The aim of the diploma thesis is to design the pump impeller. The classical design of the impeller is made for one operating point, in which pump is assumed to operate most of the time. The aim of this diploma thesis is to design a pump, whose pump cover and pump drive discs are designed for each other operating point and then compare the results of both design methods.

The aim of this Master’s thesis is to investigate the preparation and structure of nanofibres of inorganic and organic biomaterials. Nanofibres of polycaprolactone, chitosane and their composites with hydroxyapatite particle were prepared by centrifugal force spinning process, which uses centrifugal forces for nanofibres spinning. Designed nanofibres can be used in bone tissue engineering. Experimental activity has started with synthesis of hydroxyapatite nanoparticles and preparation of polymer solutions and composite suspensions at different concentrations. The solutions and the suspensions were characterized by density and viscosity which were changed in dependence on temperature and polymer concentration. The solutions and the suspensions were spun at varying speeds and using two different sizes of collectors. The dependence of spinneret head revolution speed, size of collectors and polymer concentration on nanofibres diameter was studied. Biological activity of polycaprolactone and hydroxyapatite/polycaprolactone nanofibres was tested by means of SBF.

Intermetallic alloys gama TiAl are prospective materials of future thanks its excellent machanical qualities and low density. However this alloy clash with for wider expansion to the practice on burdensomeness production and processing. Among disavantages belongs to also her bad fluidity. The diploma work is angaged in possibilities imporing fluidity alloys TiAl by the help of centrifuge casting. Casting healthy casts was achieved in experimental part.

This diploma thesis deals with problematics of the radial force effect on the runner and possibilities of the force reduction. Some pump modifications were proposed and changes of radial force magnitude in reverse blocking state and optimal flow state were examined in consequence. Following investigation was focused on the new modifications regarding to the pump efficiency and its characteristics stability. All results were carried out using the Solidworks, the Fluent and the Microsoft Excel software.

These Graduation Theses solve effects of tribological behaviour of materials pairs on the basic of the SIGMA GROUP a.s. requirements. For available materials there was a target to design tribological pairs and check their behaviour.

This diploma thesis deals with the design of the centrifugal switch of water turbine. The centrifugal switch is the security feature that stops the unit when the permitted unit speed is exceeded. In the first part of this thesis, the currently used types of centrifugal switches are described. This section deals also with the new centrifugal switch design and dynamics analysis of individual switch pins.

Centrifugal compressors with high pressure ratio are widely used in small aircraft turbine engines and turbocharges. At high rotational speeds they have narrow stable operating region and commonly used impellers with back swept blades are not able to ensure requested stability. In order to achieve wider stable operating region, some other anti-surge measures can be used, such as an Internal Recirculation Channel (IRC) located in compressor impeller inlet. This thesis deals with an investigation of IRC influence on centrifugal compressor operational parameters. As a first, the various recirculation channel geometry was studied by using of CFD analysis on simplified computational models. Those geometry, which indicated best results in terms of mass flow and looses in channel were used for testing on a model test device. Subsequently the same geometry was tested on real centrifugal compressor in experimental turbine engine to verify influence of IRC on compressor performance map – pressure ratio and efficiency. Simultaneously the CFD analyses of IRC with a 3D model of compressor impeller were performed and results compared with those, gained from measurement on model and compressor. In addition the measurement of flow field downstream the recirculation channel outlet slot with using of 3-hole pressure probe was performed and compared with flow velocity profiles evaluated from numerical simulations.

La stabilité d’un fluide Newtonien diélectrique confiné dans un anneau cylindrique et soumis à un gradient radial de température et à un champ électrique est étudiée. Le gradient de température induit une stratification de la permittivité électrique du fluide et de sa masse volumique. Trois poussées thermiques rentrent alors en jeu : la gravité terrestre créée la poussée d’Archimède, la rotation des cylindres engendre la poussée centrifuge, et le champ électrique induit la poussée diélectrophorétique. L’effet de ces poussées est étudié dans différentes combinaisons, principalement à travers l’étude de la stabilité linéaire, mais également par la simulation numérique directe. / The stability of a Newtonian dielectric fluid confined in a cylindrical annulus and submitted to a radial temperature gradient and an electric field is studied. The temperature gradient induces a stratification of the electric permittivity and of the density. Thus three thermal buoyancies intervene: the Earth gravity creates the Archimedean buoyancy, the rotation of the cylinders generates the centrifugal buoyancy, and the electric field induces the dielectrophoretic buoyancy. The effect of these buoyancies is studied in different combination, principally through the linear stability analysis, but also by direct numerical simulation.

Platelet derivatives are an attractive source of natural growth factors and they are widely used in various tissue engineering and regenerative medicine applications. The aim of this study was to optimize cell culture conditions using platelet lysate and to develop platelet-functionalized fibrous scaffolds as a controlled drug delivery system for native growth factors. Fibrous scaffolds were prepared by electrostatic and centrifugal spinning of PCL and they were functionalized by the platelets by surface adhesion or their encapsulation using emulsion spinning techniques. The cell culture study determined the 7% platelet lysate to be the optimum concentration as a medium supplement in keratinocyte and fibroblast culture. Additionally, following surface adhesion of the platelets to PCL electrospun nanofibres, the platelets were activated due to their contact with the nanofibre nanotopography, resulting in formation of fibrin network. Fibrin served as a reservoir of the growth factors, prolonging the half-time of EGF release to 1.7 days. Such platelet-functionalized samples fostered proliferation of keratinocytes, fibroblasts and melanocytes. Furthermore, adhesion of platelets to centrifugally spun nanofibrous scaffolds resulted in almost two-fold increase in the amount of immobilized platelet-derived...

The effects of impeller-diffuser interaction are investigated through numerically simulating the modified wedge vane profiles. Steady and time-accurate, 3D- viscous RANSsolver is used to perform flow field computations. The original design is modified to obtain better aerodynamic performance. Five morechanges are made to the leading edge profile of the new design, in order to assess different degrees of unsteadiness. These changes show that their contribution on stageefficiency is rather minor, while they have a huge reduction on blade loadings. Moreover, it is shown that the shorter radial distance of vaneless space does not necessarilymean an increased loading thanks to the eliminating in-phase fluctuations on pressureand suction sides. It is found that the impeller reacts to the upstream static pressure disturbance, whichis caused by the applied geometry change and its resultant flow field in the wedge diffuser, but not to the radial location of a certain profile. In addition, the results indicatethat the wedge diffuser aerodynamic performance is driven by time-averaged flow fieldbehaviour.