Typescript, etc. / Digitized by Kansas Correctional Industries

Typescript (photocopy). / Digitized by Kansas Correctional Industries

This is a piece for mixed chamber ensemble (flute doubling piccolo and alto flute, bass clarinet, piano, percussion [crotales and vibraphone] violins 1&2, viola, and cello). The total performance length of the piece is approximately fifteen minutes. The structure of the work is based on the exploration of formlessness as form, a piece of music where the drifting, seemingly aimless instrumental lines create a complex texture that becomes more than the sum of its parts. Instead of relying on a clearly delineated form based on goal-oriented structures, this work gradually transforms its elements without ever feeling the need to go anywhere other than where it already is. In this sense, the music is in a constant state of becoming itself, a goal that it can never really achieve.

Pericentriolar satellites (PS) are electron dense granules surrounding the centrosome, the major microtubule-organizing centre in eukaryotic cells. In cycling cells the centrosome promotes spindle assembly and the faithful execution of mitosis. In non-cycling cells it is involved in forming the cilium, a plasma membrane-resident organelle, which mediates crucial signalling pathways in development and tissue homeostasis. PS are thought to contribute to centrosome formation, through the microtubule-dependent transport of centrosome components, and they are involved in ciliogenesis and stress response. Moreover, several proteins that localize to PS are mutated in human ciliopathies and neurodevelopmental disorders. The precise roles of PS in the various molecular pathways and diseases are however poorly understood, in part due to the limited knowledge of their composition. In the first part of my study I performed a comprehensive analysis of the pericentriolar satellite proteome. This was achieved by sucrose sedimentation of PS, combined with affinity purification of a key PS component, PCM1. To eliminate contamination by centrosomes, the PS proteome was determined from wild-type cells as well as from two cell lines genetically engineered to lack centrosomes. Mass spectrometry identified 170 PS components including most of the previously described PS proteins, confirming the validity of the approach. Having determined the proteomic composition of PS from DT40 cells, I then performed validation studies both in chicken and human cell lines. In the second part of my study, I aimed to use the list of PS proteins to uncover new biological roles for pericentriolar satellites. I devised two distinct approaches to gain functional insights. First, I generated a cell line lacking PCM1 as a tool to study the role(s) of PS and PS components. Second, I performed loss-of-function studies on a set of new PS proteins to determine their function(s) in maintaining the canonical PS distribution and in forming primary cilia.

Typescript (photocopy). / Digitized by Kansas Correctional Industries / Department: English.

Prepositions describes relations between different things. In this collection thosethings refers to the soft and moving body, hard and stiff sculptural shapes, colours,prints, fabrics and shoes.I have a great passion for sculptural shapes and for this collection I have used thispassion as an important source for inspiration. Interesting and challenging meetingsbetween the choice of especially materials and colours is another aspect of this project.Wholeness has a significant meaning to me, as the important thing is not to put focuson the garments themselves rather than the combination of all elements, in the compositionof each outfit and in the line-up. I have looked at the different componentssuch as the sculptural shapes, garments, colours, prints and shoes as if they wherebuilding blocks. I have arranged and rearranged and combined those building blocksin different ways trying to achieve a dynamic and balanced composition. I have triedto simplify all parts as much as possible when aiming for a clear and strong result. / Program: Modedesignutbildningen

Prepositions describes relations between different things. In this collection thosethings refers to the soft and moving body, hard and stiff sculptural shapes, colours,prints, fabrics and shoes.I have a great passion for sculptural shapes and for this collection I have used thispassion as an important source for inspiration. Interesting and challenging meetingsbetween the choice of especially materials and colours is another aspect of this project.Wholeness has a significant meaning to me, as the important thing is not to put focuson the garments themselves rather than the combination of all elements, in the compositionof each outfit and in the line-up. I have looked at the different componentssuch as the sculptural shapes, garments, colours, prints and shoes as if they wherebuilding blocks. I have arranged and rearranged and combined those building blocksin different ways trying to achieve a dynamic and balanced composition. I have triedto simplify all parts as much as possible when aiming for a clear and strong result. / Program: Modedesignutbildningen

The use of similar musical material from one work to another in Beat Furrer’s works is what unites them in an unmistakable identity. What makes each work unique, however, is the way new networks of meaning for the material become established as the composer reworks his material for a given work. I argue that in Furrer’s Hörtheater FAMA, composed in 2004-2005, the reworking of the glissando as a compositional resource is strongly influenced by the textual subject matter, Arthur Schnitzler’s monodrama Fräulein Else. Furrer’s presentation of the musical material acts as a musical staging of the title character. And like Schnitzler’s novel, FAMA can be viewed as a comment on political and cultural issues.

Umberto Eco states that the list is the origin of culture, a way of making infinity comprehensible. Lists and catalogues are a way of creating order though history. I am currently, as a composer, working on a piece for choir using a list of angels as its text. Lists of angels deal with infinity, the list as such converges the three different monotheistic religions under the same roof. In my research I have tried to create a short overview of the history of lists in music, along with the musical presentation of angels in music - a subject that has fascinated many composers. Composers of last century such as Arnold Schoenberg, Oliver Messiaen and Karlheinz Stockhausen, to mention just a few, dealt with the representation of the angelic and divine in their music. Their different religious backgrounds suggested different strategies in their works dealing with angelic subjects.

This paper describes the development of OM-Darwin, a generalized system for composing with genetic algorithms (GA), realized as a library for OpenMusic. It provides a simple GA engine, along with sophisticated devices for genotype encoding, phenotype mapping and modular fitness function design, while offering a collection of objects that represent common musical forms and rules. A comparison with other optimization methods reveals some advantages in the GA approach, in particular the capability of defining frequency-based rules and producing partial solutions to difficult musical problems. Reference is made to the author's Future Perfect (2010) for 13 instruments, composed entirely using OM-Darwin.