Computational Fluid Dynamics is used to analyze the formation of under-expanded jets and to investigate the three-dimensional flow field associated with the impingement of free jets onto stationary deflectors. This investigation was performed to develop a verified modeling ability for such problems. Predictions were compared with the experimental results obtained by Donaldson and Snedeker [1]. Computational models for free and impinging jets were created according to the data provided in Ref. 1. Numerical results for each of the experiments performed in this benchmark report are presented. Three different turbulent free jets produced by a simple convergent nozzle were analyzed. These include a subsonic jet with p₁/pâ =1 and M₁=0.57, a moderately under-expanded jet with p₁/pâ =1.42 and M₁=1, and a highly under-expanded jet with p₁/pâ =3.57 and M₁=1. The reflecting shocks associated with the moderately under-expanded jet as well as the shock disk associated with the highly under-expanded jet were fully resolved. Velocity profile data predicted at locations downstream of the nozzle exit agreed very well with the experimental results. The impingement of a moderately under-expanded jet with p₁/pâ =1.42 and M₁=1 was also investigated. The interaction of the high speed jet with circular flat plates at angles of 60° and 45° relative to the center axis of the jet are presented. Wall jet velocity profiles on the surface of the flat plate are fully resolved and compare well with experimental results. The CFD solver controls and method used to obtain these results are summarized and justified. / Master of Science

Sensory signals are represented and propagated as spiking activity in multiple neuronal populations to lead to cognitive or motor behavior in organisms. Neural processing underlying sensory-motor behavior is understood by uncovering the governing computational principles and the biophysical mechanisms that implement the principles. While these mechanisms have been studied extensively at the single-neuron and system levels, activity within neuronal networks significantly impact neural processing. For example, there are spatiotemporal interactions (neural correlations) between responses of neurons within populations that could potentially impact signal representation and propagation. Furthermore, the effects of associative plasticity are also expected to alter network activity and its propagation. The effects of plasticity on network activity cannot be predicted from individual neuronal responses due to the complex, non-linear interactions within neuronal networks. Thus examining neural correlations in network activity and the propagation of network activity, requires recording spiking activity from large, heterogeneous, populations of spatially distributed neurons simultaneously. Studies addressing the propagation of network activity have been limited to theoretical approaches. Empirical studies have been limited by the technical difficulties in recording from a large number of neurons simultaneously. To overcome this challenge we developed a novel technique, dithered random-access functional calcium imaging. This imaging technique records and extracts suprathreshold activity from a large number of neurons. This technique also has a high spike detection efficiency and millisecond temporal precision. We applied this technique to measure the propagation of activity and neural correlations in activity evoked by afferent, thalamocortical inputs in the recurrent cortical networks of the mouse barrel cortex. We found that the cortical activity evoked by novel (naïve), thalamocortical inputs showed limited propagation of activity and decrease in propagation of neural correlations (measured from neuronal pairs within each population) from L4 to L2/3 network of the responding column. However, associative cortical plasticity was induced from pairing thalamocortical inputs with intracortical inputs. This pairing resulted in increased propagation of activity. The pairing also modified the propagation of neural correlations. Our results suggest that synaptic plasticity in intracortical circuits contributes to the modified propagation of activity and neural correlations. The modified propagation of neural correlations could in turn contribute to behavioral performance in vivo following perceptual learning. / text

Orientador: Luiz Otavio Saraiva Ferreira / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-08-06T21:02:18Z (GMT). No. of bitstreams: 1 Oliveira_LuizClaudioMarangonide_D.pdf: 9710529 bytes, checksum: 4fc22426f2b4d1d845715c4742df71a2 (MD5) Previous issue date: 2006 / Resumo: Scanners são dispositivos que defletem um feixe luminoso e transfonnam um feixe puntual em uma linha de varredura, com amplitude e freqüência controladas. Diversos equipamentos utilizam este padrão luminoso para codificar ou decodificar infonnações, exemplos mais comuns são os leitores de código de barras de bancada, utilizados em supennercados, e as impressoras laser. V ários fenômenos podem ser empregados para defletir um feixe luminoso. Neste trabalho, os scanners utilizam o princípio da reflexão da luz por um espelho em movimento hannônico e ressonante sob ação de forças de origem eletromagnética. Tais forças são geradas pela interação de correntes induzi das na annadura, com o campo magnético produzido por ímãs pennanentes. A principal vantagem deste tipo de scanner é a ausência de conexões elétricas entre as partes móveis e fixas do dispositivo, o que simplifica o processo de fabricação e o toma mais robusto e menos suceptível a falhas. Parte dos scanners similares existentes atualmente são dispositivos eletro-mecânicos complexos, fabricados em série. Trabalhos anteriores demonstraram a viabilidade da geometria planar e da utilização de processos de fabricação em lotes, derivados da microeletrônica, neste tipo de scanner. Os protótipos fabricados, embora funcionais, apresentaram consumo de potência acima da média para este tipo de dispositivo, o que demonstrava a necessidade de melhorias em seu projeto. O processo de fabricação, embora confiável, foi desenvolvido com materiais e métodos baseados no Silício e originários da microeletrônica, o que dificultava sua implantação em indústrias em território nacional. Neste trabalho, foram pr9postos aprimoramentos à tecnologia dos scanners ressonantes planares atuados por indução para tomar seu desempenho compatível com o d~ dispositivos similares, e também para viabilizar sua fabricação utilizando materiais e métodos disponíveis no país. Uma metodologia de projeto, em conjunto com uma série de contribuições ao modelo, foi proposta e avaliada. Para viabilizar a fabricação propôs-se a utilização do Bronze-fosforoso, como material estrutural, e a utilização de foto-fabricação, como processo de fabricação. As contribuições propostas neste trabalho possibilitaram a redução do consumo de potência de 2, 2 W para cerca de 5 m W por grau óptico, e o aumento da freqüência de operação do circuito de cerca de 1 kHz para 4 kHz, com um ângulo de deflexão óptico típico de 20° pico-a-pico, parâmetros compatíveis com os de dispositivos similares, mas mecanicamente mais complexos e fabricados por processo serial / Abstract: Scanners are devices that deftects a light beam and converts a spot light in a well controlled amplitude and frequency scan line. Several applications uses the generated pattem to code or decode data, common examples ar,e barcode readers, and laser printers. A light beam can be deftected by different means. In this work, the scanner deftects the light by reftection in a moving mirror, in a resonant and harmonic movement, subjected to forces of electromagnetic nature. Such forces are generated by the interaction between an induced current in the armature, and a magnetic field, generated by permanent magnets. The main advantage of this kind of scanner is the absence of electrical connections between the mobile, and fixed parts of the device, that simplifies the fabrication process, and make its more reliable and less fault susceptible. Part of the similar devices available today are complex eIectro-mechanical devices, manufactured by serial processo Earlier works established that the planar geometry, and the use of batch fabrication process, derived from microelectronics, are feasible with this kind of device. A1though functional, the earlier prototypes presented a high power consumption, that shown the demand for an improved designo The Silicon-based fabrication process adopted makes the use of materiaIs and methods that are not readily accessible to the Brazilian industry. In this work improvements were proposed to the induction actuated planar resonant scanners technology. The goal was to make its performance compatible with the performance of similar devices, and to enable its fabrication using materiaIs and methods available to the Brazilian industry. A design m~thodology, and a set of model contributions were proposed and validated. The use of Phosphor-bronze, as structural material, and the photqfabrication process, as the machining method, were proposed as an option to the Silicon-based fabrication method. The contributions ofthis work had enabled the reduction ofthe power consumptlon from 2,2 W to about 5 m W per optical degree, and an increase in the working frequency from 1 kHz to 4kHz, with a optical deftection angle of about 20° peak-to-peak. Such parameters are fully compatible with similar devices, mechanically more complexes and manufactured by serial processes / Doutorado / Mecanica dos Sólidos e Projeto Mecanico / Doutor em Engenharia Mecânica

This master thesis is focused on design and aerodynamic analysis of subsonic turbine engine inlet in NACA duct configuration for unmanned aircraft. The first part of this paper is methodics for design considerations for NACA duct, which is based on theoretical analysis of this type of inlet. The acquired knowledge is used to design an inlet for the specified unmanned aircraft that is subject of CFD analysis. The impact of deflectors is considered in the evaluation and the solution is compared to the S-duct inlet. The proposed inlet with deflectors meets DC60 distortion criterion for all specified cases and the pressure losses requirements are met for lower velocities. Based on the results, the recommended application is for aircraft that flies in optimal design conditions for most of the mission.

La révolution en cours des outils optogénétiques - des protéines photosensibles génétiquement induites qui peuvent activer, inhiber et enregistrer l'activité neuronale - a permis d'ouvrir une nouvelle voie pour relier l'activité neuronale et la cognition. Néanmoins, pour profiter au mieux de ces outils nous avons besoin de méthodes optiques qui peuvent projeter des schémas d'illumination complexes dans le cerveau. Pendant mon doctorat, j'ai travaillé sur deux nouveaux systèmes complémentaires pour la stimulation de l'activité neuronale. Le premier système combine des déflecteurs acousto-optiques et une illumination Gaussienne à faible ouverture numérique pour produire une photo activation rapide des outils optogénétiques. La capacité d'accès aléatoire du système permet de délivrer des séquences d'illumination spatialement et temporellement complexes qui simulent avec succès les schémas physiologiques de l'activité des fibres moussues dans des tranches de cerveaux. Ces résultats démontrent que les schémas de stimulation optogénétique peuvent être utilisés pour recréer l'activité en cours et étudier les microcircuits du cerveau dans un environnement physiologique. Alternativement, l'holographie générée par ordinateur (HGO) permet d'améliorer grandement les stimulations optogénétiques en répartissant efficacement la lumière sur plusieurs cibles cellulaires simultanément. Néanmoins, le confinement axial se dégrade pour des schémas d'illuminations larges. Afin de d'améliorer ce point, l’HGO peut être combinée avec une technique de focalisation temporelle qui confine axialement la fluorescence sans dépendre de l'allongement latéral. Les précédentes configurations maintiennent l'excitation non linéaire à un unique plan focal spatiotemporel. Dans cette thèse, je décris deux méthodes différentes qui permettent de dépasser ces limitations et de permettre la génération de schémas focalisés tridimensionnellement, à la fois spatialement et temporellement. / The ongoing revolution of optogenetic tools – genetically encoded light-sensitive proteins that can activate, silence and monitor neural activity – has opened a new pathway to bridge the gap between neuronal activity and cognition. However, to take full advantage of these tools we need optical methods that can deliver complex light patterns in the brain. During my doctorate, I worked on two novel and complementary optical systems for complex spatiotemporally neural activity stimulation. The first system combined acousto-optic deflectors and low numerical aperture Gaussian beam illumination for fast photoactivation of optogenetic tools. The random-access capabilities of the system allowed to deliver complex spatiotemporal illumination sequences that successfully emulated physiological patterns of cerebellar mossy fiber activity in acute slices. These results demonstrate that patterned optogenetic stimulation can be used to recreate ongoing activity and study brain microcircuits in a physiological activity context. Alternatively, Computer Generated Holography (CGH) can powerfully enhance optogenetic stimulation by efficiently shaping light onto multiple cellular targets simultaneously. Nonetheless, the axial confinement degrades for laterally extended illumination patterns. To address this issue, CGH can be combined with temporal focusing that axially confines fluorescence regardless of lateral extent. However, previous configurations restricted nonlinear excitation to a single spatiotemporal focal plane. In this thesis, I describe two alternative methods to overcome this limitation and enable three-dimensional spatiotemporal focused pattern generation.