In this thesis, we present an approach for identifying near-miss interaction clones in reverse-engineered UML behavioural models. Our goal is to identify patterns of interaction ("conversations") that can be used to characterize and abstract the run-time behaviour of web applications and other interactive systems. In order to leverage robust near-miss code clone technology, our approach is text-based, working on the level of XMI, the standard interchange serialization for UML. Behavioural model clone detection presents several challenges - first, it is not clear how to break a continuous stream of interaction between lifelines (lifelines represent the objects or actors in the system) into meaningful conversational units. Second, unlike programming languages, the XMI text representation for UML is highly non-local, using attributes to reference information in the model file remotely. In this work we use a set of contextualizing source transformations on the XMI text representation to reveal the hidden hierarchical structure of the model and granularize behavioural interactions into conversational units. Then we adapt NiCad, a near-miss code clone detection tool, to help us identify conversational clones in reverse-engineered behavioural models. These conversational clones are then analysed to find worrisome patterns of security access violations. / Thesis (Master, Computing) -- Queen's University, 2014-03-03 19:36:25.776

The problem of this study concerned the difference in relationships between major teaching behaving styles and dominant personality interests expressed in values.

We put forth a multiple representation approach to deriving the behavioral model of a digital circuit automatically from its structure and the behavioral simulation models of its components. One representation supports temporal reasoning for composition and amplification, another supports simulation and a third helps to partition the translation problem. A working prototype, FUNSTRUX, is described.

Objetivo: o presente estudo teve como objetivo avaliar o estresse oxidativo em animais diabéticos e não diabéticos submetidos ao modelo experimental de depressão, o nado forçado, e os efeitos do clonazepam, um modulador positivo GABAA, correlacionado os efeitos comportamentais com as alterações bioquímicas. Metodologia: ratos Wistar machos com 30 dias de idade, foram induzidos ao Diabetes por estreptozotocina e submetidos ao teste de natação forçada 21 dias após a indução. Após uma ambientação, o clonazepam foi administrado na dose 0,5 mg/Kg, bem como solução salina nos controles, 24, 5 e 1 hora antes do teste. A freqüência e a duração dos comportamentos neste teste foi registrada em vídeo cassete para avaliação etológica dos comportamentos por pesquisador treinado. Trinta minutos após o teste, os animais foram sacrificados por decapitação e foram separados o plasma e os eritrócitos, bem como os tecidos cerebrais córtex pré-frontal, estriado e hipocampo. Foram avaliadas as espécies reativas ao ácido tiobarbitúrico (TBARS) e a reatividade antioxidante total (TAR), bem como a atividade das enzimas antioxidantes catalase (CAT) e superóxido dismutase (SOD). Resultados e discussão: os resultados mostraram um aumento significativo do TBARS e uma diminuição significativa do TAR no plasma de animais diabéticos, efeitos estes revertidos pelo clonazepam. Não houve alteração na atividade da SOD e da CAT em eritrócitos. No hipocampo observou-se um aumento significativo no TBARS nos diabéticos, também revertido pelo clonazepam, sendo que nenhuma alteração foi verificada na medida do TAR. O aumento significativo do TBARS no córtex de ratos diabéticos, um indicador de lipoperoxidação, e a diminuição significativa do TAR no córtex dos animais diabéticos, um indicador da capacidade de modulação da ação dos radicais livres produzidos, não foram revertidos pela administração do clonazepam neste tecido cerebral. Ainda, não houve alteração do TBARS e do TAR no estriado dos grupos testados. O clonazepam foi capaz de reverter a imobilidade dos animais diabéticos submetidos ao teste de natação forçada. Não foi verificada correlação significativa entre a imobilidade e as medidas de TBARS e TAR. Conclusão: considerando a conhecida ação ansiolítica e antidepressiva do clonazepam, sugere-se que ele possa ser uma alternativa terapêutica na depressão em pacientes diabéticos, uma vez que ele não altera a glicemia e, pelos resultados aqui apresentados, teria uma ação protetora contra os radicais livres, os quais sabidamente contribuem para o desenvolvimento das complicações secundárias de Diabete Mellitus. / Objective: the present study had as objective to evaluate the oxidative stress from diabetic animals submitted to an experimental model of depression (forced swimming) and the effects of clonazepan, a GABA agonist, correlating behavioral with biochemical effects. Methodology: male Wistar rats, 30 days years old, were induced to diabetes with streptozotocin and submitted to forced swimming test 21 days after induction. After to be accustomed with the environment, clonazepan was administered to rats in a dose of 0,5 mg/kg, as well as saline solution to control rats, 24, 5 and 1 hours before test. The frequency and duration of behaviour in the test were filmed for ethologic evaluation by a trained pearson. Thirty minutes after test, the animals were sacrified by decapitation, and plasma and erythrocytes were separated, as well as hippocamp, cortex and striatum. Reactive species of tiobarbituric acid (TBARS) and total antioxidant reactivity (TAR), as well as antioxidant enzyme activities catalase (CAT) and superoxide dismutase (SOD) were evaluated. Results and discussion: results showed a significant increase of TBARS and a significant decrease of TAR in plasma from diabetic animals, which was altered by clonazepan. There were no effect of CAT and SOD activities in erytrocytes from tested animals. The results observed in hippocamp showed a significative increase of TBARS from diabetics rats, inverted by clonazepan, and no one alteration was verified in TAR. The significant increase of TBARS in cortex from diabetic rats, an indicator of lipoperoxidation, and the significant decrease of TAR in cortex from diabetic rats, an indicator of modulation capability against free radicals, were not altered by clonazepan administration. Besides, there were no alteration of TBARS and TAR in striatum from tested animals. Clonazepan was capable to alter the immobility from diabetic animals submitted to forced swimming. There was no significative correlation between immobility and TBARS neither TAR measurements. Conclusion: considering the ansiolitic and antidepressive action of clonazepan, it’s suggested that it could be an alternative therapeutic for depression to diabetic patients, once clonazepan do not alter glycemia and, by the results here presented, could give a protection against free radicals, which are known to contribute to the development of complications in Mellitus Diabetes.

Objetivo: o presente estudo teve como objetivo avaliar o estresse oxidativo em animais diabéticos e não diabéticos submetidos ao modelo experimental de depressão, o nado forçado, e os efeitos do clonazepam, um modulador positivo GABAA, correlacionado os efeitos comportamentais com as alterações bioquímicas. Metodologia: ratos Wistar machos com 30 dias de idade, foram induzidos ao Diabetes por estreptozotocina e submetidos ao teste de natação forçada 21 dias após a indução. Após uma ambientação, o clonazepam foi administrado na dose 0,5 mg/Kg, bem como solução salina nos controles, 24, 5 e 1 hora antes do teste. A freqüência e a duração dos comportamentos neste teste foi registrada em vídeo cassete para avaliação etológica dos comportamentos por pesquisador treinado. Trinta minutos após o teste, os animais foram sacrificados por decapitação e foram separados o plasma e os eritrócitos, bem como os tecidos cerebrais córtex pré-frontal, estriado e hipocampo. Foram avaliadas as espécies reativas ao ácido tiobarbitúrico (TBARS) e a reatividade antioxidante total (TAR), bem como a atividade das enzimas antioxidantes catalase (CAT) e superóxido dismutase (SOD). Resultados e discussão: os resultados mostraram um aumento significativo do TBARS e uma diminuição significativa do TAR no plasma de animais diabéticos, efeitos estes revertidos pelo clonazepam. Não houve alteração na atividade da SOD e da CAT em eritrócitos. No hipocampo observou-se um aumento significativo no TBARS nos diabéticos, também revertido pelo clonazepam, sendo que nenhuma alteração foi verificada na medida do TAR. O aumento significativo do TBARS no córtex de ratos diabéticos, um indicador de lipoperoxidação, e a diminuição significativa do TAR no córtex dos animais diabéticos, um indicador da capacidade de modulação da ação dos radicais livres produzidos, não foram revertidos pela administração do clonazepam neste tecido cerebral. Ainda, não houve alteração do TBARS e do TAR no estriado dos grupos testados. O clonazepam foi capaz de reverter a imobilidade dos animais diabéticos submetidos ao teste de natação forçada. Não foi verificada correlação significativa entre a imobilidade e as medidas de TBARS e TAR. Conclusão: considerando a conhecida ação ansiolítica e antidepressiva do clonazepam, sugere-se que ele possa ser uma alternativa terapêutica na depressão em pacientes diabéticos, uma vez que ele não altera a glicemia e, pelos resultados aqui apresentados, teria uma ação protetora contra os radicais livres, os quais sabidamente contribuem para o desenvolvimento das complicações secundárias de Diabete Mellitus. / Objective: the present study had as objective to evaluate the oxidative stress from diabetic animals submitted to an experimental model of depression (forced swimming) and the effects of clonazepan, a GABA agonist, correlating behavioral with biochemical effects. Methodology: male Wistar rats, 30 days years old, were induced to diabetes with streptozotocin and submitted to forced swimming test 21 days after induction. After to be accustomed with the environment, clonazepan was administered to rats in a dose of 0,5 mg/kg, as well as saline solution to control rats, 24, 5 and 1 hours before test. The frequency and duration of behaviour in the test were filmed for ethologic evaluation by a trained pearson. Thirty minutes after test, the animals were sacrified by decapitation, and plasma and erythrocytes were separated, as well as hippocamp, cortex and striatum. Reactive species of tiobarbituric acid (TBARS) and total antioxidant reactivity (TAR), as well as antioxidant enzyme activities catalase (CAT) and superoxide dismutase (SOD) were evaluated. Results and discussion: results showed a significant increase of TBARS and a significant decrease of TAR in plasma from diabetic animals, which was altered by clonazepan. There were no effect of CAT and SOD activities in erytrocytes from tested animals. The results observed in hippocamp showed a significative increase of TBARS from diabetics rats, inverted by clonazepan, and no one alteration was verified in TAR. The significant increase of TBARS in cortex from diabetic rats, an indicator of lipoperoxidation, and the significant decrease of TAR in cortex from diabetic rats, an indicator of modulation capability against free radicals, were not altered by clonazepan administration. Besides, there were no alteration of TBARS and TAR in striatum from tested animals. Clonazepan was capable to alter the immobility from diabetic animals submitted to forced swimming. There was no significative correlation between immobility and TBARS neither TAR measurements. Conclusion: considering the ansiolitic and antidepressive action of clonazepan, it’s suggested that it could be an alternative therapeutic for depression to diabetic patients, once clonazepan do not alter glycemia and, by the results here presented, could give a protection against free radicals, which are known to contribute to the development of complications in Mellitus Diabetes.

Objetivo: o presente estudo teve como objetivo avaliar o estresse oxidativo em animais diabéticos e não diabéticos submetidos ao modelo experimental de depressão, o nado forçado, e os efeitos do clonazepam, um modulador positivo GABAA, correlacionado os efeitos comportamentais com as alterações bioquímicas. Metodologia: ratos Wistar machos com 30 dias de idade, foram induzidos ao Diabetes por estreptozotocina e submetidos ao teste de natação forçada 21 dias após a indução. Após uma ambientação, o clonazepam foi administrado na dose 0,5 mg/Kg, bem como solução salina nos controles, 24, 5 e 1 hora antes do teste. A freqüência e a duração dos comportamentos neste teste foi registrada em vídeo cassete para avaliação etológica dos comportamentos por pesquisador treinado. Trinta minutos após o teste, os animais foram sacrificados por decapitação e foram separados o plasma e os eritrócitos, bem como os tecidos cerebrais córtex pré-frontal, estriado e hipocampo. Foram avaliadas as espécies reativas ao ácido tiobarbitúrico (TBARS) e a reatividade antioxidante total (TAR), bem como a atividade das enzimas antioxidantes catalase (CAT) e superóxido dismutase (SOD). Resultados e discussão: os resultados mostraram um aumento significativo do TBARS e uma diminuição significativa do TAR no plasma de animais diabéticos, efeitos estes revertidos pelo clonazepam. Não houve alteração na atividade da SOD e da CAT em eritrócitos. No hipocampo observou-se um aumento significativo no TBARS nos diabéticos, também revertido pelo clonazepam, sendo que nenhuma alteração foi verificada na medida do TAR. O aumento significativo do TBARS no córtex de ratos diabéticos, um indicador de lipoperoxidação, e a diminuição significativa do TAR no córtex dos animais diabéticos, um indicador da capacidade de modulação da ação dos radicais livres produzidos, não foram revertidos pela administração do clonazepam neste tecido cerebral. Ainda, não houve alteração do TBARS e do TAR no estriado dos grupos testados. O clonazepam foi capaz de reverter a imobilidade dos animais diabéticos submetidos ao teste de natação forçada. Não foi verificada correlação significativa entre a imobilidade e as medidas de TBARS e TAR. Conclusão: considerando a conhecida ação ansiolítica e antidepressiva do clonazepam, sugere-se que ele possa ser uma alternativa terapêutica na depressão em pacientes diabéticos, uma vez que ele não altera a glicemia e, pelos resultados aqui apresentados, teria uma ação protetora contra os radicais livres, os quais sabidamente contribuem para o desenvolvimento das complicações secundárias de Diabete Mellitus. / Objective: the present study had as objective to evaluate the oxidative stress from diabetic animals submitted to an experimental model of depression (forced swimming) and the effects of clonazepan, a GABA agonist, correlating behavioral with biochemical effects. Methodology: male Wistar rats, 30 days years old, were induced to diabetes with streptozotocin and submitted to forced swimming test 21 days after induction. After to be accustomed with the environment, clonazepan was administered to rats in a dose of 0,5 mg/kg, as well as saline solution to control rats, 24, 5 and 1 hours before test. The frequency and duration of behaviour in the test were filmed for ethologic evaluation by a trained pearson. Thirty minutes after test, the animals were sacrified by decapitation, and plasma and erythrocytes were separated, as well as hippocamp, cortex and striatum. Reactive species of tiobarbituric acid (TBARS) and total antioxidant reactivity (TAR), as well as antioxidant enzyme activities catalase (CAT) and superoxide dismutase (SOD) were evaluated. Results and discussion: results showed a significant increase of TBARS and a significant decrease of TAR in plasma from diabetic animals, which was altered by clonazepan. There were no effect of CAT and SOD activities in erytrocytes from tested animals. The results observed in hippocamp showed a significative increase of TBARS from diabetics rats, inverted by clonazepan, and no one alteration was verified in TAR. The significant increase of TBARS in cortex from diabetic rats, an indicator of lipoperoxidation, and the significant decrease of TAR in cortex from diabetic rats, an indicator of modulation capability against free radicals, were not altered by clonazepan administration. Besides, there were no alteration of TBARS and TAR in striatum from tested animals. Clonazepan was capable to alter the immobility from diabetic animals submitted to forced swimming. There was no significative correlation between immobility and TBARS neither TAR measurements. Conclusion: considering the ansiolitic and antidepressive action of clonazepan, it’s suggested that it could be an alternative therapeutic for depression to diabetic patients, once clonazepan do not alter glycemia and, by the results here presented, could give a protection against free radicals, which are known to contribute to the development of complications in Mellitus Diabetes.

No description available.

In recent years, the research focus has moved from core microarchitecture to uncore microarchitecture. Cycle-accurate models for many-core processors featuring hundreds or even thousands of cores are out of reach for simulating realistic workloads. A large portion of the simulation time is spend in the cores, and it is this portion that grows linear with every processor generation. Approximate simulation methodologies, which trade off accuracy for simulation speed, are necessary for conducting certain research. Multicore processors also demand for more advanced and rigorous simulation methodologies. Many popular methodologies designed by computer architects for simulation of single core architectures must be adapted or even rethought for simulation of multicore architectures.In this thesis, we have shown that behavioral core modeling is a competitive option for multicore studies where the research focus is in the uncore microarchitecture and considering independent tasks. We demonstrated that behavioral core models can bring speedups between one and two orders of magnitude with average CPI errors of less than 5%. We have also demonstrated that behavioral core models can help in the problem of selecting multiprogram workloads for the evaluation of multicore throughput.

No description available.

Animals detect, recognize and localize relevant objects in noisy, multi-source environments. Female crickets locate potential mates in choruses of simultaneously calling males using acoustic signals, a behaviour termed phonotaxis. The mechanisms underlying cricket phonotaxis are now understood across multiple levels: biophysical, neurobiological and behavioural. Phonotaxis has, however, rarely been tested in the complex real-world acoustic environments and no attempts have been made to predict acoustic orientation behaviour in these conditions despite our extensive understanding of its underlying mechanisms. In this thesis, I first characterized the acoustic environments faced by female crickets of the species Plebeiogryllus guttiventris in the field. Phonotaxis behaviour of females was then characterized under laboratory conditions using two sound sources. The data obtained were used to develop a simulation that predicted this behaviour. The predictions of the simulation were then tested against the phonotaxis behaviour of females in realistic, multi-source conditions in the field. My field studies of male behaviour showed that males of this species produced complex and variable songs in choruses where multiple males called simultaneously. The acoustic ranges of males in these choruses overlapped extensively and females performing phonotaxis in such choruses would hear multiple males simultaneously. The acoustic interactions of simultaneously calling males were also characterized for their timing relationships with each other and the changes they made to the temporal patterns of their songs. Males did not either synchronise or alternate their chirps, however they made changes to the temporal patterns of song in a way that is likely to make them more attractive to females. I then characterized the closed-loop walking phonotaxis behaviour of P. guttiventris females in the presence of two active sound sources playing conspecific song. Both the baseline and relative SPLs of the two speakers were systematically varied and female phonotactic paths were obtained. Females were found to preferentially approach louder songs. Several aspects of this behaviour were characterized, in particular orientation ability and motor behaviour under varied conditions of stimulus intensity. A stochastic simulation of closed-loop walking phonotaxis behaviour was developed using both current understanding of field cricket physiology and my data on closed-loop walking phonotaxis. The simulation was demonstrated to both qualitatively and quantitatively recapture female behaviour. It was also able to qualitatively recapture female behaviour in two previously published classical experiments in which the hearing of female crickets was disrupted. Female phonotaxis was then tested under real-world multi-source conditions. The behaviour of real females was compared to the predictions of the simulation. The simulation was found to recapture both female preference and phonotactic path forms at the population level. To my knowledge, this is the first study to both examine and successfully predict phonotaxis behaviour in complex real-world acoustic conditions.