The thesis with the topic of proposing new therapeutic materials for clients diagnosed with aphasia brings more profound understanding of separate field of speech therapy, which is aphasiology. The first part of the thesis introduces the theoretical basis to the issues of aphasia, concentrates on fundamental definition of aphasia, etiology and symptomatology. Moreover, the thesis describes the possibilities of aphasia therapy and lastly, it covers the differential diagnostics of aphasia. The second part of the thesis covers in detail the Boston Classification System of Aphasia, introduces to the reader the foundations that were the basis for the propositions of the therapeutic materials. The second part describes in detail the very process of designing therapeutic materials in general and it also provides concrete propositions of such materials with possible applications. The appendix includes examples of proposed materials, both theoretically explained and physically created for the reader to examine.

This diploma thesis deals with practical measurement and diagnostics on chosen Hyundai Santa Fe vehicle and on the training panel. The thesis is divided into two parts. The first part is to familiarize the reader with the fuel system of the diesel engine with the common-rail pressure magazine, with the concept of serial and parallel diagnostics. In the second part, the diplomat performs serial and parallel diagnostics of the diesel engine fuel system on the vehicle and on the training panel. The diplomant will further describe the measured data and evaluate the differences in the measurements.

The thesis deals with possibilities of application of VAG-COM PROFI diagnostic kit in forensic engineering. After defining a theoretical basis, according to possibilities of evaluation of technical condition of a vehicle, the thesis is focused on applying diagnostic methods using above mentioned diagnostic kit. With respect to opportunities of identification of driving parameters, possibility of acceleration measurement and estimation of engine power are introduced. Describing of methodology and making the final statement are contained in the thesis as a part of every single measurement.

The aim of the Master‘s Thesis is the measurement and analysis of vibrations on the machine tool parts using a vibration sensor. This work also contains an overview of the current knowledge regarding the issue of the vibrations and the vibration diagnostics, measurement itself and analysis of the measured vibrations.

The diploma thesis deals with relation of students to the future, connections between time perspective and achievement motivation and possibilities of diagnostic strategies of researched areas. The diploma thesis is divided into two parts - practical and theoretical one. Emphasis is given on practical part. Theoretical part looks into scientific solutions of time perspective by way of cognitive and personality concepts of motivation (Nuttina, Zimbarda, Pavelková work). I minutely deal with relation between time perspective and achievement motivation which is presented within theoretical approaches of Atkinson, Raynor, Heckhasen. Theoretical part deals with theoretical conception of achievement motivation (in order to deep insight to these issues) as well as it deals with diagnostic approaches and methods of time perspective and achievement motivation. Practical part presents research which took place in period from March to May 2013 in Vysočina region and was focused on high school students. The research focuses on looking for student's relation to future with concentration on achievement fear aspects, relation between time perspective and achievement motivation, possibilities of diagnostic methods and restrictions of observed areas. Heart of the diploma thesis is elaborating of "Method of...

This Diploma thesis thematizes the problem of students' time perspective and its diagnostics. The whole text is divided into two parts - theoretical and practical with emphasis on the theoretical part. The theoretical part will look upon the conceptions of time perspective. Ideas of time perception, the influence of time on human behavior and a connection of time pespective with an achievement motivation are presented. The personality-motivational concept of time perspective by European expert of motivational psychology Jopeph Nuttin are analyzed. From the domestic authors I describe the concept of perpsective orientation by Isabella Pavelkova. These theories are completed with information gained by Rayner, Gjesme and Fraisse. The important section is a chapter where diagnostics and specifics methods are presented. The empirical section contains the results of research provided by 5 classes of high school students with an eight year (or four year) study plan in April 2012 in Caslav. Using two questionaries (Motivational Induction Method and Perspective Orientation Questionary). Motivational Induction Method investigates objects of students' time perspective and summarized these themes into exact time frames. The Perspective Orientation Questionnaire helps investigate external validity. Key words:...

Human carbonic anhydrases are metalloenzymes that are involved in many physiological processes in the body, but also play an important role in the pathogenesis of numerous diseases. Under regular conditions, expression of carbonic anhydrase IX (CAIX) is very limited, unlike that of other 14 human carbonic anhydrase isozymes. But in hypoxic tumors this enzyme is highly overexpressed on the cell surface. For this reason, this enzyme represents a good target for therapy and diagnosis of tumors and thus various anti-CAIX monoclonal antibodies and specific inhibitors are being developed. In this work we investigated the possibility to use fluorescent polymer conjugate carrying a CAIX specific inhibitor for florescent labeling of tumor cells. Specific binding of polymer conjugate to different cell lines was investigated by flow cytometry and confocal microscopy. Binding properties of the polymer conjugate was compared to CAIX specific monoclonal antibody M75 and its single-chain fragment scFv M75. Ability of the polymer conjugate to inhibit CAIX enzyme activity was also investigated. For these experiments, recombinant protein CAII was prepared and purified, which was also used for protein crystallization. Tests of inhibitory activities allowed to identify novel inhibitors CAIX with better inhibitory...

Pulmonary arterial thromboembolism (PATE) is the third most common acute cardiovascular disease after myocardial infarction and stroke. Frequently individual symptoms are nonspecific making clinical diagnosis of acute PATE difficult. Computed tomographic (CT) pulmonary angiography has become the first line examination performed in patients with suspected acute PATE. Severity of acute PATE directs treatment strategies and allows prognostication of outcomes. It is reported that patients with normal blood pressure and impaired RV function have a larger average PATE-related short-term mortality compared to patients with normal RV function. Cardiopulmonary CT with retrospective electrocardiographic synchronization allows simultaneous evaluation of pulmonary arterial bed, cardiac function, coronary arteries and thoracic aorta. We have used cardiopulmonary CT to detect right and left ventricular changes in the setting of acute PATE, to describe relationship between reduced right ventricular function and pulmonary arterial thromboembolic burden and to find best predictors of markedly reduced right ventricular ejection fraction. Reproducibility of right ventricular measurements in cardiopulmonary CT images and quality analysis of cardiopulmonary CT for evaluation of coronary arteries and thoracic aorta were done. Results of the study show that both the right and left ventricles develop detectable changes in acute PATE patients, the decrease of the right ventricular ejection fraction... [to full text] / Plaučių arterijos trombinė embolija (PATE) – sunki ūminė ir neretai atkrintanti širdies ir kraujagyslių liga. Tik miokardo infarktas ir galvos smegenų insultas yra dažnesni negu ūminė PATE. Ūminės PATE diagnostika nėra lengva. Klinikiniai simptomai dažnai esti neraiškūs ar nespecifiniai. Šiuolaikinėje klinikinėje praktikoje pirmo pasirinkimo tyrimas įtariant ūminę PATE yra plaučių arterijos kompiuterinės tomografijos (KT) angiografija. Sergančiųjų, kuriems dėl plaučių embolijos dar nėra išsivysčiusi sisteminė arterinė hipotenzija, mirštamumo rizika priklauso nuo embolijos apimties ir dešiniojo skilvelio būklės. Šie rodikliai rodo ligos sunkumą, kurį svarbu įvertinti parenkant ūminės PATE gydymą ir nusakant ligos prognozę. Taikydami sinchronizuotą su elektrokardiograma širdies ir plaučių KT norėjome aptikti dešiniojo ir kairiojo skilvelių būklės pokyčius sergantiesiems ūmine PATE, nustatyti sutrikusios dešiniojo skilvelio veiklos sąsajas su embolijos apimtimi bei aptikti rodiklius, tiksliausiai prognozuojančius ženklų dešiniojo skilvelio išstūmimo frakcijos sumažėjimą. Patikrinome, kaip tiksliai gali būti atkartojami dešiniojo skilvelio tūrio ir morfometrijos matavimai. Taip pat atlikome širdies ir plaučių KT vainikinių arterijų ir krūtininės aortos vaizdumo analizę. Nustatėme, kad įvykus ūminei PATE aptinkami ne tik dešiniojo bet ir kairiojo širdies skilvelio būklės pokyčiai, kad dešiniojo skilvelio išstūmimo frakcija mažėja proporcingai embolijos apimčiai, o dešiniojo ir... [toliau žr. visą tekstą]

Plaučių arterijos trombinė embolija (PATE) – sunki ūminė ir neretai atkrintanti širdies ir kraujagyslių liga. Tik miokardo infarktas ir galvos smegenų insultas yra dažnesni negu ūminė PATE. Ūminės PATE diagnostika nėra lengva. Klinikiniai simptomai dažnai esti neraiškūs ar nespecifiniai. Šiuolaikinėje klinikinėje praktikoje pirmo pasirinkimo tyrimas įtariant ūminę PATE yra plaučių arterijos kompiuterinės tomografijos (KT) angiografija. Sergančiųjų, kuriems dėl plaučių embolijos dar nėra išsivysčiusi sisteminė arterinė hipotenzija, mirštamumo rizika priklauso nuo embolijos apimties ir dešiniojo skilvelio būklės. Šie rodikliai rodo ligos sunkumą, kurį svarbu įvertinti parenkant ūminės PATE gydymą ir nusakant ligos prognozę. Taikydami sinchronizuotą su elektrokardiograma širdies ir plaučių KT norėjome aptikti dešiniojo ir kairiojo skilvelių būklės pokyčius sergantiesiems ūmine PATE, nustatyti sutrikusios dešiniojo skilvelio veiklos sąsajas su embolijos apimtimi bei aptikti rodiklius, tiksliausiai prognozuojančius ženklų dešiniojo skilvelio išstūmimo frakcijos sumažėjimą. Patikrinome, kaip tiksliai gali būti atkartojami dešiniojo skilvelio tūrio ir morfometrijos matavimai. Taip pat atlikome širdies ir plaučių KT vainikinių arterijų ir krūtininės aortos vaizdumo analizę. Nustatėme, kad įvykus ūminei PATE aptinkami ne tik dešiniojo bet ir kairiojo širdies skilvelio būklės pokyčiai, kad dešiniojo skilvelio išstūmimo frakcija mažėja proporcingai embolijos apimčiai, o dešiniojo ir... [toliau žr. visą tekstą] / Pulmonary arterial thromboembolism (PATE) is the third most common acute cardiovascular disease after myocardial infarction and stroke. Frequently individual symptoms are nonspecific making clinical diagnosis of acute PATE difficult. Computed tomographic (CT) pulmonary angiography has become the first line examination performed in patients with suspected acute PATE. Severity of acute PATE directs treatment strategies and allows prognostication of outcomes. It is reported that patients with normal blood pressure and impaired RV function have a larger average PATE-related short-term mortality compared to patients with normal RV function. Cardiopulmonary CT with retrospective electrocardiographic synchronization allows simultaneous evaluation of pulmonary arterial bed, cardiac function, coronary arteries and thoracic aorta. We have used cardiopulmonary CT to detect right and left ventricular changes in the setting of acute PATE, to describe relationship between reduced right ventricular function and pulmonary arterial thromboembolic burden and to find best predictors of markedly reduced right ventricular ejection fraction. Reproducibility of right ventricular measurements in cardiopulmonary CT images and quality analysis of cardiopulmonary CT for evaluation of coronary arteries and thoracic aorta were done. Results of the study show that both the right and left ventricles develop detectable changes in acute PATE patients, the decrease of the right ventricular ejection fraction... [to full text]

Tarp įvairių amžiaus grupių žmonių gana dažnai pasitaikančios anemijos yra susiję su geležies (Fe) ir jos junginių stoka. Geležies koncentracijos nustatymo kraujo serume tyrimas yra reikšmingas rodiklis Fe stokos anemijos diagnostikoje. Tyrimo tikslas - įvertinti raudonojo kraujo rodiklių ir geležies koncentracijos kraujo serume pokyčius kaip geležies stokos anemijos žymenis. Tyrimo uždaviniai: įvertinti raudonojo kraujo rodiklių pokyčius ir jų reikšmę vertinant Fe koncentracijos kraujo serume kitimą, šių rodiklių pokyčius priklausomai nuo tiriamų pacientų lyties, amžiaus ir sezono. Medžiaga ir metodai. Ištirta VšĮ Rokiškio psichiatrijos ligoninės 150 pacientų. Nustatyta: eritrocitų skaičius (RBC), hematokritas (HCT), vidutinis eritrocito tūris (MCV), eritrocitų pasiskirstymas pagal dydį (RDW), hemoglobinas (Hb), vidutinis hemoglobino kiekis eritrocite (MCH), vidutinė hemoglobino koncentracija eritrocituose (MCHC), geležis (Fe). Tyrimai atlikti pusiau automatiniais analizatoriais: RBC - impedansinis, Hb – cianmethemoglobininis, HCT analizatorius apskaičiuoja daugindamas eritrocitų skaičių iš vidutinio eritrocitų tūrio, MCHC analizatorius apskaičiuoja dalindamas hemoglobino koncentraciją iš hematokrito, MCV analizatorius nustato tiesiogiai, RDW - išreiškiamas eritrocitų tūrio variacijos koeficientu, MCH yra santykis tarp hemoglobino koncentracijos ir eritrocitų skaičiaus, Fe – kinetinis. Rezultatai ir išvados. Tyrimo rezultatai parodė, kad 25% tiriamų asmenų geležies... [toliau žr. visą tekstą] / Frequent occurrences of anaemia among people of various age groups are caused by a shortage of iron (Fe) and its compounds. Testing of serum iron concentration is a significant indicator of Fe deficiency in diagnosing anaemia. The aim of the research is to assess changes in red blood cell indicators and in serum iron concentration as signs of iron-deficiency anaemia. Objectives of the research: to assess changes in red blood cell indicators and their importance in assessing changes in serum iron concentration; to assess changes in these indicators that depend on the sex and age of the patients and the season of the year. Material and methods. One hundred and fifty patients at the Rokiškis Psychiatric Hospital were tested. The following was determined: erythrocyte count (RBC), hematocrit (HCT), mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin (Hb), mean corpuscular haemoglobin (MCH), mean cell haemoglobin concentration (MCHC), and iron (Fe). Testing was carried out using semi-automatic analysers: RBC—impedance; Hb—cianmethaemoglobin; the HCT analyser calculates by multiplying the red blood cell count by the MCV value; the MCHC analyser calculates by dividing the haemoglobin concentration by the hematocrit; the MCV analyser makes a direct count; RDW is an expression of the coefficient of variation in red cell volume distribution; MCH is derived from the ratio between the amount of haemoglobin and the number of erythrocytes present; and... [to full text]