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Inductively coupled plasma-mass spectrometry (ICP-MS) for the analysis of heavy metals in teeth and their use as bio-markers of environmental exposureLee, Karen Mary January 1999 (has links)
No description available.
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Behavioural evidence for magnetic orientation in rodents / Behavioural evidence for magnetic orientation in rodentsOLIVERIUSOVÁ, Ludmila January 2015 (has links)
Magnetoreception in rodents was studied in this Ph.D. thesis. Behavioural evidence for compass magnetic orientation was found in two subterranean African rodents: the social giant mole-rat (Fukomys mechowii) and solitary silvery mole-rat (Heliophobius argenteocinereus) and epigeic rodent bank vole (Clethrionomys glareolus). The study is also focused on the role of magnetic orientation in solving the orientation task in Morris water maze in bank vole.
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Magnetická orientace norníka rudého (\kur{Myodes glareolus}) / Magnetic orientation in the bank vole (\kur{Myodes glareolus})NOVÁKOVÁ, Monika January 2013 (has links)
The magnetic orientation was established in several species of rodents, but the mechanism of its perception has not been determined. Aim of this work was to verify magnetic sense in the bank vole (Myodes glareolus) and try to solve the nature of its magnetoreception in tests carried out in total darkness and when the horizontal component was reversed and the vertical component was inverted. A spontaneous directional preference in the magnetic field was tested in circular arena.
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La dynamique évolutive du campagnol roussâtre (Myodes glareolus) : structure spatiale des variations morphométriques / The evolutive dynamic of the bank vole (Myodes glareolus) : Spatial structure of the morphometric variationsLedevin, Ronan 25 October 2010 (has links)
Les fluctuations climatiques Quaternaires (<2.5 Ma) offrent un contexte approprié à l’étude de l’impact du changement climatique actuel sur la biodiversité. La dernière glaciation, dont le maximum glaciaire s'est terminé il y a environ 19 000 ans, a ainsi largement participé à la distribution des espèces actuelles. Les derniers milliers d'années constituent donc une période propice à l'étude de la mise en place et du maintien de la biodiversité.L'objectif de ma thèse a été de mieux comprendre comment une espèce de rongeur forestier apparue il y a environ 2 Ma, le campagnol roussâtre (Myodes glareolus), a répondu à ces cycles du Quaternaire. Mon étude s’est basée sur une approche morphométrique de plusieurs caractères impliqués dans la mastication (mandibule et molaires), visant à quantifier la différenciation de forme associée à l’influence de différents facteurs.Des résultats contrastés ont été obtenus selon le caractère considéré, la mandibule montrant une importante variabilité liée aux variations de la structure d’âge des populations. Au contraire, les molaires ont pu être utilisées comme marqueur de la structuration biogéographique du campagnol roussâtre.L'étude dans l'actuel des variations de taille et de forme des molaires et mandibules du campagnol roussâtre Myodes glareolus a nécessité l'intégration de thématiques variées touchant au patrimoine génétique des organismes, à leur développement, aux traits d'histoire de vie, à l'environnement, etc. Ceci a permis de mieux appréhender la complexité des processus conduisant à la grande diversité des patrons de forme observés chez le campagnol roussâtre. / The climatic fluctuations of the Quaternary (<2.5 Ma) provide an appropriate background to the study of the influence of the actual climatic change on the biodiversity. For example, the last glaciation, including the Last Glacial Maximum (~19000 yrs), shaped the geographic distribution observed on actual species.The aim of my thesis was to better understand how a forest-related species of rodent, the bank vole (Myodes glareolus), was affected by the Quaternary cycles. In this way, I used a morphometric approach of diverse characters involved in the mastication process (mandible and molars) to quantify the shape differentiation related to the influence of several factors.Contrasted results were observed, the mandible being widely influenced by the age structure of the studied populations. In contrary, molars can be used as relevant markers of the biogeographic structuration of the bank vole.The study on the size and shape variations of actual specimens needed the integration of various fields of research, dealing with the genetic heritage of the organisms, their development, the environment etc.It allowed a better comprehension of the complexity of the processes leading to a wide diversity of shape patterns within the bank vole.
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The bank vole (Myodes glareolus) – a novel animal model for the study of diabetes mellitusBlixt, Martin January 2010 (has links)
The bank vole (Microtus arvalis) develops glucose intolerance both when kept in captivity and in the wild state. Glucose intolerant bank voles kept in captivity exhibited polydipsia, polyuria, hyperglycemia, hyperinsulinemia, islet autoantibodies and a markedly changed islet structure resembling so–called hydropic degeneration. Islets showing hydropic degeneration have reduced β–cell mass. However, the relative islet size to total pancreas area was not changed. Pancreatic islet isolated from glucose intolerant bank voles had an altered islet function showing signs of being exposed to an increased functional demand on their β–cells. Also, islets from male bank voles seem more affected than the islets from females. Islets isolated from glucose tolerant male bank voles cultured for 5 days at 28 mM glucose did not reveal any change in insulin gene expression or insulin biosynthesis rate. However, islets from female bank voles displayed a glucose concentration dependent response. This suggests that there is gender difference in that, islets of female more easily than islets of males adapt to elevated glucose concentration. Furthermore, islets isolated from glucose tolerant males had reduced insulin gene expression after exposure to proinflammatory cytokines for 48 hrs. This effect seemed to be NO-independent since only a minor elevation of nitrite accumulation in the medium was seen, and the use of iNOS inhibitor could not counteract the cytokine effect. The observed response seen in bank vole islets upon exposure to various glucose concentrations or proinflammatory cytokines is similar to those seen in studies of human islets. The bank vole may therefore represent a novel animal model for the study of diabetes. An unresolved issue is the role of the Ljungan virus which is found in the bank vole colony. Bank voles developing glucose intolerance display features of both human type 1 and type 2 diabetes, where environmental factors seems to play an important role as determinant. Our findings suggest that bank voles bred in the laboratory may develop more of a type 2 diabetes. However, bank voles caught in nature instead may rather develop a type 1 form of the disease.
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Stanovení personality na základě zpětných odchytů u norníka rudého (\kur{Clethrionomys glareolus}) / Assessment of animal personality based on recaptures in bank vole (\kur{Clethrionomys glareolus})ELEXHAUSEROVÁ, Anna January 2013 (has links)
The aim of this study was to investigate the personality of bank vole using recaptures. Some behavioural types were determined (for example shy and bold) and influence of some factors on animal personality was defined (especially the daytime). The rate of repeatability of behaviour was also specified and the dependence of behaviour change on number of days between two captures was defined. Last, two types of tests used for animal personality were compared, indicating the differences between them.
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Species-specific effects of dioxin exposure on xenobiotic metabolism and hard tissue in volesMurtomaa-Hautala, M. (Mari) 25 March 2012 (has links)
Abstract
The evaluation of the effects and levels of contaminants in wildlife is an essential part of assessing risks for chemical exposure in the environment. Although the circumstances are not as controlled as in laboratory, wildlife studies offer the concept of environmental exposure in its entirety, with all the natural variation.
In the present study, two wild vole species, bank vole (Myodes glareolus) and field vole (Microtus agrestis), were used in assessing environmental levels of dioxins. The effects of dioxin exposure on tooth and bone development were studied in order to determine whether they could be used as biomarkers for environmental exposure. Xenobiotic metabolism activity after dioxin exposure – both natural and experimental – was studied by quantifying selected cytochrome P-450 (CYP) enzymes.
The results confirmed the fact that dioxins are ubiquitous in the environment, also in areas far from contaminant sources and human activity. The development of the third molar in bank vole was found to be a sensitive biomarker for dioxin exposure. The two vole species under study do not respond similarly to environmental concentrations of dioxins; there were significant differences in body burdens and activity levels of xenobiotic metabolizing enzymes. / Tiivistelmä
Haitallisten kemikaalien tason ja vaikutusten arviointi ympäristössä on olennainen osa kemikaalien riskin arviointia. Vaikka laboratoriossa olosuhteita kontrolloidaan ja tutkimukseen vaikuttava variaatio on paremmin hallittavissa, luonnonvaraisten lajien tutkiminen luo kokonaisvaltaisen ja todenmukaisen kuvan ympäristön kemikaalialtistuksesta kaikkine todellisine vaihteluineen.
Tässä väitöskirjassa tarkastellaan kahden luonnonvaraisen pikkunisäkkään, metsämyyrän (Myodes glareolus) ja peltomyyrän (Microtus agrestis), käyttöä ympäristön kemikaalitason arvioinnissa. Pääpaino on dioksiinien kaltaisissa yhdisteissä. Työssä tutkitaan yhdisteiden kertymistä myyriin kahdessa ympäristössä: voimakkaasti dioksiineilla saastuneella maa-alueella sekä kaukana ihmistoiminnasta sijaitsevassa erämaassa. Herkiksi tiedettyjä vasteita – hampaiden ja luiden kehitystä – käytetään dioksiinialtistuksen indikaattoreina. Vierasainemetaboliasta vastaavien entsyymien (sytokromi P450 eli CYP) aktiivisuutta kartoitetaan molemmilla myyrälajeilla, jotta saadaan tietoa entsyymien indusoinnista luonnonvaraisilla myyrillä yleensä ja selvitetään havaittuja lajien välisiä eroja dioksiinivasteissa.
Tulokset vahvistavat, että dioksiinit ovat laajalle levinneitä yhdisteitä, joita löytyy paitsi läheltä päästölähdettä myös kaukana ihmistoiminnasta olevilta alueilta. Metsämyyrällä kolmannen poskihampaan kehitys osoittautuu herkäksi dioksiinialtistuksen biomarkkeriksi. Samasta elinympäristöstä huolimatta tutkituista myyrälajeista mitatut dioksiinipitoisuudet eroavat huomattavasti toisistaan, samoin kuin vierasainemetaboliasta vastaavien entsyymien aktiivisuus ja niiden induktio TCDD-altistuksen jälkeen.
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Adaptivní změny rozšíření populací v odpovědi na klimatické změny / Adaptive population shifts in response to climate changeHorníková, Michaela January 2021 (has links)
Adaptive population shifts in response to climate change Ing. Michaela Horníková, Doctoral thesis Abstract Understanding of species' reactions to past climate and environmental changes is a hot topic in many fields of biology as it is relevant also for addressing species' future under the contemporary climate change. Using an emerging model species, the bank vole, I combine genomic phylogeographic data with information on known intraspecific functional variability and environmental niche modelling and aim to elucidate the particular role of intraspecific variation and ultimately selection in shaping the species' response to the climatic and environmental changes after the end of the last glaciation. Based on the mtDNA markers, bank voles exhibit a complex phylogeographic pattern suggesting population replacement events during the postglacial recolonization of Europe and thus possible involvement of selection in the process. An extensive dataset of more than 6000 SNPs was used to search for signs of population replacement in the bank vole genomic DNA and to investigate the species' postglacial recolonization history throughout its European distribution range. The genomic data revealed even more complex population history than previously detected with mtDNA markers, including not only admixture but also...
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