réaction impliquant un faisceau d'ions radioactifs est ensuite présentée. Il s'agit de la réaction 19Ne(p,gamma)20Na et plus particulièrement de la résonance à 448 keV au dessus du seuil 19Ne+p. Une limite supérieure de 15.2 meV avec un niveau de confiance de 90% est obtenue. Cette limite supérieure améliore légèrement les résultats de mesures antérieures. / In explosive astrophysical environments such as novae or X-ray bursts, the temperature and the hydrogen density are so large that the time between two reactions involving protons is smaller than the live time of radioactive ions. The cross section of such reactions is an important ingredient of the modeling of such environments. In this work, a new experimental device, allowing the study of resonance strength of (p,gamma) reactions, is presented. This setup, called ARES (Astrophysical REcoil Separator), is first characterized using the study of the well known reaction, 19F(p,gamma)20Ne and more precisely the measurement of the resonance strength of the 635 keV level above the 19F+p threshold. The simulation of this experiment is found in good agreement with the measurement. Then the first resonance strength measurement of a reaction involving radioactive ions beams is presented, i.e. the resonance strength of the 448 keV level above the 19Ne+p threshold in the 19Ne(p,gamma)20Na reaction. An upper limit of 15.2 meV with a confidence level of 90% is obtained. This upper limit improves slightly the results of previous measurements.

La présente recherche porte sur le dieu de la guerre des Grecs anciens, Arès. La communauté historienne s’entend pour affirmer qu’Arès était un dieu de second ordre et un dieu mal aimé par les Grecs de l’époque. Les investigations des historiens du XXe siècle sont axées sur les documents littéraires et elles ne font que reformuler, dans la majorité des cas, le contenu de ceux-ci. Alors, afin de bénéficier d’un regard nouveau sur le dieu, on a étudié Arès au travers les documents épigraphiques pour corroborer ou non nos présentes connaissances. Le dieu de la guerre tel que présenté dans les écrits littéraires est-il le même que celui qui est véhiculé dans l’épigraphie de l’époque? La réponse à cette question nous permettra d’établir si nos connaissances actuelles sont valables et elle les complètera. La recherche épigraphique s’effectue en cinq étapes. D’abord, on voit si le côté militaire d’Arès était également prédominant au sein des inscriptions. Ensuite, on porte une attention particulière aux documents épigraphiques pouvant démontrer un Arès mal aimé. Le tout se poursuit avec la mise en relation du dieu et des anciens serments. Enfin, on termine avec une approche plus géographique qui nous permet de définir deux foyers importants du dieu de la guerre, soit la cité de Métropolis et l’île de Crète. À la suite de ce parcours on a déterminé que l’appréciation et l’importance que les Grecs accordaient à ce dieu n’était pas unanime. Le ressentiment des Grecs variaient selon les individus et les lieux. On a aussi été capable d’établir des faits au sujet d’Arès : son domaine d’action prédominant restait le militaire dans les inscriptions; il était un réel dieu, présent, respecté et loué; il possédait d’importants lieux de culte à Lato et Métropolis. Compte tenu d’une redéfinition notable du profil d’Arès, une révision des sources littéraires propres à Arès s’impose ainsi qu’une évaluation complète de toutes les autres sources (iconographique, archéologique, numismatique, épigraphique, etc.). / This study talks about the god of war for the ancient Greeks, Ares. The historical community asserts that Ares was a god of second order and unloved by the Greeks of this period. Investigations of historians of XXe century are focus on literary sources and they simply restate, in most cases, the content of them. To gain a new perspective on the god, Ares was studied through the epigraphic documents to corroborate or not our present knowledge. We want to know if the Ares, as presented in the literature, has been the same as that was transmitted in the ancient Greek epigraphy. The answer to this question will help us to see if our current knowledge is right and deepening it. The epigraphic research is done in five steps. First, we determine whether the military side of Ares was also predominant in the inscriptions. Then we pay a specific attention to documents that propose an unloved Ares in the epigraphy. After, we establish some links between the former oath and Ares. Finally, we close the epigraphic study with a geographic approach who allows us to determine two important sites that belong to the god of war, the city of Metropolis and the island of Crete. Through this process we were able to determine the appreciation and the importance, which the Greeks gave to this god, were not unanimous. The resentment of the Greeks varied among individuals and places. We were also able to establish some facts about Ares : his dominant sphere remained the military in the inscriptions; he was a reel god, present, respected and praised; he possessed important places of worship in Lato and Metropolis. In conclusion, we redefine Ares profile, so it would be interesting that a research reviews the literacy sources about him. Furthermore, an evaluation of all the sources (iconographic, archaeological, numismatic, epigraphic etc…) would also be appropriated.

This diploma thesis deals with the analysis of the requirements, design and implementation of the System for monitoring of insolvency register and commercial register from administrative register of economical subjects. The system has an extendable design which allows further sources to be added at a later date to suit the client's needs. The design process is oriented at small business customers and emphasises the need for simplicity and understandability of the marketed solution. System requirements are analysed first, subsequently, several models with decreasing levels of abstraction are formulated and the System is then implemented, according to these models, using several funkcional increments.

Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2016-10-05T17:36:37Z No. of bitstreams: 1 2011 - Jaqueline da Luz Ferreira.pdf: 1165394 bytes, checksum: 070be4cb2b1887d709e6272f02554b70 (MD5) / Made available in DSpace on 2016-10-05T17:36:37Z (GMT). No. of bitstreams: 1 2011 - Jaqueline da Luz Ferreira.pdf: 1165394 bytes, checksum: 070be4cb2b1887d709e6272f02554b70 (MD5) Previous issue date: 2011-03-25 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / This work aims to describe and reflect on the experience of implementing the Program of Technical Assistance to Social and Environmental Reform (Ates) in some settlements in the northern region of Esp?rito Santo by a cooperative established and managed by members of the Landless Workers Movement. The institutional format of the program enabled entities other than public agencies to receive resources for service provision in the settlements, under the coordination of the National Institute of Colonization and Land Reform (INCRA). Since then, many expectations about how to provide assistance appear everyday during the provision of services in the settlements. In the case of Espirito Santo, for instance, the LWM takes on the task of providing technical assistance in settlements where it is present through Cooptraes. With this, the movement brings in the subject of political activism, which becomes the characteristic of the work of the cooperative's technical staff. Thus, this setup program Ates in Esp?rito Santo causes significant changes in the relationship between the actors involved, which can be seen everyday in services, either through dispute over material and symbolic resources, the appearance of new demands or through the actors' own adaptation to the dynamics of the program's execution. The aim of this study was to analyze the position and understanding of the actors on this process, and from this analysis, to examine the limits and possibilities of this experience. For both aims, we interviewed Incra employees, technicians, leaders and LWM settled families, and monitored the work of a technicians team of Cooptraes in four settlements in the northern region of the state. From the analysis of data and from the dialogue with the literature and policy documents of the Program (laws, operating manuals, executive standards, among others) we could identify a field of tensions between the actors, which is directly related to the fact that LMV is the executor of the Program, due to the way the movement operates. From this field research we could identify new practices and meanings in the relationship between the actors involved (especially Incra and MST). On one hand we observe that the the presence of LWM has enhanced the performance of the service (because of its proximity to the target population), on the other hand, we found there are also some continuities in the experience with regard to the history of technical assistance in the settlements, for example, the poor conditions in which the services are provided / Esta disserta??o buscou descrever e refletir sobre a experi?ncia de implementa??o do Programa de Assessoria T?cnica Social e Ambiental ? Reforma Agr?ria (Ates) em alguns assentamentos da regi?o norte do Esp?rito Santo por uma cooperativa criada e gerida por integrantes do Movimento dos Trabalhadores Sem Terra - MST. O formato institucional do Programa Ates possibilitou que outras entidades al?m dos ?rg?os p?blicos recebessem os recursos para a presta??o do servi?o nos assentamentos, sob a coordena??o do Instituto Nacional de Coloniza??o e Reforma Agr?ria (Incra). A partir de ent?o, diversas expectativas sobre como prestar a assessoria s?o conjugadas no dia a dia da presta??o dos servi?os nos assentamentos. No caso do Esp?rito Santo, por exemplo, o MST toma para si a tarefa de prestar a assessoria t?cnica nos assentamentos em que se encontra presente por meio da Cooptraes. Com isso traz para esta experi?ncia a dimens?o da milit?ncia, que passa a ser a caracter?stica do trabalho da equipe t?cnica desta cooperativa. Dessa forma, essa configura??o do Programa Ates no Esp?rito Santo promove altera??es significativas nas rela??es entre os atores envolvidos, que podem ser percebidas no cotidiano da presta??o dos servi?os, seja por meio de disputa em torno dos recursos materiais e simb?licos, da gera??o de novas demandas, ou por meio da pr?pria adapta??o dos atores ? din?mica da execu??o do Programa. O objetivo deste trabalho foi analisar o posicionamento e compreens?o dos atores sobre este processo, e a partir desta an?lise pensar os limites e potencialidades desta experi?ncia. Para tanto, foram entrevistados servidores do Incra, t?cnicos, dirigentes do MST e fam?lias assentadas, assim como acompanhou-se o trabalho de uma das equipes t?cnicas da Cooptraes em quatro assentamentos da regi?o norte do estado. A partir da an?lise dos dados produzidos e do di?logo com a bibliografia e documentos normativos do Programa (leis, manuais operacionais, normas executivas, entre outros) foi poss?vel perceber um campo de tens?es entre os atores que est? diretamente relacionado ao fato do MST entrar em cena como executor do Programa, por conta de sua forma de atua??o. A partir deste campo de tens?es a pesquisa conseguiu identificar novas pr?ticas e significados nas rela??es entre os agentes envolvidos (em especial Incra e MST). Se por um lado observamos que a entrada em cena do MST potencializou a execu??o do servi?o (por conta da sua proximidade com o p?blico benefici?rio), por outro lado, observamos tamb?m existem nesta experi?ncia algumas continuidades, no que diz respeito ao hist?rico da assist?ncia t?cnica nos assentamentos, como por exemplo, a precariedade das condi??es de execu??o do servi?o.

La présente recherche porte sur le dieu de la guerre des Grecs anciens, Arès. La communauté historienne s’entend pour affirmer qu’Arès était un dieu de second ordre et un dieu mal aimé par les Grecs de l’époque. Les investigations des historiens du XXe siècle sont axées sur les documents littéraires et elles ne font que reformuler, dans la majorité des cas, le contenu de ceux-ci. Alors, afin de bénéficier d’un regard nouveau sur le dieu, on a étudié Arès au travers les documents épigraphiques pour corroborer ou non nos présentes connaissances. Le dieu de la guerre tel que présenté dans les écrits littéraires est-il le même que celui qui est véhiculé dans l’épigraphie de l’époque? La réponse à cette question nous permettra d’établir si nos connaissances actuelles sont valables et elle les complètera. La recherche épigraphique s’effectue en cinq étapes. D’abord, on voit si le côté militaire d’Arès était également prédominant au sein des inscriptions. Ensuite, on porte une attention particulière aux documents épigraphiques pouvant démontrer un Arès mal aimé. Le tout se poursuit avec la mise en relation du dieu et des anciens serments. Enfin, on termine avec une approche plus géographique qui nous permet de définir deux foyers importants du dieu de la guerre, soit la cité de Métropolis et l’île de Crète. À la suite de ce parcours on a déterminé que l’appréciation et l’importance que les Grecs accordaient à ce dieu n’était pas unanime. Le ressentiment des Grecs variaient selon les individus et les lieux. On a aussi été capable d’établir des faits au sujet d’Arès : son domaine d’action prédominant restait le militaire dans les inscriptions; il était un réel dieu, présent, respecté et loué; il possédait d’importants lieux de culte à Lato et Métropolis. Compte tenu d’une redéfinition notable du profil d’Arès, une révision des sources littéraires propres à Arès s’impose ainsi qu’une évaluation complète de toutes les autres sources (iconographique, archéologique, numismatique, épigraphique, etc.). / This study talks about the god of war for the ancient Greeks, Ares. The historical community asserts that Ares was a god of second order and unloved by the Greeks of this period. Investigations of historians of XXe century are focus on literary sources and they simply restate, in most cases, the content of them. To gain a new perspective on the god, Ares was studied through the epigraphic documents to corroborate or not our present knowledge. We want to know if the Ares, as presented in the literature, has been the same as that was transmitted in the ancient Greek epigraphy. The answer to this question will help us to see if our current knowledge is right and deepening it. The epigraphic research is done in five steps. First, we determine whether the military side of Ares was also predominant in the inscriptions. Then we pay a specific attention to documents that propose an unloved Ares in the epigraphy. After, we establish some links between the former oath and Ares. Finally, we close the epigraphic study with a geographic approach who allows us to determine two important sites that belong to the god of war, the city of Metropolis and the island of Crete. Through this process we were able to determine the appreciation and the importance, which the Greeks gave to this god, were not unanimous. The resentment of the Greeks varied among individuals and places. We were also able to establish some facts about Ares : his dominant sphere remained the military in the inscriptions; he was a reel god, present, respected and praised; he possessed important places of worship in Lato and Metropolis. In conclusion, we redefine Ares profile, so it would be interesting that a research reviews the literacy sources about him. Furthermore, an evaluation of all the sources (iconographic, archaeological, numismatic, epigraphic etc…) would also be appropriated.

This work identifies the Fragile X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMC). FXR1 was identified as an HuR interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression is induced in diseased, but not normal arteries. SiRNA knock down of FXR1 increases abundance and stability of inflammatory mRNAs, while overexpression of FXR1 reduces their abundance and stability. RNA-EMSA and RIP demonstrate that FXR1 directly interacts with an ARE and a previously uncharacterized element in the 3’UTR of TNFa. FXR1 expression is increased in VSMC challenged with the anti-inflammatory cytokine IL-19, and FXR1 is required for IL-19 reduction of HuR. This suggests FXR1 is an anti-inflammation responsive, HuR counter-regulatory protein that reduces abundance of pro-inflammatory transcripts. Additionally, we observed significantly increased poly-A-Binding protein (PABP) expression localizing to discrete punctate structures in both vascular smooth muscle (VSMC) and endothelial cells (EC) of the aortic arch of Ldlr-/- mice, as compared to WT controls. EIF2α phosphorylation, requisite for SG formation, was also induced by clotrimazole and oxLDL in these cells. Interestingly, VSMCs pre-treated with anti-inflammatory cytokine IL-19 followed by clotrimazole significantly reduced the formation of SGs and eIF2a phosphorylation, suggesting a relationship between inflammation and SG formation in vascular cells. Reduction of SG component G3BP1 by siRNA knockdown significantly reduced stress granule formation and inflammatory gene abundance in hVSMC. Microtubule inhibitors reduced SG formation in hVSMC. These results support the hypothesis that SG formation in atherosclerosis is driven by inflammation, SG may mediate the cellular response to inflammation, and that anti-inflammatory treatment may lessen atherosclerosis progression and plaque formation by reduction of SGs. / Biomedical Sciences

In the context of the growing political instability and deepening economic crisis in Uruguay during the 1960s and early 1970s, the thesis examines two propositions. The first is that politically informed intellectuals, though disaffected or marginalised, will integrate themselves into the political mainstream if circumstances demand and a suitable vehicle allows them to participate usefully in the political process. The second is that, in the Uruguayan case, an expanded notion of dialogue is essential in analysing how this was accomplished, partly because the idea of dialogue was a necessary part of how they worked together and communicated with their public, and partly because dialogue was seen as a crucial element in reforming the nation and as the basis of the relationship between the political party that was to be the agent of such reform and its potential constituency. The thesis begins by examining how the so-called 1945 and 1960s generations overcame intergenerational squabbles and worked together, with the help of an expanding publishing industry, to create a public for their meditations on Uruguay's problems. Then, after briefly outlining the importance of dialogue to the essay as a genre and its role in developing national identity in Latin America, the study examines essays on the state of Uruguay by four major writers in the 1960s: Roberto Ares Pons, Alberto Methol Ferr??, Carlos Maggi and Washington Lockhart. The thesis then traces the intelligentsia's role in the several attempts to heal the rifts within the Uruguayan left and in the formation of the centre left coalition, the Frente Amplio, in 1971, to show how the notion of dialogue was incorporated into its structure, mode of operation and political program. The final section, a case study of Mario Benedetti's political activities and propagandist essays of 1971-1973, examines the contradictions of working as a committed intellectual when the very conditions necessary for intellectual life are breaking down. The thesis concludes that the resurrection of the nation as a site for dialogue with and among all members of society, a project in which the intelligentsia had enthusiastically participated, foundered because drastic political polarisation permitted only one militarist and monologic solution.