The next generation of extremely large telescopes (ELTs) have the potential to image habitable rocky planets, if suitably optimized. This will require the development of fast high order "extreme" adaptive optics systems for the ELTs. Located near the excellent site of the future GMT, the Magellan AO system (MagAO) is an ideal on-sky testbed for high contrast imaging development. Here we discuss planned upgrades to MagAO. These include improvements in WFS sampling (enabling correction of more modes) and an increase in speed to 2000 Hz, as well as an H2RG detector upgrade for the Clio infrared camera. This NSF funded project, MagAO-2K, is planned to be on-sky in November 2016 and will significantly improve the performance of MagAO at short wavelengths. Finally, we describe MagAO-X, a visible-wavelength extreme-AO "afterburner" system under development. MagAO-X will deliver Strehl ratios of over 80% in the optical and is optimized for visible light coronagraphy.

Depuis l'arrêt définitif des essais nucléaires, la Direction des Applications Militaires (DAM) du CEA s'appuiesur le triptyque modélisation physique - validation expérimentale - simulation numérique pour comprendre,prévoir et garantir le fonctionnement des armes nucléaires. Parmi les grands équipements contribuant à lavalidation des modèles physiques implémentés dans les logiciels de calcul, le Laser MegaJoule permetd'étudier expérimentalement des phénomènes de même nature que ceux intervenant dans les armes. La familled'objets expérimentés sur cette installation est dénommée « microcibles laser». Les microballons intégrés dansces microcibles sont caractérisés par des techniques de radiographie X. Les brusques variations de niveau degris observées sur les clichés X de microballons témoignent de la 'présence d'un phénomène de contraste dephase, contraste s'ajoutant au contraste d'absorption. L'information contenue dans ce phénomène est utiliséepour une détection de contours du microballon radiographié. Les points trouvés lors de la détection de contourssont alors utilisés par un algorithme d'estimation des défauts de formes des surfaces des microballons. Uneétude paramétrique permet d'identifier le nombre de clichés nécessaire à l'estimation des défauts de forme enfonction du nombre de modes souhaités. L'incertitude de la méthode d'estimation est calculée permettant lacaractérisation complète du microballon. / Since 1996, the CEA's Military Applications Division (DAM) guaranties the reliability and safety of Frenchnuclear warheads without conducting any further nuclear test. It relies particularly on major facilities forvalidating the equations used to model the functioning of nuclear weapons. Among them, the Megajoule Laser(LMJ) allows studying experimentally, as "laboratory" measurements, representative phenomena gatheringtime·scale and space distribution of extreme temperature and pressure conditions. These experiments are ledwith millimetric objects named microshells. Before experimenting them, these microshells are characterizedusing X·rays technics. On the radiographies, one can observe straight gray level variations which are generatedby the phase contrast phenomenon added to x·rays absorption contrast. Information included in this formercontrast is used to sharply determine microshell's edges. The delimiting points of these edges are thenintegrated as input data to compute microshell's surface form defects. A study is also led to determine theoptimized number of radiographies needed for estimating the search defect modes. Measurement uncertainty isfinally evaluated, thus giving a complete microshell's characterization.

Clinical relevance: Mobility and fall risk may be important considerations in choosing between intraocular lenses. Background: Fall risk in older adults increases when wearing multifocal spectacles, but little is known about mobility among individuals with different types of intraocular lenses. This study compared visual function, fall risk and balance control following bilateral implantation of monofocal or multifocal intraocular lenses. Methods: This was a non-randomised, cross-sectional study involving adults with bilateral intraocular lenses. Participants completed questionnaires concerning physical functioning, fall history and balance-related confidence. Binocular visual acuity, contrast sensitivity (Pelli-Robson chart and computerized testing), depth perception and glare sensitivity were assessed. Physical performance measures included the Sensory Organization Test, preferred gait speed, Dynamic Gait Index and wayfinding in a virtual environment. Results: Fifteen participants (mean ± standard deviation, 67.1 ± 6.8 years) had monofocal intraocular lenses and 14 participants (68.1 ± 6.1 years) had multifocal intraocular lenses. Contrast sensitivity in the monofocal group was significantly better than that in the multifocal group (p = 0.02) at intermediate and high spatial frequencies. Contrast sensitivity of the monofocal group also was less affected by glare than the contrast sensitivity of the multifocal group, at an intermediate spatial frequency (p = 0.02). However, the multifocal group had significantly better Dynamic Gait Index scores (p = 0.04), even after controlling for perceived physical function. Conclusions: The participants with monofocal intraocular lenses generally had better contrast sensitivity than did those with multifocal intraocular lenses. However, the scores on a mobility test that is associated with fall risk were worse for those with monofocal lenses.

Behavioral contrast has been interpreted as a function of either (1) the reduction of frequency of reinforcement in one component of a multiple schedule or (2) the suppression of responses in one component regardless of reinforcement frequency. These explanations are discussed in terms of their adequacy in accounting for several recent experimental results. Two alternative explanations are considered. First, contrast is interpreted as a function of the relative summation of excitatory and inhibitory effects of stimuli. Second, contrast is discussed as a possible function of a switch from a response-reinforcer contingency to a stimulus-reinforcer contingency as seen in auto-pecking. Both avenues are considered promising in terms of accounting for behavioral contrast.

No description available.

Static Visual Acuity (SVA) has been called into question for some time as a measure of overall visual system function and as a predictor of performance on real-life tasks requiring vision (i.e., operating an automobile). Specifically, it has been pointed out that the targets employed in most SVA testing (high contrast, stationary letters) are an insufficient analog to actual targets encountered in everyday activities, which are often in motion and/or of less-than-perfect contrast. In addition, the size-threshold methodology typically used to measure SVA is incongruent with current theories of a multi-channel visual system. Dynamic Visual Acuity (DVA) and Contrast Sensitivity have been suggested as alternatives to SVA, but while each mitigates specific weaknesses of the SVA measure, neither addresses the shortcomings completely. Traditional DVA measures employ moving targets, but these targets are usually of perfect contrast and a size-threshold methodology is used to specify acuity levels. Contrast Sensitivity employs a contrast-threshold methodology and allows measurement of specific visual channels, but stationary targets are utilized. The present study combined the DVA and Contrast Sensitivity measures in an effort to retain the unique qualities of each while addressing their shortcomings, resulting in a more detailed picture of the human visual system and functioning than has yet been possible. By measuring contrast sensitivity to targets at a set of spatial frequencies spanning the human "window of visibility" and under conditions of motion representative of that encountered in everyday activities, it was hoped that a more powerful predictor of actual visual performance would be created. In addition, normative data was established for two separate age populations, in the hopes of learning more about specific changes that occur to the visual system during the aging process. Indeed, several effects and interactions among the three main variables (spatial frequency, velocity, age) were uncovered, which appears to indicate that the new test may provide more information about the visual system than DVA or contrast sensitivity by themselves. The ramifications of this effort to human factors and visual performance research are discussed along with recommendations for the continuation and application of this line of research.

The thesis explores the relationship of light, architecture, and humans focusing on both the mathematics of solar movement that informs the architecture and the experiential and spiritual response of human perception to it. The exploration uses the celestial realm as the inspiration and canvas that the design process was built on. The light tunnels, the design concept explored in detail, investigate the consequences of architectural form and space in combination with volumetric, reflected, dispersed, or absorbed light. The design process transforms an instrument derived from the sun dial to a living piece of architecture that responds to human perception to variably objectify and reveal spiritual conditions of the celestial sky. / Master of Architecture / The thesis explores the relationship of light, architecture and humans focusing on both the movement of the sun and the perceptive response to it. The Pilgrimage of the 'temples of inexplicable' is a complex with several pavilions that engage with light and dark to create a space that allows the coexistence of spirituality and science in harmony. The thesis looks into one pavilion in detail – The light tunnels that investigate the movement of the light source, its nature as an object or revelation, and the human perception. The design process transforms an instrument to a living piece of architecture.

No description available.

No description available.

Macromolecular magnetic resonance imaging (MRI) contrast agents have unique localization and contrast enhancement properties. We have designed and studied a monodisperse paramagnetic β-cyclodextrin click cluster (Gd10) decorated with Gd-containing arms and unique contrast enhancing polymers. To synthesize Gd10, a novel alkyne-functionalized diethylenetriaminetetraacetic acid chelate was created and coupled to a per-azido-β-cyclodextrin core and chelated with Gd(III) to yield the precursor macromolecule. Luminescence measurements were carried out using an analogous structure Eu(III)-containing structure and indicated that each lanthanide has an average of 1.8 water exchange sites. Gd10 yields a high relaxivity profile (6.2 mM⁻¹ s⁻¹ per Gd(III) at 9.4 T). Gd10 shows toxicity higher than clinically used contrast agents such as Magnevist&trade in vitro in cardiomyoblast cells. No acute toxicity was observed in the rats (n = 9) and contrast enhanced image analysis indicates renal processes may be involved in clearance. The contrast enhancing polymers we developed are new macromolecular beacons that allow the delivery of nucleic acids to be visualized at different biological scales. They contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and Gd(III)/Eu(III) chelates. The chelated lanthanides allow the visualization of the delivery vehicle via microscopy and via magnetic resonance imaging (MRI). We demonstrate that these new delivery beacons effectively bind plasmid DNA(pDNA) and protect their cargo nucleic acids from nuclease damage. The lanthanide-chelate materials have been found to efficiently deliver pDNA into cultured cells and do not exhibit toxicity. Micrographs of cultured cells exposed to the nanoparticle complexes formed with fluorescein-labeled pDNA and the europium-chelated polymers reveal effective intracellular imaging of the delivery process. MRI of bulk cells exposed to the complexes formulated with pDNA and the gadolinium-chelated structures show bright image contrast, allowing visualization of effective intracellular delivery on the tissue-scale. Because of their versatility as imaging probes, these delivery beacons posses remarkable potential for tracking and understanding nucleic acid transfer in vitro and have promise for in vivo imaging applications. In later studies the Ln-chelating polymers were co-polymerized with dimethylgalacterate which definitively increases luciferase gene expression (up 50x enhancement) and cellular uptake (up to 2x enhancement). / Ph. D.