Parkinson’s disease causes among other symptoms also writing disorder. Parkinson's dysgrafia is disease the writing of parkinsonics. The aim of the work is to show the importance of examinig the parametres of Parkinson's dysgrafia and to find writing parametres, which could distinguish healthy subjects from the pacient and also it could monitoring progress of pakinson's disease. Some of the parametrs showed marked differences and therefore could distinguish healthy people from those with Parkinson’s disease.

El trabajo realizado en esta tesis doctoral tiene como objetivo mejorar las metodologías de la química teórica y computacional en la descripción de los efectos del entorno en sistemas químicos. La primera parte se centra en el efecto del solvente, en concreto en el desarrollo de modelos cuánticos continuos de solvatación, y en la derivación de modelos de solvatación fraccional obtenidos a partir de métodos continuos capaces de descomponer energías libres de solvatación y de transferencia entre solventes en contribuciones asociadas a fragmentos químicos de una molécula. Esto permite obtener el perfil tridimensional de las regiones hidrofóbicas/hidrofílicas de una molécula a partir de sus contribuciones fraccionales a la solvatación, siendo esta información muy útil en el establecimiento de relaciones cuantitativas estructura-actividad para el desarrollo de nuevos fármacos, o en la definiciones de índices de similaridad hidrofóbicos, basados en la similitud de este perfil tridimensional entre dos compuestos. Con este objetivo se ha parametrizado satisfactoriamente el modelo continuo MST para la predicción de coeficientes de partición octanol/agua y de energías libres de solvatación en agua, cloroformo, tetracloruro de carbono y octanol, tanto a nivel ab initio HF/6-31G(d) como a niveles semiempíricos AM1 y PM3. También se ha parametrizado el modelo MST para el estudio de especies iónicas en solución. Finalmente, se ha llevado a cabo una comparación entre la respuesta electrostática obtenida a partir de diferentes modelos continuos SCRF (MST, SM5.42R y MPE), ilustrando las grandes diferencias que se pueden encontrar entre las contribuciones electrostáticas y no electrostáticas según sea el modelo usado, y poniendo así de manifiesto la estrecha relación que hay que considerar entre estas contribuciones a la solvatación y la parametrización específica de cada modelo continuo. La metodología de solvatación fraccional usada ha permitido además ilustrar la dependencia de estas contribuciones fragmentales respecto a efectos electrónicos, estéricos o tautoméricos. La segunda parte de este trabajo se centra en el desarrollo de metodologías eficientes y precisas para la descripción de las fuerzas de polarización en campos de fuerzas clásicos. Se han estudiado dos metodologías, una basada en un tratamiento implícito de estas fuerzas a partir de un modelo de doble carga, que permite describir satisfactoriamente la distribución de carga de una molécula en un entorno aislado, y frente a la acción de un campo externo, respectivamente, permitiendo reproducir de forma adecuada las energías de polarización para una serie de complejos por puente de hidrógeno y catión-pi. También se ha estudiado la inclusión de los efectos de polarización mediante dipolos puntuales inducidos. En este sentido, se ha profundizado en una metodología capaz de obtener modelos distribuidos de polarizabilidades atómicas isotrópicas muy eficiente computacionalmente y que permite reproducir de forma precisa la polarizabilidad global de las moléculas para la serie de derivados bencénicos estudiados, así como la contribución de polarización en sus energías de interacción catión-pi con un catión de sodio. / The objective of this work is the improvement of the methodologies available in the field of theoretical and computacional chemistry for the description of the effects of environment in chemical systems.First, it is presented a set of studies on the effect of the solvent, in particular on the development of quantum continuum solvation models and the decomposition of free energies of solvation and transfer into contributions associated to chemical fragments of a molecule. In this way, it can be obtained a 3D picture of the hydrophobic/hydrophylic regions of a molecule, and this information is very valuable in the establishment of quantitative structure-activity relationships for the development of new drugs, and permits also the definition of a hydrophobic similarity index based on the the hydrophobic profile of two different compounds. The parametrization of the MST model presented is able to satisfactorily reproduce octanol/water partition coefficients and free energies of solvation in water, chloroform, carbon tetrachloride and octanol, both at the ab initio HF/6-31G(d) and semiempirical AM1 and PM3 levels of theory. The hydration of ionic species has also been revised in the framework of the MST model. Finally, a comparison of the electrostatic response obtained from different SCRF continuum models (MST, SM5.42R and MPE) is presented. A different balance between the electrostatic and nonelectrostatic contributions has been obtained from the different models, and show that it is necessary to mantain a close correspondece between each SCRF formalism and the specific details of its parametrization. Finally, the transferability of fragmental contributions to solvation has been explored. The second part of this work is aimed at the development of efficient methodologies for the description of polarization forces in classical force fields. Two methodologies has been explored. The first is based on an implicit treatment of these forces through a dual charge model, that represent the charge distribution of a molecule alone and in response to an external field, respectively. Finally, the explicit treatment of polarization effects through induced point dipoles has been studied. In particular, it has been explored an efficient methodology to obtain distributed models of atomic isotropic polarizabilities.

Made available in DSpace on 2016-06-02T20:28:27Z (GMT). No. of bitstreams: 1 4698.pdf: 604113 bytes, checksum: 033e879a6c06b9c3ad1884a3611729fe (MD5) Previous issue date: 2012-08-10 / Universidade Federal de Sao Carlos / We study the behavior, as t ∞, of the energy for the solutions of the Cauchy problem for some strictly hyperbolic linear second order equations with coeficients very rapidly oscillating. / Nós estudamos o comportamento da energia, para t ∞, das soluções do problema de Cauchy para algumas equações estritamente hiperbólicas de segunda ordem com coeficientes que oscilam rapidamente.

The content of this diploma thesis is study of interactions between humic acids and model probes (such as organic dyes and ions of heavy metals) by the simple diffusion experiments in diffusion cell. The main aim was to desctibe the influence of charge of different diffusion sonds (solved substances) on interactions with humic acids imobilized in model gel phase. As a appropriete model probe was chosen copper ions (as a representation of heavy metals) and organic dyes (methylene blue, rhodamine, fluorescein and chicago blue). Experimental results could be used to improve knowledge based on natural barier properties of humic acids and to inovate simple diffusion laboratory techniques for characterization of reaktivity of biopolymers in general.

Magistro darbe tiriamas segetinės floros paplitimas įprastinės ir ekologinės žemdirbystės sąlygomis. Tyrimų objektas – segetinės floros paplitimas įprastinės ir ekologinės gamybos ūkiuose Marijampolės apskrityje, Šakių rajone, Griškabūdžio seniūnijoje, Bliuviškių kaime. Darbo tikslas - lauko tyrimais įvertinti segetinės floros paplitimą pasirinktuose varpinių javų pasėliuose įprastinės ir ekologinės žemdirbystės sąlygomis dulkiškų priemolių karbonatingų glėjiškų rudžemių rajone. Darbo metodai. Siekiant ištirti segetinės floros gausumą įprastinio ir ekologinio ūkio pasėliuose, įprastiniame ūkyje piktžolės buvo imamos iš 5 laukų, o ekologiniame ūkyje piktžolės imamos iš 3 laukų. Segetinės floros kiekis ir botaninė sudėtis buvo nustatoma išskiriant 0,5 m² mikrolaukelius lauko pradžioje, viduryje ir gale kiekviename tyrimo lauke. Gauti duomenys perskaičiuoti 1 m². Išskirtuose laukeliuose piktžolių pavyzdžiai imami trim etapais: vegetacijos pradžioje, viduryje ir prieš derliaus nuėmimą. Tyrimų laukeliuose piktžolės raunamos su šaknimis, nuo jų nupurtomos žemės, sudedamos į atskiras krūveles pagal tyrimo laukelio numerį. Tą pačią dieną nustatoma piktžolių botaninė sudėtis ir žalia masė. Piktžolės džiovinamos saulės neapšviestoje patalpoje. Joms išdžiūvus nustatoma orasausė masė. Darbo rezultatai. Nustatyta, kad įprastinės ir ekologinės gamybos ūkiuose didžiausia piktžolių įvairovė buvo vegetacijos viduryje. Įprastinės gamybos ūkyje 15 piktžolių rūšių. Ekologinės gamybos ūkyje... [toliau žr. visą tekstą] / There in the master thesis the research was focused on spread of segetic flora in the conventional and organic farms. Researh object: The spread of segnetic flora in organic and conventional farms in Marijampole county, Šakiai region, Griškabūdis monitory, Bliuviškiai village. The aim of the research: To measure the spread of the segetic flora in the chosen cereals on the organic and conventional farming conditions in the region of dusty loam carbonaceous glay brown-land. Methods of the research: On purpose to estimate the abudance of segnetic flora in organic and conventional farms, the weeds were taken from 5 fields in the conventional farm. The weeds were taken from 3 fields in the organic farm. The amount of segetic flora and botanical composition was estimated in 0,5m2 microfields which were separated at the beginning, in the middle and at the end of earch field. Data was translated to 1m2. The samples of the weeds in the microfields are taken in 3 stages: at the beginning of vegetation, in the middle of vegetation and before gathering. The weeds are teared up the roots, the soil is shaked down and put in different piles depending on the number of the field.Botanical composition and the green weight of the weeds is estimated at the same day. Weeds are dried in the untill room and air-dried weight is estimated. The results of the research:The biggest variety of the weeds are estimated in the middle of the vegetation in boath organic and conventional farms... [to full text]

The feeding experiment was performed with fry of vimba bream (Vimba vimba) during the first 24 days from the beginning of exogenous nutrition. Six diets were used: algae (Chlorella vulgaris), starter fodder BioOptimal 0,8 mm by Biomar company ? for cyprinids, live nauplii of Artemia salina, combination of alga and starter fodder BioOptimal, combination of alga and nauplii of Artemia salina, combination of starter fodder BioOptimal and nauplii of Artemia salina. Individual weight, total lenght, survival rate of larvae, specific growth rate (SGR) and conditions of the fry (condition coefficient according to Fulton ? FWC) were observed during the experiment. The results were compared statistically using the method of one ? way analysis of variance (ANOVA ? = 0,05; Microsoft Excel).

<p>Tri soja gljive bukovače, P. ostreatus NS 77, P. ostreatus NS 355 i P. ostreatus 244,<br />gajena su na supstratima četiri biljne vrste, p&scaron;enica, kukuruz, soja i suncokret, kao<br />samostalni supstrati i u kombinaciji sa p&scaron;eničnom slamom. Nakon plodono&scaron;enja<br />vr&scaron;ena su ispitivanja odgajivačkih, morfolo&scaron;kih, hemijskih, svojstva gljiva, kao i<br />hemijske i mikrobiolo&scaron;ke&nbsp;&nbsp;&nbsp; sirovim supstratima u odnosu na sadržaj celuloze u<br />supstratima nakon plodono&scaron;enja sojeva, dok je kod sadržaja pepela obrnuto, u sirovim<br />supstratima je niži u odnosu na supstrate nakon plodono&scaron;enja. Koncentracija ukupnog<br />broja mikroorganizama, brojnost amonifikatora i brojnost saprofitnih gljiva na<br />nesterilisanim supstratima je niža nego na iskori&scaron;tenim supstratima. Dehidrogenazna<br />aktivnost&nbsp; je najvi&scaron;a na supstratima nakon plodono&scaron;enja soja NS 244, dok kod<br />enzimskog kompleksa celulaza varira u zavisnosti od soja i supstrata Kod sva tri soja<br />maksimalni prinosi su bili na supstratu Soja (S5), a minimlni na supstratu P&scaron;enica<br />(S1). Na osnovu morfolo&scaron;kih osobine konstatovana je velika varijabilnist između<br />sojeva. Supstrat Kukuruz (S6) se pokazao kao najbolji, sa aspekta vodnog režima, dok<br />se Suncokret (S7) pokazao kao najlo&scaron;iji. Na supstratu Kukuruz (S6) je najvi&scaron;i, a na<br />supstratu P&scaron;enica (S1) je najniži sadržaj pepela. Sadržaj natrijuma u nožici je veći od<br />sadržaja u &scaron;e&scaron;iru, &scaron;to je obrnuto u odnosu na druge mikroelemente i makroelemente.<br />Sadržaj celuloze je vi&scaron;i u svim&nbsp; sirovim supstratima, dok&nbsp; je kod sadržaja pepela<br />obrnuto. Brojnost svih mikroorgnaizma na nesterilisanim supstratima je niža nego na<br />iskori&scaron;tenim supstratima.&nbsp; Dehidrogenazna&nbsp; je najvi&scaron;a na supstratima nakon<br />plodono&scaron;enja soja NS 244, dok kod enzimskog kompleksa celulaza varira u zavisnosti<br />od soja i supstrata.</p> / <p>Three strains of oyster mushroom (P. ostreatus NS 77, NS 355, and 244) were grown on substrates made from four crops (wheat, maize, soybean, and sunflower), as individual substrates or in combination with wheat straw. After fruit maturity,&nbsp; mushroom growing, morphological, and chemical properties were analysed, as well as chemical and microbiological analyses of fresh and used substrates. All three strains showed maximum yields on soybean substrate (S5), and minimum yields on wheat substrate (S1). A large variability among the strains was observed based on the morphological properties. The strain NS 77 has caps of the smallest weight,&nbsp; width and length, the largest number of fruiting bodies, and the longest stalks. The&nbsp; strain NS 244 have caps of the largest weight, width and length, the lowest number of fruiting bodies and stalk length, but the largest width of the stalks. Regarding water regime, maize substrate (S6) was the best, while sunflower (S7) was the poorest. Ash content was the highest in maize substrate (S6) and the lowest in wheat&nbsp; substrate (S1). Potassium content in the stalk was higher than in the cap, which is opposite from other micro- and macro elements. Cellulose content was higher in all fresh substrates than in the used substrates after the strains have fruited, while ash content was higher in the used substrates. Concentration of total number of microorganisms, abundance of ammonifiers and saprophytic fungi in the unsterilized substrates were lower than in the used ones. Dehydrogenase activity was the highest in substrates after fruiting of NS 244, while cellulose enzyme complex varied regarding the strain and substrate.</p>

The thesis focuses on constructing dynamic model - synchronous generator with using magnetic equivalent circuit diagrams. The model construction is based on knowledge of geometric parameters, magnetic characteristic of used material and fyzical deployment of vindings placed in stator slots. Computed reults are compared with results optained from model created with finite element method.

Title: Comparison of individual methods of basal metabolism determination Objectives: The aim of the work is to compare the individual methods of basal metabolism. These values were measured by indirect calorimetry, plethysmography, bioelectric impedance and predictive equations. Methods: The research was attended by 31 people, including eight men and twenty-three women. All participants of my research were aged 21-30 years. None of the participants was a professional athlete, they were all healthy and none of the women were pregnant or had menstruation. The indirect calorimetry, bioelectronics impedance device Tanita MC - 980 and BOD POD were used to collect the data. Basal metabolic rates were calculated from the prediction equations by Harris & Benedict, Fleisch's equation and Schofield's equation using measured anthropometric values. Results: The results of the methods that have been used for this group of people vary, but the difference is not significant. If we choose as a reference method indirect calorimetry, we can't replace it by any other method. The results for other methods are not significantly different, so we can replace one method with another, except indirect calorimetry. From calculations, we also found out that fat free mass greatly influences the results of basal metabolic rate...

This master´s thesis is focused on assessment of properties of vibropressed concrete products. The important point of the thesis is measuring fresh concrete air permeability by Qaver control tool and confrontation this results with results of hardened concrete. The relationship between results obtained is examined.