<p>Modern ski-treadmills allow cross-country skiers, biathletes and ski-orienteers to test their physical performance in a laboratory environment using classical and freestyle techniques on roller skis. For elite athletes the differences in performance between test occasions are quite small, thus emphasising the importance of knowing the roller skis’ rolling resistance coefficient, µ_R, in order to allow correct comparisons between the results, as well as providing the opportunity to study work economy between different athletes, test occasions and core techniques.</p><p>Thus, one of the aims of this thesis was to evaluate how roller skis’ µ_R is related to warm-up, mass, velocity and inclination of the treadmill. It was also necessary to investigate the methodological variability of the rolling resistance measurement system, RRMS, specially produced for the experiments, with a reproducibility study in order to indicate the validity and reliability of the results.</p><p>The aim was also to study physiological responses to different µ_R during roller skiing with freestyle and classical roller skis and techniques on the treadmill as a case in which all measurements were carried out in stationary and comparable conditions.</p><p>Finally, the aim was also to investigate the work economy of amateurs and female and male junior and senior cross-country skiers during treadmill roller skiing, i.e. as a function of skill, age and gender, including whether differences in body mass causes significant differences in external power per kg due to differences in the roller skis’ µ_R.</p><p>The experiments showed that during a warm-up period of 30 minutes, µ_R decreased to about 60-65% and 70-75% of its initial value for freestyle and classical roller skis respectively. For another 30 minutes of rolling no significant change was found. Simultaneous measurements of roller ski temperature and m_R showed that stabilized m_R corresponds to a certain running temperature for a given normal force on the roller ski. The study of the influence on m_R of normal force, velocity and inclination produced a significant influence of normal force on m_R, while different velocities and inclinations of the treadmill only resulted in small changes in m_R. The reproducibility study of the RRMS showed no significant differences between paired measurements with either classical or the freestyle roller skis.</p><p>The study of the effects on physiological variables of ~50% change in µ_R,showed that during submaximal steady state exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a significantly changed maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non significant or small.</p><p>The final part of the thesis, which focused on work economy, found no significant difference between the four groups of elite competitors, i.e. between the two genders and between the junior and senior elite athletes. It was only the male amateurs who significantly differed among the five studied groups. The study also showed that the external power per kg was significantly different between the two genders due to differences in body mass and m_R, i.e. the lighter female testing groups were roller skiing with a relatively heavier rolling resistance coefficient compared to the heavier testing groups of male participants.</p> / Sporttech

Modern ski-treadmills allow cross-country skiers, biathletes and ski-orienteers to test their physical performance in a laboratory environment using classical and freestyle techniques on roller skis. For elite athletes the differences in performance between test occasions are quite small, thus emphasising the importance of knowing the roller skis’ rolling resistance coefficient, µR, in order to allow correct comparisons between the results, as well as providing the opportunity to study work economy between different athletes, test occasions and core techniques. Thus, one of the aims of this thesis was to evaluate how roller skis’ µR is related to warm-up, mass, velocity and inclination of the treadmill. It was also necessary to investigate the methodological variability of the rolling resistance measurement system, RRMS, specially produced for the experiments, with a reproducibility study in order to indicate the validity and reliability of the results. The aim was also to study physiological responses to different µR during roller skiing with freestyle and classical roller skis and techniques on the treadmill as a case in which all measurements were carried out in stationary and comparable conditions. Finally, the aim was also to investigate the work economy of amateurs and female and male junior and senior cross-country skiers during treadmill roller skiing, i.e. as a function of skill, age and gender, including whether differences in body mass causes significant differences in external power per kg due to differences in the roller skis’ µR. The experiments showed that during a warm-up period of 30 minutes, µR decreased to about 60-65% and 70-75% of its initial value for freestyle and classical roller skis respectively. For another 30 minutes of rolling no significant change was found. Simultaneous measurements of roller ski temperature and mR showed that stabilized mR corresponds to a certain running temperature for a given normal force on the roller ski. The study of the influence on mR of normal force, velocity and inclination produced a significant influence of normal force on mR, while different velocities and inclinations of the treadmill only resulted in small changes in mR. The reproducibility study of the RRMS showed no significant differences between paired measurements with either classical or the freestyle roller skis. The study of the effects on physiological variables of ~50% change in µR,showed that during submaximal steady state exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a significantly changed maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non significant or small. The final part of the thesis, which focused on work economy, found no significant difference between the four groups of elite competitors, i.e. between the two genders and between the junior and senior elite athletes. It was only the male amateurs who significantly differed among the five studied groups. The study also showed that the external power per kg was significantly different between the two genders due to differences in body mass and mR, i.e. the lighter female testing groups were roller skiing with a relatively heavier rolling resistance coefficient compared to the heavier testing groups of male participants. / Sporttech

The advent of wide band-gap semiconductors in power electronics has led to the scope of efficient power conversion being pushed further than ever before. This development has allowed for systems to operate at higher and higher voltages than previously achieved. One area of consideration during this high voltage transition is the synchronous rectifier, which is traditionally designed as an afterthought. Prior research in synchronous rectifiers have been limited to low voltage, high current converters. There is practically no research in high voltage synchronous rectification. Therefore, this dissertation focuses on discovering the unknown nuances behind high voltage synchronous rectifier design, and ultimately developing a practical, scalable solution. There are three main issues that must be addressed when designing a high voltage synchronous rectifier: (1) high voltage sensing; (2) light load effects; (3) accuracy. The first hurdle to designing a high voltage SR system is the high voltage itself. Traditional methods of synchronous rectification (SR) attempt to directly sense voltage or current, which is not possible with high voltage. Therefore, a solution must be designed to limit the voltage seen by the sensing mechanism without sacrificing accuracy. In this dissertation, a novel blocking solution is proposed, analyzed, and tested to over 1-kV. The solution is practical enough to be implemented on practically any commercial drain-source SR controller. The second hurdle is the light load effect of the SR system on the converter. A large amount of high voltage systems utilize a LLC-based DC transformers (DCX) to provide an efficient means of energy conversion. The LLC-DCX's attractive attributes of soft-switching and high efficiency allure many architects to combine it with an SR system. However, direct implementation of SR on a LLC-DCX will result in a variety of light load oscillation issues, since the rectifier circuitry can excite the resonant tank through a false load transient phenomena. A universal limiting solution is proposed and analyzed, and is validated with a commercial SR controller. The final hurdle is in optimizing the SR system itself. There is an inherent flaw with drain-source sensing, namely parasitic inductance in the drain-source sense loop. This parasitic inductance causes an error in the sensed voltage, resulting in early SR turn-off and increased losses through the parallel diode. The parasitic will always be present in the circuit, and current solutions are too complex to be implemented. Two solutions are proposed depending on the rectifier architecture: (1) multilevel gate driving for single switch rectifiers; (2) sequential parallel switching for parallel switch rectifiers. In summary, this dissertation focuses on developing a practical and reliable high voltage SR solution for LLC-DCX converters. Three main issues are addressed: (1) high voltage sensing; (2) light load effects; (3) accuracy. Novel solutions are proposed for all three issues, and validated with commercial controllers. / Doctor of Philosophy / High voltage power electronics are becoming increasing popular in the electronics industry with the help of wide band-gap semiconductors. While high voltage power electronics research is prevalent, a key component of high voltage power converters, the synchronous rectifier, remains unexplored. Conventional synchronous rectifiers are implemented on high current circuits where diode losses are high. However, high voltage power electronics operate at much lower current levels, necessitating changes in current synchronous rectifier methods. This research aims to identify and tackle issues that will be faced by both systems and IC designers when attempting to implement high voltage synchronous rectifiers on LLC-DCXs. While development takes planes on a LLC-DCX, the research is applicable to most resonant converters and applications utilizing drain-source synchronous rectifier technology. This dissertation focuses primarily on three areas of synchronous rectifier developments: (1) high voltage compatibility; (2) light load effects; (3) accuracy. The first issue opens the gate to high voltage synchronous rectifier research, by allowing high voltage sensing. The second issue explores issues that high voltage synchronous rectifiers can inadvertently influence on the LLC-DCX itself - a light load oscillation issue. The third issue explores novel methods of improving the sensing accuracy to further reduce losses for a single and parallel switch rectifier. In each of these areas, the underlying problem is root-caused, analyzed, and a solution proposed. The overarching goal of this dissertation is to develop a practical, low-cost, universal synchronous rectifier system that can be scaled for commercial use.

The aim of this thesis was to investigate roller ski characteristics; classical and freestyle roller skis’ rolling resistance coefficients (μR) and classical style roller skis’ static friction coefficients (μS), and to study the influence of different μR and μS on cross-country skiers’ performance and both physiological and biomechanical indices. The aim was also to study differences in skiing economy and efficiency between recreational skiers, female and male junior and senior elite cross-country skiers.The experiments showed that during a time period of 30 minutes of rolling on a treadmill (warm-up), μR decreased significantly (p&lt;0.05) to about 60-65 % and 70-75 % of its initial value for freestyle and classical roller skis respectively. Also, there was a significant influence of normal force on μR, while different velocities and inclinations of the treadmill only resulted in small changes in μR.The study of the influence on physiological variables of a ~50 % change in μR showed that during submaximal steady rate exercise, external power, oxygen uptake, heart rate and blood lactate were significantly changed, while there were non-significant or only small changes to cycle rate, cycle length and ratings of perceived exertion. Incremental maximal tests showed that time to exhaustion was significantly changed and this occurred without a change in maximal power, maximal oxygen uptake, maximal heart rate and blood lactate, and that the influence on ratings of perceived exertion was non-significant or small.The study of classical style roller skis μS showed values that were five to eight times more than the values of μS reported from on-snow skiing with grip-waxed cross-country skis.The subsequent physiological and biomechanical experiments with different μS showed a significantly lower skiing economy (~14 % higher v̇O2), higher heart rate, lower propulsive forces coming from the legs and shorter time to exhaustion (~30 %) when using a different type of roller ski with a μS similar to on-snow skiing, while there was no difference between tests when using different pairs of roller skis with a (similar) higher μS.The part of the thesis which focused on skiing economy and efficiency as a function of skill, age and gender, showed that the elite cross-country skiers had better skiing economy and higher gross efficiency (5-18 %) compared with the recreational skiers, and the senior elite had better economy and higher efficiency (4-5 %) than their junior counterparts, while no differences could be found between the genders. / Syftet med denna avhandling var att undersöka fristils- och klassiska rullskidors rullmotståndskoefficienter (μR) och klassiska rullskidors statiska friktionskoefficienter (μS) samt effekter av olika μR och μS på längdskidåkares prestation vid rullskidåkning på rullande band. Syftet var även att undersöka s.k. åkekonomi och mekanisk verkningsgrad mellan motionärer och kvinnliga och manliga junior- och seniorlängdskidåkare på elitnivå.Experimenten visade att under en period av 30 minuters kontinuerligt rullande, på rullande band, så sjönk μR signifikant (p&lt;0.05) till 60-65 % och 70-75 % av initiala värden, för fristils- respektive klassiska rullskidor. Undersökandet av olika normalkrafter, hastigheter och lutningars påverkan på μR resulterade i en signifikant, negativ korrelation för μR som funktion av normalkraft, medan olika hastigheter och lutningar endast medförde små förändringar av μR.Studien som undersökte fysiologiska effekter av olika μR visade, vid submaximala konstanta arbetsbelastningar, att yttre effekt, syreupptagning, hjärtfrekvens och blodlaktat förändrades signifikant vid ~50 % förändring av μR. Försökspersonernas frekvens och sträcka per frekvens samt skattning av upplevd ansträngning resulterade dock i mestadels icke signifikanta eller små förändringar. Protokollen med successivt ökande arbetsbelastning (maxtest) resulterade i signifikant förändrad tid till utmattning, vid ~50 % förändring av μR. Detta inträffade utan signifikant skillnad i maximal syreupptagning, hjärtfrekvens och blodlaktat, vilket även mestadels gällde för skattning av upplevd ansträngning.Experimenten som undersökte klassiska rullskidors μS visade att dessa erhöll värden som är fem till åtta gånger högre än vad som rapporterats från studier av μS på snö med fästvallade skidor.Den efterföljande studien som undersökte fysiologiska och biomekaniska influenser av olika μS visade, vid submaximala konstanta arbetsbelastningar, att åkekonomin försämrades (~14 % högre syreförbrukning), hjärtfrekvensen ökade, den framåtdrivande kraften från benen på rullskidorna minskade samt att det blev kortare tid till utmattning (~30 %), vid maxtest, när skidåkarna använde rullskidor med en μS i likhet med vad som rapporterats för skidåkning på snö. För arbetsförsöken med olika rullskidor av olika fabrikat med en högre, och likartad, μS förelåg ingen skillnad i de undersökta variablerna.Studien som undersökte åkekonomi och mekanisk verkningsgrad som funktion av prestationsnivå, ålder och kön, visade att elitskidåkarna hade bättre åkekonomi och verkningsgrad (5-18 %) i jämförelse med motionärerna, att seniorerna hade bättre åkekonomi och verkningsgrad (4-5 %) än juniorerna och att ingen skillnad kunde konstateras mellan könen.

La spectroscopie par résonance magnétique nucléaire (RMN) est un outil puissant permettant d’acquérir des profils biochimiques du cerveau et de quantifier de nombreux paramètres cellulaires in vivo. Au cours de ce travail de thèse, nous nous sommes intéressés à trois techniques : (i) la spectroscopie RMN du 1H pondérée en diffusion, (ii) la spectroscopie RMN du carbone-13 (13C) et (iii) de l’oxygène-17 (17O) pour étudier la microstructure et la fonction cellulaire in vivo.Les métabolites cérébraux sont des traceurs endogènes spécifiques d’un type cellulaire (neurones et astrocytes) dont la diffusion dépend des nombreuses propriétés cellulaires (par exemple la viscosité du cytosol et la restriction intracellulaire). L’étude de la dépendance du coefficient de diffusion (ADC) aux temps de diffusion (td) permet de quantifier chacun de ces paramètres. En particulier, la mesure de l’ADC aux td longs permet d’évaluer la compartimentation des métabolites. Dans une première étude, nous avons mesuré l’ADC de plusieurs métabolites neuronaux et astrocytaires sur une large gamme de td (de ~80 ms à ~1 s) dans un large voxel dans le cerveau du macaque. Aucune dépendance de l’ADC de l’ensemble des métabolites au td n’a été observée suggérant que les métabolites diffusent majoritairement dans les prolongements neuronaux (axones, dendrites) et astrocytaires et ne sont pas confinés dans le corps cellulaire ou les organelles (mitochondries, noyau). La grande taille du voxel, liée à la sensibilité de détection limitée, ne nous a pas permis d’étudier la compartimentation des métabolites dans la substance blanche (SB) et la substance grise (SG). C’est pourquoi, une nouvelle étude a été réalisée dans le cerveau de l’Homme. Les résultats montrent que les métabolites diffusent dans des structures fibrillaires dans la SG et la SB. Enfin, une dernière étude, avec une gamme de td jusqu’à 2 s chez le macaque, nous a permis d’estimer, à l’aide de modèles analytiques simples mimant la structure cellulaire, la longueur des fibres neuronales (~110 μm) et astrocytaires (~70 μm). L’oxydation du glucose au sein des mitochondries permet de produire l’ATP (adénosine triphosphate), la principale source d’énergie de l’organisme. La spectroscopie du 13C permet de mesurer la vitesse de dégradation du glucose dans le cycle de Krebs (VTCA). Cette méthode est largement reconnue pour l’étude du métabolisme. Néanmoins, de nombreuses limitations, en termes de modélisation des données en détection indirecte ou de puissance émise dans le contexte du découplage hétéronucléaire en détection directe, ont été rencontrées sur notre scanner IRM. C’est pourquoi, la spectroscopie du 17O a ensuite été développée afin de quantifier la vitesse de consommation de l’oxygène pendant la phosphorylation oxydative (CMRO2). Des développements méthodologiques et technologiques ont été nécessaires et sont encore en cours pour mettre en place et valider cette technique qui n’a encore jamais été utilisée chez le macaque. / Magnetic Resonance Spectroscopy is a unique tool that allows acquiring brain biochemical profiles and quantifying many cellular parameters in vivo. During this thesis, three different techniques have been developed: (i) 1H diffusion-weighted, (ii) carbone-13 (13C) and (iii) oxygen-17 (17O) NMR spectroscopy to study brain structure and function in vivo. Brain metabolites are cell-specific endogeneous tracers of the intracellular space whose translational diffusion depends on many cellular properties (e.g.: cytosol vicosity and intracellular restriction). Studying the variation of the diffusion coefficient (ADC) as a function of diffusion time (td) allows untangling and quantifying those parameters. In particular, measuring metabolites ADC at long diffusion times gives information about the metabolites compartmentation in cells. In a first study, we measured neuronal and astrocytic metabolites ADC over a large time window (from ~80 ms to ~1 s) in a large voxel in the macaque brain. No dependence of all metabolites ADC on td was observed suggesting that metabolites primarily diffuse in neuronal (dendrites and axons) and astrocytic processes and are not confined inside the cell body and organelles (nucleus, mitochondria). The large size of the voxel, due to low detection sensitivity, did not allow us to study metabolites compartmentation in pure white (WM) and grey matters (GM). Therefore, we performed a new study in the human brain. Results showed that in both WM and GM metabolites diffuse in fiber-like cell structure. Finally, using an even larger time window (up to 2 s) in the macaque brain and analytical models mimicking the cell structure, we estimated the length of neuronal (~110 μm) and astrocytic (~70 μm) processes. ATP (adenosine triphosphate), the main source of energy in the organism, is produced thanks to glucose oxidation inside the mitochondria. 13C NMR spectroscopy is a well-known technique to study brain energy metabolism and can be used to estimate the rate of glucose degradation within the Krebs cycle (VTCA). However, many limitations, concerning data modeling when performing indirect detection or power deposition due to heteronuclear decoupling during direct detection, were encountered on our MRI scanner. Therefore, 17O NMR spectroscopy was developed to quantify the rate of oxygen consumption during oxidative phosphorylation (CMRO2). Methodological and technological developments were necessary and are still ongoing to validate this technique, which has never been used with macaque.