<p>Because of their compatibility and precise results bio-optical methods based on measurements of the optical tissue properties gain importance in non-invasive medical therapy and diagnostic. For development and standardization of medical devices optical phantoms are suitable. The present report handles the creation and evaluation of solid tissue phantoms, made up of Agar, Vasolipid and ink utilizing different mixture ratios. After cutting the models in slices of 0.2 to 1.1 mm thickness the absorption- and scattering coefficient were measured using a collimated laser beam setup. As result of the study a formula for the preparation of solid optical tissue phantoms with desired optical properties was found, that is valid for models containing 1.12 % Agar.</p>

Because of their compatibility and precise results bio-optical methods based on measurements of the optical tissue properties gain importance in non-invasive medical therapy and diagnostic. For development and standardization of medical devices optical phantoms are suitable. The present report handles the creation and evaluation of solid tissue phantoms, made up of Agar, Vasolipid and ink utilizing different mixture ratios. After cutting the models in slices of 0.2 to 1.1 mm thickness the absorption- and scattering coefficient were measured using a collimated laser beam setup. As result of the study a formula for the preparation of solid optical tissue phantoms with desired optical properties was found, that is valid for models containing 1.12 % Agar.

Measurements of the neutron emission, resulting from nuclear fusion reactions between the hydrogen isotopes deuterium and tritium, can provide a wealth of information on the confinement properties of fusion plasmas and how these are affected by Magneto-Hydro-Dynamic (MHD) instabilities. This thesis describes work aimed to develop neutron measurement techniques for nuclear fusion plasma experiments, specifically regarding the performance and design of collimated neutron flux monitors (neutron cameras) for the Mega Ampere Spherical Tokamak, MAST, and for MAST Upgrade. The first part of the thesis focuses on the characterization of a prototype neutron camera installed at MAST and provides an account of the very first measurements of the neutron emissivity along its collimated fields of view. It is shown that the camera has sufficient temporal and spatial resolution to measure the effect of MHD instabilities on the neutron emissivity. The neutron camera fulfils the requirement on the measurements of the neutron count rate profile with less than 10 % statistical uncertainty in a time resolution of 1 ms. The instrument's more rudimentary capabilities to provide information on the neutron energy distribution are also presented and discussed. The encouraging results obtained with the prototype neutron camera show the potential of a collimated neutron flux monitor at MAST and suggest that an upgraded instrument for MAST Upgrade will provide crucial information on fast ions behavior and other relevant physics issues. The design of such an upgraded instrument for MAST Upgrade is discussed in the second part of the thesis. Two design options are explored, one consisting of two collimator arrays in the horizontal direction, another more traditional design with lines-of-sight in the poloidal cross section plane. On the basis of the experience gained with the prototype neutron camera and on the exploratory design and estimated performance for the upgraded camera presented here, a conceptual design of a neutron camera upgrade is proposed.

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<p>Non-destructive characterization of multi-layered structures that can be accessed from only a single side is important for applications such as well-bore integrity inspection. Collimated beam ultrasound systems are a technology for imaging inside multi-layered structures such as geothermal wells. These systems work by using a collimated narrow-band ultrasound transmitter that can penetrate through multiple layers of heterogeneous material. A series of measurements can then be made at multiple transmit frequencies. However, commonly used reconstruction algorithms such as Synthetic Aperture Focusing Technique (SAFT) tend to produce poor quality reconstructions for these systems both because they do not model collimated beam systems and  they do not jointly reconstruct the multiple frequencies.</p> <p><br></p> <p>In this thesis, we first propose a multi-frequency ultrasound model-based iterative reconstruction (UMBIR) algorithm designed for multi-frequency collimated beam ultrasound systems. The combined system targets reflective imaging of heterogeneous, multi-layered structures. For each transmitted frequency band, we introduce a physics-based forward model to accurately account for the propagation of the collimated narrow-band ultrasonic beam through the multi-layered media. We then show how the joint multi-frequency UMBIR reconstruction can be computed by modeling the direct arrival signals, detector noise, and incorporating a spatially varying image prior.</p> <p><br></p> <p>We also propose a ringing artifact reduction method for ultrasound image reconstruction that uses a multi-agent consensus equilibrium (RARE-MACE) framework. Our approach integrates a physics-based forward model that accounts for the propagation of a collimated ultrasonic beam in multi-layered media, a spatially varying image prior, and a denoiser designed to suppress the ringing artifacts that are characteristic of reconstructions from high-fractional bandwidth ultrasound sensor data.</p> <p><br></p> <p>Results using both simulated and experimental data indicate that multi-frequency UMBIR reconstruction yields much higher reconstruction quality than either single frequency UMBIR or SAFT. In addition, our results demonstrate the capability of our RARE-MACE method to suppress ringing artifacts and substantially improve the image quality over single frequency UMBIR and SAFT.</p>

The γ-ray characterizing possibility of the neutron collimated flux monitor (in short, Neutron Camera) at the Mega Ampere Spherical Tokamak (MAST) is explored. Typically used to monitor neutron emission, the Neutron Camera has excellent neutron/γ-ray discrimination properties and thus presents the opportunity to measure spatially and temporally resolved γ-ray emission - a possibility of an additional fusion diagnostics method with already existing equipment. An Online Data Analysis (ODA) code was used to analyze the data on γ-rays from several plasma discharges with similar plasma parameters. A high statistics temporal distribution of the γ-ray emission and a lower statistics spatial distribution were analyzed. However, the low energy resolution and range for the Neutron Camera γ-ray measurements revealed few conclusive results on the origin of the higher energy γ-rays. Detection systems with higher energy resolution and range are suggested for an extensive analysis of γ-ray emission at MAST Upgrade.

The research developed a UV Taylor Couette reactor for disinfecting milk as a model opaque fluid. The principal of the reactor was to generate laminar vortices to support efficient mixing and homogenous UV photon distribution. The UV reactor parameters were optimized to generate laminar vortices that were stabilized by modification of the unit with baffles. A model was developed to predict the UV dose required to inactivate model microbes in milk. Through verification trials it was noted the predicted UV dose underestimated that required to support a 5 log cfu reduction of microbes. It was subsequently identified that the deviation from predicted values could be attributed to fat content that enhances the UV inactivation of microbes in milk with proteins providing protection to microbes. In conclusion, the UV Taylor Couette reactor has strong potential for disinfecting opaque fluids although matrix effects need to be considered when undertaking validation trials.

The goal of this project was to develop a measuring method and software code to determine and compare the focal ratio degradation of optical fibers for two different coupling technologies. One of the couplings used a fusing technology to splice the fiber, and the other coupling used a refractive index matching technology. Also, an optical fiber without any cleaving or splicing was used as a reference. A collimated beam test was developed as a method for measuring the focal ratio degradation for these different fiber couplings, and a software code was developed to process the results of the experiment. Using the collimated beam test and software code, the focal ratio degradation was calculated and compared between the couplings, and the results clearly stated that the reference fiber had the least focal ratio degradation. The fusing technology used for splicing the fiber had in comparison the least focal ratio degradation of the two different coupling technologies. The results were as expected and therefore the developed measuring method and software were estimated to have been carried out successfully. However, improvements to the measuring method and parts of the software could be done, especially regarding the background light which was a substantial source of error. In conclusion, the goal of the project was reached. / Inom astronomisk forskning används ofta optiska fibrer som informationslänk mellan teleskop och mätinstrument, eftersom de bidrar till att mätningar blir mer tillförlitliga då vibrationer och yttre miljöfaktorer får en mindre påverkan på resultaten. Inom detta projekt undersöktes ett par olika kopplingar av optiska fibrer och deras ljusförluster inom benämningen FRD (Focal ratio degradation). En mätmetod utvecklades tillsammans med en mjukvara som användes för nödvändiga beräkningar och analyser som ledde till att FRD kunde bestämmas. Metoden som användes kallas collimated beam test och innebar att parallellt ljus skickades in i ena fiberänden, vilket genererade en ring av ljus från den andra fiberänden. Mätningarna utfördes på tre olika fiber: en fiber var klyvd och sedan sammansmält, en annan fiber var klyvd och sedan ihopkopplad med hjälp av en vätska av matchande refraktionsindex och den tredje fibern var inte klyvd och fungerade som referens. Resultaten givna av mätningarna och mjukvaran var som man hade förväntat sig; FRD var minst för referensfibern och som högst för fibern med en koppling där refraktionsindex-matchande vätska användes. Även om det finns goda möjligheter att utveckla och förbättra mätmetoden, påvisades ett godtagbart resultat och målet med projektet ansågs därför vara uppnått.

L'hadronthérapie joue un rôle de plus en plus important au sein des techniques de radiothérapie grâce aux propriétés balistiques des ions et, dans le cas de ceux plus lourds que les protons, à une augmentation de l'efficacité biologique dans la région tumorale. Ces caractéristiques permettent une meilleure conformation de la dose délivrée au volume tumoral et elles permettent en particulier de traiter des tumeurs radio-résistantes. Elles conduisent cependant à une grande sensibilité du parcours des ions aux incertitudes du traitement. C'est dans ce contexte qu'a été proposée la détection de radiations secondaires émises lors des interactions nucléaires induites par les ions incidents dans le patient. La tomographie par émission de positons et la détection des rayons gamma prompts ont notamment fait l'objet d'une recherche intense ces dernières années. Le réseau de formation européen ENTERVISION, soutenu par la communauté ENLIGHT, a été crée fin 2009 pour développer ce type d'imagerie et, plus généralement, traiter les incertitudes de traitement en hadronthérapie. Le travail présenté dans ce manuscrit et intitulé ≪ Modélisation et simulation des processus physiques pour l'imagerie en ligne de l'hadronthérapie ≫ est l'un des nombreux travaux issus de ce projet. Bien que le sujet soit particulièrement large, le fil conducteur de ce travail a été une étude systématique visant in fine une implémentation d'un dispositif d'imagerie ≪ gamma prompts ≫ utilisable à la fois en faisceau de protons et d'ions carbone / Hadrontherapy is taking an increasingly important role in radiotherapy thanks to the ballistic properties of ions and, for those heavier than protons, an enhancement in the relative biological effectiveness in the tumour region. These features allow for a higher tumour conformality possible and gives the opportunity to tackle the problem of radioresistant tumours. However, they may lead to a great sensitivity of ion range to treatment uncertainties, namely to morphological changes along their path. In view of this, the detection of secondary radiations emitted after nuclear interactions between the incoming ions and the patient have been long proposed as ion range probes and, in this regard, positron emitters and prompt gammas have been the matter of intensive research. The European training network ENTERVISION, supported by the ENLIGHT community, was created in the end of 2009 in order to develop such imaging techniques and more generally to address treatment uncertainties during hadrontherapy. The present work is one of the many resulting from this project, under the subject “Modelling and simulation of physics processes for in-beam imaging in hadrontherapy”. Despite the extensive range of the topic, the purpose was always to make a systematic study towards the clinical implementation of a prompt-gamma imaging device to be used for both proton and carbon ion treatments