Global ETD Search

1	A Neuron Emulator and Headstage Circuit for Patch Clamp Setups Wu, Yen-cheng 15 August 2012 (has links) This thesis presents a neuron emulator and headstage circuit for patch clamp setups and provides simulation, measurement and verification results. The circuit implemented on a printed circuit board (PCB) is battery powered and portable. The emulator provides both passive (resting potential) and active (action potential) electrical properties of a live neuron as seen from a single electrode by using the headstage circuit. It can be used to test electrophysiological equipment such as current-clamp, voltage-clamp or patch-clamp amplifiers. The action potentials (APs) are generated with a voltage-dependent frequency controlled by a microcontroller implementing a firing range from -60 mV to -30 mV and firing frequency from 1 Hz to10 Hz. The charge released by firing the neuron is initially stored on a 110 pC capacitor. Compared to directly using a current or voltage source, this design results in a more realistic simulation of the APs generated by ionic currents in a live neuron. The measured results from a prototype demonstrate that the neuron emulator meets the design specifications and it is capable of performing voltage clamp and rate responsive current clamp functionality. Measured results using a commercial clamp amplifier are provided to confirm the emulator operation in a practical recording environment. patch clamp neuron emulator headstage single electrode action potential current clamp voltage clamp
2	Optogenetic Tools for In-Vitro Neurophysiology Norman, Olivia Rose January 2014 (has links) No description available. Biomedical Engineering Neurosciences Biology Optogenetics Channelrhodopsin-2 Voltage Clamp Current Clamp HEK-293 MC3T3-E1 Gap Junctions
3	Distinct Modulatory Actions Enable Network Neuron Recruitment and Regulation Fahoum, Savanna-Rae Hakam 21 July 2023 (has links) No description available. Biology Neurosciences recruitment neuronal switching reconfiguration intrinsic properties ion channels synaptic properties synapses modulation neuromodulation central pattern generator CPG rhythmic circuits rhythmic motor system regulation entrainment Gly1-SIFamide crustacean stomatogastric STG STNS electrophysiology current clamp voltage clamp
4	Subthreshold Oscillations and Persistent Activity Modulate Spike Output in the Rodent Dentate Gyrus Anderson, Ross William 09 February 2015 (has links) No description available. Animals Biology Biophysics Health Sciences Neurobiology Neurosciences Physiology In vivo recordings whole cell patch clamp hippocampus mouse dentate gyrus granule cell mossy cell interneuron acetylcholine head-fixed awake recordings persistent firing plateau potential current clamp subthreshold oscillations alpha
5	Measuring the Acute Physiological Effects of Leptin in the Carotid Body Pye, Richard Laurence 21 December 2015 (has links) No description available. Biomedical Research Leptin Carotid Body Calcium imaging Electrophysiology Voltage-clamp Current-clamp CB type I cell Glomus cell Carotid sinus nerve recording Chemosensory response
6	Altered Skeletal Muscle Excitation-Contraction Coupling in the R6/2 Transgenic Mouse Model for Huntington's Disease Miranda, Daniel R. January 2021 (has links) No description available. Biomedical Research Biology Physiology action potential duration prolonged calcium Ca2+ force excitation-contraction coupling EC coupling chloride potassium Cl- K+ inwardly rectifying Kir ClC-1 skeletal muscle Huntington's disease huntingtin release flux voltage gated KV KV1.5 KV3.4 trains electrophysiology current-clamp

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