Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Conselho Nacional de Desenvolvimento Científico e Tecnológico / Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro / Nesta tese são apresentadas a medida da taxa de produção de eventos difrativos e a extração da função de estrutura do antipróton para eventos de difração simples. A análise aqui apresentada é baseada em dados do detector DØ no Tevatron/Fermilab, colisor de prótons-antiprótons à energia de centro de massa de 1.96 TeV. A seleção de eventos difrativos é feita através de intervalos de rapidez - região do detector desprovida de partículas - determinados através da deposição de energia nas células do calorímetro DØ. A função de estrutura obtida nessa análise é comparada com resultados existentes dos experimentos H1 e CDF. / In this thesis we present a measurement of the diffractive to non-diffractive production rate and the extraction of the antiproton diffractive structure function. The analysis presented uses data from the DØ proton-antiproton collider at Tevatron/Fermilab with = 1.96 TeV. The data sample was selected using rapidity gap signatures determined through the sum of energy depositions in the DØ calorimeter cells. The measurements were performed on 0.19 pb-1 of Run IIa DØ data. The results are compared to H1 and CDF results."

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Conselho Nacional de Desenvolvimento Científico e Tecnológico / Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro / Nesta tese são apresentadas a medida da taxa de produção de eventos difrativos e a extração da função de estrutura do antipróton para eventos de difração simples. A análise aqui apresentada é baseada em dados do detector DØ no Tevatron/Fermilab, colisor de prótons-antiprótons à energia de centro de massa de 1.96 TeV. A seleção de eventos difrativos é feita através de intervalos de rapidez - região do detector desprovida de partículas - determinados através da deposição de energia nas células do calorímetro DØ. A função de estrutura obtida nessa análise é comparada com resultados existentes dos experimentos H1 e CDF. / In this thesis we present a measurement of the diffractive to non-diffractive production rate and the extraction of the antiproton diffractive structure function. The analysis presented uses data from the DØ proton-antiproton collider at Tevatron/Fermilab with = 1.96 TeV. The data sample was selected using rapidity gap signatures determined through the sum of energy depositions in the DØ calorimeter cells. The measurements were performed on 0.19 pb-1 of Run IIa DØ data. The results are compared to H1 and CDF results."

German question and Ostpolitik within the years 1963-1966 Petra Matějů MATĚJŮ, Petra. Německá a východní politika v letech 1963-1966. Praha, 2011. 103 s. Diplomová práce (Mgr.) Univerzita Karlova, Fakulta sociálních věd, Institut mezinárodních studií. Katedra německých a rakouských studií. Vedoucí diplomové práce PhDr. Tomáš Nigrin, Ph.D. The master thesis German question and Ostpolitik within the years 1963-1966 is focused on the attitudes of the parliamentary parties in the Federal Republic of Germany - CDU/CSU (Christian Democratic Union and Social Democratic Party of Germany), FDP (Free Democratic Party) and SPD (Social Democratics Party of Germany) - to the policy towards the countries of the Eastern Bloc and with the changes in these attitudes in the period from 1963 to 1966, when the Federal Cabinet of Ludwig Erhard held rule. The main thesis of this study is the premise that in all the parliamentary parties in the Federal Republic of Germany a significant shift in the approach to the German question and Ostpolitik within the years 1963-1966 occurred. This thesis should be verified or refuted by means of a detailed chronological description and analysis of the progress of the issue, followed by the comparative analysis of the attitudes of the parties in view to the policy towards the Soviet...

The diploma thesis "The Question of Turkish Minority Integration in Germany During the Governing Period of the Black-Yellow Coalition 2009-2011" focuses on a widely discussed debate about the model of integration of the new coalition government CDU/CSU and FDP. The main purpose of the paper is to collect, analyse and interpret information about a current issue in Germany: social and cultural integration of the Turkish minority into the German mainstream culture. The topic is narrowed only to the first two years of the coalition project and focuses mainly on the events shortly before the final agreement and ends with the last occurrences in 2011. The main goal is to answer the main research question how the integration model of the current coalition changed and if there is a new strategy or continuity with the previous governments. The bodies which influence the long-term integration of this group are twofold: on one side are the German ministries and state institutions, on the other are Turkish representatives including those non-governmental organization that have their field of action within Germany. Apart from analysing the primary and secondary sources, expert interviews with relevant representatives of the institutions and distinct researchers will also be presented.

The aim of this in vitro study was to analyse the performance of CAD/CAM resin-based composites for the fabrication of long-term temporary fixed dental prostheses (FDP) and to compare it to other commercially available alternative materials regarding its long-term stability. Four CAD/CAM materials [Structur CAD (SC), VITA CAD-Temp (CT), Grandio disc (GD), and Lava Esthetic (LE)] and two direct RBCs [(Structur 3 (S3) and LuxaCrown (LC)] were used to fabricate three-unit FDPs. 10/20 FDPs were subjected to thermal cycling and mechanical loading by chewing simulation and 10/20 FDPs were stored in distilled water. Two FDPs of each material were forwarded to additional image diagnostics prior and after chewing simulation. Fracture loads were measured and data were statistically analysed. SC is suitable for use as a long-term temporary (two years) three-unit FDP. In comparison to CT, SC featured significantly higher breaking forces (SC > 800 N; CT < 600 N) and the surface wear of the antagonists was (significantly) lower and the abrasion of the FDP was similar. The high breaking forces (1100–1327 N) of GD and the small difference compared to LE regarding flexural strength showed that the material might be used for the fabrication of three-unit FDPs. With the exception of S3, all analysed direct or indirect materials are suitable for the fabrication of temporary FDPs.

L'étude systématique de l'hémostase post-thrombolytique a été peu étudiée. Chez 80 malades thrombolysés consécutifs, une étude prospective a comporté l'étude – aux heures 0, 2 et 24 – des facteurs de l'hémostase suivants: fibrinogène, plasminogène, PDF (produits de dégradation de la fibrine et du fibrinogène), D-dimères, alpha2-antiplasmine et facteur XIII, ainsi que l'hématocrite et la numération plaquettaire. Des calculs statistiques approfondis ont exploré les corrélations des variations des facteurs hémostatiques entre eux et avec 37 paramètres cliniques et étiologiques. Processus moléculaires post-thrombolytiques. Le rt-PA induit deux processus, indépendants statistiquement à la 2ème heure: d'une part une élévation des PDF et des D-dimères; d'autre part, une baisse du fibrinogène, corrélée à une baisse du plasminogène (r=0,48, p=0.01), de l'alpha2-antiplasmine (r=0.48, p =0.004) et du facteur XIII (r=0.44, p=0.01). La baisse du plasminogène est corrélée significativement avec celle de l'alpha2-antiplasmine (r=0.77, p<0.001), et du facteur XIII (r=0.47, p=0.02). La mise en jeu de facteurs anti-fibrinolytiques, qui n'avait jamais été décrite précédemment, peut jouer un rôle dans une limitation de la fibrinolyse et dans la rethrombose. Des corrélations sont notées entre la baisse précoce du plasminogène et l'étiologie cardioembolique (p=0.04), et un mauvais pronostic final (p=0.03), possiblement en rapport la thrombolyse intense de gros caillots. Les hématomes intra-cérébraux parenchymateux (HP) sont liés significativement à la baisse du fibrinogène (p=0.01) et à l'augmentation des PDF (p=0.01). Une baisse du fibrinogène au-dessous de 2g/L multiplie la probabilité de HP précoce par un facteur 12,82. Ainsi est confirmé le modèle d'une “coagulopathie précoce avec dégradation du fibrinogène”», prédictive de l'hématome, proposé par l'équipe lyonnaise de thrombolyse en 2004 / A systematic study of post-thrombolytic haemostasis has rarely been performed. In 80 consecutive patients, we have prospectively studied at hours 0, 2 and 24 the following parameters: fibrinogen, plasminogen, alpha2-antiplasmin, factor XIII, fibrin(ogen) Degradation Products (FDP), D-dimers, haematocrit and platelet count. Comprehensive statistical studies calculated correlations of the haemostatic values betwen themselves and with 38 etiological and clinical parameters. Molecular dynamics. Two changes between h0 and h2 were statistically independent: an increase in FDP and D-Dimers; a decrease in fibrinogen, plasminogen, alpha2-antiplasmin and factor XIII. At h2, the decrease in fibrinogen was significantly correlated with that of plasminogen (0.48, p = 0.01), alpha2-antiplasmin (0.48, p = 0.004), and factor XIII (0.44, p = 0.01). The decrease in plasminogen was significantly correlated with those of antifibrinolytic components, alpha2-antiplasmin (r=0.77, p<0.001) and factor XIII (0.47, p=0.02). To our knowledge, such an activation of antifibrinolytic components had not hitherto been mentioned. The h2 decrease of plasminogen was correlated with cardioembolic etiology (p=0.04) and final poor oucome (p=0.03), a fact possibly due to intense thrombolysis of large clots. Patients having early parenchymal hematomas (PH) showed h2 haemostasis disturbances: high FDP (p=0.01), and low fibrinogen (p=0.01). The decrease in fibrinogen less than 2g/L multiplies the odds of early PH by a factor 12.82. Thus, we confirm the model of an “early fibrinogen degradation coagulopathy” predictive of hematomas, which had been coined by the Lyon thrombolysis team in 2004

<div><div>In the forensic science community, there is a vast need for tools to help assist investigations when standard DNA profiling methods are uninformative. Methods such as Forensic DNA Phenotyping (FDP) and proteomics aims to help this problem and provide aid in investigations when other methods have been exhausted. FDP is useful by providing physical appearance information, while proteomics allows for the examination of difficult samples, such as hair, to infer human identity and ancestry. To create a “biological eye witness” or develop informative probability of identity match statistics through proteomically inferred genetic profiles, it is necessary to constantly strive to improve these methods. </div><div><br></div><div>Currently, two developmentally validated FDP prediction assays, ‘HIrisPlex’ and ‘HIrisplex-S’, are used on the capillary electrophoresis to develop a phenotypic prediction for eye, hair, and skin color based on 41 variants. Although highly useful, these assays are limited in their ability when used on the CE due to a 25 variant per assay cap. To overcome these limitations and expand the capacities of FDP, we successfully designed and validated a massive parallel sequencing (MPS) assay for use on both the ThermoFisher Scientific Ion Torrent and Illumina MiSeq systems that incorporates all HIrisPlex-S variants into one sensitive assay. With the migration of this assay to an MPS platform, we were able to create a semi-automated pipeline to extract SNP-specific sequencing data that can then be easily uploaded to the freely accessible online phenotypic prediction tool (found at https://hirisplex.erasmusmc.nl) and a mixture deconvolution tool with built-in read count thresholds. Based on sequencing reads counts, this tool can be used to assist in the separation of difficult two-person mixture samples and outline the confidence in each genotype call.<br></div><div><br></div><div>In addition to FDP, proteomic methods, specifically in hair protein analysis, opens doors and possibilities for forensic investigations when standard DNA profiling methods come up short. Here, we analyzed 233 genetically variant peptides (GVPs) within hair-associated proteins and genes for 66 individuals. We assessed the proteomic methods ability to accurately infer and detect genotypes at each of the 233 SNPs and generated statistics for the probability of identity (PID). Of these markers, 32 passed all quality control and population genetics criteria and displayed an average PID of 3.58 x 10-4. A population genetics assessment was also conducted to identify any SNP that could be used to infer ancestry and/or identity. Providing this information is valuable for the future use of this set of markers for human identification in forensic science settings. </div></div><div><br></div>

Die gesetzliche Grundlage kommunaler Baumschutzsatzungen ist in Sachsen das Naturschutzgesetz. Es ermächtigt die Gemeinden, per Satzung Teile von Natur und Landschaft als geschützte Landschaftsbestandteile festzusetzen. Die CDU/FDP-Koalition hatte im Jahr 2010 mit der Novelle des Sächsischen Naturschutzgesetzes den kommunalen Baumschutz beschnitten („Baum-Ab-Gesetz“).

Ziel dieser In-vitro-Studie war es, die Leistungsfähigkeit von kunststoffbasierten CAD/CAM-Kompositen für die Herstellung von langzeitprovisorischem, festsitzendem Zahnersatz (FDP) zu analysieren und sie hinsichtlich ihrer Langzeitstabilität mit anderen handelsüblichen Alternativmaterialien zu vergleichen. Vier CAD/CAM-Materialien [Structur CAD (SC), VITA CAD-Temp (CT), Grandio disc (GD) und Lava Esthetic (LE)] und zwei direkte RBC's [(Structur 3 (S3) und LuxaCrown (LC)] wurden zur Herstellung von dreigliedrigen Brücken verwendet. 10/20 Brücken wurden einer Alterungssimulation mittels Thermocycling und mechanischer Belastung durch Kausimulation unterzogen und die anderen 10 Brücken wurden in destilliertem Wasser gelagert. Zwei Brücken von jedem Material wurden vor und nach der Kausimulation einer zusätzlichen Bilddiagnostik unterzogen. Die Bruchbelastung wurde gemessen und die Daten wurden statistisch ausgewertet.:Inhaltsverzeichnis 1. Einführung 1 1.1 Einleitung 1 1.2 Werkstoffe auf Kunststoffbasis für die subtraktive CAD/CAM-Technologie 3 1.3 Werkstoffbezogene Parameter 5 1.3.1 Zeitraffende Beanspruchung 6 1.3.2 Abrasion 7 1.3.3 Oberflächenrauheit 8 1.3.4 Mikrostruktur 9 1.3.5 Mechanische Belastbarkeit 10 1.4 Zielsetzung und Fragestellung der vorliegenden Studie 10 2. Publikationsmanuskript 12 3. Zusammenfassung der Arbeit 28 4. Literaturverzeichnis 32 5. Anlagen 38 5.1 Darstellung des eigenen Beitrags zur Publikationspromotion 38 5.2 Erklärung über die eigenständige Abfassung der Arbeit 39