In der vorliegenden Arbeit sollten die in der veterinärmedizinischen Literatur bisher diskutierten Ursachen für LJD bei Makropoden hinsichtlich ihrer tatsächlichen Bedeutung abgeklärt und die Eignung einer formalininaktivierten, bestandsspezifischen Adsorbatvakzine zur Prophylaxe von LJD getestet werden. Da LJD eine parodontale Erkrankung darstellt, wurden auch die für Entstehung einer humanen Parodontitis prädisponierenden Faktoren mit in die Untersuchung einbezogen. Es wurden Tupferproben zur bakteriologischen Untersuchung von insgesamt 15 gesunden und 11 an LJD erkrankten Kängurus entnommen. Dabei konnten gramnegative Anaerobier bei allen Tieren isoliert werden. Fusobacterium nucleatum wurde in 82% der von an LJD erkrankten und nur in 33% der von gesunden Tieren entnommenen Tupferproben nachgewiesen, womit sich ein signifikanter Zusammenhang (P < 0,05) zwischen diesem Erreger und LJD ergab. Weitere überwiegend bei erkrankten Makropoden nachgewiesene Anaerobier stellten Prevotella oris/oralis (bei 73% der LJD-Fälle und bei 40% der gesunden Tiere) sowie Capnocytophaga spp. (45% vs. 13%) dar. Bacteroides spp. und Porphyromonas gingivalis wurden – wenn auch nur mit 3 bzw. 2 Nachweisen – ausschließlich bei kranken Tieren isoliert. Fusobacterium necrophorum wurde jeweils in 27% der Kängurus gefunden und spielte damit in dieser Studie keine Rolle für die Entstehung von LJD. In Übereinstimmung mit der Literatur konnten Moraxella spp. ausschließlich bei gesunden Makropoden isoliert werden. Vertreter dieser Gattung gehören damit offensichtlich zur normalen Maulflora der Kängurus. Für die Zoos in Halle und Leipzig wurde eine formalininaktivierte, bestandsspezifische Adsorbatvakzine gegen die bei einem an LJD erkrankten Känguru des jeweiligen Bestandes isolierten gramnegativen Anaerobier hergestellt. 7 Tiere (2 Rote Riesenkängurus, 5 Bennettwallabies) des Leipziger Zoos und 6 Bennettkängurus des Zoos in Halle wurden geimpft, wobei Auffrischungsimpfungen nach 4 bzw. 8 Wochen und nach 6 bzw. 12 Monaten erfolgten. Die spezifischen AK gegen das Prüfantigen Fusobacterium necrophorum wurden im SLA bestimmt. Es konnte keine Erhöhung der AK-Titer induziert werden und auch die Todesrate infolge von LJD senkte sich während des Untersuchungszeitraumes von 42 Monaten in den beiden Zoos nicht. Die höchsten AK-Level (1:512 bis 1:2048) ließen sich im Serum von natürlich infizierten und letztendlich tödlich erkrankten Bennettwallabies des Zoos in Hoyerswerda feststellen. Der Nachweis von AK-Titern im Serum von nicht geimpften Jungtieren lässt vermuten, dass AK via Kolostrum oder Dottersackplazenta auf die Jungtiere übertragen werden. Die Untersuchungen hinsichtlich der Fütterung zeigten, dass im Zoo Leipzig eine azidotische Stoffwechsellage induziert wurde, was sich bei den Leipziger Bennettkängurus in einem mit 7,53 signifikant niedrigeren Vormagen-pH-Wert im Vergleich zu den Hallenser und Auer Tieren (8,25 und 8,38) offenbarte. Dies schlug sich auch in erhöhten K-, Cholesterol- und &#61537;-Amylasewerten im Serum der Leipziger Wallabies nieder, womit gezeigt werden konnte, dass sich diese Parameter offenbar auch bei Makropoden zur Diagnostik einer chronischen Azidose eignen. Die Versorgung der Bennettkängurus in Magdeburg und Halle mit Ca und P war zwar nicht ausreichend, spiegelte sich aber nicht in veränderten Blutwerten dieser Mengenelemente wider. Die Aktivität der AP nimmt mit zunehmenden Alter ähnlich wie bei anderen Tierarten ab. Ihre negative Korrelation mit dem Alter der Tiere war dabei hochsignifikant (P < 0,001, r = 0,77 bzw. 0,62). Beim direkten Vergleich gesunder mit an LJD erkrankten Tieren konnte weder eine Störung im Ca/P-Stoffwechsel noch eine Azidose in Verbindung zu LJD gebracht werden. In allen Zoos erfolgte eine Überversorgung mit Vitamin A, wobei die Bedarfswerte für Schaflämmer um das 3,5fache bis 41fache übertroffen wurden. Den Bedarfswerten am nächsten lagen die Versorgungswerte der Bennettkängurus vom TP Aue und der Östlichen Grauen Riesenkängurus vom Zoo Magdeburg, beides Bestände ohne LJD. Die ermittelten Retinolplasmakonzentrationen standen in keiner Beziehung zu den Vitamin-A-Gehalten im Futter, was darauf hindeutet, dass sich Retinolbestimmungen im Blutplasma ebenso wie bei anderen Tierarten nur in extremsten defizitären Situationen zur Einschätzung des Vitamin-A-Status eignen. Ob eine Hypervitaminose A für die Entstehung von LJD tatsächlich eine Rolle spielt, muss in zukünftigen Arbeiten unter Einbeziehung von Retinolesterbestimmungen in der Leber abgeklärt werden. Die Glukosewerte lagen mit 8,57 mmol/l (M. rufus) bzw. 6,51 mmol/l (M. rufogriseus) über den bisher bekannten Werten aus der Literatur. Da die Werte bei an LJD erkrankten Kängurus niedriger waren als bei gesunden Tieren, kann ein Diabetes mellitus als Ursache für LJD ausgeschlossen werden. Weder die Durchsicht von 144 Sektionsprotokollen noch die Bestimmung der Kreatinin- und Harnstoffkonzentration im Serum von an LJD erkrankten Tieren ließen einen Zusammenhang zwischen Erkrankungen der Nieren und LJD erkennen. 30 Tiere verendeten an LJD, wovon 20% auch an den Nieren erkrankt waren. Allerdings wiesen auch 16,7% der anderweitig gestorbenen Kängurus eine Nierenerkrankung auf. Die Serumkonzentrationen von Harnstoff bzw. Kreatinin der an LJD erkrankten Makropoden unterschieden sich nicht von den für die gesunden Roten Riesenkängurus (7,40 mmol bzw. 114 mmol/l) und Bennettwallabies (7,81 mmol/l bzw. 86 mmol/l) ermittelten Werten. Insgesamt 184 Sera von 107 Kängurus wurden auf AK gegen MaHV-1 und MaHV-2 mittels Neutralisationtest geprüft. Während 94,4% bzw. 97,2% der Roten Riesenkängurus serologisch positiv für MaHV-1 bzw. MaHV-2 waren, reagierten von den 71 überprüften Bennettkängurus nur 4 bzw. 3 Tiere positiv. Unter den Wallabies befanden sich auch 21 an LJD erkrankte Tiere, wovon lediglich 2 Tiere gegen MaHV-1 und 1 Tier gegen MaHV-2 eine Serokonversion zeigten. Die AK-Titer der Roten Riesenkängurus ließen keine Unterschiede zwischen gesunden und an LJD leidenden Tieren zu und die entnommenen Serumpaarproben von 5 zum Zeitpunkt der Blutentnahme an LJD leidenden Riesenkängurus zeigten kein einheitliches Verhalten im Sinne einer Serokonversion. Somit ließ sich der Verdacht, dass die Reaktivierung latenter Herpesinfektionen die Ursache für LJD sein könnte, nicht bestätigen. Im Ergebnis der vorliegenden Studie und im Zusammenhang mit den Angaben aus der Literatur stellt sich LJD primär als eine Infektion mit gramnegativen Anaerobiern dar, wovon Fusobacterium nucleatum, Bacteroides spp., Prophyromonas gingivalis und Fusobacterium necrophorum, Biovar A die größte Bedeutung haben dürften. Den Abschluss der Arbeit bilden Empfehlungen für die Haltung von Kängurus in zoologischen Einrichtungen und für die Therapie von LJD. Im Anhang finden sich Röntgenaufnahmen und Photographien von erkrankten und gesunden Makropoden. / The aim of this thesis was the investigation of the aetiology of Lumpy Jaw Disease (LJD) in macropods concentrating specifically on the causes of the diseases in current veterinary medicine literature and to evaluate the use of a group-specific Al(OH)3-adjuvanted, formalin-inactivated whole-cell vaccine for the control of LJD in kangaroos kept in zoos. LJD is regarded as periodontal disease, therefore the risk factors for the development of human periodontitis were also included in this study. The oral flora from 15 healthy macropods and 11 animals suffering from LJD was isolated. At least one anaerobic gram-negative bacterial species was found in swabs of each macropod. The occurrence of Fusobacterium nucleatum was associated with LJD (P < 0.05) by detecting this bacterium in 82% of the kangaroos suffering from LJD compared to only in 33% of the healthy animals. Prevotella oris/oralis and Capnocytophaga spp. were also predominantly found in diseased animals in comparison with healthy macropods (73% vs. 40% and 45% vs. 13% respectively). Bacteroides spp. and Porphyromonas gingivalis were isolated in only 3 and 2 kangaroos suffering from LJD, respectively. Contrary to previously published studies about LJD Fusobacterium necrophorum was not associated with LJD, as this anaerobe was detected in only 27% of the diseased as well as healthy macropods. Moraxella spp. seem to be a part of the normal oral flora of macropods and was found exclusively in healthy animals. 11 Red-necked Wallabies (Macropus rufogriseus) and 2 Red Kangaroos (Macropus rufus) were immunized with a group-specific Al(OH)3-adjuvanted, formalin-inactivated whole-cell vaccine containing previously in a kangaroo suffering from LJD isolated gramnegative anaerobs. The kangaroos were re-vaccinated after 1, 2, 6 and 12 months. Blood was collected from each animal at the same time. Antibodies were titrated against Fusobacterium necrophorum in an agglutination assay. The vaccine failed to induce increased levels of antibodies as well as to protect wallabies and kangaroos against LJD. As the highest antibody titres were detected in most severely diseased wallabies kept in the Hoyerswerda zoo, the protective role of the humoral immune response in LJD seems to be doubtful. The finding of detectable levels of antibodies in unvaccinated joeys supports the theory, that there is a transmission of antibodies from the mother to the offspring via colostrum or yolk-sac placenta. The diet of the Red-necked Wallabies in one zoo has induced an acidosis: The pH of the forestomach fluid collected by probang was lower in the animals of this zoo (pH = 7.53) than in the wallabies of two other zoos (pH = 8.25 and 8.38, respectively). Potassium, cholesterol and &#61537;-amylase were also higher in the blood of the animals of this zoo in comparison to the wallabies of the two other ones, hence these blood values seem to be helpful for the diagnosis of chronic acidosis in macropods. There was a calcium and phosphor deficiency in the nutrition of the wallabies in two zoos, but the blood concentration of both of these minerals was not changed. The activity of the ALP correlated negative with the age of the Bennett`s Wallabies (P < 0.001, r = -.77 and r = -.62 respectively, depending on the instruments). All of the above mentioned blood values showed no differences between healthy and diseased animals and could so far not support the assumption, that an imbalance in Ca and P metabolism or an acidosis are important factors for LJD. The macropods of all investigated zoos were fed on a diet rich in vitamin A ranging from the 3.5 to the 41fold requirement for lambs. The vitamin A content of the diets for the 2 collections without a history of LJD was the lowest in this study. These results raised the point, that a hypervitaminosis A could be a more predisposing factor for LJD than a vitamin A deficiency. Due to the fact the plasma retinol concentration was independent from the vitamin A content of the diet and so not helpful in diagnosis of a vitamin A deficiency or toxicity, further investigations regarding the role of vitamin A in the aetiopathogenesis of LJD should include measurements of the liver tissue content of retinol esters. The glucose plasma concentration of the healthy Red Kangaroos (8.57 mmol/l) as well as the Red-necked Wallabies (6.51 mmol/l) was higher than previously published values for macropods, but also higher than the results of the diseased animals in this study. Therefore diabetes mellitus can be ruled out as an underlying factor for LJD. The analysis of 144 pathological records showed, that 30 animals died because of LJD, 20% of them and 16.7% of the other 114 macropods had a concurrent kidney disease. The urea and creatinin concentration in serum samples of healthy animals was not higher than the values of diseased animals. In conclusion, these results suggest kidney diseases are not important for the development of LJD. Altogether 184 sera collected from 107 kangaroos were tested for antibodies against MaHV-1 and MaHV-2 using a neutralisation assay. The prevalence of the MaHV-1- as well as MaHV-2-antibodies was high among the Red Kangaroos (94.4% and 97.2% respectively), but low among the Red-necked Wallabies (5.6% and 4.2% respectively). Seroconversion for MaHV-1 was seen in 2 out of 21 wallabies suffering from LJD, only 1 of these animals also had antibodies against MaHV-2. The antibody-titres against both of the macropodid herpes viruses also did not differ between Red Kangaroos with and without LJD, therefore a reactivation of a latent herpesvirus infection does not appear to be causative for LJD. In summary, considering the results of this study and previously published literature LJD is an infectious disease caused by gramnegative anaerobic bacteria with Fusobacterium nucleatum, Bacteroides spp., Porphyromonas gingivalis and Fusobacterium necrophorum subsp. necrophorum being of most significance. Recommendations concerning the keeping of kangaroos in captivity and the management of LJD are listed in the conclusion of this thesis. Some radiographs and photos of diseased and healthy kangaroos are attached.

Os objetivos deste estudo foram obter medidas antropométricas faciais, a medida interincisiva máxima e proporções faciais em crianças, verificar se há diferença estatisticamente significativa entre as médias das medidas e proporções faciais, segundo idade e sexo, comparar a distância do canto externo do olho ao cheilion do lado direito com o lado esquerdo da face e comparar as médias das medidas antropométricas faciais desta amostra com os padrões de normalidade para crianças norte-americanas. Participaram 254 crianças, 117 do sexo masculino e 137 do sexo feminino, com idades entre 7,0 e 11,11 anos, leucodermas, em dentição mista, sem queixas fonoaudiológicas e/ou histórico de tratamento fonoaudiológico prévio e/ou atual. As medidas antropométricas faciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face e distância entre o canto externo do olho e o cheilion no lado direito e esquerdo da face. As proporções faciais obtidas foram as estabelecidas entre o lábio superior e o lábio inferior, entre o terço superior da face e o terço médio da face e entre o terço médio da face e o terço inferior da face. O instrumento utilizado foi o paquímetro digital marca Starrett Série 727. Os resultados mostraram que, para o lábio superior e para o filtro, não houve diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. Nas demais medidas faciais, observou-se diferença estatisticamente significativa entre as médias, segundo idade. Na maioria das medidas faciais, as meninas apresentaram médias inferiores às obtidas para os meninos. As proporções faciais não apresentaram diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. As médias da distância entre o canto externo do olho e o cheilion no lado direito da face foram estatisticamente maiores do que as médias dessa distância no lado esquerdo da face. Os resultados obtidos nesta amostra para o lábio superior, o lábio inferior e o terço inferior da face encontram-se abaixo das médias descritas para as crianças norte-americanas. Os resultados desta amostra, referentes ao filtro, coincidem com as médias descritas para as crianças norte-americanas. / The purposes of this study were to obtain anthropometric facial measurements, the maximum distance between incisors and facial proportions in children, to verify if there is statistically significant difference among the averages of the facial measurements and proportions, according age and sex, to compare the distance from the exocanthion to the cheilion of the right side that of the left side of the face and to compare the averages of the anthropometric facial measurements of this sample with the North American norms. 254 children participated, 117 male and 137 female, with ages ranging from 7,0 to 11,11 years, leukoderm, in mixed dentition period, with no history of speech and swallowing disorders or treatment. The collected anthropometric facial measurements were upper lip, lower lip, philtrum, upper face, middle face, lower face and the distance from the exocanthion to the cheilion of each side of the face. The collected facial proportions were between the upper lip and lower lip, between the upper face and middle face and between middle face and lower face. The used instrument was the electronic digital sliding caliper Starrett Series 727. The results showed that there was no statistically significant difference among averages according age, in both sexes, to the upper lip and to the philtrum. In others facial measurements, statistically significant difference among averages according age was observed. In the majority of facial measurements, girls showed lower averages than boys. The facial proportions did not show statistically significant difference among averages according to age, in both sexes. The averages of the distance from the exocanthion to the cheilion in right side of the face were statistically higher than the averages of the distance from the exocanthion to the cheilion in left side of the face. The results of this sample referring to upper lip, lower lip and lower face were lower than the North American norms for children. The results of this sample referring the philtrum were the same as the North American norms for children.

A avaliação da morfologia orofacial sob o enfoque antroposcópico, bem como a mensuração das estruturas orofaciais, é importante aspecto do exame fonoaudiológico, contribuindo para a determinação do diagnóstico, do planejamento terapêutico e do prognóstico dos indivíduos com respiração oral. Os objetivos desta tese foram: 1. descrever as características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais, segundo a idade; 2. descrever as medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade e; 3. comparar as medidas e proporções orofaciais de crianças respiradoras orais com as medidas e proporções orofaciais de crianças sem queixas fonoaudiológicas, segundo a idade. A tese encontra-se dividida em três estudos: Estudo I -Características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais: enfoque antroposcópico; Estudo II - Medidas e proporções orofaciais de crianças respiradoras orais; e Estudo III -Comparação entre medidas e proporções orofaciais de crianças respiradoras orais e de crianças sem queixas fonoaudiológicas. Participaram dos estudos 100 crianças, de ambos os sexos, com idades entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista, com diagnóstico de respiração oral. No Estudo III, o grupo controle foi composto de 254 crianças, de ambos os sexos, na faixa etária entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista e sem queixas fonoaudiológicas. As características posturais e morfológicas dos órgãos fonoarticulatórios das crianças respiradoras orais pesquisadas no Estudo I foram posição habitual de lábios e de língua, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão labial, mordida e morfologia do lábio inferior, das bochechas e do palato duro, por meio da antroposcopia. Os resultados indicaram que os aspectos mais comuns na amostra foram posição habitual de lábios entreaberta, posição habitual de língua no assoalho oral, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão dos lábios, mordida alterada, lábio inferior com eversão, simetria de bochechas e palato duro alterado. Nos Estudos II e III, as crianças foram submetidas à avaliação antropométrica, sendo que as medidas orofaciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face, lados da face e distância interincisiva máxima. O instrumento utilizado foi o paquímetro eletrônico digital marca Starrett Série 727. Os resultados do Estudo II evidenciaram que não houve diferença estatisticamente entre a maioria das médias das medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade. Os resultados do Estudo III mostraram que para algumas medidas e proporções orofaciais houve diferença estatística entre as duas populações estudadas. Conclui-se, ao analisar os três estudos, que as alterações antroposcópicas parecem ser mais evidentes nos respiradores orais do que as alterações antropométricas. Por fim, tem-se que a antropometria mostra-se útil na avaliação fonoaudiológica, complementando o julgamento visual com medidas quantitativas. / The evaluation of the orofacial morphology made by anthroposcopic approach, as well as the measurement of orofacial structures, is an important aspect from the speech-language pathology assessment that contributes to determination of diagnosis, management and prognosis of mouth breathing individuals. The purposes of this thesis were: 1. to describe the postural and morphologic characteristics of the stomatognathic system of mouth breathing children, according to age; 2. to describe the orofacial measurements and proportions of mouth breathing children, according to age and; 3. to compare the orofacial measurements and proportions of mouth breathing children to those of children with no history of speech-language pathology disorders, according to age. The thesis is divided in three studies: Study I - Postural and morphologic characteristics of the stomatognathic system of mouth breathing children: anthroposcopic approach; Study II - Orofacial measurements and proportions of mouth breathing children; and Study III - Comparation between measurements and proportions of mouth breathing children and children with no history of speech-language pathology disorders. 100 children participated in the studies, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with mouth breathing diagnosis. In Study III, the control group was comprised of 254 children, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with no history of speech-language pathology disorders. The postural and morphologic characteristics of the stomatognathic system of mouth breathing children researched in Study I were labial and lingual resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, bite and morphology of lower lip, cheeks and hard palate, observed by anthroposcopy approach. The results indicated that the most common aspects in the sample were half-open lips in resting position, tongue lowered on the mouth\'s floor in resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, alteration of the bite, labioverted, symmetry of the cheeks and alteration of the hard palate. In Studies II and III, the children were submitted to anthropometric assessment and the orofacial measurements obtained were upper lip, lower lip, philtrum, upper face, middle face, lower face, sides of the face and maximum interincisal distance. The instrument used was the electronic digital sliding caliper Starrett Series 727. The results of Study II showed that there was no statistically difference between the most of averages of the orofacial measurements and proportions of mouth breathing children, according to ages. The results of Study III showed that in some orofacial measurements and proportions there was statistically difference between the two studied populations. In analysis of the three studies, it can be concluded that the anthroposcopic alterations seems to be more evident in mouth breathers than anthropometric alterations. Finally, the anthropometry shows useful in speech-language pathology assessment and supplements visual judgment with quantitative measurements.

Os objetivos deste estudo foram obter medidas antropométricas faciais, a medida interincisiva máxima e proporções faciais em crianças, verificar se há diferença estatisticamente significativa entre as médias das medidas e proporções faciais, segundo idade e sexo, comparar a distância do canto externo do olho ao cheilion do lado direito com o lado esquerdo da face e comparar as médias das medidas antropométricas faciais desta amostra com os padrões de normalidade para crianças norte-americanas. Participaram 254 crianças, 117 do sexo masculino e 137 do sexo feminino, com idades entre 7,0 e 11,11 anos, leucodermas, em dentição mista, sem queixas fonoaudiológicas e/ou histórico de tratamento fonoaudiológico prévio e/ou atual. As medidas antropométricas faciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face e distância entre o canto externo do olho e o cheilion no lado direito e esquerdo da face. As proporções faciais obtidas foram as estabelecidas entre o lábio superior e o lábio inferior, entre o terço superior da face e o terço médio da face e entre o terço médio da face e o terço inferior da face. O instrumento utilizado foi o paquímetro digital marca Starrett Série 727. Os resultados mostraram que, para o lábio superior e para o filtro, não houve diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. Nas demais medidas faciais, observou-se diferença estatisticamente significativa entre as médias, segundo idade. Na maioria das medidas faciais, as meninas apresentaram médias inferiores às obtidas para os meninos. As proporções faciais não apresentaram diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. As médias da distância entre o canto externo do olho e o cheilion no lado direito da face foram estatisticamente maiores do que as médias dessa distância no lado esquerdo da face. Os resultados obtidos nesta amostra para o lábio superior, o lábio inferior e o terço inferior da face encontram-se abaixo das médias descritas para as crianças norte-americanas. Os resultados desta amostra, referentes ao filtro, coincidem com as médias descritas para as crianças norte-americanas. / The purposes of this study were to obtain anthropometric facial measurements, the maximum distance between incisors and facial proportions in children, to verify if there is statistically significant difference among the averages of the facial measurements and proportions, according age and sex, to compare the distance from the exocanthion to the cheilion of the right side that of the left side of the face and to compare the averages of the anthropometric facial measurements of this sample with the North American norms. 254 children participated, 117 male and 137 female, with ages ranging from 7,0 to 11,11 years, leukoderm, in mixed dentition period, with no history of speech and swallowing disorders or treatment. The collected anthropometric facial measurements were upper lip, lower lip, philtrum, upper face, middle face, lower face and the distance from the exocanthion to the cheilion of each side of the face. The collected facial proportions were between the upper lip and lower lip, between the upper face and middle face and between middle face and lower face. The used instrument was the electronic digital sliding caliper Starrett Series 727. The results showed that there was no statistically significant difference among averages according age, in both sexes, to the upper lip and to the philtrum. In others facial measurements, statistically significant difference among averages according age was observed. In the majority of facial measurements, girls showed lower averages than boys. The facial proportions did not show statistically significant difference among averages according to age, in both sexes. The averages of the distance from the exocanthion to the cheilion in right side of the face were statistically higher than the averages of the distance from the exocanthion to the cheilion in left side of the face. The results of this sample referring to upper lip, lower lip and lower face were lower than the North American norms for children. The results of this sample referring the philtrum were the same as the North American norms for children.

A avaliação da morfologia orofacial sob o enfoque antroposcópico, bem como a mensuração das estruturas orofaciais, é importante aspecto do exame fonoaudiológico, contribuindo para a determinação do diagnóstico, do planejamento terapêutico e do prognóstico dos indivíduos com respiração oral. Os objetivos desta tese foram: 1. descrever as características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais, segundo a idade; 2. descrever as medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade e; 3. comparar as medidas e proporções orofaciais de crianças respiradoras orais com as medidas e proporções orofaciais de crianças sem queixas fonoaudiológicas, segundo a idade. A tese encontra-se dividida em três estudos: Estudo I -Características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais: enfoque antroposcópico; Estudo II - Medidas e proporções orofaciais de crianças respiradoras orais; e Estudo III -Comparação entre medidas e proporções orofaciais de crianças respiradoras orais e de crianças sem queixas fonoaudiológicas. Participaram dos estudos 100 crianças, de ambos os sexos, com idades entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista, com diagnóstico de respiração oral. No Estudo III, o grupo controle foi composto de 254 crianças, de ambos os sexos, na faixa etária entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista e sem queixas fonoaudiológicas. As características posturais e morfológicas dos órgãos fonoarticulatórios das crianças respiradoras orais pesquisadas no Estudo I foram posição habitual de lábios e de língua, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão labial, mordida e morfologia do lábio inferior, das bochechas e do palato duro, por meio da antroposcopia. Os resultados indicaram que os aspectos mais comuns na amostra foram posição habitual de lábios entreaberta, posição habitual de língua no assoalho oral, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão dos lábios, mordida alterada, lábio inferior com eversão, simetria de bochechas e palato duro alterado. Nos Estudos II e III, as crianças foram submetidas à avaliação antropométrica, sendo que as medidas orofaciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face, lados da face e distância interincisiva máxima. O instrumento utilizado foi o paquímetro eletrônico digital marca Starrett Série 727. Os resultados do Estudo II evidenciaram que não houve diferença estatisticamente entre a maioria das médias das medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade. Os resultados do Estudo III mostraram que para algumas medidas e proporções orofaciais houve diferença estatística entre as duas populações estudadas. Conclui-se, ao analisar os três estudos, que as alterações antroposcópicas parecem ser mais evidentes nos respiradores orais do que as alterações antropométricas. Por fim, tem-se que a antropometria mostra-se útil na avaliação fonoaudiológica, complementando o julgamento visual com medidas quantitativas. / The evaluation of the orofacial morphology made by anthroposcopic approach, as well as the measurement of orofacial structures, is an important aspect from the speech-language pathology assessment that contributes to determination of diagnosis, management and prognosis of mouth breathing individuals. The purposes of this thesis were: 1. to describe the postural and morphologic characteristics of the stomatognathic system of mouth breathing children, according to age; 2. to describe the orofacial measurements and proportions of mouth breathing children, according to age and; 3. to compare the orofacial measurements and proportions of mouth breathing children to those of children with no history of speech-language pathology disorders, according to age. The thesis is divided in three studies: Study I - Postural and morphologic characteristics of the stomatognathic system of mouth breathing children: anthroposcopic approach; Study II - Orofacial measurements and proportions of mouth breathing children; and Study III - Comparation between measurements and proportions of mouth breathing children and children with no history of speech-language pathology disorders. 100 children participated in the studies, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with mouth breathing diagnosis. In Study III, the control group was comprised of 254 children, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with no history of speech-language pathology disorders. The postural and morphologic characteristics of the stomatognathic system of mouth breathing children researched in Study I were labial and lingual resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, bite and morphology of lower lip, cheeks and hard palate, observed by anthroposcopy approach. The results indicated that the most common aspects in the sample were half-open lips in resting position, tongue lowered on the mouth\'s floor in resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, alteration of the bite, labioverted, symmetry of the cheeks and alteration of the hard palate. In Studies II and III, the children were submitted to anthropometric assessment and the orofacial measurements obtained were upper lip, lower lip, philtrum, upper face, middle face, lower face, sides of the face and maximum interincisal distance. The instrument used was the electronic digital sliding caliper Starrett Series 727. The results of Study II showed that there was no statistically difference between the most of averages of the orofacial measurements and proportions of mouth breathing children, according to ages. The results of Study III showed that in some orofacial measurements and proportions there was statistically difference between the two studied populations. In analysis of the three studies, it can be concluded that the anthroposcopic alterations seems to be more evident in mouth breathers than anthropometric alterations. Finally, the anthropometry shows useful in speech-language pathology assessment and supplements visual judgment with quantitative measurements.