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Enzymatic desymmetrization of prochiral cyclohexanones : synthesis of a non-peptidic NK2 antagonistHernandez, Maria Luisa Escudero January 2000 (has links)
No description available.
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Aspects of the chemistry of enol ethers : Synthesis and reactionsMortimore, M. P. January 1988 (has links)
No description available.
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Studies on 1,2 metallate rearrangements : application to Callystatin AWildman, Tanya January 2003 (has links)
No description available.
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Structure elucidation and studies relating to the synthesis of plasmalopentaene-12 /Keyes, Robert F., January 1992 (has links)
Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 204-213). Also available via the Internet.
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A Study of the Synthesis and Reactions of Enol LactonesPapalos, John George 08 1900 (has links)
The purpose of this investigation was to study the syntheses of enol lactones and to prepare a series of amide derivatives of these compounds.
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Hydroalkynylation of Oxocarbenium Intermediates via Au(I) CatalysisSmith, Courtney Smith 28 February 2017 (has links)
Au(I) catalysis has recently emerged as a powerful tool for the realization of a broad range of organic transformations. Despite this rapid development, attaining selectivity and maintaining catalyst stability remain significant challenges. Rational ligand design, such as the employment of NHC or TA ligands, has been used to confront these issues. This thesis focuses on the use of Au(I) catalysts bearing these ligands for the selective hydroalkynylation of enol ethers. By employing a TA-Au stabilized catalyst, [(OAr)3PAu(TA-H)]OTf, the intermolecular hydroalkynylation of enol ethers, a substrate that is well-known to promote decomposition of the gold cation, was efficiently achieved. As an expansion of this reaction, the NHC-Au catalyst, IPrAuNTf2, was utilized in a multicomponent system to promote the tandem hydroalkynylation of enol ethers formed in-situ via the cycloisomerization of alkynols. Further exploration of this tandem reaction revealed that IPrAuNTf2 catalyzes a cascade ring-expansion of the alkynylated heterocycles to form oxepines. The mechanistic and synthetic insight obtained from these developed reactions has the potential to be applied towards future studies in gold catalysis.
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Nouvelle voie de synthèse par catalyse de dérivés fonctionnalisés du stilbène.Nicks, Francois 22 October 2009 (has links)
La famille des phytoalexines est formée de molécules constituant une réponse de certains végétaux à différentes agressions comme par exemple, une attaque fongique, lexposition au rayonnement ultraviolet ou à lozone. Parmi les membres de cette famille, on trouve notamment le resvératrol, le picéatannol, les combretastatines et encore bien dautres composés dont la structure est basée sur un motif stilbénique. Ces dérivés possèdent des propriétés pharmacochimiques dun grand intérêt dans de nombreux domaines comme ceux des antioxydants, des antibactériens, des antiviraux et également dans la lutte contre le cancer et le diabète. La synthèse chimique est la voie la plus économique pour produire en masse ces substances. Parmi les nombreuses méthodes de synthèse mises au point, nous avons évalué la réaction de couplage décarbonylatif de Heck entre un ester dénol et un dérivé du styrène. Cette voie catalytique se base sur lutilisation de réactifs bon marché et conduit à la formation dacétone et de monoxyde de carbone comme uniques sous-produits. Ce couplage décarbonylatif ainsi que la synthèse préalable dun ester dénol ont été étudiés afin dêtre optimisés.
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The allylic amination of silyl enol ethers using N, N-bis-(trichloroethoxycarbonyl) sulfur diimide and efforts towards the synthesis of proaporphine alkaloidsRoberts, James Jackson 12 November 2013 (has links)
This doctoral dissertation described herein will be comprised of two parts. The first portion will address our efforts towards the synthesis of [alpha]-amino carbonyls from silyl enol ethers and the second portion will describe our unrelated efforts towards the synthesis of proaporphine alkaloids. A full discussion of the relevant literature, experiments and development of the methodologies will be provided along with all relevant experimental data. Part I: The [alpha]-amino carbonyl moiety has great potential for being a very useful synthetic intermediate for the incorporation of nitrogen owing to the synthetic utility and versatility of the carbonyl functional group. Despite this potential the synthesis has long been problematic owing to their tendency to undergo condensation reactions. We aimed to synthesize them utilizing a protected carbonyl in the form of a triisopropylsilyl enol ether and an electrophilic nitrogen source that could incorporate the nitrogen via an ene-[2,3] sigmatropic reaction sequence. To this end we used an N-sulfinyl carbamate as an electrophilic source of nitrogen that could be utilized for a regiospecific allylic amination of alkenes or could be used to form a highly reactive sulfur diimide that could be used for the allylic amination of alkenes or silyl enol ethers. Part II: Many pharmacologically important and synthetically interesting alkaloids have been formed in nature by the o,p oxidative phenolic coupling of various benzyl-tetrahydroisoquinoline alkaloids. One major class of alkaloids derived from this generalized oxidation is the proaporphine alkaloids and they possess an acid labile spirocyclic-dienone system obtained from this coupling. These compounds have great potential for being used for their anesthetic properties. Despite the relative ease of synthesizing the benzylisoquinoline alkaloids the application of the biomimetic oxidative coupling to make the quaternary center of these compounds gives very poor yields. We opted to form this spiro-dienone system by using a two step Suzuki coupling-para phenolate alkylation methodology that had been used to synthesize the related alkaloids codeine and narwedeine. In doing this we opted to extend the practical application of this methodology by the displacement of an alcohol derived leaving group. / text
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Cobalt(II) Catalyzed Asymmetric Hydrovinylation of Alkyl- and Trialkylsilyloxy-1,3-DienesPage, Jordan P. January 2012 (has links)
No description available.
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Structure elucidation and studies relating to the synthesis of plasmalopentaene-12Keyes, Robert F. 06 June 2008 (has links)
The glycerol enol ether, fecapentaene-12, is a direct acting fecal mutagen that is formed in the lower portion of the gastrointestional tract by anaerobic bacteria. The biological precursor to fecapentaene-12 is a natural product of mammalian origin whose role in the etiology of colon cancer is unknown.
Preliminary evidence indicated that the precursor may be a plasmalogen with an intact pentaenol ether moiety. Further structural studies by means of degradative methods and chromatographic techniques enabled the structure of the precursor to be elucidated. Based on the structure of the precursor, the name plasmalopentaene-12 was coined.
Synthetic methodology was developed for obtaining synthetic plasmalopentaene12. This was necessary in order to confirm the structure and to determine the precursor's biological role. The synthetic methodology proceeded through a novel "acyl migration" which enables the highly labile pentaenol ether to be generated late in the synthesis. Model studies indicated that this was a feasible pathway. It was also determined that this methodology may be highly adaptable to the synthesis of other plasmalogens and may also provide a new synthetic route to fecapentaene-12. / Ph. D.
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