Moricizine is a novel phenothiazine antiarrhythmic agent that depresses the activity of ectopic foci, has a low incidence of adverse effects relative to other agents, and is useful in treating pediatric atrial ectopic tachycardia. A study was conducted to determine the pharmacokinetics of moricizine in children after oral administration. Moricizine was isolated from frozen serum obtained from four male patients (ages 7, 8, 9, and 18 years) receiving the drug for supraventricular tachycardia and analyzed by high-performance liquid chromatography with ultraviolet detection according to an established protocol. Peak serum levels were between 400 and 2000 ng/mL. Elimination of moricizine did not follow simple single-compartment pharmacokinetics. In three patients we observed an increase or slower decline in blood level occurring after 4 hours. Because of the paroxysmal nature of the tachycardias, decreases in patient heart rate could not be correlated with moricizine blood level. These results suggest that the pediatric pharmacokinetics of moricizine excretion are complex and may differ from those seen in adults.

Rapid economic development and urban expansion of the Bangkok Metropolitan Region (BMR) places pressure on biomes and communities alike. In a world suffering from the increasing effects of climate change, unchecked urbanisation comes at the expense of carbon sequestrating environments. The modernisation, concretisation and gentrification of this low-lying, deltaic, monsoonal metropolis has seen its traditional, water-based urban morphology replaced with a solid state of perception, parallel to a loss of flood mitigating infrastructure. As the metropolis’ boundaries expand into its hinterlands, agriculturally productive land is being converted to residential, commercial and industrial development and the fate of low-income urban populations and farmers lies in the hands of speculators hoping to capitalise on increasing land values. Combatting this backdrop of neoliberal urbanisation is legislative framework intended to prevent speculation, yet it results in additional ecological damage as landowners clear natural-growth forests and mangroves to meet tax-reducing criterium. The purpose of this thesis is to examine the reasons behind and consequences of under-regulated urbanisation and gentrification and the effects this has had on the vulnerable ecology and communities of the BMR. It provides lessons on how previous short sighted and poor development regulations will have enduring social and environmental consequences long into the future and how adoption of traditional morphological ways-of-life and legislative amendments can limit further damage. The legacy of neoliberal urban development resulting in gentrification and underpinned by conflicting local planning laws are analysed and supported by various theoretical materials, field studies and interviews.

The task of this diploma’s thesis was processing construction-technology project to revitalization the mining towers because of its current worsened state and subsequent adjustments for cultural activities.

<p>Civil engineering structures must provide an adequate and safe performance during their time of service, and the owners of these structures must have a reliable inspection strategy to ensure time-dependent damage does not become excessive. Visual inspection is the first step in every structural inspection; however, many elements in the majority of structures are difficult to access and require specialized personal and equipment. In an attempt to reduce the risk of the inspector and the cost of additional equipment, the use of Unmanned Aircraft Systems (UAS) has been increasing in the last years. The absence of standards and regulations regarding the use of UAS in inspection of structures has allowed the market to widely advertise Unmanned Aerial Vehicles (UAV) without protocols or qualifications that prove their effectiveness, leaving the owners of the structures to solely rely on claims of the vendors before deciding which technology suits their particular inspection needs. Focusing primarily on bridge inspection, this research aimed to address the lack of performance-based evaluation and standards for UAS, developing a validation criterion to evaluate a given UAS based on a repeatable test that resembles typical conditions in a structure. </p><p><br></p><p>Current applications of UAS in inspection of structures along with its advantages and limitations were studied to determine the current status of UAS technologies. A maximum typical rotor-tip-to-rotor-tip distance of an UAV was determined based on typical UAVs used in bridge inspection, and two main parameters were found to be relevant when flying close to structures: proximity effects in the UAV and availability of visual line of sight. Distances where proximity effects are relevant were determined based on several field inspections and flights close to structures. In addition, the use of supplementary technologies such as Global Positioning System (GPS) and Inertial Measurement Units (IMU) was studied to understand their effect during inspection. </p><p><br></p><p>Following the analysis, the author introduces the idea of a series of obstacles and elements inside an enclosed space that resemble components of bridge structures to be inspected using UAVs, allowing repeatability of the test by controlling outside parameters such as lighting condition, wind, precipitation, temperature, and GPS signal. Using distances based on proximity effects, maximum typical rotor-tip-to-rotor-tip distance, and a gallery of bridges and situations when flying close to bridge structures, a final arrangement of elements is presented as the evaluation chamber. Components inside the evaluation chamber include both “real” steel and concrete specimens as well as those intended to simulate various geometric configurations on which other features are mounted. Pictures of damages of steel and concrete elements have been placed in the internal faces of the obstacles that can be assessed either in real-time flight or in post-processing work. A detailed comparison between the objectives of this research project and the results obtained by the evaluation chamber was performed using visual evaluation and resolution charts for the images obtained, the availability of visual line of sight during the test, and the absence of GPS signal.</p><p><br></p><p>From the comparison and analysis conducted and based on satisfactory flight results as images obtained during flights, the evaluation chamber is concluded to be a repeatable and reliable tool to apply to any UAS prior to inspect bridges and other structures, and the author recommends to refrain from conducting an inspection if the UAS does not comply with the minimum requirements presented in this research work. Additionally, this research provided a clearer understanding of the general phenomenon presented when UAVs approach structures and attempts to fill the gap of knowledge regarding minimum requirements and criterion for the use of UAS technologies in inspection of structures.</p>

Die Entwicklung mechanischer Antriebskonzepte für nichtlineare Bewegungsaufgaben stellt bis heute ein komplexes und domänenübergreifendes Fachgebiet des Maschinenbaus dar. Auf dem Gebiet der ebenen Koppelgetriebe gibt es dabei seit vielen Jahren Versuche, die optimale Lösung für eine Aufgabe unter Berücksichtigung kinetischer Kenngrößen zu finden. Die vorliegende Arbeit stellt eine Methodik vor, die sowohl den klassischen Verfahren der Getriebetechnik als auch den Ansätzen der Mechanik zum Ausgleich der Massenwirkungen im Getriebe gerecht wird. Der entwickelte Ansatz des modulbasierten Analyse-Synthese-Parameter-Abgleiches (ASPA) erlaubt erstmals eine domänenübergreifende Simulation komplexer Antriebskonzepte auf Basis einer neuartigen modularen Synthesebibliothek. Diese lässt sich dank umfangreicher Dokumentation und der dargestellten Programmablaufpläne in beliebige Software implementieren. Die exemplarisch im Systemsimulator SimulationX implementierte Bibliothek ermöglicht somit unter anderem die Anwendung der klassischen Drei- und Vierlagensynthese im bewegten oder ruhenden Bezugssystem für Dreh- und Schubgelenkketten. Neben der Ausgabe gerundeter Getriebeabmessungen eröffnet der beschriebene Ansatz somit die Berücksichtigung kinetischer Kenngrößen wie den Pendelschwingungen in spielbehafteten Gelenken oder der Änderung der Trägheitskenngrößen während der Synthese. Weiterführend kann eine multikriterielle Optimierung der noch freien Syntheseparameter erfolgen. / Developing nonlinear transmitting planar coupler linkages represents a domain spanning area in mechanical engineering. In recent years many efforts have been made to determine the optimal planar linkage regarding kinetic characteristics. This thesis introduces a method linking classical synthesis procedures with mechanical approaches for a dynamically balanced mechanism. For the first time, the module based analysis-synthesis-parameter-adjustment (ASPA) allows for a domain spanning simulation of complex drive assemblies based on a novel modular synthesis library. Due to an extensive documentation and detailed program flow charts it is possible to implement the library in arbitrary software environments. The exemplarily implemented library in SimulationX allows to apply the classical three- and four-position synthesis within a steady or moving reference frame of revolute or prismatic joint chains. Further, the modules return rounded link dimensions. By applying this library according to ASPA it is now possible to account for kinetic boundaries such as pendulum oscillations of joints with joint clearance or the change of mass properties during the position synthesis. Thus, a multi-criteria optimization of the remaining free synthesis parameters can be applied.