Title: Utilization of physical activity to the influence of the health of top managerr Author: Bc. Martin Vojáček Supervisor: Prof. Ing. Václav Bunc CSc. Objective: Author of the diploma thesis Utilization of physical activity to the influence of the health of top managers deals with health issues stemming from the specific nature of the job of top managers. A key issue is the work related stress and its impact on the health of managers. The negative effects of stress and poor lifestyle are "lifestyle diseases" such as diabetes, obesity, hypertension, ischemic heart disease, disorders of the musculoskeletal system, burnout syndrom and chronic fatigue syndrome. Appropriately chosen physical activity based on the temperament can reduce risk, mitigate health problems and prevent the development of disease in all the aforementioned cases. The research survey conducted for 6 months on a group of five top managers attending in Fitness Slavia showed that exercise programs individually prepared on the basis of temperament have a positive impact both on mental and physical health of top managers. Methods: In this thesis these methods are used: measuring and testing, interviews, observation, study of specific literature and research. Results: The results obtained should help formulate the basis of the next...

This dissertation thesis touches very current and among public and experts often discussed topic. It concerns particularly matter of papillomaviral infections and vaccination against them. The research proved vaccination-coverage level of respondents and also their knowledge level. The vaccination-coverage level of girls is very high (almost 80%). A lot of girls also used possibility of full vaccination in the age of 13. This dissertation thesis should serve as a source and summary information about HPV viruses, diseases caused by them, about ways of transmission and epidemiological measures. Furthermore it also informs about cervical cancer, risk factors, diagnostical possibilities, therapy and at last but not lest about prevention of cervical carcinoma.

Considering contemporary lifestyle and possibility of travelling imported infections accrued and some illnesses come back that have not occurred nearly at us more. Not only haemorrhagic fevers and other highly infectious illnesses but also hospital multiresistant bacterial strains that mean high risk for patients constitute a threat. The number of nosocomial infectious grows still. The patient is in the case of suspicion or already diagnosed infectious illness isolated and treated in the infectious department or in the tribal department in the room with increased hygienic-epidemiologic regime. The patient is saved in a single room, the possibility of visits is reduced and the staff uses personal protective equipment. The man is holistic being and it can come due to isolation to lack of satisfaction of his/her bio-psycho-social needs. The aim of this thesis is to identify unsatisfied bio-psycho-social needs of patients in increased hygienic-epidemiologic regime and to describe changes in needs of the patient depending on the time of hospitalisation. The theoretic part describes the problematics of infectious illnesses, system of the care for the patient with infectious illness and changes in human needs in the period of the illness. The empiric part of the thesis deals with unsatisfied bio-psycho-social needs of isolated individual through quantitative research. The research suite was made up of 10 patients who were hospitalised in the room with increased hygienic-epidemiologic regime. The survey was carried out in the Hospital Jihlava by semistructured interview and the results of the survey were processed by opened coding by method paper and pencil. It is emphasized that the most needs of the patient have biological, psychical, social and even spiritual aspects. The rate of satisfaction with caregiving depends on the health condition and personality of the patient. Not small influence has the length of the hospitalisation, too. It was found out during the survey that the patients have not enough information about specifics of the care in the infectious department and that is why there is often a misunderstanding of necessity of barrier measures. It is possible to avoid useless misunderstanding through timely and suitable education. It was created an educational material with the title "Guide for patients hospitalised in the infectious department of Hospital Jihlava" for this purpose. Employees of the infectious department of Hospital Jihlava were informed with results of the research during a workshop, too.

: This thesis focuses on monitoring attitudes of general practitioners in Southern Bohemia toward non-conventional medicine. In its theoretical part, the thesis deals with clarifying the concepts of non-conventional medicine, alternative medicine, and scientific medicine. Furthermore, the thesis describes various approaches to non-conventional medicine. In its practical part I examined the level of knowledge about non-conventional medicine among doctors. The research was conducted through anonymous questionnaires filled in by general practitioners. The questionnaires were then used for creating the charts. These charts indicate how doctors view various approaches to non-conventional medicine, to what extent they support using these methods among their patience, and how they view the quality of medical education in this area in the Czech Republic.

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The diploma work concerns the actual problem of papilomavirus infection and the vaccination against its originators. The gravity lies in the human-organism attack and the further proceeding changes in the human cells and mucous membranes. In many cases this leads to the pre-cancer states or even worse, to the cervix carcinoma. The work is divided into two parts, first theory, and second practice. The aim was to evaluate the vaccination against papilomviruses at the female-students of the University firstly, secondly to map the topic knowledge, and thirdly to monitor if the female-students visit their gynaecologist on regular basis. The theory concerns all the epidemiology, virology, clinical and diagnosis aspects of the papilomavirus infections, including the vaccination as a prevention possibility. In practice, there were run two anonymous questionnaire searches, first aimed on the female-students, second on the male-students only. The questions were focused on the level of the topic knowledge and the level of the both sex students vaccination, including the reasons of their non-interest in the possible vaccination, next the frequency of the girls? screenings in the gynaecologist practices. The research proved certain level of the respondents? topic knowledge and compared the existing differences among faculties. Another research conclusion is that the vaccination of the female-respondents is not very high, only 23,75% has already been vaccinated against the virus. Many young ladies underestimate the vaccination, and have more or less serious reasons why not to have them vaccinated. More than half of the respondents don?t do so because of the vaccine high price. This work should serve the women and young ladies, but also the young men as a source of the needed information. This means to improve the virus knowledge itself, its means of transmission, the diagnosis process or the treatment possibilities; overall the ways of primary prevention, with the ways of infection expanding prevention.

The thesis deals with the prevention of lifestyle diseases in the elderly, is focused on cardiovascular disease and diabetes mellitus II. type. In the theoretical part, I describe the specifics of senior age. Consequently, the theoretical part deals with the the cardiovascular diseases that occur in the elderly and diabetes mellitus II. type, risk and protective factors for these diseases. In the practical part I focuse on the survey, which examines the level of awareness of seniors on cardiovascular diseases and diseases of diabetes mellitus II. type, the differences in awareness between men and women and relationship between level of education and awareness. The questionnaire survey was attended by 98 respondents. The questionnaire contained 12 questions that examined how respondents are aware of the issue. The obtained data were collected in January and February 2014, and subsequent evaluation in March and April 2014. The obtained data were analyzed using statistical methods. Identified responses were transformed into single tables and compared. Was examined overall awareness of the difference in awareness in relation to sex and then examined the effect of education on awareness issues.

Sex is a natural means of reproduction, but by far it is not practised solely for that purpose. In recent years there has been a large release of morality and today we would hardly find a young person with a belief that sex serves for reproduction only. Sexual life is no longer taboo and therefore it is necessary to speak also about the adverse phenomena that accompany it. There is unwanted pregnancy and the spread of sexually transmitted diseases. Sexually transmitted diseases present a serious global problem that does not fudge even our society. Young people represent the largest risk group in terms of infection who go through various relationsship selecting a permanent partner. The primary prevention is the most important way how to fight against sexually transmitted diseases, and it is important particularly for those who have not begun yet to live sexually. For this reason it is often implemented in the form of prevention programs in school facilities. The current situation of sexually transmitted diseases in the Czech Republic was charted in the theoretical part of this work. The goal of the practical part of this work was to obtain an overview of the effectiveness of prevention programs in the primary prevention of sexually transmitted diseases among students of Health and Social Studies University of South Bohemia. There were defined four hypotheses for this purpose. The first hypothesis: Young people get more information about the dangers of sexually transmitted diseases from the media and from their peers than from schools and parents. The second hypothesis: Experience with random sex has a quarter of respondents. The third hypothesis was formulated as follows: Women have more knowledge about sexually transmitted diseases than men. The fourth hypothesis: Women observe the principles of safe sex more than men. The quantitative research, questioning method and questionnaire technique were used to collect empirical data. The questionnaire was anonymous and had electronic form. The research sample consisted of full-time bachelor programs students of Health and Social Studies University of South Bohemia, who belong by their age structure into the most vulnerable group of infection of sexually transmitted diseases. Respondents. The research was attended by 531 respondents. The first, third and fourth hypothesis were not confirmed on the based of a statistical test. The third hypothesis was confirmed statistically. The descriptive statistics shows that young adults do not have sufficient knowledge about sexually transmitted diseases and have no fear of the disease, which is also reflected in their behavior. The prevention programs for primary prevention of sexually transmitted diseases in the Czech Republic are not quite sufficient, according to the achieved results and in my opinion, and we can not talk about their proven effectiveness. It can be said they provide at least some awareness of the risks associated with sexual intercourse. In my opinion, it is necessary to establish the precise form of the curriculum and to incorporate sex education into the framework of the educational plan as a separate subject in school facilities as basic and secondary. It is necessary to involve parents into the process of primary prevention by increasing their awareness and to pass the acquired information. It is also necessary to promote a form of barrier contraception and introduce general preventive programs in the fight against sexually transmitted diseases.

Human papillomaviruses, also known in English as human papillomavirus, shortened HPV, are uncoated DNA viruses, called naked, that belong to the family Papoviridae. These are viruses which are known as small tumour viruses. Today, more than 100 types of human papillomaviruses are known, of which more than 40 infect the genital tract of men and women. Human papillomavirus is not only an agent of genital warts, which have been known and described in the medicine for two millennia, but also plays an important role in the development of cancer. Since the first thoughts about the relationship of viral infections and tumour, the development of knowledge came to the current view of HPV as an independent risk factor, particularly in the pathogenesis of cervical cancer. Papillomavirus types 16 and 18 play an important role in the pathogenesis of cervical cancer. Today, it has been scientifically proven that papillomavirus infection is a starting factor for cervical cancer. Cervical cancer is not only a serious health problem but also a medical and social one in Europe. It is the second most common cancer in women worldwide. HPV infection is currently the most common sexually transmitted disease. Up to 80 % of sexually active population meet HPV infection during their life, the highest prevalence rate of HPV is found in the age group of 18-25 years. Cervical cancer is a preventable disease after the development of a vaccine against HPV and introduced screening. The first, theoretical, part of the paper gives a comprehensive overview of various aspects of human papillomavirus infections based on the study of professional literature. In the second, research, part of my paper I focused on evaluating the approaches to the prevention of human papillomavirus infection as well as the cervical cancer in girls and women in České Budějovice and also the level of vaccination in students of the Faculty of Health and Social Studies against HPV. Based on the objectives of the paper hypotheses were drawn. Both objectives of the paper have been achieved.

Huntington's disease (HD) is an autosomal dominant hereditary neurodegenerative disease characterized by motor, cognitive and behavioral disorders. HD is caused by expansion of CAG triplet (cytosine-adenosine-guanine) located in a gene on the short arm of the fourth chromosome. This expansion encodes an aberrant polyglutamine chain in the protein huntingtin. Physiological and mutated huntingtin (in case of HD) are expressed in almost all tissues and influences many cellular functions. The prevalence of HD in population is about 1 per 10.000. The disease is currently incurable and its mechanisms are not sufficiently understood. Besides affecting the central nervous system HD also affects peripheral tissues, including skeletal muscles. HD disrupts mitochondrial function and damages oxidative phosphorylation system, which has the task of producing energy in the form of ATP in cells. Research of transgenic minipig model for HD could help elucidate the mechanisms of disease's pathogenesis and potential therapeutic strategy. In this diploma thesis, immunodetection with help of specific antibodies to detect changes in amount of 14 selected mitochondrial proteins in skeletal muscle tissue of three age groups of transgenic HD minipigs - 24, 36 and 48 months old was used. Gradual progression in reduced...